Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0062 | 0.3831 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.0087 | 0.0087 |
Trypanosoma cruzi | hexokinase, putative | 0.1103 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0153 | 0.0091 |
Leishmania major | pyruvate kinase | 0.0034 | 0.0153 | 0.0091 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0293 | 0.0293 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0178 | 0.0178 |
Echinococcus multilocularis | hexokinase type 2 | 0.1103 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.1103 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.1103 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.1103 | 1 | 1 |
Brugia malayi | CHE-14 protein | 0.0043 | 0.0237 | 0.0208 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | glutamate receptor | 0.0081 | 0.0582 | 0.0576 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0021 | 0.0029 | 0.0024 |
Echinococcus granulosus | hexokinase | 0.1103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0237 | 0.0231 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0293 | 0.0265 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0153 | 0.0153 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0073 | 0.0512 | 0.0484 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0034 | 0.0153 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0062 | 0.3831 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0006 | 0.0006 |
Plasmodium falciparum | hexokinase | 0.1103 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0153 | 0.0147 |
Mycobacterium ulcerans | pyruvate kinase | 0.0034 | 0.0153 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0346 | 0.3022 | 0.3022 |
Onchocerca volvulus | 0.1103 | 1 | 1 | |
Leishmania major | hexokinase, putative | 0.1103 | 1 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0062 | 0.3831 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.083 | 0.7479 | 0.7479 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.0305 | 0.0305 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0153 | 0.0091 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.0237 | 0.0237 |
Brugia malayi | Hexokinase family protein | 0.0341 | 0.2983 | 0.2962 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0153 | 0.0147 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0101 | 0.0766 | 0.0739 |
Entamoeba histolytica | hexokinase 2 | 0.1103 | 1 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0101 | 0.0766 | 0.0713 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0753 | 0.0748 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.3069 | 0.3065 |
Loa Loa (eye worm) | hexokinase type II | 0.1103 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0153 | 0.0147 |
Chlamydia trachomatis | pyruvate kinase | 0.0034 | 0.0153 | 1 |
Echinococcus granulosus | hexokinase | 0.1103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0062 | 0.0057 |
Loa Loa (eye worm) | hexokinase | 0.1103 | 1 | 1 |
Giardia lamblia | Pyruvate kinase | 0.0034 | 0.0153 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0326 | 0.0321 |
Onchocerca volvulus | Hexokinase homolog | 0.0692 | 0.6214 | 0.619 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0092 | 0.0683 | 0.0683 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0222 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0029 | 0.0024 |
Echinococcus multilocularis | hexokinase | 0.1103 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0222 | 0.0222 |
Brugia malayi | Hexokinase family protein | 0.1103 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.1103 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.0237 | 0.0237 |
Onchocerca volvulus | 0.0051 | 0.0305 | 0.0244 | |
Onchocerca volvulus | 0.0049 | 0.0293 | 0.0233 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0144 | 0.1164 | 0.1164 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.0237 | 0.0237 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0099 | 0.0753 | 0.0753 |
Trypanosoma cruzi | hexokinase, putative | 0.1103 | 1 | 1 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0034 | 0.0153 | 0.0124 |
Onchocerca volvulus | 0.1103 | 1 | 1 | |
Onchocerca volvulus | 0.1103 | 1 | 1 | |
Echinococcus granulosus | tumor protein p63 | 0.0346 | 0.3022 | 0.3022 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0068 | 0.0461 | 0.0461 |
Schistosoma mansoni | hexokinase | 0.1103 | 1 | 1 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0021 | 0.0029 | 0.0024 |
Loa Loa (eye worm) | hexokinase | 0.0341 | 0.2983 | 0.2979 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0178 | 0.0178 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0293 | 0.0293 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0062 | 0.0004 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0102 | 0.0781 | 0.0781 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0351 | 0.3069 | 0.3065 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0099 | 0.0753 | 0.0753 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0062 | 0.0004 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0153 | 0.0153 |
Plasmodium vivax | hexokinase, putative | 0.1103 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0692 | 0.6214 | 0.6211 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0039 | 0.0201 | 0.0201 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0062 | 0.3831 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0153 | 0.0153 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0062 | 0.3831 |
Leishmania major | pyruvate kinase | 0.0034 | 0.0153 | 0.0091 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0101 | 0.0766 | 0.0766 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0062 | 0.0057 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0144 | 0.1164 | 0.1164 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0222 | 0.0222 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0178 | 0.012 |
Echinococcus multilocularis | hexokinase | 0.1103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0305 | 0.0299 |
Trypanosoma brucei | hexokinase, putative | 0.1103 | 1 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0068 | 0.0461 | 0.0461 |
Brugia malayi | hexokinase type II | 0.0351 | 0.3069 | 0.3049 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0062 | 0.0033 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0062 | 0.3831 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.2067 | 0.2062 |
Echinococcus granulosus | hexokinase type 2 | 0.1103 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.0237 | 0.0237 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0293 | 0.0293 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0062 | 0.0004 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0153 | 0.0091 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0062 | 0.0033 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0178 | 0.012 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0222 | 0.0222 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0034 | 0.0153 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0178 | 0.012 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0034 | 0.0153 | 0.0124 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.0153 | 0.0153 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0178 | 0.0149 |
Plasmodium falciparum | pyruvate kinase | 0.0034 | 0.0153 | 0.0153 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.0237 | 0.0237 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0068 | 0.0461 | 0.0461 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0242 | 0.2067 | 0.2067 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0081 | 0.0582 | 0.0554 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0034 | 0.0153 | 0.0153 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0062 | 0.0033 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0178 | 0.012 |
Loa Loa (eye worm) | hexokinase | 0.1103 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.1103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0062 | 0.0057 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.0237 | 0.0231 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0237 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.0034 | 0.0153 | 0.0153 |
Brugia malayi | hypothetical protein | 0.0242 | 0.2067 | 0.2044 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0242 | 0.2067 | 0.2067 |
Plasmodium vivax | pyruvate kinase, putative | 0.0034 | 0.0153 | 0.0153 |
Trypanosoma brucei | hexokinase | 0.1103 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0178 | 0.0178 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0153 | 0.0147 |
Brugia malayi | Hexokinase family protein | 0.0692 | 0.6214 | 0.6202 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0101 | 0.0766 | 0.0766 |
Echinococcus granulosus | expressed conserved protein | 0.0095 | 0.071 | 0.071 |
Echinococcus multilocularis | expressed conserved protein | 0.0095 | 0.071 | 0.071 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0062 | 0.3831 |
Echinococcus granulosus | pyruvate kinase | 0.0034 | 0.0153 | 0.0153 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0062 | 0.3831 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0058 | 0.0052 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0039 | 0.0201 | 0.0172 |
Entamoeba histolytica | hexokinase 1 | 0.1103 | 1 | 1 |
Onchocerca volvulus | 0.0692 | 0.6214 | 0.619 | |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0062 | 0.3831 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0062 | 0.3831 |
Loa Loa (eye worm) | hypothetical protein | 0.0753 | 0.6769 | 0.6768 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0766 | 0.0761 |
Leishmania major | hexokinase, putative | 0.1103 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0024 | 0.0058 | 0.0052 |
Loa Loa (eye worm) | glutamate receptor | 0.0032 | 0.0131 | 0.0125 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.