Detailed information for compound 846330

Basic information

Technical information
  • TDR Targets ID: 846330
  • Name: N,N-diethyl-4-oxo-2,3,3a,5-tetrahydro-1H-pyrr olo[1,2-a]quinoxaline-7-sulfonamide
  • MW: 323.411 | Formula: C15H21N3O3S
  • H donors: 1 H acceptors: 3 LogP: 1.43 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc2c(c1)NC(=O)C1N2CCC1)CC
  • InChi: 1S/C15H21N3O3S/c1-3-17(4-2)22(20,21)11-7-8-13-12(10-11)16-15(19)14-6-5-9-18(13)14/h7-8,10,14H,3-6,9H2,1-2H3,(H,16,19)
  • InChiKey: DAKYRIUIGYQQFY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,N-diethyl-4-keto-2,3,3a,5-tetrahydro-1H-pyrrolo[1,2-a]quinoxaline-7-sulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.0031 0.0819 0.0819
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.2828 0.2828
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.3493 0.8837
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0361 0.1331
Loa Loa (eye worm) phosphofructokinase 0.0112 0.3792 0.3792
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.3255 0.4183
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0962 0.0849
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.1223 0.1709
Loa Loa (eye worm) hypothetical protein 0.0025 0.0587 0.0587
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.3255 0.372
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0074 0.0074
Entamoeba histolytica hypothetical protein 0.0036 0.1012 0.2422
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0271 0.0639
Trypanosoma brucei ISWI complex protein 0.0016 0.027 0.029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0271 0.029
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0587 0.0325
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0575 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0587 0.0325
Schistosoma mansoni chromobox protein 0.0072 0.232 0.232
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0074
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0067 0.014
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0074 0.0074
Trichomonas vaginalis hypothetical protein 0.0035 0.0962 0.0849
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0074 0.0074
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0177 0.0168
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0336 0.0336
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0074 0.0104
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.3255 0.4548
Brugia malayi 6-phosphofructokinase 0.0112 0.3792 0.3792
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0617 0.0356
Loa Loa (eye worm) helicase 0.0012 0.0123 0.0123
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0801 0.0686
Onchocerca volvulus 0.0086 0.2828 0.3221
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0123 0.056
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0801 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0271 0.0946
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.1166 0.4754
Brugia malayi Associated with TFs and helicases family protein 0.0012 0.0123 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0074 0.0074
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.1278 0.1278
Echinococcus granulosus dnaJ subfamily C 6 0.0063 0.2003 0.2799
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.3255 0.3171
Onchocerca volvulus 0.0245 0.8624 1
Brugia malayi CHD4 protein 0.0014 0.0195 0.0195
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0801 0.2301
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.2082 0.2082
Mycobacterium ulcerans 6-phosphofructokinase 0.0112 0.3792 0.3619
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0801 0.3199
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1708 0.2387
Onchocerca volvulus 0.0043 0.1249 0.1374
Brugia malayi Bromodomain containing protein 0.0081 0.2655 0.2655
Echinococcus granulosus geminin 0.0205 0.7156 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0117 0.0117
Brugia malayi RNA binding protein 0.0065 0.2082 0.2082
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0408 0.0408
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0012 0.0123 0.0123
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0166 0.0166
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0793 0.1108
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0271 0.0271
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.3255 0.3171
Entamoeba histolytica hypothetical protein 0.0043 0.1278 0.3147
Loa Loa (eye worm) hypothetical protein 0.0154 0.5325 0.5325
Echinococcus granulosus bloom syndrome protein 0.0025 0.0598 0.0836
Plasmodium vivax M18 aspartyl aminopeptidase, putative 0.0074 0.24 1
Leishmania major ATP-dependent phosphofructokinase 0.0112 0.3792 0.4883
Onchocerca volvulus 0.0032 0.0848 0.0904
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0012 0.0123 0.0172
Entamoeba histolytica hypothetical protein 0.0043 0.1278 0.3147
Loa Loa (eye worm) hypothetical protein 0.004 0.1166 0.1166
Brugia malayi steroid hormone receptor 0.001 0.0074 0.0074
Trichomonas vaginalis protein kinase inhibitor, putative 0.0063 0.2003 0.1903
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0074 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.3255 0.3171
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0587 0.0868
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0074 0.0104
Loa Loa (eye worm) hypothetical protein 0.0046 0.1363 0.1363
Giardia lamblia Kinase, PLK 0.0098 0.3255 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0074 0.0104
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0325 0.0148
Brugia malayi jmjC domain containing protein 0.001 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0043 0.1278 0.3147
