TDR Targets

Basic information

Technical information

TDR Targets ID: 847326
Name: N-(2,4-dichlorophenyl)-2-(2,4-difluorophenyl) acetamide
MW: 316.13 | Formula: C14H9Cl2F2NO
H donors: 1 H acceptors: 1 LogP: 4.15 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(cc1Cl)Cl)Cc1ccc(cc1F)F
InChi: 1S/C14H9Cl2F2NO/c15-9-2-4-13(11(16)6-9)19-14(20)5-8-1-3-10(17)7-12(8)18/h1-4,6-7H,5H2,(H,19,20)
InChiKey: YWXRGMCTPWVMIZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,4-dichlorophenyl)-2-(2,4-difluorophenyl)ethanamide
CBMicro_019388
ZINC00136080
ST029184
BIM-0019450.P001
Oprea1_551120

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	excitatory GABA receptor EXP-1A	0.0019	0.0483	0.1901
Onchocerca volvulus		0.0019	0.0483	0.5
Schistosoma mansoni	nAChR subunit	0.0019	0.0483	0.0175
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0017	0.0313	0.5
Leishmania major	trypanothione reductase	0.0048	0.254	1
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0019	0.0483	0.0175
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.254	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.011	0.6906	0.8837
Onchocerca volvulus		0.0019	0.0483	0.5
Schistosoma mansoni	nAChR subunit	0.0019	0.0483	0.0175
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0019	0.0483	0.0761
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0483	0.0761
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0019	0.0483	0.1901
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0017	0.0313	0.5
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0483	0.0761
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0122	0.7773	1
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0019	0.0483	0.0761
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.011	0.6906	0.8837
Trichomonas vaginalis	mercuric reductase, putative	0.0017	0.0313	0.5
Mycobacterium tuberculosis	Probable oxidoreductase	0.0122	0.7773	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0017	0.0313	0.5
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0019	0.0483	0.0761
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.254	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0483	0.1901
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0313	0.1234
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0019	0.0483	0.0761
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0483	0.0761
Echinococcus granulosus	glycine receptor subunit beta	0.0019	0.0483	0.0761
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0122	0.7773	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0483	0.1901
Brugia malayi	Cation transporter family protein	0.0019	0.0483	0.1901
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0019	0.0483	0.0761
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0019	0.0483	0.0175
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.011	0.6906	0.8837
Trypanosoma brucei	trypanothione reductase	0.0048	0.254	1
Echinococcus multilocularis	glycine receptor subunit beta	0.0019	0.0483	0.0761
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0483	0.0175
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.254	1
Onchocerca volvulus		0.0019	0.0483	0.5
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.254	1
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0019	0.0483	0.0761
Plasmodium falciparum	thioredoxin reductase	0.0048	0.254	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0019	0.0483	0.0761
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.254	1
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0017	0.0313	0.5
Onchocerca volvulus		0.0019	0.0483	0.5
Schistosoma mansoni	nAChR subunit	0.0019	0.0483	0.0175
Schistosoma mansoni	nAChR subunit	0.0019	0.0483	0.0175
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0019	0.0483	0.0761
Mycobacterium tuberculosis	Probable dehydrogenase	0.011	0.6906	0.8837
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0019	0.0483	0.0761
Brugia malayi	Cation transporter family protein	0.0019	0.0483	0.1901
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0483	0.1901
Toxoplasma gondii	thioredoxin reductase	0.0048	0.254	1
Onchocerca volvulus	Putative nachr subunit	0.0019	0.0483	0.5
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0019	0.0483	0.0761
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0017	0.0313	0.5
Loa Loa (eye worm)	glutathione reductase	0.0048	0.254	1
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0019	0.0483	0.1901
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0017	0.0313	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0019	0.0483	0.0761
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0019	0.0483	0.0761
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0019	0.0483	0.1901
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0483	0.1901
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0483	0.0761
Echinococcus granulosus	glycine receptor subunit beta	0.0019	0.0483	0.0761
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0483	0.1901
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0483	0.1901
Echinococcus granulosus	nAChR subunit	0.0019	0.0483	0.0761
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0483	0.1901
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0483	0.0175
Plasmodium falciparum	glutathione reductase	0.0048	0.254	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0122	0.7773	1
Plasmodium vivax	glutathione reductase, putative	0.0048	0.254	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0019	0.0483	0.1901
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0019	0.0483	0.1901
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0019	0.0483	0.1901
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0019	0.0483	0.1901
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.011	0.6906	0.8837
Brugia malayi	Thioredoxin reductase	0.0048	0.254	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0483	0.0761
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0017	0.0313	0.5
Echinococcus multilocularis	nAChR subunit	0.0019	0.0483	0.0761
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0019	0.0483	0.1901
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0019	0.0483	0.0761
Schistosoma mansoni	nAChR subunit	0.0019	0.0483	0.0175
Treponema pallidum	NADH oxidase	0.0017	0.0313	0.5
Brugia malayi	Cation transporter family protein	0.0019	0.0483	0.1901
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0019	0.0483	0.0761
Brugia malayi	glutathione reductase	0.0048	0.254	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.254	0.2985
Trichomonas vaginalis	glutathione reductase, putative	0.0017	0.0313	0.5
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0019	0.0483	0.0761
Onchocerca volvulus		0.0019	0.0483	0.5
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0019	0.0483	0.1901
Echinococcus multilocularis	glycine receptor subunit beta	0.0019	0.0483	0.0761
Onchocerca volvulus		0.0019	0.0483	0.5
Schistosoma mansoni	nAChR subunit	0.0019	0.0483	0.0175
Mycobacterium tuberculosis	Probable reductase	0.011	0.6906	0.8837
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0019	0.0483	0.0175
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0019	0.0483	0.0175
Schistosoma mansoni	nAChR subunit	0.0019	0.0483	0.0175
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0019	0.0483	0.0761

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 847326