Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0964 | 0.5333 | 0.5333 |
Mycobacterium tuberculosis | Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) | 0.0591 | 0.1957 | 0.3495 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0994 | 0.5599 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0515 | 0.1272 | 0.1272 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0617 | 0.2195 | 0.3921 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.0515 | 0.1272 | 0.1272 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.1481 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0515 | 0.1272 | 0.128 |
Giardia lamblia | 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase | 0.0994 | 0.5599 | 1 |
Entamoeba histolytica | MTA/SAH nucleosidase, putative | 0.0994 | 0.5599 | 1 |
Mycobacterium ulcerans | bifunctional Mta/Sah nucleosidase Mtn | 0.0994 | 0.5599 | 1 |
Treponema pallidum | pfs protein (pfs) | 0.0994 | 0.5599 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Brugia malayi | Raf kinase | 0.1429 | 0.9534 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0964 | 0.5333 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.0964 | 0.5333 | 0.7203 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.0964 | 0.5333 | 0.5368 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0888 | 0.4648 | 0.5 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.084 | 0.4208 | 0.4235 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0888 | 0.4648 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0515 | 0.1272 | 0.1272 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0964 | 0.5333 | 0.5333 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Plasmodium vivax | purine nucleoside phosphorylase, putative | 0.0617 | 0.2195 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Loa Loa (eye worm) | raf kinase | 0.1474 | 0.9935 | 1 |
Mycobacterium tuberculosis | Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase | 0.0994 | 0.5599 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.0964 | 0.5333 | 0.5333 |
Entamoeba histolytica | purine nucleoside phosphorylase, putative | 0.0617 | 0.2195 | 0.3921 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.0964 | 0.5333 | 0.5333 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0888 | 0.4648 | 0.8301 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0617 | 0.2195 | 0.3921 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0964 | 0.5333 | 1 |
Chlamydia trachomatis | AMP nucleosidase | 0.0374 | 0 | 0.5 |
Brugia malayi | purine nucleoside phosphorylase I, inosine and guanosine-specific family protein | 0.0888 | 0.4648 | 0.4875 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Toxoplasma gondii | Purine nucleoside phosphorylase | 0.0617 | 0.2195 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Brugia malayi | MTAP | 0.0964 | 0.5333 | 0.5594 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1481 | 1 | 1 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0964 | 0.5333 | 1 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0964 | 0.5333 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0888 | 0.4648 | 0.8301 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Trichomonas vaginalis | purine nucleoside phosphorylase, putative | 0.0617 | 0.2195 | 0.3921 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0888 | 0.4648 | 0.4648 |
Plasmodium falciparum | purine nucleoside phosphorylase | 0.0617 | 0.2195 | 0.5 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0888 | 0.4648 | 0.8301 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.