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.139 1
Loa Loa (eye worm) acetyltransferase 0.0152 0.5247 0.5247
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0962 0.0849
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0336 0.047
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0123 0.00000000015598
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0012 0.0123 0.056
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0819 0.5745
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.1166 0.2844
Loa Loa (eye worm) hypothetical protein 0.0048 0.1462 0.1462
Brugia malayi hypothetical protein 0.0012 0.0123 0.0123
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.4195 0.4195
Schistosoma mansoni thyroid hormone receptor 0.001 0.0074 0.0074
Entamoeba histolytica aspartyl aminopeptidase, putative 0.0074 0.24 0.6208
Brugia malayi SET domain containing protein 0.0013 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0074 0.24 0.24
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0067
Loa Loa (eye worm) bromodomain containing protein 0.0022 0.0493 0.0493
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.3293 0.4602
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0325 0.0148
Schistosoma mansoni bromodomain containing protein 0.0069 0.2213 0.2213
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0801 1
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0074 0.24 0.24
Loa Loa (eye worm) hypothetical protein 0.0074 0.24 0.24
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0195 0.0195
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0123 0.00000000015598
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.5005 0.6994
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0587 0.0587
Echinococcus multilocularis peregrin 0.0036 0.1016 0.1419
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.2082 0.2082
Echinococcus multilocularis transcription factor btf3 0.0036 0.1012 0.1414
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0801 0.0686
Brugia malayi glutathione reductase 0.0046 0.1359 0.1359
Loa Loa (eye worm) hypothetical protein 0.0025 0.0587 0.0587
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0801 0.3199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0074 0.0074
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0587 0.0325
Brugia malayi Bromodomain containing protein 0.0036 0.1016 0.1016
Loa Loa (eye worm) glutaminase 0.0283 1 1
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0074 0.24 0.3068
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.1249 0.1249
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.1012 0.4096
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0587 0.0325
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0074 0.0074
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0271 0.0149
Trypanosoma brucei polo-like protein kinase 0.0098 0.3255 0.4183
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1708 0.2387
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0123 0.0319
Trypanosoma cruzi hypothetical protein, conserved 0.022 0.7714 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1708 0.2387
Loa Loa (eye worm) hypothetical protein 0.0154 0.5325 0.5325
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0123 0.0319
Plasmodium vivax heterochromatin protein 1, putative 0.0012 0.0123 0.0319
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.1359 0.2985
Trichomonas vaginalis set domain proteins, putative 0.0245 0.8624 0.8607
Brugia malayi jmjC domain containing protein 0.0099 0.3293 0.3293
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.3792 0.3714
Echinococcus multilocularis geminin 0.0205 0.7156 1
Plasmodium falciparum thioredoxin reductase 0.0046 0.1359 0.5574
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0271 0.029
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.2828 0.2828
Loa Loa (eye worm) hypothetical protein 0.0012 0.0123 0.0123
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1708 0.2387
Schistosoma mansoni hypothetical protein 0.001 0.0053 0.0053
Schistosoma mansoni coup transcription factor 0.001 0.0074 0.0074
Plasmodium falciparum thioredoxin reductase 0.0016 0.0271 0.0946
Brugia malayi chromobox protein homolog 3 0.004 0.1166 0.1166
Schistosoma mansoni chromobox protein 0.0072 0.232 0.232
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.3255 0.3171
Brugia malayi PHD-finger family protein 0.003 0.0793 0.0793
Echinococcus multilocularis 6 phosphofructokinase 0.0112 0.3792 0.5299
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.3255 0.4548
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0074 0.0104
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.139 0.5703
Plasmodium vivax hypothetical protein, conserved 0.003 0.0793 0.3165
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0271 0.029
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1456 0.135
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0123 0.0123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0123 0.00000000015598
Loa Loa (eye worm) hypothetical protein 0.0048 0.1435 0.1435
Mycobacterium ulcerans glutaminase 0.0283 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0123 0.00000000015598
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0617 0.05
Schistosoma mansoni hypothetical protein 0.0016 0.027 0.027
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0074 0.0074
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.2828 0.3952
Loa Loa (eye worm) hypothetical protein 0.0018 0.0361 0.0361
Brugia malayi AF-10 protein 0.001 0.0053 0.0053
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0575 0.3927
