Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.3186 | 0.4188 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.3186 | 0.4188 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0.0199 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0851 | 0.0914 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0.0199 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0518 | 0.0559 |
Brugia malayi | hypothetical protein | 0.0041 | 0.3194 | 0.3056 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.9254 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.3194 | 0.3861 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.0333 | 0.0173 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0.0199 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0199 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0199 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0851 | 0.084 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0.0199 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0.0199 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0518 | 0.0411 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.3194 | 0.4199 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0022 | 0.0199 | 0.0215 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0199 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0851 | 0.0914 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4357 | 0.4709 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0.0199 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0.0199 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.1264 | 0.1086 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.3194 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0.0199 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0069 | 0.7332 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.3611 | 0.3902 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.4024 | 0.4348 |
Brugia malayi | Bromodomain containing protein | 0.0044 | 0.3599 | 0.3469 |
Schistosoma mansoni | bromodomain containing protein | 0.0073 | 0.7956 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.3194 | 0.3861 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0.0199 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.3194 | 0.4199 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0333 | 0.0188 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.3194 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0069 | 0.7332 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0333 | 0.0188 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.3194 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0.0199 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0.0199 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.3194 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.