Detailed information for compound 848091

Basic information

Technical information
  • TDR Targets ID: 848091
  • Name: 5-[(3-chloro-5-ethoxy-4-hydroxyphenyl)methyli dene]-1-methyl-1,3-diazinane-2,4,6-trione
  • MW: 324.716 | Formula: C14H13ClN2O5
  • H donors: 2 H acceptors: 4 LogP: 1.75 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(C=C2C(=O)NC(=O)N(C2=O)C)cc(c1O)Cl
  • InChi: 1S/C14H13ClN2O5/c1-3-22-10-6-7(5-9(15)11(10)18)4-8-12(19)16-14(21)17(2)13(8)20/h4-6,18H,3H2,1-2H3,(H,16,19,21)/b8-4-
  • InChiKey: PRXCCJQIGTZSRJ-YWEYNIOJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-5-[(3-chloro-5-ethoxy-4-hydroxyphenyl)methylidene]-1-methyl-1,3-diazinane-2,4,6-trione
  • 5-[(3-chloro-5-ethoxy-4-hydroxy-phenyl)methylene]-1-methyl-hexahydropyrimidine-2,4,6-trione
  • (5Z)-5-[(3-chloro-5-ethoxy-4-hydroxy-phenyl)methylene]-1-methyl-hexahydropyrimidine-2,4,6-trione
  • 5-[(3-chloro-5-ethoxy-4-hydroxyphenyl)methylene]-1-methylhexahydropyrimidine-2,4,6-trione
  • (5Z)-5-[(3-chloro-5-ethoxy-4-hydroxyphenyl)methylene]-1-methylhexahydropyrimidine-2,4,6-trione
  • 5-(3-chloro-5-ethoxy-4-hydroxy-benzylidene)-1-methyl-barbituric acid
  • (5Z)-5-(3-chloro-5-ethoxy-4-hydroxy-benzylidene)-1-methyl-barbituric acid
  • (5Z)-5-[(3-chloro-5-ethoxy-4-hydroxy-phenyl)methylidene]-1-methyl-1,3-diazinane-2,4,6-trione
  • 5-[(3-chloro-5-ethoxy-4-hydroxy-phenyl)methylidene]-1-methyl-1,3-diazinane-2,4,6-trione
  • ZINC00446988
  • CBMicro_017608
  • BIM-0017687.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0109 0.0109
Brugia malayi Carboxylesterase family protein 0.0285 0.4918 0.4918
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0083
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0063 0.0883 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0915 0.3579
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0063 0.0883 0.567
Echinococcus granulosus tar DNA binding protein 0.0062 0.0868 0.0926
Entamoeba histolytica hypothetical protein 0.0019 0.0083 0.0559
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0915 0.6137
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0083 0.0089
Brugia malayi nuclear hormone receptor family member nhr-6 0.0041 0.0494 0.0494
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.017 0.017
Schistosoma mansoni hypothetical protein 0.0531 0.9372 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0248 0.3975
Brugia malayi intermediate filament protein 0.0026 0.0222 0.0222
Echinococcus granulosus acetylcholinesterase 0.0285 0.4918 0.5248
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0117 0.0458
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1449 0.1546
Entamoeba histolytica hypothetical protein 0.0025 0.02 0.1339
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.0459 0.8643
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0096 0.1478 0.1478
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0938 0.1001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0096 0.1478 0.1577
Echinococcus granulosus geminin 0.0531 0.9372 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1449 0.1546
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0514 0.0548
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0382 0.0407
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0146
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0422 0.045
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0041 0.0494 0.0527
Loa Loa (eye worm) hypothetical protein 0.0048 0.0617 0.0617
Echinococcus granulosus Protein patched homolog 1 0.0097 0.1494 0.1594
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0248 0.097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0054 0.0726 0.0726
Schistosoma mansoni nuclear receptor nhr-48 0.0041 0.0494 0.0527
Onchocerca volvulus 0.0048 0.0617 0.0566
Loa Loa (eye worm) hypothetical protein 0.003 0.0295 0.0295
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0083 0.0089
Trichomonas vaginalis importin beta-1, putative 0.0025 0.02 0.0825
Brugia malayi laminin alpha chain 0.0024 0.017 0.017
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0096 0.1478 0.1478
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.04 0.1563
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0096 0.1478 0.1577
Trichomonas vaginalis ran, putative 0.0023 0.0158 0.0526
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0472 0.1846
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0514 1
Loa Loa (eye worm) carboxylesterase 0.0048 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.04 0.2243
Brugia malayi DnaJ domain containing protein 0.007 0.1021 0.1021
Mycobacterium tuberculosis Carboxylesterase LipT 0.0048 0.0617 0.2414
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.0459 1
Trypanosoma brucei unspecified product 0.0034 0.0355 0.1388
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0096 0.1478 0.1577
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0083
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.04 0.1563
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0041 0.0494 0.0527
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0131 0.2123 0.8301
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0096 0.1478 0.1478
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1491 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Trichomonas vaginalis spcc417.12 protein, putative 0.0048 0.0617 0.3787
Brugia malayi hypothetical protein 0.0041 0.0494 0.0494
Schistosoma mansoni ap endonuclease 0.002 0.0109 0.0116
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0054 0.0726 0.0726
Leishmania major hypothetical protein, conserved 0.0039 0.0459 0.1794
Brugia malayi nuclear receptor NHR-67 0.0041 0.0494 0.0494