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.3493 0.8837
Echinococcus multilocularis phd:f box containing protein 0.001 0.0048 0.0067
Leishmania major hypothetical protein, conserved 0.022 0.7714 1
Schistosoma mansoni zinc finger protein 0.0016 0.027 0.027
Trichomonas vaginalis chromobox protein, putative 0.0043 0.1278 0.1169
Brugia malayi M-phase phosphoprotein, mpp8 0.0012 0.0123 0.0123
Onchocerca volvulus Alhambra homolog 0.003 0.0793 0.084
Toxoplasma gondii thioredoxin reductase 0.0046 0.1359 0.9774
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0177 0.0168
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0801 0.0686
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0067 0.0067
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.1166 0.1277
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0074 0.0074
Echinococcus multilocularis aspartyl aminopeptidase 0.0074 0.24 0.3354
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0074 0.24 0.2306
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0074 0.0074
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.1278 0.1786
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0271 0.029
Giardia lamblia PHD finger protein 15 0.003 0.0793 0.2276
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.3255 0.3255
Brugia malayi Aspartyl aminopeptidase 0.0074 0.24 0.24
Brugia malayi Heterochromatin protein 1 0.0072 0.232 0.232
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0048 0.0067
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0177 0.0146
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0793 0.0793
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.3255 0.4183
Schistosoma mansoni phd/f-box containing protein 0.001 0.0048 0.0048
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.3792 0.3792
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.1462 0.1462
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0271 0.029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0271 0.029
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0067 0.0094
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0543 0.0759
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0012 0.0123 0.0123
Brugia malayi jmjC domain containing protein 0.001 0.0048 0.0048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0074 0.0104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0271 0.029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0123 0.0123
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.3255 0.3255
Brugia malayi hypothetical protein 0.0043 0.1278 0.1278
Trichomonas vaginalis glutaminase, putative 0.0283 1 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0018 0.0361 0.0361
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.3493 0.8837
Loa Loa (eye worm) 6-phosphofructokinase 0.0112 0.3792 0.3792
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.3255 0.3171
Echinococcus multilocularis zinc finger protein 0.0024 0.0565 0.079
Schistosoma mansoni hypothetical protein 0.0205 0.7156 0.7156
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0543 0.0543
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0575 0.0313
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0048
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0271 0.029
Schistosoma mansoni jumonji domain containing protein 0.001 0.0048 0.0048
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0053 0.0033
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0587 0.1265
Brugia malayi jmjC domain containing protein 0.0038 0.1096 0.1096
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0271 0.0149
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0271 0.1659
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.001 0.0053 0.0019
Trichomonas vaginalis chromobox protein, putative 0.0043 0.1278 0.1169
Mycobacterium tuberculosis Probable aminopeptidase PepC 0.0074 0.24 0.584
Brugia malayi Muscleblind-like protein 0.0154 0.5325 0.5325
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0048 0.0067
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0271 0.029
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0801 0.0686
Mycobacterium tuberculosis Probable reductase 0.0104 0.3493 0.8837
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0094 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0587 0.0868
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.3255 0.4183
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.3293 0.4602
Schistosoma mansoni protein phosphatase 2C 0.001 0.0048 0.0048
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0801 0.0686
Loa Loa (eye worm) hypothetical protein 0.0012 0.0123 0.0123
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0575 0.5744
Brugia malayi Thioredoxin reductase 0.0046 0.1359 0.1359
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.2078 0.2904
Mycobacterium leprae PROBABLE AMINOPEPTIDASE PEPC 0.0074 0.24 0.5461
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0043 0.1278 0.1278
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0048
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0053 0.0006
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.3792 0.4883
Loa Loa (eye worm) hypothetical protein 0.0018 0.0361 0.0361
Brugia malayi beta-NAC-like protein 0.0036 0.1012 0.1012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0123 0.0123
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0074 0.0074
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.1096 0.1531
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.3918 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.139 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0123 0.00000000015598
