TDR Targets

Basic information

Technical information

TDR Targets ID: 846000
Name: 8-[6-methoxy-3-(4-methoxyphenyl)sulfonylquino lin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
MW: 470.538 | Formula: C24H26N2O6S
H donors: 0 H acceptors: 3 LogP: 3 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)c(N1CCC3(CC1)OCCO3)c(cn2)S(=O)(=O)c1ccc(cc1)OC
InChi: 1S/C24H26N2O6S/c1-29-17-3-6-19(7-4-17)33(27,28)22-16-25-21-8-5-18(30-2)15-20(21)23(22)26-11-9-24(10-12-26)31-13-14-32-24/h3-8,15-16H,9-14H2,1-2H3
InChiKey: SVSDOXXJTMWZIZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

8-[6-methoxy-3-(4-methoxyphenyl)sulfonyl-4-quinolyl]-1,4-dioxa-8-azaspiro[4.5]decane
8-[6-methoxy-3-(4-methoxyphenyl)sulfonyl-quinolin-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane
MLS000418862
SMR000236840

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	solute carrier family 5 (sodium/choline cotransporter), member 7	Starlite/ChEMBL	No references
Homo sapiens	fatty acid synthase	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium leprae	PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma mansoni	high-affinity choline transporter	Get druggable targets OG5_131601	All targets in OG5_131601
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma japonicum	IPR001734,Na+/solute symporter,domain-containing	Get druggable targets OG5_131601	All targets in OG5_131601
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	Get druggable targets OG5_126633	All targets in OG5_126633
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	GH02984p	Get druggable targets OG5_131601	All targets in OG5_131601
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	KR domain domain-containing protein, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks12	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma japonicum	High affinity choline transporter 1, putative	Get druggable targets OG5_131601	All targets in OG5_131601
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks3	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	Get druggable targets OG5_126633	All targets in OG5_126633
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	Get druggable targets OG5_126633	All targets in OG5_126633
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Onchocerca volvulus		Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Echinococcus multilocularis	high affinity choline transporter 1	Get druggable targets OG5_131601	All targets in OG5_131601
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks2	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	acyl carrier protein	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	Short-chain dehydrogenase/reductase SDR, related	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131601	All targets in OG5_131601
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	Get druggable targets OG5_126633	All targets in OG5_126633
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	Soraphen polyketide synthase A, related	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Cryptosporidium parvum	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Echinococcus granulosus	high affinity choline transporter 1	Get druggable targets OG5_131601	All targets in OG5_131601
Mycobacterium ulcerans	polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	Get druggable targets OG5_126633	All targets in OG5_126633
Onchocerca volvulus	Fatty acid synthase homolog	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks4	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0056	0.0113
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.0261	0.3423
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0056	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0056	0.0113
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0245	0.2725	1
Chlamydia trachomatis	3-oxoacyl-ACP synthase	0.0008	0.0003	0.5
Echinococcus multilocularis	3 oxoacyl (acyl carrier protein) synthase	0.0008	0.0003	0.0003
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.0414	0.1336
Mycobacterium ulcerans	polyketide synthase Pks9	0.002	0.0144	0.1875
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0298	0.0298
Schistosoma mansoni	hypothetical protein	0.0033	0.0298	0.063
Schistosoma mansoni	cpg binding protein	0.0031	0.0273	0.0578
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.003	0.0261	0.0546
Brugia malayi	beta-lactamase	0.0043	0.0414	0.0872
Loa Loa (eye worm)	beta-lactamase	0.0043	0.0414	0.0872
Mycobacterium tuberculosis	Conserved protein	0.0009	0.002	0.0063
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0056	0.0118
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.1122	0.237
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0024	0.0193	0.253
Mycobacterium ulcerans	polyketide synthase MbtD	0.0009	0.0022	0.0258
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0414	0.1459
Echinococcus granulosus	high affinity choline transporter 1	0.042	0.4728	1
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0046	0.0447	0.0945
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0056	0.0118
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0414	0.1513
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.0261	0.3423
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0741	0.1562
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0056	0.0118
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0056	0.0113
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.0282	0.0909
Brugia malayi	Sodium:solute symporter family protein	0.0046	0.0447	0.094
Echinococcus granulosus	dnaJ subfamily B	0.042	0.4727	0.9998
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.003	0.0261	0.581
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0056	0.0113
Onchocerca volvulus	Fatty acid synthase homolog	0.0054	0.0537	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.0414	0.1336
Schistosoma mansoni	coup transcription factor	0.0012	0.0056	0.0118
Echinococcus multilocularis	high affinity choline transporter 1	0.042	0.4728	0.4728
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0298	0.0625
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0024	0.0193	0.4155
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0757	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0757	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0056	0.0113
Echinococcus granulosus	solute carrier family 5	0.0046	0.0447	0.0945
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0024	0.0193	0.253
Mycobacterium leprae	Probable lipase LipE	0.0043	0.0414	0.9591
Schistosoma mansoni	cpg binding protein	0.0029	0.0254	0.0537
Echinococcus granulosus	cpg binding protein	0.0031	0.0273	0.0578
Brugia malayi	ecdysteroid receptor	0.0012	0.0056	0.0113
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0032	0.0282	0.6337
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0254	0.0532
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0056	0.0056
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0056	0.0118
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0025	0.0203	0.4398
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0254	0.0532
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.001	0.0035	0.0111
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1122	0.237
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0056	0.0118
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0757	0.16
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0056	0.0118
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.0414	0.1513
Onchocerca volvulus		0.0043	0.0414	0.7449
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0056	0.0113
