Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0.13 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0494 | 0.3801 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0494 | 0.3801 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0494 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0494 | 0.3801 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.13 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.13 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.13 | 0.0848 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0494 | 0.3801 |
Onchocerca volvulus | 0.001 | 0.0494 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0036 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.13 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0.13 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0012 | 0.13 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.13 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.13 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0494 | 0.3801 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0494 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0494 | 0.3801 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0494 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0494 | 0.3801 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.13 | 0.0848 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.