Detailed information for compound 847952

Basic information

Technical information
  • TDR Targets ID: 847952
  • Name: 2-[2-(4-bromophenyl)-2-oxoethyl]sulfanyl-4,6- dimethyl-N-phenylpyridine-3-carboxamide
  • MW: 455.367 | Formula: C22H19BrN2O2S
  • H donors: 1 H acceptors: 3 LogP: 5.4 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nc(SCC(=O)c2ccc(cc2)Br)c(c(c1)C)C(=O)Nc1ccccc1
  • InChi: 1S/C22H19BrN2O2S/c1-14-12-15(2)24-22(20(14)21(27)25-18-6-4-3-5-7-18)28-13-19(26)16-8-10-17(23)11-9-16/h3-12H,13H2,1-2H3,(H,25,27)
  • InChiKey: CNYIAYHBWAUFDV-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[2-(4-bromophenyl)-2-oxo-ethyl]sulfanyl-4,6-dimethyl-N-phenyl-pyridine-3-carboxamide
  • 2-[[2-(4-bromophenyl)-2-oxoethyl]thio]-4,6-dimethyl-N-phenyl-3-pyridinecarboxamide
  • 2-[[2-(4-bromophenyl)-2-keto-ethyl]thio]-4,6-dimethyl-N-phenyl-nicotinamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0007 0.0015
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0007 0.0007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0007 0.0007
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0008 0.0002 0.0002
Brugia malayi hypothetical protein 0.0008 0.0004 0.0009
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0009 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0024
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0009 0.0006 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Onchocerca volvulus Protein cycle homolog 0.0016 0.0025 0.039
Brugia malayi hypothetical protein 0.0008 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.0004
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0016 0.0024 0.0053
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0002 0.0002
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0002 0.0002
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0205 0.0527 0.0527
Echinococcus multilocularis Smad4 0.0008 0.0002 0.0002
Onchocerca volvulus Huntingtin homolog 0.0053 0.0124 0.2284
Loa Loa (eye worm) hypothetical protein 0.0076 0.0184 0.0184
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Echinococcus granulosus smad 0.0008 0.0002 0.0002
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0078 0.1472
Trypanosoma brucei Aminopeptidase M1, putative 0.0205 0.0527 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.009 0.009
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0034 0.0654
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0007 0.0015
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0007 0.0007
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0007 0.0054
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0205 0.0527 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0007 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0034 0.0034
Loa Loa (eye worm) sema domain-containing protein 0.0008 0.0004 0.0004
Brugia malayi MH2 domain containing protein 0.0113 0.0284 0.062
Echinococcus granulosus plexin a4 0.0024 0.0046 0.0045
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0002 0.0002
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0002 0.0002
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0009 0.0006 0.0117
Echinococcus granulosus microtubule associated protein 2 0.0351 0.0917 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0002 0.0002
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0205 0.0527 0.0527
Echinococcus granulosus neuropeptide s receptor 0.0249 0.0646 0.0646
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0013 0.0015 0.0176
Loa Loa (eye worm) hypothetical protein 0.0053 0.0124 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Echinococcus multilocularis geminin 0.0244 0.0631 0.0631
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0011 0.0025
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0205 0.0527 1
Brugia malayi hypothetical protein 0.0016 0.0025 0.0054
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0205 0.0527 0.0527
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0008 0.0002 0.0002
Leishmania major protein kinase, putative 0.0012 0.0014 0.0257
Brugia malayi ecdysteroid receptor 0.001 0.0007 0.0015
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0009 0.0006 0.0006
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0009 0.0006 0.0117
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0007 0.0015
Echinococcus granulosus geminin 0.0244 0.0631 0.0631
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0013 0.0015 0.0015
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0205 0.0527 0.0527
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0011 0.0011 0.0201
Onchocerca volvulus 0.0205 0.0527 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0002 0.0002
Trypanosoma cruzi aminopeptidase, putative 0.0205 0.0527 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0007 0.0007
Schistosoma mansoni plexin 0.0012 0.0013 0.0013
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0094 0.0094
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0011 0.0011
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0205 0.0527 0.0527
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0007 0.0054
Echinococcus multilocularis aryl hydrocarbon receptor 0.0023 0.0043 0.0043
Echinococcus granulosus aryl hydrocarbon receptor 0.0023 0.0043 0.0043
