Detailed information for compound 846706

Basic information

Technical information
  • TDR Targets ID: 846706
  • Name: (5E)-5-(pyridin-4-ylmethylidene)-1,3-thiazoli dine-2,4-dione
  • MW: 206.221 | Formula: C9H6N2O2S
  • H donors: 1 H acceptors: 3 LogP: 1.13 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)S/C/1=C/c1ccncc1
  • InChi: 1S/C9H6N2O2S/c12-8-7(14-9(13)11-8)5-6-1-3-10-4-2-6/h1-5H,(H,11,12,13)/b7-5+
  • InChiKey: SNBCHQYHZKXQQY-FNORWQNLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-5-(4-pyridylmethylene)thiazolidine-2,4-dione
  • (5E)-5-(4-pyridylmethylene)thiazolidine-2,4-quinone
  • BAS 00253495
  • 5-Pyridin-4-ylmethylene-thiazolidine-2,4-dione
  • SDCCGMLS-0065154.P001
  • ZINC01269289
  • STK089719
  • BIM-0019644.P001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens monoamine oxidase A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) Get druggable targets OG5_130722 All targets in OG5_130722
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi amine oxidase, flavin-containing family protein monoamine oxidase A 527 aa 474 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0988 0.1136
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0022 0.0357 0.0406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0025 0.0459 0.0525
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0025 0.0459 0.3006
Onchocerca volvulus 0.0155 0.4173 0.5057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Toxoplasma gondii NADPH-glutathione reductase 0.0022 0.0357 0.2336
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0027
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0759 0.4438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0667 0.6753
Brugia malayi hypothetical protein 0.0297 0.8229 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.1611 0.1935
Loa Loa (eye worm) animal heme peroxidase 0.0155 0.4173 0.4771
Brugia malayi SWIRM domain containing protein 0.0025 0.0459 0.0531
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0759 0.0417
Plasmodium falciparum glutathione reductase 0.0063 0.1527 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0357 0.1913
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0156 0.0619
Loa Loa (eye worm) hypothetical protein 0.0036 0.0759 0.0868
Onchocerca volvulus 0.0155 0.4173 0.5057
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0233 0.0627
Brugia malayi beta-lactamase family protein 0.0036 0.0759 0.0896
Loa Loa (eye worm) hypothetical protein 0.0015 0.0176 0.0201
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0459 0.1749
Schistosoma mansoni hypothetical protein 0.0297 0.8229 0.9717
Echinococcus multilocularis geminin 0.0168 0.4549 0.5516
Treponema pallidum NADH oxidase 0.0022 0.0357 0.5
Schistosoma mansoni peroxidasin 0.0155 0.4173 0.4914
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0022 0.0357 0.1913
Plasmodium vivax glutathione reductase, putative 0.0063 0.1527 1
Loa Loa (eye worm) beta-lactamase 0.0036 0.0759 0.0868
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0025 0.0459 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0667 0.6753
Loa Loa (eye worm) follicle stimulating hormone receptor 0.023 0.6315 0.7219
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1125 0.1342
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0759 0.0896
Brugia malayi beta-lactamase 0.0036 0.0759 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0411 0.4161
Schistosoma mansoni thyroid hormone receptor 0.0135 0.3599 0.4235
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0156 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0732 0.7408
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0759 0.0871
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0342 0.3465
Plasmodium falciparum thioredoxin reductase 0.0022 0.0357 0.0959
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0759 0.0417
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.1611 0.1899
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0733 0.4337
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0357 0.1913
Leishmania major UDP-galactopyranose mutase 0.0025 0.0459 0.2572
Loa Loa (eye worm) hypothetical protein 0.0036 0.0759 0.0868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0988 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0063 0.1527 0.1833
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0156 0.0162
Leishmania major trypanothione reductase 0.0063 0.1527 0.9457
Brugia malayi RE40412p 0.0017 0.0233 0.0255
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.0459 0.2572
Brugia malayi Peroxidasin 0.0155 0.4173 0.5057
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Trichomonas vaginalis glutathione reductase, putative 0.0022 0.0357 0.3611
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0759 0.0451
Schistosoma mansoni hypothetical protein 0.0305 0.8468 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0025 0.0459 0.0531
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0156 0.0619
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.1527 0.9457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0412 0.4171
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0022 0.0357 0.1526
Brugia malayi Thioredoxin reductase 0.0063 0.1527 0.1833
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.3312 0.4008
Brugia malayi Animal haem peroxidase family protein 0.0155 0.4173 0.5057
Echinococcus multilocularis thioredoxin glutathione reductase 0.0063 0.1527 0.1833
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0022 0.0357 0.0406
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0357 0.1913
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0269 0.0279
Onchocerca volvulus Peroxidasin homolog 0.0155 0.4173 0.5057
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0176 0.0186
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0176 0.0186
