Detailed information for compound 847030

Basic information

Technical information
  • TDR Targets ID: 847030
  • Name: N-(5-chloro-2-methylphenyl)-1-(4-methoxypheny l)-5-methyltriazole-4-carboxamide
  • MW: 356.806 | Formula: C18H17ClN4O2
  • H donors: 1 H acceptors: 3 LogP: 3.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)n1nnc(c1C)C(=O)Nc1cc(Cl)ccc1C
  • InChi: 1S/C18H17ClN4O2/c1-11-4-5-13(19)10-16(11)20-18(24)17-12(2)23(22-21-17)14-6-8-15(25-3)9-7-14/h4-10H,1-3H3,(H,20,24)
  • InChiKey: DPXHTZFRSZLCGG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(5-chloro-2-methyl-phenyl)-1-(4-methoxyphenyl)-5-methyl-triazole-4-carboxamide
  • N-(5-chloro-2-methylphenyl)-1-(4-methoxyphenyl)-5-methyl-4-triazolecarboxamide
  • N-(5-chloro-2-methyl-phenyl)-1-(4-methoxyphenyl)-5-methyl-1,2,3-triazole-4-carboxamide
  • ZINC02715843

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.015 0.0694 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.5
Brugia malayi ecdysone receptor 0.0071 0.0316 0.4354
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.5
Schistosoma mansoni nuclear hormone receptor 0.015 0.0694 0.0694
Brugia malayi Nuclear hormone receptor family member nhr-25 0.015 0.0694 1
Brugia malayi hypothetical protein 0.0079 0.0356 0.4958
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.0316 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-31 0.015 0.0694 1
Loa Loa (eye worm) DR-78 0.0071 0.0316 0.4349
Echinococcus granulosus cpg binding protein 0.0033 0.0138 0.0122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.015 0.0694 1
Brugia malayi Nuclear hormone receptor-like 1 0.015 0.0694 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0071 0.0316 0.4349
Brugia malayi nuclear receptor RXR 0.0079 0.0356 0.4958
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.015 0.0694 0.0694
Schistosoma mansoni cpg binding protein 0.0033 0.0138 0.0138
Schistosoma mansoni nuclear receptor nhr-48 0.0071 0.0316 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.015 0.0694 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0356 0.4954
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.015 0.0694 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0025 0.001
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0167 0.0158
Schistosoma mansoni nuclear receptor 0.0071 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0079 0.0356 0.4954
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0071 0.0316 0.3306
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0079 0.0356 0.0341
Brugia malayi conserved hypotetical protein 0.0071 0.0316 0.4354
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.015 0.0694 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349
Onchocerca volvulus 0.0071 0.0316 0.3306
Echinococcus multilocularis ecdysone induced protein 78C 0.015 0.0694 0.0706
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.015 0.0694 0.0706
Echinococcus multilocularis FTZ F1 alpha 0.015 0.0694 0.0706
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0071 0.0316 0.0301
Brugia malayi CXXC zinc finger family protein 0.0032 0.0129 0.1565
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.015 0.0694 0.0694
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.015 0.0694 0.0706
Loa Loa (eye worm) hypothetical protein 0.015 0.0694 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.015 0.0694 1
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0167 0.0167
Brugia malayi nuclear receptor NHR-67 0.0071 0.0316 0.4354
Schistosoma mansoni steroid hormone receptor ad4bp 0.015 0.0694 0.0694
Brugia malayi Nuclear hormone receptor family member nhr-19 0.015 0.0694 1
Entamoeba histolytica hypothetical protein 0.004 0.0167 0.5
Schistosoma mansoni thyroid hormone receptor 0.015 0.0694 0.0694
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.015 0.0694 0.0679
Loa Loa (eye worm) hypothetical protein 0.015 0.0694 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.2022 0.9622 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0071 0.0316 0.0312
Echinococcus granulosus FTZ F1 alpha 0.015 0.0694 0.0679
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0013 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0079 0.0356 0.4958
Brugia malayi hypothetical protein 0.004 0.0167 0.2135
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0298 0.0298
Brugia malayi orphan nuclear receptor NR2E1 0.0071 0.0316 0.4354
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.0316 0.0301
Loa Loa (eye worm) hypothetical protein 0.015 0.0694 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0016 0.0016
Schistosoma mansoni nuclear hormone receptor 0.0071 0.0316 0.0316
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0013 0.5
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0071 0.0316 0.0312
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349
Trichomonas vaginalis helicase, putative 0.0007 0.0013 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.2101 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0071 0.0316 0.0316
Echinococcus granulosus thyroid hormone receptor alpha 0.0071 0.0316 0.0301
Brugia malayi hypothetical protein 0.0071 0.0316 0.4354
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.015 0.0694 0.0679
Brugia malayi nuclear hormone receptor 0.0071 0.0316 0.4354
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.015 0.0694 0.0706
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.015 0.0694 0.0694
Loa Loa (eye worm) hypothetical protein 0.015 0.0694 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0071 0.0316 0.4349
Brugia malayi ecdysteroid receptor 0.015 0.0694 1
Loa Loa (eye worm) hypothetical protein 0.015 0.0694 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0025 0.0009
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0079 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349