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0123 0.00000000041997
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0074 0.0074
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0598 0.0481
Mycobacterium ulcerans hypothetical protein 0.0025 0.0587 0.0325
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0361 0.0248
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0053 0.0006
Plasmodium falciparum M18 aspartyl aminopeptidase 0.0074 0.24 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0617 0.0742
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0575 0.0864
Echinococcus granulosus Chromo domain 0.0012 0.0123 0.0172
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.3918 1
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0598 0.0836
Mycobacterium ulcerans hypothetical protein 0.0025 0.0617 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.1012 0.0899
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.3255 0.3171
Trypanosoma cruzi ISWI complex protein 0.0016 0.027 0.029
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.1012 0.1257
Schistosoma mansoni zinc finger protein 0.0024 0.0565 0.0565
Onchocerca volvulus 0.0025 0.0587 0.06
Echinococcus granulosus FTZ F1 alpha 0.001 0.0074 0.0104
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0819 0.1144
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0962 0.0849
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0575 0.3927
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0074
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0074 0.0074
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0587 0.0587
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0195 0.0273
Brugia malayi Pre-SET motif family protein 0.0215 0.754 0.754
Brugia malayi hypothetical protein 0.0156 0.5391 0.5391
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0074 0.0104
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.1278 0.1407
Onchocerca volvulus 0.0012 0.0123 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2082 0.2082
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.1462 0.1462
Schistosoma mansoni hypothetical protein 0.0205 0.7156 0.7156
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0067 0.0067
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0271 0.0271
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.3792 0.3792
Brugia malayi nuclear hormone receptor 0.001 0.0074 0.0074
Leishmania major basic transcription factor 3a, putative 0.0036 0.1012 0.1257
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.1963 0.1963
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.3493 0.8837
Echinococcus granulosus Chromobox protein 3 0.0012 0.0123 0.0172
Leishmania major hypothetical protein, conserved 0.0016 0.027 0.029
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0048 0.0067
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0074 0.24 0.2306
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0067 0.008
Plasmodium vivax hypothetical protein, conserved 0.001 0.0053 0.0019
Schistosoma mansoni glutaminase 0.0283 1 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0361 0.1331
Echinococcus granulosus phd:f box containing protein 0.001 0.0048 0.0067
Brugia malayi nuclear receptor NHR-88 0.001 0.0074 0.0074
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0801 0.3199
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.3792 0.3714
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.012 0.0168
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.5247 0.7333
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0325 0.0148
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0074 0.0104
Echinococcus granulosus tar DNA binding protein 0.0065 0.2082 0.2909
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0123 0.00000000041997
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1456 0.135
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.1462 0.2043
Echinococcus multilocularis Chromo domain 0.0012 0.0123 0.0172
Onchocerca volvulus 0.0012 0.0123 0.0057
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0336 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1708 0.1708
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0123 0.00000000015598
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0035 0.0962 0.0849
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.4195 0.4195
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2082 0.2082
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.1012 0.4096
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.3792 1
Schistosoma mansoni hypothetical protein 0.0021 0.0471 0.0471
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.1024 0.1431
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0271 0.029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0123 0.00000000015598
Plasmodium falciparum glutathione reductase 0.0016 0.0271 0.0946
Trypanosoma cruzi aspartyl aminopeptidase, putative 0.0074 0.24 0.3068
Schistosoma mansoni hypothetical protein 0.0012 0.0123 0.0123
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0587 0.0037
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0012 0.0123 0.056
Echinococcus granulosus muscleblind protein 0.0154 0.5325 0.7442
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0305 0.1093
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0074 0.0074
Schistosoma mansoni chromobox protein 0.0012 0.0123 0.0123
Entamoeba histolytica hypothetical protein 0.0012 0.0123 0.00000000041997
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0074 0.0074
Schistosoma mansoni chromobox protein 0.0012 0.0123 0.0123