Onchocerca volvulus 0.001 0.0007 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0007 0.0015
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0205 0.0527 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0076 0.0184 0.0184
Schistosoma mansoni hypothetical protein 0.0244 0.0631 0.0631
Trypanosoma cruzi aminopeptidase, putative 0.0205 0.0527 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0205 0.0527 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0011 0.0011
Brugia malayi MH2 domain containing protein 0.0008 0.0002 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0007 0.0015
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0013 0.0015 0.0291
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0007 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0205 0.0527 0.5874
Brugia malayi steroid hormone receptor 0.001 0.0007 0.0015
Brugia malayi Peptidase family M1 containing protein 0.0205 0.0527 0.1151
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0009 0.0006 0.0013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0039 0.0039
Onchocerca volvulus 0.0023 0.0043 0.0735
Echinococcus multilocularis microtubule associated protein 2 0.0351 0.0917 0.0916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0007 0.0007
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0205 0.0527 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0007 0.0015
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0205 0.0527 0.0527
Trypanosoma cruzi target of rapamycin kinase 3 0.0009 0.0006 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Schistosoma mansoni hypothetical protein 0.0244 0.0631 0.0631
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0007 0.0007
Onchocerca volvulus 0.002 0.0036 0.0601
Leishmania major phosphatidylinositol kinase related protein, putative 0.0009 0.0006 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0034 0.0654
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0034 0.5
Brugia malayi hypothetical protein 0.0023 0.0043 0.0093
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0002 0.0038
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0094 0.0094
Brugia malayi Peptidase family M1 containing protein 0.0205 0.0527 0.1151
Loa Loa (eye worm) phosphatidylinositol 3 0.0009 0.0006 0.0006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0007 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.009 0.009
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0008 0.0002 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0007 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0007 0.0007
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0011 0.0011
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0008 0.0002 0.0002
Brugia malayi hypothetical protein 0.0205 0.0527 0.1151
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0007 0.0007
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0002 0.0002
Loa Loa (eye worm) peptidase family M1 containing protein 0.0205 0.0527 0.0527
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0007 0.0007
Echinococcus granulosus FTZ F1 alpha 0.001 0.0007 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0007 0.0015
Echinococcus multilocularis leukotriene A 4 hydrolase 0.3762 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0008 0.0002 0.0002
Mycobacterium ulcerans aminopeptidase N PepN 0.0205 0.0527 1
Echinococcus multilocularis semaphorin 5B 0.0008 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0016 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0007 0.0054
Echinococcus multilocularis neuropeptide s receptor 0.0249 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0335 0.0874 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0034 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0009 0.0006 0.0118
Schistosoma mansoni smad1 5 8 and 0.0008 0.0002 0.0002
Loa Loa (eye worm) TATA binding protein associated factor 0.0205 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0011 0.0011
Echinococcus granulosus neuropeptide receptor A26 0.0249 0.0646 0.0646
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0002 0.0002
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0084 0.0184
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0034 0.0654
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0002 0.0002
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0205 0.0527 0.0527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0007 0.0007
Entamoeba histolytica aminopeptidase, putative 0.0205 0.0527 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.009 0.009
Brugia malayi MH1 domain containing protein 0.0008 0.0002 0.0005
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0205 0.0527 0.0527
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0013 0.0015 0.0033
Toxoplasma gondii aminopeptidase N protein 0.0335 0.0874 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0205 0.0527 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0041 0.009 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0007 0.0015
Mycobacterium leprae Possible regulatory protein 0.0007 0 0.5
Brugia malayi hypothetical protein 0.1727 0.4581 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0002 0.0002
Echinococcus granulosus semaphorin 1A 0.0008 0.0004 0.0004
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0002 0.0002