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0759 0.7682
Loa Loa (eye worm) blistered cuticle protein 3 0.0155 0.4173 0.4771
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0233 0.0627
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0027
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0759 0.0451
Mycobacterium tuberculosis Conserved protein 0.0036 0.0759 0.0451
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0328 0.1729
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0759 0.0871
Loa Loa (eye worm) glutathione reductase 0.0063 0.1527 0.1746
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.1611 1
Schistosoma mansoni thyroid hormone receptor 0.0135 0.3599 0.4235
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0022 0.0357 0.1913
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.1611 0.1935
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0176 0.0201
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0023 0.0027
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0022 0.0357 0.1526
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0759 0.0451
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0412 0.4171
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0988 0.5982
Loa Loa (eye worm) hypothetical protein 0.0025 0.0459 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0732 0.7408
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0733 0.4337
Loa Loa (eye worm) hypothetical protein 0.0122 0.3238 0.3701
Loa Loa (eye worm) hypothetical protein 0.0315 0.8747 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0759 0.7682
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0733 0.4337
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0176 0.0186
Trypanosoma brucei trypanothione reductase 0.0063 0.1527 0.9457
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0759 0.4505
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0667 0.6753
Echinococcus granulosus conserved hypothetical protein 0.0017 0.0233 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0667 0.6753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0667 0.6753
Trichomonas vaginalis esterase, putative 0.0036 0.0759 0.7682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0477 0.4826
Echinococcus granulosus protein cereblon 0.0297 0.8229 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.1611 0.1935
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0025 0.0459 0.2542
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0025 0.0459 0.0516
Echinococcus granulosus peroxidasin 0.0155 0.4173 0.5057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0156 0.1579
Echinococcus multilocularis cdgsh iron sulfur domain containing protein 0.0288 0.7971 0.9686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0156 0.1579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0576 0.5829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0484 0.4901
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.1611 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0759 0.0451
Entamoeba histolytica hypothetical protein, conserved 0.0297 0.8229 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Mycobacterium tuberculosis Conserved protein 0.0036 0.0759 0.0451
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0025 0.0459 0.0516
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0357 0.1913
Loa Loa (eye worm) hypothetical protein 0.0036 0.0759 0.0868
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0759 0.0896
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0256 0.1264
Brugia malayi glutathione reductase 0.0063 0.1527 0.1833
Giardia lamblia GTOR 0.0044 0.0988 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1125 0.1286
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0156 0.0619
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0027
Loa Loa (eye worm) RecQ helicase 0.0021 0.0342 0.0391
Mycobacterium ulcerans oxidoreductase 0.0025 0.0459 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0412 0.4171
Brugia malayi RE40412p 0.0017 0.0233 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0484 0.4901
Schistosoma mansoni hypothetical protein 0.0168 0.4549 0.536
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0988 0.5982
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0822 0.0973
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0759 0.7682
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Echinococcus granulosus geminin 0.0168 0.4549 0.5516
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0022 0.0357 0.0959
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0156 0.1579
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0988 0.1176
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 1 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0025 0.0459 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0357 0.1913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0411 0.4161
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0176 0.0186
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0759 0.7682
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0022 0.0357 0.2336
Loa Loa (eye worm) hypothetical protein 0.0017 0.0233 0.0266
Loa Loa (eye worm) hypothetical protein 0.0033 0.0685 0.0784
Schistosoma mansoni hypothetical protein 0.0015 0.0176 0.018
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0988 0.5982
Loa Loa (eye worm) hypothetical protein 0.0017 0.022 0.0251
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0759 0.0451
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0732 0.7408
Onchocerca volvulus Peroxidasin homolog 0.0155 0.4173 0.5057
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0988 0.1129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0667 0.6753
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0357 0.1913