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0112 0.3792 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0587 0.0587
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.139 0.1282
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0074 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0074 0.0074
Echinococcus multilocularis tar DNA binding protein 0.0065 0.2082 0.2909
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0361 0.171
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.1012 0.0899
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0074
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0074 0.0104
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0052 0.1578 0.1578
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0298 0.1863
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0575 0.0313
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0801 0.1846
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1708 0.1708
Schistosoma mansoni thyroid hormone receptor 0.001 0.0074 0.0074
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0067 0.0094
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0587 0.0703
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0074 0.0074
Brugia malayi phosphofructokinase 0.0112 0.3792 0.3792
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0575 0.0687
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0048 0.0048
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0271 0.0946
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0123 0.0319
Loa Loa (eye worm) ICD-1 protein 0.0036 0.1012 0.1012
Trypanosoma cruzi hypothetical protein, conserved 0.022 0.7714 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0112 0.3792 0.9623
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0271 0.029
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0012 0.0123 0.0319
Plasmodium vivax glutathione reductase, putative 0.0046 0.1359 0.5574
Loa Loa (eye worm) hypothetical protein 0.0025 0.0587 0.0587
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.012 0.0168
Brugia malayi Protein cec-1. 0.0012 0.0123 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0736 0.062
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.1462 0.2043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0074 0.0104
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0035 0.0962 0.0849
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0177 0.0168
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.3493 0.8731
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0801 0.5609
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0048 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.0123 0.0123
Brugia malayi ecdysteroid receptor 0.001 0.0074 0.0074
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0271 0.029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0325 0.0148
Loa Loa (eye worm) hypothetical protein 0.0012 0.0123 0.0123
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0012 0.0123 0.0123
Trypanosoma brucei trypanothione reductase 0.0046 0.1359 0.171
Onchocerca volvulus 0.0156 0.5391 0.6218
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0074 0.0074
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0123 0.00000000015598
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0074 0.0104
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.232 0.232
Brugia malayi jmjC domain containing protein 0.001 0.0048 0.0048
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0801 0.0686
Echinococcus granulosus jumonji domain containing protein 0.0042 0.1223 0.1709
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0123 0.00000000015598
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0012 0.0123 0.0172
Trypanosoma brucei aspartyl aminopeptidase, putative 0.0074 0.24 0.3068
Echinococcus multilocularis chromobox protein 2 0.0012 0.0123 0.0172
Echinococcus multilocularis chromobox protein 1 0.0072 0.232 0.3242
Loa Loa (eye worm) hypothetical protein 0.0156 0.5391 0.5391
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.1012 0.0899
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0048 0.0048
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0471 0.0471
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.1359 0.171
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0067 0.014
Brugia malayi jmjC domain containing protein 0.001 0.0048 0.0048
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.5247 0.5247
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0271 0.029
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.1096 0.1096
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0271 0.1659
Loa Loa (eye worm) TAR-binding protein 0.0065 0.2082 0.2082
Trichomonas vaginalis conserved hypothetical protein 0.004 0.1166 0.1056
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.1278 0.1786
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0074 0.0074
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0598 0.0481
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0271 0.0946
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0587 0.1265
Brugia malayi Valyl-tRNA synthetase 0.0012 0.0123 0.0123
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0053 0.0033
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0195 0.0273
Schistosoma mansoni hypothetical protein 0.003 0.0793 0.0793
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.3255 0.3255
Schistosoma mansoni aspartyl aminopeptidase (M18 family) 0.0074 0.24 0.24
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0617 0.0356
Loa Loa (eye worm) hypothetical protein 0.0032 0.0848 0.0848
Loa Loa (eye worm) RNA binding protein 0.0065 0.2082 0.2082