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0472 0.1846
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0048 0.0617 0.0659
Entamoeba histolytica hypothetical protein 0.0035 0.0382 0.2561
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0382 0.0407
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0938 0.0938
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0131 0.2123 0.8225
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0915 0.3579
Schistosoma mansoni zinc finger protein 0.0041 0.0494 0.0527
Echinococcus granulosus slit 2 protein 0.0024 0.017 0.0181
Echinococcus granulosus lamin 0.0026 0.0222 0.0237
Schistosoma mansoni hypothetical protein 0.0066 0.0938 0.1001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0096 0.1478 0.1478
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0096 0.1478 0.1577
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0938 0.0938
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0083 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0096 0.1478 0.1478
Schistosoma mansoni steroid hormone receptor ad4bp 0.0096 0.1478 0.1577
Echinococcus granulosus pikachurin 0.0024 0.017 0.0181
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0083 0.0089
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0083 0.0083
Echinococcus multilocularis para nitrobenzyl esterase 0.0048 0.0617 0.0659
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0158 0.0168
Loa Loa (eye worm) hypothetical protein 0.0048 0.0617 0.0617
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0131 0.2123 0.8225
Schistosoma mansoni RAR-like nuclear receptor 0.0096 0.1478 0.1577
Echinococcus granulosus acetylcholinesterase 0.0285 0.4918 0.5248
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0146
Brugia malayi CHE-14 protein 0.0097 0.1494 0.1494
Schistosoma mansoni cell polarity protein 0.0024 0.017 0.0181
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0868 0.0926
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.0459 0.1794
Brugia malayi TAR-binding protein 0.0062 0.0868 0.0868
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.017 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0117 0.0458
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.04 0.268
Trichomonas vaginalis protein kinase inhibitor, putative 0.007 0.1021 0.6651
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0096 0.1478 0.1478
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0158 0.1384
Echinococcus multilocularis lamin dm0 0.0026 0.0222 0.0237
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0083 0.0089
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0096 0.1478 0.1478
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0472 0.1483
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0285 0.4918 0.5248
Schistosoma mansoni slit 0.0024 0.017 0.0181
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0134 0.2173 0.8496
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.02 0.0781
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0083 0.0089
Echinococcus granulosus FTZ F1 alpha 0.0096 0.1478 0.1577
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0041 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0036 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0048 0.0617 0.0617
Echinococcus multilocularis dna polymerase kappa 0.004 0.0472 0.0504
Brugia malayi hypothetical protein 0.0041 0.0494 0.0494
Echinococcus multilocularis slit 2 protein 0.0024 0.017 0.0181
Brugia malayi hypothetical protein 0.0048 0.0617 0.0617
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0514 0.3052
Brugia malayi hypothetical protein 0.0028 0.0248 0.0248
Schistosoma mansoni acetylcholinesterase 0.0048 0.0617 0.0659
Loa Loa (eye worm) hepatopoietin HPO2 0.0039 0.0459 0.0459
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0155 0.2557 1
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0039 0.0459 0.049
Entamoeba histolytica hypothetical protein 0.0035 0.0382 0.2561
Entamoeba histolytica Ran family GTPase 0.0023 0.0158 0.1056
Loa Loa (eye worm) hypothetical protein 0.0096 0.1478 0.1478
Echinococcus granulosus dna polymerase kappa 0.004 0.0472 0.0504
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0109 0.0427
Schistosoma mansoni hypothetical protein 0.007 0.1021 0.109
Loa Loa (eye worm) hypothetical protein 0.0028 0.0248 0.0248
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0096 0.1478 0.1577
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0472 0.1846
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0096 0.1478 0.1478
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0155 0.2557 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0096 0.1478 0.1478
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0041 0.0494 0.0527
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.04 0.0426
Brugia malayi ecdysone receptor 0.0041 0.0494 0.0494
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0131 0.2123 0.8301
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0915 0.3579
Brugia malayi conserved hypotetical protein 0.0041 0.0494 0.0494
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0096 0.1478 0.1798
Loa Loa (eye worm) steroid hormone receptor 0.0096 0.1478 0.1478
Echinococcus multilocularis GPCR, family 2 0.0066 0.0938 0.1001
Brugia malayi Inositol-1 0.0042 0.0514 0.0514
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0494 0.0527
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1449 0.1546
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0868 0.0926
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0158 0.0626
Echinococcus multilocularis carboxylesterase 5A 0.0285 0.4918 0.5248