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0685 0.0807
Echinococcus granulosus GPCR family 2 0.0015 0.0176 0.0186
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0022 0.0357 0.0395
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0025 0.0459 0.0531
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.3599 0.4358
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0233 0.0627
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.1611 0.1842
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0759 0.0868
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0215 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0732 0.7408
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0988 0.5982
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0357 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0459 0.0525
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0156 0.0619
Toxoplasma gondii histone lysine-specific demethylase 0.0025 0.0459 0.3006
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0156 0.0619
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0759 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0357 0.1913
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0022 0.0357 0.0959
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.0459 0.0531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.006 0.0607
Onchocerca volvulus 0.0017 0.0233 0.0255
Onchocerca volvulus 0.0017 0.0233 0.0255
Brugia malayi Animal haem peroxidase family protein 0.0155 0.4173 0.5057
Echinococcus multilocularis GPCR, family 2 0.0015 0.0176 0.0186
Brugia malayi Uncharacterized hematopoietic stem/progenitor cells protein MDS029 0.0122 0.3238 0.3917
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0759 0.4505
Echinococcus granulosus cdgsh iron sulfur domain containing protein 0.0288 0.7971 0.9686
Mycobacterium tuberculosis Conserved hypothetical protein 0.0025 0.0459 0.0115
Toxoplasma gondii PfMNL-2 CISD1 family iron-sulfur protein, putative 0.0017 0.0233 0.1523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0805 0.8147
Loa Loa (eye worm) animal heme peroxidase 0.0155 0.4173 0.4771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0988 1
Loa Loa (eye worm) thioredoxin reductase 0.0063 0.1527 0.1746
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.0459 0.2572
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0333 0.9277 1
Onchocerca volvulus Peroxidase homolog 0.0155 0.4173 0.5057
Loa Loa (eye worm) hypothetical protein 0.0025 0.0459 0.0525
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0016 0.0192 0.0206
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.1611 0.188
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0023 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0412 0.4171
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.627 0.6629
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.3312 0.4008
Onchocerca volvulus Chorion peroxidase homolog 0.0155 0.4173 0.5057
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0025 0.0459 0.2266
Loa Loa (eye worm) hypothetical protein 0.0036 0.0759 0.0868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0667 0.6753
Echinococcus granulosus bloom syndrome protein 0.0021 0.0342 0.0389
Toxoplasma gondii thioredoxin reductase 0.0063 0.1527 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0988 0.1176
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0022 0.0357 0.5
Mycobacterium tuberculosis Conserved protein 0.0036 0.0759 0.0451
Echinococcus multilocularis protoporphyrinogen oxidase 0.0025 0.0459 0.0531
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0988 0.1142
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0156 0.0162
Onchocerca volvulus 0.0036 0.0759 0.0896
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0988 0.5982
Mycobacterium ulcerans dehydrogenase 0.0025 0.0459 0.0106
Onchocerca volvulus 0.0155 0.4173 0.5057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0732 0.7408
Loa Loa (eye worm) animal heme peroxidase 0.0155 0.4173 0.4771
Leishmania major hypothetical protein, conserved 0.0036 0.0759 0.4505
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.1611 1
Leishmania major hypothetical protein, unknown function 0.0017 0.0233 0.1113
Brugia malayi hypothetical protein 0.0155 0.4173 0.5057
Loa Loa (eye worm) hypothetical protein 0.0297 0.8229 0.9407
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0022 0.0357 0.1913
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0022 0.0357 0.1913
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0022 0.0357 0.1913
Plasmodium falciparum protoporphyrinogen oxidase 0.0025 0.0459 0.1749
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.1611 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1125 0.1342
Schistosoma mansoni hypothetical protein 0.0125 0.3312 0.3895
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Mycobacterium ulcerans monoamine oxidase 0.0025 0.0459 0.0106
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0342 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0549 0.5555
Mycobacterium ulcerans lipase LipD 0.0036 0.0759 0.0417
Schistosoma mansoni hypothetical protein 0.0015 0.0176 0.018
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0667 0.4369
Loa Loa (eye worm) hypothetical protein 0.0017 0.0233 0.0266
Schistosoma mansoni amine oxidase 0.0025 0.0459 0.0516
Schistosoma mansoni hypothetical protein 0.0015 0.0176 0.018
Echinococcus multilocularis protein cereblon 0.0297 0.8229 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0027
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0063 0.1527 0.1312
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0156 0.0162
Mycobacterium leprae Probable lipase LipE 0.0036 0.0759 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0759 0.0896