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.3255 0.8537
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0617 0.095
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0598 0.0598
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0801 0.3199
Brugia malayi MH2 domain containing protein 0.0123 0.4195 0.4195
Trichomonas vaginalis chromobox protein, putative 0.0072 0.232 0.2224
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.3918 1
Schistosoma mansoni transcription factor btf3 0.0036 0.1012 0.1012
Trypanosoma cruzi metallo-peptidase, Clan MH, Family M20 0.0074 0.24 0.3068
Brugia malayi PHD-finger family protein 0.0029 0.0766 0.0766
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.5247 0.5247
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0587 0.0703
Leishmania major aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 0.0074 0.24 0.3068
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0048 0.0048
Echinococcus granulosus chromobox protein 1 0.0072 0.232 0.3242
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0793 0.1108
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1708 0.1708
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.139 0.1942
Loa Loa (eye worm) glutathione reductase 0.0046 0.1359 0.1359
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0488 0.1872
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.3493 0.8837
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.139 0.1282
Echinococcus multilocularis chromobox protein 1 0.0072 0.232 0.3242
Plasmodium falciparum heterochromatin protein 1 0.0012 0.0123 0.0319
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0177 0.0054
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.1012 0.1257
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.1096 0.1096
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.3255 0.3171
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.2828 0.3952
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0575 0.0687
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.3792 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.1096 0.1096
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0112 0.3792 0.4883
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0793 0.0793
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0777 0.1086
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0074 0.0104
Loa Loa (eye worm) hypothetical protein 0.0012 0.0125 0.0125
Loa Loa (eye worm) RecQ helicase 0.0025 0.0598 0.0598
Schistosoma mansoni DNA helicase recq5 0.001 0.0067 0.0067
Trypanosoma brucei hypothetical protein, conserved 0.022 0.7714 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0617 0.0742
Loa Loa (eye worm) hypothetical protein 0.0086 0.2828 0.2828
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0617 0.0862
Loa Loa (eye worm) DnaJ domain-containing protein 0.0063 0.2003 0.2003
Echinococcus multilocularis dnaJ subfamily C 6 0.0063 0.2003 0.2799
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2082 0.2082
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0271 0.0946
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.1359 0.5574
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0587 0.0325
Brugia malayi TAR-binding protein 0.0065 0.2082 0.2082
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0074 0.24 0.2306
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0587 0.0325
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0361 0.0093
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0074
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.0048 0.0048
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0575 0.224
Trypanosoma cruzi ISWI complex protein 0.0016 0.027 0.029
Toxoplasma gondii NAC domain-containing protein 0.0036 0.1012 0.7182
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0271 0.029
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0271 0.0378
Brugia malayi 6-phosphofructokinase 0.0112 0.3792 0.3792
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0048 0.0067
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0067 0.0094
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0123 0.00000000015598
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0117 0.0117
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0543 0.0759
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.004 0.1166 0.1056
Entamoeba histolytica phosphofructokinase, putative 0.0112 0.3792 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0271 0.0378
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.2078 0.2904
Brugia malayi Bromodomain containing protein 0.0043 0.1271 0.1271
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0123 0.00000000015598
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0074 0.0104
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.1382 0.1931
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0587 0.1265
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.1012 0.1257
Echinococcus granulosus peregrin 0.0036 0.1016 0.1419
Echinococcus granulosus chromobox protein 2 0.0012 0.0123 0.0172
Echinococcus multilocularis muscleblind protein 1 0.0154 0.5325 0.7442
Loa Loa (eye worm) hypothetical protein 0.0018 0.0361 0.0361
Mycobacterium tuberculosis Conserved protein 0.0025 0.0617 0.095
Entamoeba histolytica hypothetical protein 0.0043 0.1278 0.3147
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0587 0.0703
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0801 0.1505
Trichomonas vaginalis Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase 0.0035 0.0962 0.0849
Schistosoma mansoni hypothetical protein 0.0063 0.2003 0.2003