Onchocerca volvulus		0.0043	0.0414	0.7449
Toxoplasma gondii	type I fatty acid synthase, putative	0.0032	0.0282	0.3707
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0109	0.0226
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0633	0.1338
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0056	0.0113
Echinococcus multilocularis	solute carrier family 5	0.0046	0.0447	0.0447
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.1122	0.237
Loa Loa (eye worm)	fatty acid synthase	0.003	0.0256	0.0537
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0414	0.1459
Schistosoma mansoni	hypothetical protein	0.0033	0.0298	0.063
Mycobacterium ulcerans	polyketide synthase	0.0032	0.0282	0.3707
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0056	0.0113
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0056	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0414	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0056	0.0113
Brugia malayi	Methyltransferase-like protein 4	0.0009	0.002	0.0037
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0238	0.0498
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0056	0.0056
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0414	0.1459
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0414	0.0877
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0032	0.0282	0.6337
Brugia malayi	beta-lactamase family protein	0.0043	0.0414	0.0872
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.0414	0.0877
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0298	0.063
Onchocerca volvulus		0.0052	0.0516	0.9555
Schistosoma mansoni	hypothetical protein	0.0072	0.0741	0.1567
Plasmodium falciparum	3-oxoacyl-acyl-carrier protein synthase I/II	0.0008	0.0003	0.5
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0298	0.0298
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0021	0.0044
Entamoeba histolytica	hypothetical protein, conserved	0.0245	0.2725	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.1122	0.237
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0056	0.0113
Mycobacterium tuberculosis	Polyketide synthetase MbtD (polyketide synthase)	0.0009	0.0022	0.007
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0056	0.0113
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0056	0.0118
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0757	0.244
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0414	0.0872
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0298	0.0298
Echinococcus granulosus	GPCR family 2	0.0033	0.0298	0.063
Mycobacterium ulcerans	polyketide synthase	0.003	0.0261	0.3423
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0757	0.0757
Onchocerca volvulus		0.0028	0.0238	0.3783
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0056	0.0118
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.0261	0.3423
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0056	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0447	0.094
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0056	0.0118
Toxoplasma gondii	ABC1 family protein	0.0043	0.0414	0.5463
Schistosoma mansoni	inositol transporter	0.0046	0.0447	0.0945
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0056	0.0056
Schistosoma mansoni	sodium/solute symporter	0.0046	0.0447	0.0945
Giardia lamblia	Rrm3p helicase	0.0245	0.2725	1
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0298	0.0625
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.0414	0.1336
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.1593	0.3369
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.0282	0.3707
Mycobacterium tuberculosis	Hypothetical protein	0.0009	0.002	0.0063
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0056	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0298	0.0625
Onchocerca volvulus		0.0043	0.0414	0.7449
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.002	0.014	0.1818
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0056	0.0118
Toxoplasma gondii	type I fatty acid synthase, putative	0.0021	0.0161	0.2106
Trichomonas vaginalis	esterase, putative	0.0043	0.0414	0.1459
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0757	0.277
Leishmania major	hypothetical protein, conserved	0.0009	0.002	0.0064
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0056	0.0113
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0017	0.0112	0.036
Mycobacterium ulcerans	fatty acid synthase Fas	0.0009	0.0024	0.0288
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.0261	0.084
Mycobacterium ulcerans	thioesterase	0.0025	0.0203	0.2661
Brugia malayi	steroid hormone receptor	0.0012	0.0056	0.0113
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.1593	0.3369
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0278	0.31	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0056	0.0056
Leishmania major	hypothetical protein, conserved	0.0043	0.0414	0.1513
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0028	0.0238	0.0498
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0245	0.2725	0.2725
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0046	0.0447	0.0447
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0556	0.734
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0414	0.0872
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.1593	0.3369
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0021	0.0038
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.003	0.0261	0.084
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0056	0.0113
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0022	0.0164	0.0527
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.0414	0.0877
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.0414	0.0872
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0056	0.0113
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0757	0.16
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0146	0.1593	0.3369
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0056	0.0056
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.0414	0.1336
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0021	0.0021
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0056	0.0118
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0146	0.1593	0.1593
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0046	0.0447	0.0447
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.003	0.0261	0.084
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.0741	0.1562
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0056	0.0113
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.0414	0.1336
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0057	0.0569	0.1199
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0056	0.0056
Mycobacterium leprae	Polyketide synthase Pks13	0.0045	0.0431	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0056	0.0113
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0019	0.0035
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.0033	0.0298	0.063
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0012	0.0055	0.0178
Echinococcus multilocularis	dnaJ subfamily B	0.042	0.4727	0.4727
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.0414	0.9591
Onchocerca volvulus		0.0029	0.0254	0.4112
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0056	0.0118
Mycobacterium ulcerans	lipase LipD	0.0043	0.0414	0.5463
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0414	0.1336
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0015	0.009	0.1163
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0245	0.2725	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0298	0.063