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0002 0.0002
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0007 0.0007
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0205 0.0527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Brugia malayi Sema domain containing protein 0.0008 0.0004 0.0009
Schistosoma mansoni plexin 0.002 0.0036 0.0036
Toxoplasma gondii aminopeptidase n, putative 0.0335 0.0874 1
Loa Loa (eye worm) Smad1 0.0008 0.0002 0.0002
Mycobacterium ulcerans aminopeptidase N PepN 0.0205 0.0527 1
Echinococcus multilocularis neuropeptide receptor A26 0.0249 0.0646 0.0646
Brugia malayi plexin A 0.0024 0.0046 0.0099
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0024
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0023 0.0043 0.0043
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0002 0.0002
Brugia malayi Sema domain containing protein 0.0008 0.0004 0.0009
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0007 0.0007
Echinococcus granulosus semaphorin 5B 0.0008 0.0004 0.0004
Schistosoma mansoni aminopeptidase A (M01 family) 0.0205 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.0004
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0009 0.0006 0.0006
Brugia malayi TATA binding protein associated factor 0.0205 0.0527 0.1151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Brugia malayi Cyclic-nucleotide gated cation channel 0.0008 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0205 0.0527 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0015 0.0291
Loa Loa (eye worm) hypothetical protein 0.0033 0.0071 0.0071
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0007 0.0015
Echinococcus multilocularis muscleblind protein 1 0.0076 0.0184 0.0184
Brugia malayi hypothetical protein 0.0053 0.0124 0.027
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0024
Echinococcus multilocularis serine protein kinase ATM 0.0013 0.0015 0.0015
Schistosoma mansoni smad1 5 8 and 0.0008 0.0002 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0113 0.0284 0.0284
Loa Loa (eye worm) sema domain-containing protein 0.0008 0.0004 0.0004
Echinococcus multilocularis smad 0.0008 0.0002 0.0002
Schistosoma mansoni ap endonuclease 0.002 0.0034 0.0034
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0205 0.0527 0.0527
Brugia malayi nuclear receptor NHR-88 0.001 0.0007 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0007 0.0015
Echinococcus multilocularis plexin a4 0.0024 0.0046 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Brugia malayi Smad1 0.0008 0.0002 0.0005
Schistosoma mansoni semaphorin 5-related 0.0008 0.0004 0.0004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0007 0.0015
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0205 0.0527 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0034 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0009 0.0006 0.0006
Leishmania major phosphatidylinositol 3-kinase, putative 0.0009 0.0006 0.0117
Brugia malayi MH2 domain containing protein 0.0008 0.0002 0.0005
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0205 0.0527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0007 0.0007
Loa Loa (eye worm) plexin A 0.0024 0.0046 0.0046
Brugia malayi MH1 domain containing protein 0.0008 0.0002 0.0005
Loa Loa (eye worm) aminopeptidase N 0.0205 0.0527 0.0527
Brugia malayi Plexin repeat family protein 0.002 0.0036 0.0078
Echinococcus multilocularis hypothetical protein 0.0008 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0015 0.0021 0.0021
Toxoplasma gondii aminopeptidase N, putative 0.0335 0.0874 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0007 0.0015
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0034 0.0543
Echinococcus multilocularis aminopeptidase N 0.0205 0.0527 0.0527
Loa Loa (eye worm) transcription factor SMAD2 0.0113 0.0284 0.0284
Brugia malayi Calcitonin receptor-like protein seb-1 0.0022 0.0039 0.0086
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0205 0.0527 1
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0016 0.0025 0.0054
Brugia malayi hypothetical protein 0.0205 0.0527 0.1151
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0034 0.0075
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0205 0.0527 0.0527
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0205 0.0527 0.0527
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0205 0.0527 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Schistosoma mansoni thyroid hormone receptor 0.001 0.0007 0.0007
Schistosoma mansoni ap endonuclease 0.002 0.0034 0.0034
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0024 0.0024
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0009 0.0006 0.0117
Echinococcus granulosus muscleblind protein 0.0076 0.0184 0.0184
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0009 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0007 0.0007
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0205 0.0527 0.0527
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0022 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0007 0.0007
Schistosoma mansoni nuclear hormone receptor 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0335 0.0874 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0002 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0022 0.0039 0.0086
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0016 0.0025 0.0025
