TDR Targets

Basic information

Technical information

TDR Targets ID: 846993
Name: 1-(4-chlorophenyl)-N-(3,4-dimethoxyphenyl)-5- methyltriazole-4-carboxamide
MW: 372.806 | Formula: C18H17ClN4O3
H donors: 1 H acceptors: 3 LogP: 3.49 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(ccc1OC)NC(=O)c1nnn(c1C)c1ccc(cc1)Cl
InChi: 1S/C18H17ClN4O3/c1-11-17(21-22-23(11)14-7-4-12(19)5-8-14)18(24)20-13-6-9-15(25-2)16(10-13)26-3/h4-10H,1-3H3,(H,20,24)
InChiKey: JXBBUDHCNCDMRW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(4-chlorophenyl)-N-(3,4-dimethoxyphenyl)-5-methyl-triazole-4-carboxamide
1-(4-chlorophenyl)-N-(3,4-dimethoxyphenyl)-5-methyl-4-triazolecarboxamide
1-(4-chlorophenyl)-N-(3,4-dimethoxyphenyl)-5-methyl-1,2,3-triazole-4-carboxamide
ZINC04316320

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	slit 2 protein	0.0026	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Entamoeba histolytica	hypothetical protein	0.0071	0.5776	1
Onchocerca volvulus	Slit protein homolog	0.0026	0.1621	0.1045
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Schistosoma mansoni	rab6-interacting	0.002	0.1039	0.1039
Brugia malayi	Blistered cuticle protein 3	0.008	0.6611	1
Schistosoma mansoni	hypothetical protein	0.0026	0.1621	0.1621
Schistosoma mansoni	septate junction protein	0.0026	0.1621	0.1621
Entamoeba histolytica	hypothetical protein	0.0071	0.5776	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Schistosoma mansoni	cell polarity protein	0.0026	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.1039	0.1039
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0026	0.1621	0.2453
Schistosoma mansoni	laminin gamma-3 chain	0.0026	0.1621	0.1621
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Echinococcus granulosus	neurogenic locus notch protein 4	0.0026	0.1621	0.1621
Brugia malayi	hypothetical protein	0.002	0.1039	0.1571
Echinococcus granulosus	peroxidasin	0.008	0.6611	0.6611
Echinococcus multilocularis	neural cadherin	0.0026	0.1621	0.1621
Entamoeba histolytica	hypothetical protein	0.0071	0.5776	1
Echinococcus multilocularis	peroxidasin	0.008	0.6611	0.6611
Echinococcus multilocularis	protein jagged 2	0.0026	0.1621	0.1621
Schistosoma mansoni	hypothetical protein	0.002	0.1039	0.1039
Schistosoma mansoni	hypothetical protein	0.0026	0.1621	0.1621
Brugia malayi	Animal haem peroxidase family protein	0.008	0.6611	1
Loa Loa (eye worm)	animal heme peroxidase	0.008	0.6611	1
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.1039	0.5
Echinococcus granulosus	neurogenic locus notch protein	0.0026	0.1621	0.1621
Schistosoma mansoni	notch	0.0026	0.1621	0.1621
Schistosoma mansoni	hypothetical protein	0.0026	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.002	0.1039	0.1571
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Schistosoma mansoni	notch	0.0026	0.1621	0.1621
Schistosoma mansoni	peroxidasin	0.008	0.6611	0.6611
Brugia malayi	EGF-like domain containing protein	0.0026	0.1621	0.2453
Loa Loa (eye worm)	Notch2	0.0026	0.1621	0.2453
Loa Loa (eye worm)	hypothetical protein	0.002	0.1039	0.1571
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Echinococcus multilocularis	notch	0.0026	0.1621	0.1621
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.1039	0.1039
Brugia malayi	notch-like transmembrane receptor	0.0026	0.1621	0.2453
Echinococcus multilocularis	neurogenic locus notch protein	0.0026	0.1621	0.1621
Brugia malayi	EGF-like domain containing protein	0.0026	0.1621	0.2453
Schistosoma mansoni	polycystin 1-related	0.002	0.1039	0.1039
Brugia malayi	EGF-like domain containing protein	0.0026	0.1621	0.2453
Brugia malayi	hypothetical protein	0.002	0.1039	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Schistosoma mansoni	peroxidasin	0.008	0.6611	0.6611
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0026	0.1621	0.1045
Schistosoma mansoni	notch	0.0026	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Schistosoma mansoni	notch	0.0026	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0026	0.1621	0.1621
Onchocerca volvulus		0.0026	0.1621	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Brugia malayi	EGF-like domain containing protein	0.0026	0.1621	0.2453
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.1039	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Onchocerca volvulus		0.008	0.6611	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0026	0.1621	0.1621
Echinococcus granulosus	neurogenic locus notch protein	0.0026	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Brugia malayi	GCC2 and GCC3 family protein	0.0026	0.1621	0.2453
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Giardia lamblia	NADPH oxidoreductase, putative	0.0077	0.6369	1
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0026	0.1621	0.2453
Brugia malayi	Calcium binding EGF domain containing protein	0.0026	0.1621	0.2453
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Brugia malayi	Animal haem peroxidase family protein	0.008	0.6611	1
Entamoeba histolytica	hypothetical protein	0.0071	0.5776	1
Echinococcus multilocularis	protein jagged 1	0.0026	0.1621	0.1621
Brugia malayi	hypothetical protein	0.008	0.6611	1
Brugia malayi	Doublecortin family protein	0.002	0.1039	0.1571
Loa Loa (eye worm)	blistered cuticle protein 3	0.008	0.6611	1
Onchocerca volvulus	Neurogenic locus notch homolog	0.0026	0.1621	0.1045
Onchocerca volvulus	Putative cubilin	0.0026	0.1621	0.1045
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Schistosoma mansoni	transcription factor LCR-F1	0.0071	0.5776	0.5776