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0032	0.0282	0.0909
Schistosoma mansoni	high-affinity choline transporter	0.042	0.4728	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0056	0.0118
Echinococcus granulosus	sodium:glucose cotransporter	0.0046	0.0447	0.0945
Mycobacterium ulcerans	polyketide synthase Pks13	0.0045	0.0431	0.5683
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0045	0.0431	0.139
Loa Loa (eye worm)	hypothetical protein	0.042	0.4728	1
Mycobacterium ulcerans	hypothetical protein	0.0043	0.0414	0.5463
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.0414	0.1459
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.0414	0.0414
Schistosoma mansoni	cpg binding protein	0.0031	0.0273	0.0578
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0029	0.025	0.0806
Brugia malayi	AMP-binding enzyme family protein	0.0009	0.0022	0.0041
Brugia malayi	GH02984p	0.042	0.4728	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0146	0.1593	0.3366
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0056	0.0113
Echinococcus multilocularis	cpg binding protein	0.0031	0.0273	0.0273
Schistosoma mansoni	3-oxoacyl-[ACP] synthase	0.0008	0.0003	0.0005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0056	0.0118
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0056	0.0118
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0146	0.1593	0.3369
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0245	0.2725	1
Schistosoma mansoni	inositol transporter	0.0046	0.0447	0.0945
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0414	0.0872
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0056	0.0113
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0245	0.2725	1
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.003	0.0261	0.581
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.0414	0.5463
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0056	0.0113
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0757	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0056	0.0113
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.0414	0.1336
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0056	0.0118
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.002	0.0144	0.1875
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.0414	0.5463
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.002	0.0144	0.2941
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0028	0.0238	0.0767
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0056	0.0113
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0056	0.0056
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0414	1
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0245	0.2725	1
Mycobacterium ulcerans	beta-lactamase	0.0043	0.0414	0.5463
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0414	0.1336
Mycobacterium tuberculosis	Conserved protein	0.0043	0.0414	0.1336
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0032	0.0282	0.0909
Brugia malayi	beta-lactamase family protein	0.0043	0.0414	0.0872
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0056	0.0113
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0245	0.2725	1
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0056	0.0118
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.0414	0.1513
Schistosoma mansoni	hypothetical protein	0.0245	0.2725	0.5764
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0414	0.0872
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0046	0.0447	0.0945
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0146	0.1593	0.3366
Schistosoma mansoni	methyltransferase-related	0.0009	0.002	0.0042
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0245	0.2725	0.5764
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0056	0.0118
Schistosoma mansoni	hypothetical protein	0.0033	0.0298	0.063
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0056	0.0113
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0032	0.0282	0.3707
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0056	0.0118
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0046	0.0447	0.0447
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0056	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0056	0.0113
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0056	0.0113
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0056	0.0113
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0146	0.1593	0.1593
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.0414	0.1459
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0056	0.0056
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0029	0.025	0.0806
Onchocerca volvulus		0.0046	0.0447	0.812
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0056	0.0113
Brugia malayi	nuclear hormone receptor	0.0012	0.0056	0.0113
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0025	0.0198	0.0637
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0757	0.16
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0056	0.0113
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.0261	0.3423
Loa Loa (eye worm)	acyl carrier protein	0.0014	0.0075	0.0152
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0046	0.0447	0.5891
Mycobacterium ulcerans	thioesterase TesA	0.0025	0.0203	0.2661
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0245	0.2725	0.5
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0495	0.1042
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0056	0.0118
Schistosoma mansoni	hypothetical protein	0.042	0.4727	0.9998
Wolbachia endosymbiont of Brugia malayi	3-oxoacyl-ACP synthase	0.0008	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0056	0.0113
Trichomonas vaginalis	conserved hypothetical protein	0.0245	0.2725	1
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0045	0.0431	0.139
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0032	0.0282	0.6337
Echinococcus granulosus	3 oxoacyl acyl carrier protein synthase	0.0008	0.0003	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0414	0.0872
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0046	0.0447	0.0945
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0757	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0298	0.0625
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0025	0.0203	0.0655
Mycobacterium tuberculosis	Probable fatty acid synthase Fas (fatty acid synthetase)	0.0009	0.0024	0.0078
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0245	0.2725	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.0414	0.1336
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.0414	0.0872

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	2.7 uM	PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	4 uM	PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	13.80384265 uM	PUBCHEM_BIOASSAY: Dose responses of compounds that inhibit the Choline Transporter (CHT) - 5 point CRC. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488975, AID488997, AID493221, AID493222]	ChEMBL.	No reference
Potency (functional)	= 0.2512 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 1.4125 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.2753 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	9.285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	10 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	125.8925 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1341327
Search by Saint Jude

Bibliographic References

No literature references available for this target.

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Detailed information for compound 846000