TDR Targets

Basic information

Technical information

TDR Targets ID: 847397
Name: 6-(2-tert-butylphenoxy)-N,N-diethylhexan-1-am ine
MW: 305.498 | Formula: C20H35NO
H donors: 0 H acceptors: 0 LogP: 5.76 Rotable bonds: 11
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCCCCCOc1ccccc1C(C)(C)C)CC
InChi: 1S/C20H35NO/c1-6-21(7-2)16-12-8-9-13-17-22-19-15-11-10-14-18(19)20(3,4)5/h10-11,14-15H,6-9,12-13,16-17H2,1-5H3
InChiKey: TZNASKJVJLUHFE-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

6-(2-tert-butylphenoxy)-N,N-diethyl-hexan-1-amine
6-(2-tert-butylphenoxy)hexyl-diethyl-amine
BIM-0019882.P001
CBMicro_020099

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cysteine protease	0.0143	0.4054	0.4054
Onchocerca volvulus		0.0274	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0274	1	1
Echinococcus granulosus	cathepsin b	0.0199	0.6596	0.6596
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.4054	0.4054
Toxoplasma gondii	cathepsin B	0.0099	0.204	0.204
Onchocerca volvulus		0.0274	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0143	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Brugia malayi	Cathepsin L-like precursor	0.0274	1	1
Giardia lamblia	Cathepsin B precursor	0.0099	0.204	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	1	1
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054
Entamoeba histolytica	cysteine proteinase 1, putative	0.0143	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	1	1
Leishmania major	cathepsin L-like protease	0.0274	1	1
Leishmania major	cathepsin L-like protease	0.0274	1	1
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0274	1	1
Plasmodium vivax	unspecified product	0.0089	0.1587	0.1587
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0274	1	1
Loa Loa (eye worm)	fibroinase	0.0274	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0143	0.4054	0.253
Onchocerca volvulus		0.0274	1	1
Brugia malayi	Cathepsin L-like precursor	0.0274	1	1
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5946	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Plasmodium vivax	unspecified product	0.0143	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0185	0.5946	0.5946
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0143	0.4054	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0274	1	1
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054
Leishmania major	cathepsin L-like protease	0.0274	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0143	0.4054	0.4054
Onchocerca volvulus		0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0274	1	1
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0089	0.1587	0.1587
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0274	1	1
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0199	0.6596	0.6596
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0274	1	1
Echinococcus multilocularis	cathepsin b	0.0199	0.6596	0.6596
Entamoeba histolytica	cysteine protease, putative	0.0274	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.4054	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0185	0.5946	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054
Leishmania major	cathepsin L-like protease	0.0274	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0185	0.5946	0.5946
Echinococcus multilocularis	cysteine protease	0.0274	1	1
Loa Loa (eye worm)	hypothetical protein	0.0199	0.6596	0.6596
Onchocerca volvulus		0.0274	1	1
Loa Loa (eye worm)	cathepsin B	0.0099	0.204	0.204
Entamoeba histolytica	cysteine proteinase 2	0.0143	0.4054	0.4054
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0274	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0143	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0274	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0274	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0274	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0274	1	1
Plasmodium vivax	vivapain-1	0.0143	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0143	0.4054	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0274	1	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1587	0.1587
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Leishmania major	cathepsin L-like protease	0.0274	1	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5946	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1587	0.1587
Trypanosoma cruzi	cruzipain precursor, putative	0.0274	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.4054	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.0089	0.1587	0.1587
Loa Loa (eye worm)	hypothetical protein	0.0274	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0274	1	1
Echinococcus granulosus	cathepsin l1	0.0274	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0199	0.6596	0.6596
Plasmodium vivax	vivapain-2	0.0274	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0185	0.5946	0.5946
Giardia lamblia	Cathepsin B precursor	0.0099	0.204	1
Onchocerca volvulus		0.0274	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0143	0.4054	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0143	0.4054	0.253
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0099	0.204	0.204
Echinococcus multilocularis	cathepsin L cysteine protease	0.0274	1	1
Echinococcus multilocularis	cathepsin b	0.0199	0.6596	0.6596
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0185	0.5946	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0274	1	1
Leishmania major	cysteine peptidase A (CPA)	0.0274	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0274	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0274	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0099	0.204	0.204
Schistosoma mansoni	cathepsin F (C01 family)	0.0274	1	1
Trypanosoma cruzi	cysteine protease, putative	0.0143	0.4054	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0274	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0185	0.5946	0.5946
Leishmania major	cathepsin L-like protease	0.0274	1	1
Onchocerca volvulus		0.0185	0.5946	0.5946
Onchocerca volvulus		0.0274	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0274	1	1
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0274	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0089	0.1587	0.1587
Entamoeba histolytica	cysteine proteinase, putative	0.0143	0.4054	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0199	0.6596	0.6596
Brugia malayi	Papain family cysteine protease containing protein	0.0143	0.4054	0.4054
Echinococcus multilocularis	cysteine protease	0.0274	1	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0061	0.0299	0.0299
Echinococcus granulosus	cathepsin l1	0.0185	0.5946	0.5946
Schistosoma mansoni	cathepsin s	0.0089	0.1587	0.1587
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Brugia malayi	Cathepsin L-like precursor	0.0089	0.1587	0.1587
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0143	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	1	1
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5946	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Loa Loa (eye worm)	cysteine protease	0.0274	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0099	0.204	0.204
Leishmania major	cathepsin L-like protease	0.0274	1	1
Brugia malayi	Cathepsin L-like precursor	0.0274	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0143	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Onchocerca volvulus	Cathepsin L homolog	0.0274	1	1
Brugia malayi	Cathepsin L-like precursor	0.0274	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0274	1	1
Brugia malayi	Cathepsin L-like precursor	0.0185	0.5946	0.5946
Toxoplasma gondii	cathepsin CPL	0.0274	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0143	0.4054	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0143	0.4054	0.4054
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0089	0.1587	0.1587
Plasmodium vivax	vivapain-2	0.0274	1	1
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054
Echinococcus granulosus	cathepsin b	0.0199	0.6596	0.6596
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0199	0.6596	0.6596
Echinococcus multilocularis	cathepsin L	0.0143	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0274	1	1
Loa Loa (eye worm)	ctsf protein	0.0274	1	1
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0143	0.4054	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0274	1	1
Loa Loa (eye worm)	hypothetical protein	0.0089	0.1587	0.1587
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0143	0.4054	0.4054
Leishmania major	cathepsin L-like protease	0.0274	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	1	1
Brugia malayi	cathepsin L-like precursor	0.0185	0.5946	0.5946
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0274	1	1
Giardia lamblia	Cathepsin B precursor	0.0099	0.204	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0199	0.6596	0.6596
Brugia malayi	Cytochrome P450 family protein	0.0061	0.0299	0.0299
Plasmodium vivax	vivapain-3	0.0143	0.4054	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0199	0.6596	0.6596
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0274	1	1
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0089	0.1587	0.1587
Echinococcus multilocularis	cathepsin L cysteine protease	0.0274	1	1
Echinococcus granulosus	cathepsin L	0.0143	0.4054	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0274	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0274	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0274	1	1
Brugia malayi	Cathepsin L-like precursor	0.0185	0.5946	0.5946
Onchocerca volvulus	Cathepsin F homolog	0.0274	1	1
Entamoeba histolytica	cysteine protease, putative	0.0143	0.4054	0.4054

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 847397