Brugia malayi	Cadherin domain containing protein	0.0026	0.1621	0.2453
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Onchocerca volvulus	Chorion peroxidase homolog	0.008	0.6611	1
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0026	0.1621	0.1621
Brugia malayi	Cadherin domain containing protein	0.0026	0.1621	0.2453
Echinococcus multilocularis	protein jagged 1	0.0026	0.1621	0.1621
Echinococcus multilocularis	neurogenic locus protein delta	0.0026	0.1621	0.1621
Brugia malayi	Calcium binding EGF domain containing protein	0.0026	0.1621	0.2453
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.1039	0.1039
Onchocerca volvulus	Peroxidasin homolog	0.008	0.6611	1
Onchocerca volvulus	Dual oxidase homolog	0.008	0.6611	1
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0117	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0071	0.5776	0.5776
Echinococcus multilocularis	neurogenic locus protein delta	0.0026	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Onchocerca volvulus		0.0026	0.1621	0.1045
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.1039	0.1039
Echinococcus multilocularis	RUN	0.002	0.1039	0.1039
Echinococcus granulosus	neural cadherin	0.0026	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Echinococcus granulosus	protein jagged 1	0.0026	0.1621	0.1621
Schistosoma mansoni	hypothetical protein	0.0026	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Schistosoma mansoni	hypothetical protein	0.0026	0.1621	0.1621
Schistosoma mansoni	hypothetical protein	0.0071	0.5776	0.5776
Schistosoma mansoni	hypothetical protein	0.0026	0.1621	0.1621
Onchocerca volvulus		0.0026	0.1621	0.1045
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Loa Loa (eye worm)	animal heme peroxidase	0.008	0.6611	1
Schistosoma mansoni	slit	0.0026	0.1621	0.1621
Schistosoma mansoni	lipoxygenase	0.0082	0.6762	0.6762
Echinococcus granulosus	protein jagged 1	0.0026	0.1621	0.1621
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Brugia malayi	EGF-like domain containing protein	0.0026	0.1621	0.2453
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Brugia malayi	hypothetical protein	0.0071	0.5776	0.8737
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Brugia malayi	Animal haem peroxidase family protein	0.008	0.6611	1
Onchocerca volvulus		0.008	0.6611	1
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Loa Loa (eye worm)	notch protein	0.0026	0.1621	0.2453
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Brugia malayi	EGF-like domain containing protein	0.0026	0.1621	0.2453
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.1039	0.1039
Onchocerca volvulus	Peroxidase homolog	0.008	0.6611	1
Echinococcus granulosus	protein jagged 2	0.0026	0.1621	0.1621
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0077	0.6369	1
Onchocerca volvulus	Peroxidasin homolog	0.008	0.6611	1
Loa Loa (eye worm)	animal heme peroxidase	0.008	0.6611	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Schistosoma mansoni	hypothetical protein	0.0026	0.1621	0.1621
Loa Loa (eye worm)	doublecortin family protein	0.002	0.1039	0.1571
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0026	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Onchocerca volvulus		0.0026	0.1621	0.1045
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.1039	0.1039
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Brugia malayi	EGF-like domain containing protein	0.0026	0.1621	0.2453
Echinococcus granulosus	delta-like protein 1	0.0026	0.1621	0.1621
Schistosoma mansoni	notch	0.0026	0.1621	0.1621
Echinococcus granulosus	fibropellin Ia	0.0026	0.1621	0.1621
Schistosoma mansoni	rab6-interacting	0.002	0.1039	0.1039
Echinococcus granulosus	protein jagged 2	0.0026	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Schistosoma mansoni	notch	0.0026	0.1621	0.1621
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Onchocerca volvulus	Peroxidase homolog	0.008	0.6611	1
Loa Loa (eye worm)	hypothetical protein	0.008	0.6611	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Schistosoma mansoni	loxhd1	0.002	0.1039	0.1039
Loa Loa (eye worm)	animal heme peroxidase	0.008	0.6611	1
Brugia malayi	Animal haem peroxidase family protein	0.008	0.6611	1
Echinococcus granulosus	RUN	0.002	0.1039	0.1039
Giardia lamblia	NADPH oxidoreductase, putative	0.0077	0.6369	1
Trichomonas vaginalis	conserved hypothetical protein	0.0077	0.6369	1
Echinococcus granulosus	neurogenic locus protein delta	0.0026	0.1621	0.1621
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0077	0.6369	1
Toxoplasma gondii	EGF family domain-containing protein	0.0026	0.1621	0.5
Echinococcus multilocularis	fibropellin Ia	0.0026	0.1621	0.1621
Schistosoma mansoni	lipoxygenase	0.0117	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0058	0.4588	0.6669
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0071	0.5776	0.5776
Loa Loa (eye worm)	hypothetical protein	0.0026	0.1621	0.2453
Brugia malayi	Delta serrate ligand family protein	0.0026	0.1621	0.2453
Echinococcus granulosus	notch	0.0026	0.1621	0.1621
Brugia malayi	Peroxidasin	0.008	0.6611	1
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0077	0.6369	1
Onchocerca volvulus		0.0026	0.1621	0.1045
Onchocerca volvulus		0.008	0.6611	1
Giardia lamblia	NADPH oxidoreductase, putative	0.0077	0.6369	1
Echinococcus multilocularis	slit 2 protein	0.0026	0.1621	0.1621
Brugia malayi	Muscle positioning protein 4	0.0026	0.1621	0.2453
Brugia malayi	Animal haem peroxidase family protein	0.008	0.6611	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 846993