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0041 0.009 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0002 0.0002
Brugia malayi nuclear hormone receptor 0.001 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.0004
Onchocerca volvulus Huntingtin homolog 0.0053 0.0124 0.2284
Trypanosoma brucei aminopeptidase, putative 0.0205 0.0527 1
Loa Loa (eye worm) hypothetical protein 0.0205 0.0527 0.0527
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0002 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0002 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.009 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0041 0.009 0.009
Brugia malayi hypothetical protein 0.0016 0.0024 0.0053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0013 0.0013
Trypanosoma brucei Aminopeptidase M1, putative 0.0205 0.0527 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0205 0.0527 0.0527
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0007 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0041 0.009 0.0196
Schistosoma mansoni hypothetical protein 0.0008 0.0004 0.0004
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0007 0 0.5
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0034 0.5
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0205 0.0527 1
Toxoplasma gondii FATC domain-containing protein 0.0013 0.0015 0.0106
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.3762 1 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0036 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0007 0.0007
Onchocerca volvulus 0.0205 0.0527 1
Brugia malayi Peptidase family M1 containing protein 0.0205 0.0527 0.1151
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.0004
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0007 0.0007
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0008 0.0002 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Echinococcus multilocularis muscleblind protein 0.0076 0.0184 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0007 0.0015
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0205 0.0527 0.0527
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0009 0.0006 0.0117
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0205 0.0527 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0007 0.0007
Brugia malayi Muscleblind-like protein 0.0076 0.0184 0.0402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0007 0.0007
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.002 0.0034 0.0074
Loa Loa (eye worm) hypothetical protein 0.0008 0.0004 0.0004
Echinococcus granulosus Smad4 0.0008 0.0002 0.0002
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0205 0.0527 1
Entamoeba histolytica hypothetical protein 0.0013 0.0015 0.0176
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0034 0.0034
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0041 0.009 0.009
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0034 0.0034
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0078 0.1472
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0009 0.0006 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0007 0.0015
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0053 0.0124 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0034 0.0654
Schistosoma mansoni coup transcription factor 0.001 0.0007 0.0007
Schistosoma mansoni microtubule-associated protein tau 0.0351 0.0917 0.0917
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0034 0.0543
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0009 0.0006 0.0006
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0008 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0043
Onchocerca volvulus 0.0205 0.0527 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Brugia malayi latrophilin 2 splice variant baaae 0.0015 0.0021 0.0046
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0008 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Schistosoma mansoni smad1 5 8 and 0.0008 0.0002 0.0002
Schistosoma mansoni smad 0.0008 0.0002 0.0002
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0009 0.0006 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117
Echinococcus granulosus aminopeptidase N 0.0205 0.0527 0.0527
Schistosoma mansoni Smad4 0.0008 0.0002 0.0002
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0084 0.0084
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0009 0.0006 0.0006
Echinococcus granulosus serine protein kinase ATM 0.0013 0.0015 0.0015
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0205 0.0527 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0009 0.0006 0.0117
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0002 0.0002
Trypanosoma cruzi Aminopeptidase M1, putative 0.0205 0.0527 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0084 0.0084
Loa Loa (eye worm) leukotriene A4 hydrolase 0.3762 1 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0034 0.0654
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0205 0.0527 0.5874
Toxoplasma gondii exonuclease III APE 0.002 0.0034 0.0326
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0009 0.0006 0.0117
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0009 0.0006 0.0117

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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