TDR Targets

Basic information

Technical information

TDR Targets ID: 847054
Name: 1-(2,4-dimethylphenyl)-5-methyl-N-(4-methylph enyl)triazole-4-carboxamide
MW: 320.388 | Formula: C19H20N4O
H donors: 1 H acceptors: 3 LogP: 4.01 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)NC(=O)c1nnn(c1C)c1ccc(cc1C)C
InChi: 1S/C19H20N4O/c1-12-5-8-16(9-6-12)20-19(24)18-15(4)23(22-21-18)17-10-7-13(2)11-14(17)3/h5-11H,1-4H3,(H,20,24)
InChiKey: ISHFGZVHZLRDHV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-(2,4-dimethylphenyl)-5-methyl-N-(4-methylphenyl)-4-triazolecarboxamide
1-(2,4-dimethylphenyl)-5-methyl-N-(4-methylphenyl)-1,2,3-triazole-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Brugia malayi	Nuclear hormone receptor-like 1	0.0072	0.2785	0.4098
Echinococcus multilocularis	FTZ F1 alpha	0.0137	0.6795	0.5836
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0188	1	1
Brugia malayi	ecdysone receptor	0.0065	0.2304	0.339
Brugia malayi	conserved hypotetical protein	0.0065	0.2304	0.339
Onchocerca volvulus		0.0065	0.2304	0.339
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0188	1	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0	0.5
Onchocerca volvulus	Bile acid receptor homolog	0.0137	0.6795	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0137	0.6795	0.5836
Brugia malayi	Nuclear hormone receptor E75	0.0065	0.2304	0.339
Schistosoma mansoni	alkaline phosphatase	0.0188	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0137	0.6795	0.5836
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0072	0.2785	0.4098
Echinococcus granulosus	ecdysone induced protein 78C	0.0137	0.6795	0.5836
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2785	0.4098
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0137	0.6795	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0065	0.2304	0.339
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0137	0.6795	0.5836
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Loa Loa (eye worm)	hypothetical protein	0.0137	0.6795	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0137	0.6795	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0137	0.6795	0.5836
Brugia malayi	photoreceptor-specific nuclear receptor	0.0137	0.6795	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Schistosoma mansoni	RAR-like nuclear receptor	0.0137	0.6795	0.5836
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0	0.5
Onchocerca volvulus		0.0065	0.2304	0.339
Brugia malayi	hypothetical protein	0.0072	0.2785	0.4098
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0065	0.2304	0.339
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0188	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0137	0.6795	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0137	0.6795	0.5836
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2785	0.4098
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0137	0.6795	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0065	0.2304	0.339
Brugia malayi	nuclear hormone receptor	0.0065	0.2304	0.339
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0137	0.6795	0.5836
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0137	0.6795	0.5836
Onchocerca volvulus	Protein ultraspiracle homolog	0.0137	0.6795	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0137	0.6795	0.5836
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0	0.5
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0137	0.6795	0.5836
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0137	0.6795	1
Schistosoma mansoni	nuclear hormone receptor	0.0137	0.6795	0.5836
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0137	0.6795	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0137	0.6795	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0065	0.2304	0.339
Brugia malayi	hypothetical protein	0.0072	0.2785	0.4098
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0137	0.6795	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0137	0.6795	0.5836
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0137	0.6795	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2785	0.4098
Schistosoma mansoni	coup transcription factor	0.0137	0.6795	0.5836
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0065	0.2304	0.339
Brugia malayi	nuclear receptor NHR-67	0.0065	0.2304	0.339
Loa Loa (eye worm)	hypothetical protein	0.0137	0.6795	1
Echinococcus granulosus	alkaline phosphatase	0.0188	1	1
Brugia malayi	Nuclear hormone receptor E75	0.0065	0.2304	0.339
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0137	0.6795	1
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0072	0.2785	0.0625
Brugia malayi	ecdysteroid receptor	0.0137	0.6795	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.6795	1
Brugia malayi	steroid hormone receptor	0.0137	0.6795	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0072	0.2785	0.0625
Echinococcus multilocularis	alkaline phosphatase	0.0188	1	1
Mycobacterium ulcerans	hypothetical protein	0.0027	0	0.5
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0137	0.6795	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0137	0.6795	0.5836
Brugia malayi	nuclear receptor NHR-88	0.0065	0.2304	0.339
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0072	0.2785	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2785	0.4098
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0	0.5
Loa Loa (eye worm)	steroid hormone receptor	0.0137	0.6795	1
Brugia malayi	tailless protein	0.0065	0.2304	0.339
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Brugia malayi	hypothetical protein	0.0065	0.2304	0.339
Brugia malayi	nuclear receptor RXR	0.0065	0.2304	0.339
Schistosoma mansoni	thyroid hormone receptor	0.0137	0.6795	0.5836
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0137	0.6795	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0137	0.6795	0.5836
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0065	0.2304	0.339
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0072	0.2785	0.4098
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0137	0.6795	0.5836
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0137	0.6795	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0137	0.6795	0.5836
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Onchocerca volvulus		0.0137	0.6795	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0137	0.6795	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.6795	1
Brugia malayi	hypothetical protein	0.0065	0.2304	0.339
Brugia malayi	Nuclear hormone receptor-like 1	0.0137	0.6795	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0137	0.6795	0.5836
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0188	1	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0072	0.2785	0.0625
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0137	0.6795	1
Loa Loa (eye worm)	hypothetical protein	0.0137	0.6795	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0137	0.6795	0.5836
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0137	0.6795	1
Brugia malayi	Steroid receptor seven-up type 2	0.0137	0.6795	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Schistosoma mansoni	retinoic acid receptor RXR	0.0137	0.6795	0.5836
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0188	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0137	0.6795	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0137	0.6795	0.5836
Schistosoma mansoni	alkaline phosphatase	0.0188	1	1
Brugia malayi	nuclear receptor NHR-88	0.0137	0.6795	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0137	0.6795	0.5836
Loa Loa (eye worm)	hypothetical protein	0.0137	0.6795	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0065	0.2304	0.339
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0137	0.6795	0.5836
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0137	0.6795	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0137	0.6795	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0137	0.6795	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0137	0.6795	0.5836
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0137	0.6795	0.5836
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0137	0.6795	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2304	0.339
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2785	0.4098
Brugia malayi	nuclear hormone receptor	0.0137	0.6795	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0137	0.6795	0.5836
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0	0.5
Brugia malayi	nuclear receptor RXR	0.0072	0.2785	0.4098
Schistosoma mansoni	hypothetical protein	0.0098	0.4376	0.2693
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0137	0.6795	1
Loa Loa (eye worm)	DR-78	0.0065	0.2304	0.339
Loa Loa (eye worm)	hypothetical protein	0.0137	0.6795	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0065	0.2304	0.339
Echinococcus granulosus	FTZ F1 alpha	0.0137	0.6795	0.5836
Schistosoma mansoni	thyroid hormone receptor	0.0137	0.6795	0.5836
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0065	0.2304	0.339
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 847054