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0759 0.0451
Toxoplasma gondii ABC1 family protein 0.0036 0.0759 0.497
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0357 0.1913
Onchocerca volvulus Dual oxidase homolog 0.0155 0.4173 0.5057
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0027
Echinococcus multilocularis conserved hypothetical protein 0.0017 0.0233 0.0255
Loa Loa (eye worm) hypothetical protein 0.0025 0.0459 0.0525
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0759 0.0451
Onchocerca volvulus Protein cereblon homolog 0.0297 0.8229 1
Brugia malayi Blistered cuticle protein 3 0.0155 0.4173 0.5057
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0459 0.2266
Schistosoma mansoni hypothetical protein 0.0168 0.4549 0.536
Schistosoma mansoni CDGSH-type Zn finger-containing protein-like protein 0.0305 0.8468 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0025 0.0459 0.2266
Schistosoma mansoni hypothetical protein 0.0017 0.0233 0.0248
Trypanosoma cruzi trypanothione reductase, putative 0.0022 0.0357 0.1913
Mycobacterium ulcerans beta-lactamase 0.0036 0.0759 0.0417
Onchocerca volvulus 0.0122 0.3238 0.3917
Schistosoma mansoni peroxidasin 0.0155 0.4173 0.4914
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0988 0.5982
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0342 0.0389
Loa Loa (eye worm) hypothetical protein 0.0036 0.0759 0.0868
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0342 0.3465
Brugia malayi follicle stimulating hormone receptor 0.023 0.6315 0.7667
Brugia malayi Animal haem peroxidase family protein 0.0155 0.4173 0.5057
Plasmodium vivax thioredoxin reductase, putative 0.0063 0.1527 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0022 0.0357 0.0406
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0023 0.0027
Echinococcus multilocularis peroxidasin 0.0155 0.4173 0.5057
Brugia malayi hypothetical protein 0.0025 0.0459 0.0531
Loa Loa (eye worm) hypothetical protein 0.0036 0.0759 0.0868
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0027
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0016 0.0192 0.0206
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0156 0.0178
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0988 0.1176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0411 0.4161
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Schistosoma mansoni amine oxidase 0.0025 0.0459 0.0516
Loa Loa (eye worm) animal heme peroxidase 0.0155 0.4173 0.4771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0484 0.4901
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0477 0.4826
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0759 0.4505
Trichomonas vaginalis mercuric reductase, putative 0.0022 0.0357 0.3611
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0022 0.0357 0.1913
Plasmodium falciparum glutathione reductase 0.0022 0.0357 0.0959
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0023 0.0027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0156 0.1579
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0022 0.0357 0.1913
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0156 0.1579
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0025 0.0459 0.1749
Brugia malayi Animal haem peroxidase family protein 0.0155 0.4173 0.5057
Schistosoma mansoni hypothetical protein 0.0033 0.0685 0.0784
Mycobacterium ulcerans hypothetical protein 0.0036 0.0759 0.0417
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0023 0.0027
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0459 0.0115
Brugia malayi Animal haem peroxidase family protein 0.0155 0.4173 0.5057
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0759 0.7682
Schistosoma mansoni hypothetical protein 0.0015 0.0176 0.018
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0156 0.0619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0988 1
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0459 0.2266
Loa Loa (eye worm) hypothetical protein 0.0155 0.4173 0.4771
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0822 0.0973
Toxoplasma gondii zinc finger CDGSH-type domain-containing protein 0.0017 0.0233 0.1523
Loa Loa (eye worm) hypothetical protein 0.001 0.0023 0.0027
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0141 0.0925
Onchocerca volvulus 0.0025 0.0459 0.0531
Loa Loa (eye worm) hypothetical protein 0.0049 0.1125 0.1286
Toxoplasma gondii zinc finger cdgsh type protein 0.0017 0.0233 0.1523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0072 0.0729
Plasmodium falciparum thioredoxin reductase 0.0063 0.1527 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0176 0.0186
Brugia malayi hypothetical protein 0.0121 0.3194 0.3864
Echinococcus multilocularis 0.0025 0.0459 0.0531
Onchocerca volvulus Peroxidase homolog 0.0155 0.4173 0.5057
Onchocerca volvulus 0.0036 0.0759 0.0896
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0022 0.0357 0.1913
Onchocerca volvulus 0.0036 0.0759 0.0896
Loa Loa (eye worm) hypothetical protein 0.0025 0.0459 0.0525
Brugia malayi beta-lactamase family protein 0.0036 0.0759 0.0896
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0988 0.1136
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0176 0.0186
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.0459 0.0531

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of human recombinant MAOB by amplex red assay ChEMBL. 21742494
IC50 (binding) = 12.97 uM Inhibition of human recombinant MAOA assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline by fluorimetry ChEMBL. 21742494
IC50 (binding) = 22.27 uM Displacement of [3H]-rosiglitazone from human recombinant C-terminal His-tagged cytosolic domain of mitoNEET (32-108) by scintillation proximity assay ChEMBL. 21782425

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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