Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.0172 | 0.2006 | 0.1811 |
Echinococcus multilocularis | carbonic anhydrase | 0.0081 | 0.0546 | 0.0315 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.3804 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0172 | 0.2006 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.0081 | 0.0546 | 0.0315 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0081 | 0.0546 | 0.0546 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0239 | 0.0239 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.0723 | 0.0723 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0239 | 0.0239 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.2494 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0081 | 0.0546 | 0.1362 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.3804 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1891 | 0.1891 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0172 | 0.2006 | 0.2006 |
Echinococcus granulosus | carbonic anhydrase | 0.0081 | 0.0546 | 0.0315 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1891 | 0.1891 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0546 | 0.1362 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0172 | 0.2006 | 0.7838 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0172 | 0.2006 | 0.1811 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0284 | 0.3804 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0231 | 0.2942 | 0.72 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0546 | 0.1362 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0308 | 0.4175 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0081 | 0.0546 | 0.1362 |
Schistosoma mansoni | carbonic anhydrase | 0.0081 | 0.0546 | 0.0546 |
Echinococcus granulosus | geminin | 0.0165 | 0.1891 | 0.1693 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0172 | 0.2006 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0081 | 0.0546 | 0.0315 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0672 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0092 | 0.0723 | 0.0496 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0081 | 0.0546 | 0.1362 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0081 | 0.0546 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.0546 | 0.0546 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.3804 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0284 | 0.3804 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0284 | 0.3804 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.2494 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0308 | 0.4175 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0308 | 0.4175 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0172 | 0.2006 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0139 | 0.1476 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0172 | 0.2006 | 0.7838 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0092 | 0.0723 | 0.2149 |
Echinococcus granulosus | carbonic anhydrase | 0.0081 | 0.0546 | 0.0315 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0081 | 0.0546 | 0.1362 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.3804 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.3804 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0546 | 0.1362 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0081 | 0.0546 | 0.1362 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.3804 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0239 | 0.0239 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0672 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.3804 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0092 | 0.0723 | 0.0496 |
Echinococcus multilocularis | geminin | 0.0165 | 0.1891 | 0.1693 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0172 | 0.2006 | 0.7838 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0081 | 0.0546 | 0.1362 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0172 | 0.2006 | 0.7838 |
Onchocerca volvulus | 0.0231 | 0.2942 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0239 | 0.0239 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0172 | 0.2006 | 0.2006 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0284 | 0.3804 | 1 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0308 | 0.4175 | 0.5 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0308 | 0.4175 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0308 | 0.4175 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0308 | 0.4175 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0308 | 0.4175 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0081 | 0.0546 | 0.0315 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0172 | 0.2006 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0239 | 0.0239 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0284 | 0.3804 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0092 | 0.0723 | 0.2149 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0081 | 0.0546 | 0.0546 |
Toxoplasma gondii | hypothetical protein | 0.0081 | 0.0546 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.