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0096 0.1478 0.1478
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0938 0.1001
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0109 0.0427
Echinococcus multilocularis protein dispatched 1 0.0102 0.16 0.1707
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0096 0.1478 0.1577
Onchocerca volvulus 0.0048 0.0617 0.0566
Echinococcus multilocularis nuclear receptor nhr 48 0.0041 0.0494 0.0527
Echinococcus multilocularis musashi 0.0026 0.0222 0.0237
Echinococcus granulosus importin subunit beta 1 0.0031 0.0306 0.0327
Loa Loa (eye worm) hypothetical protein 0.0054 0.0726 0.0726
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0041 0.0494 0.0527
Entamoeba histolytica hypothetical protein 0.0035 0.0382 0.2561
Leishmania major hypothetical protein, conserved 0.0028 0.0248 0.097
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0096 0.1478 0.1577
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0083 0.0089
Loa Loa (eye worm) hypothetical protein 0.0566 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0514 0.2009
Echinococcus multilocularis ecdysone induced protein 78C 0.0096 0.1478 0.1577
Loa Loa (eye worm) nuclear hormone receptor 0.0041 0.0494 0.0494
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0096 0.1478 0.1577
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0938 0.1001
Echinococcus multilocularis acetylcholinesterase 0.0285 0.4918 0.5248
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0494 0.0527
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0083 0.0083
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0514 0.3445
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.017 0.0181
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.017 0.017
Echinococcus multilocularis thyroid hormone receptor alpha 0.0096 0.1478 0.1577
Echinococcus granulosus sterol regulatory element binding protein 0.0097 0.1494 0.1594
Brugia malayi PXA domain containing protein 0.0019 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.004 0.0466 0.0497
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0938 0.0938
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0158 0.1196
Echinococcus granulosus snurportin 1 0.0332 0.5756 0.6142
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0096 0.1478 0.1478
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0472 0.1846
Brugia malayi tailless protein 0.0041 0.0494 0.0494
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0248 0.3975
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0083 0.0083
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0726 0.0726
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0306 0.1197
Brugia malayi RNA, U transporter 1 0.0088 0.1345 0.1345
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0083 0.0083
Brugia malayi nuclear receptor RXR 0.0054 0.0726 0.0726
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0514 0.3052
Schistosoma mansoni inositol monophosphatase 0.0042 0.0514 0.0548
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0048 0.0617 0.2414
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0083
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0131 0.2123 0.8225
Echinococcus granulosus lamin dm0 0.0026 0.0222 0.0237
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0083 0.0083
Schistosoma mansoni ap endonuclease 0.002 0.0109 0.0116
Echinococcus granulosus dnaJ subfamily C 6 0.007 0.1021 0.109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0494 0.0527
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0472 0.1846
Loa Loa (eye worm) hypothetical protein 0.0096 0.1478 0.1478
Loa Loa (eye worm) inositol-1 0.0042 0.0514 0.0514
Schistosoma mansoni ran 0.0023 0.0158 0.0168
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0083 0.0089
Loa Loa (eye worm) nuclear receptor NHR-67 0.0041 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0048 0.0617 0.0617
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.02 0.0825
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0514 0.2009
Brugia malayi Calcitonin receptor-like protein seb-1 0.0208 0.352 0.352
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0472 0.1846
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0109 0.0109
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0096 0.1478 0.1577
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0131 0.2123 0.8301
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0134 0.2173 0.2173
Loa Loa (eye worm) carboxylesterase 0.0285 0.4918 0.4918
Echinococcus multilocularis Niemann Pick C1 protein 0.0193 0.3242 0.3459
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0726 0.0726
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0083 0.0089
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0472 0.1846
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0041 0.0494 0.0527
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0083 0.0089
Onchocerca volvulus 0.0048 0.0617 0.0566
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1449 0.1449
Echinococcus granulosus para nitrobenzyl esterase 0.0048 0.0617 0.0659
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0514 0.2009
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0131 0.2123 0.8301
Onchocerca volvulus Protein ultraspiracle homolog 0.0096 0.1478 0.1798
Brugia malayi hypothetical protein 0.0019 0.0083 0.0083
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0208 0.352 0.352
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0083 0.0089
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0306 0.0327
Brugia malayi hypothetical protein 0.0054 0.0726 0.0726