Brugia malayi Nuclear hormone receptor family member nhr-14 0.015 0.0694 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0264 0.5
Schistosoma mansoni zinc finger protein 0.0071 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.015 0.0694 1
Brugia malayi nuclear receptor NHR-88 0.0071 0.0316 0.4354
Brugia malayi Nuclear hormone receptor family member nhr-3 0.015 0.0694 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0079 0.0356 0.0356
Brugia malayi nuclear receptor RXR 0.0071 0.0316 0.4354
Brugia malayi nuclear receptor NHR-88 0.015 0.0694 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0071 0.0316 0.0316
Brugia malayi hypothetical protein 0.0071 0.0316 0.4354
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.015 0.0694 0.0694
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349
Onchocerca volvulus 0.0071 0.0316 0.3306
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.015 0.0694 0.0706
Echinococcus multilocularis cpg binding protein 0.0033 0.0138 0.0127
Brugia malayi hypothetical protein 0.0079 0.0356 0.4958
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.015 0.0694 0.0679
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.015 0.0694 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.5
Loa Loa (eye worm) nuclear hormone receptor 0.0071 0.0316 0.4349
Brugia malayi steroid hormone receptor 0.015 0.0694 1
Brugia malayi Nuclear hormone receptor E75 0.0071 0.0316 0.4354
Onchocerca volvulus Bile acid receptor homolog 0.015 0.0694 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0167 0.0152
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.015 0.0694 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.015 0.0694 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0356 0.4954
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0079 0.0356 0.4954
Schistosoma mansoni cpg binding protein 0.0032 0.0129 0.0129
Schistosoma mansoni RAR-like nuclear receptor 0.015 0.0694 0.0694
Entamoeba histolytica hypothetical protein 0.004 0.0167 0.5
Schistosoma mansoni cpg binding protein 0.0033 0.0138 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-49 0.015 0.0694 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0079 0.0356 0.0354
Loa Loa (eye worm) hypothetical protein 0.0079 0.0356 0.4954
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.5
Schistosoma mansoni Tr4/Tr2 (homologue) 0.015 0.0694 0.0694
Echinococcus granulosus nuclear receptor 2DBD gamma 0.015 0.0694 0.0679
Echinococcus granulosus nuclear receptor nhr 48 0.0071 0.0316 0.0301
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349
Schistosoma mansoni nuclear hormone receptor 0.0071 0.0316 0.0316
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.5
Loa Loa (eye worm) hypothetical protein 0.015 0.0694 1
Schistosoma mansoni hypothetical protein 0.004 0.0167 0.0167
Schistosoma mansoni retinoid-x-receptor (RXR) 0.015 0.0694 0.0694
Entamoeba histolytica hypothetical protein 0.004 0.0167 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.015 0.0694 0.0706
Brugia malayi Nuclear hormone receptor family member nhr-40 0.015 0.0694 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.015 0.0694 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.015 0.0694 0.0679
Echinococcus multilocularis thyroid hormone receptor alpha 0.015 0.0694 0.0706
Schistosoma mansoni thyroid hormone receptor 0.015 0.0694 0.0694
Schistosoma mansoni nuclear receptor 0.0071 0.0316 0.0316
Brugia malayi Nuclear hormone receptor-like 1 0.0079 0.0356 0.4958
Echinococcus granulosus Nuclear hormone receptor HR96 0.0071 0.0316 0.0301
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.5
Onchocerca volvulus 0.015 0.0694 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0356 0.4954
Brugia malayi Nuclear hormone receptor E75 0.0071 0.0316 0.4354
Brugia malayi Steroid receptor seven-up type 2 0.015 0.0694 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.5
Loa Loa (eye worm) hypothetical protein 0.015 0.0694 1
Entamoeba histolytica hypothetical protein 0.004 0.0167 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.015 0.0694 0.0679
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0071 0.0316 0.0312
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.015 0.0694 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0013 0.5
Schistosoma mansoni coup transcription factor 0.015 0.0694 0.0694
Onchocerca volvulus Protein ultraspiracle homolog 0.015 0.0694 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0071 0.0316 0.0301
Loa Loa (eye worm) steroid hormone receptor 0.015 0.0694 1
Brugia malayi tailless protein 0.0071 0.0316 0.4354
Brugia malayi nuclear hormone receptor 0.015 0.0694 1
Echinococcus granulosus ecdysone induced protein 78C 0.015 0.0694 0.0679
Brugia malayi Nuclear hormone receptor family member nhr-1 0.015 0.0694 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0071 0.0316 0.4354
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.015 0.0694 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0071 0.0316 0.0312
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0129 0.1558
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349
Brugia malayi nuclear hormone receptor family member odr-7 0.0071 0.0316 0.4354
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.015 0.0694 0.0706
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0071 0.0316 0.3306
Brugia malayi photoreceptor-specific nuclear receptor 0.015 0.0694 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0013 0.5
Brugia malayi nuclear hormone receptor family member nhr-6 0.0071 0.0316 0.4354
Brugia malayi Nuclear hormone receptor family member nhr-25 0.015 0.0694 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0316 0.4349

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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