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2082 0.2082
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0271 0.029
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.754 0.754
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0074
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0801 0.5609
Loa Loa (eye worm) hypothetical protein 0.0012 0.0123 0.0123
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0012 0.0123 0.00000000015598
Echinococcus granulosus aspartyl aminopeptidase 0.0074 0.24 0.3354
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0793 0.5549
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0074
Echinococcus multilocularis Chromobox protein 3 0.0012 0.0123 0.0172
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.3918 1
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0617 0.0356
Echinococcus granulosus transcription factor btf3 0.0036 0.1012 0.1414
Schistosoma mansoni jumonji domain containing protein 0.0078 0.2553 0.2553
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0801 0.0686
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0617 0.0862
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0617 0.0742
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0074 0.0074
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0587 0.0325
Loa Loa (eye worm) hypothetical protein 0.0018 0.0361 0.0361
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.1012 0.2422
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0575 0.224
Echinococcus granulosus chromobox protein 1 0.0072 0.232 0.3242
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0195 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2082 0.2082
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0074 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0074 0.0074
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0074 0.0074
Mycobacterium ulcerans hypothetical protein 0.0025 0.0617 0.0356
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1708 0.1708
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.003 0.0793 0.0793
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0074 0.0104
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0271 0.029
Entamoeba histolytica aminopeptidase, putative 0.0074 0.24 0.6208
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.1048 0.1465
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.3792 0.3714
Schistosoma mansoni nuclear hormone receptor 0.001 0.0074 0.0074
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.1048 0.1465
Loa Loa (eye worm) hypothetical protein 0.0073 0.236 0.236
Loa Loa (eye worm) aspartyl aminopeptidase 0.0074 0.24 0.24
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0074 0.0104
Echinococcus granulosus zinc finger protein 0.0024 0.0565 0.079
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0271 0.029
Echinococcus multilocularis muscleblind protein 0.0154 0.5325 0.7442
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.1382 0.1931
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0575 0.0835
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0112 0.3792 0.9655
Loa Loa (eye worm) hypothetical protein 0.004 0.114 0.114
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0067 0.0094
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0074 0.0104
Brugia malayi DnaJ domain containing protein 0.0063 0.2003 0.2003
Schistosoma mansoni kinase 0.005 0.1503 0.1503
Brugia malayi PHD-finger family protein 0.0012 0.0125 0.0125
Plasmodium vivax SET domain protein, putative 0.0031 0.0819 0.3276
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0587 0.0037
Schistosoma mansoni phosphatidylserine receptor 0.001 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0125 0.4249 0.4249
Leishmania major trypanothione reductase 0.0046 0.1359 0.171
Plasmodium falciparum glutathione reductase 0.0046 0.1359 0.5574
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0048 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0736 0.062
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.1166 0.3449
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0336 0.047
Echinococcus granulosus 6 phosphofructokinase 0.0112 0.3792 0.5299
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1708 0.1708
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.1359 0.1359
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0074 0.0074
Brugia malayi glutaminase DH11.1 0.0283 1 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0123 0.00000000041997
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0074
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0012 0.0123 0.00000000015598
Trichomonas vaginalis chromobox protein, putative 0.0072 0.232 0.2224
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0819 0.0819
Trichomonas vaginalis phosphofructokinase, putative 0.0112 0.3792 0.3714
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0793 0.5549
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0074 0.0104
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0074 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0074 0.0074
Plasmodium falciparum phd finger protein, putative 0.003 0.0793 0.3165
Schistosoma mansoni DNA helicase recq1 0.001 0.0067 0.0067
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0074 0.0074
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0801 0.5609
Schistosoma mansoni 6-phosphofructokinase 0.0112 0.3792 0.3792
Entamoeba histolytica hypothetical protein 0.0024 0.0575 0.1231

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5805 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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