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.04 0.2243
Loa Loa (eye worm) hypothetical protein 0.0048 0.0617 0.0617
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0514 0.2009
Echinococcus granulosus BC026374 protein S09 family 0.0048 0.0617 0.0659
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0096 0.1478 0.1478
Brugia malayi ecdysteroid receptor 0.0411 0.7206 0.7206
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0063 0.0883 0.567
Onchocerca volvulus 0.0041 0.0494 0.039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0096 0.1478 0.1577
Leishmania major importin beta-1 subunit, putative 0.0025 0.02 0.0781
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0096 0.1478 0.1577
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0915 0.0977
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0083 0.0083
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.04 0.0426
Loa Loa (eye worm) hypothetical protein 0.0142 0.2325 0.2325
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.04 0.0426
Echinococcus multilocularis BC026374 protein (S09 family) 0.0048 0.0617 0.0659
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0131 0.2123 0.8301
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0096 0.1478 0.1478
Loa Loa (eye worm) hypothetical protein 0.0026 0.0222 0.0222
Entamoeba histolytica hypothetical protein 0.0019 0.0083 0.0559
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0096 0.1478 0.1478
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0472 0.1846
Schistosoma mansoni hypothetical protein 0.0332 0.5756 0.6142
Plasmodium falciparum importin beta, putative 0.0031 0.0306 0.5636
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0083
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0109 0.0116
Schistosoma mansoni thyroid hormone receptor 0.0096 0.1478 0.1577
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0472 0.2757
Schistosoma mansoni importin beta-1 0.0031 0.0306 0.0327
Loa Loa (eye worm) hypothetical protein 0.0024 0.017 0.017
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0134 0.2173 0.2318
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0494 0.0527
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0048 0.0617 0.2414
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0083 0.0089
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0222 0.0222
Echinococcus granulosus nuclear receptor nhr 48 0.0041 0.0494 0.0527
Echinococcus multilocularis dnaJ subfamily C 6 0.007 0.1021 0.109
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1449 0.1546
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0494 0.0527
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.04 0.0426
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0131 0.2123 0.8225
Loa Loa (eye worm) hypothetical protein 0.0066 0.0938 0.0938
Onchocerca volvulus Bile acid receptor homolog 0.0411 0.7206 1
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0472 0.1846
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0222 0.0222
Echinococcus granulosus intermediate filament protein 0.0026 0.0222 0.0237
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0109 0.0427
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0083 0.0089
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Brugia malayi latrophilin 2 splice variant baaae 0.0142 0.2325 0.2325
Loa Loa (eye worm) hypothetical protein 0.0054 0.0726 0.0726
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0096 0.1478 0.1577
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.04 0.04
Brugia malayi hypothetical protein 0.0019 0.0083 0.0083
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0915 0.0915
Entamoeba histolytica hypothetical protein 0.0035 0.0382 0.2561
Echinococcus multilocularis snurportin 1 0.0332 0.5756 0.6142
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0472 0.1483
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0083
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0083 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0472 0.1846
Loa Loa (eye worm) hypothetical protein 0.0096 0.1478 0.1478
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0915 0.0977
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0096 0.1478 0.1478
Loa Loa (eye worm) hypothetical protein 0.0096 0.1478 0.1478
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0096 0.1478 0.1577
Brugia malayi Importin beta-1 subunit 0.0031 0.0306 0.0306
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0096 0.1478 0.1577
Loa Loa (eye worm) hypothetical protein 0.0097 0.1494 0.1494
Schistosoma mansoni gliotactin 0.0048 0.0617 0.0659
Echinococcus multilocularis lamin 0.0026 0.0222 0.0237
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0083 0.0083
Giardia lamblia DINP protein human, muc B family 0.0021 0.0117 0.0104
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0097 0.1494 0.1494
Onchocerca volvulus 0.0096 0.1478 0.1798
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0083 0.0089
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0472 0.1846
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0222 0.0222
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0131 0.2123 0.8301
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0109 0.0427
Schistosoma mansoni coup transcription factor 0.0096 0.1478 0.1577
Brugia malayi orphan nuclear receptor NR2E1 0.0041 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0285 0.4918 0.4918
Echinococcus multilocularis expressed protein 0.0365 0.6371 0.6798
Plasmodium vivax importin-beta 2, putative 0.0031 0.0306 0.5636
Schistosoma mansoni nuclear receptor 0.0041 0.0494 0.0527
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0131 0.2123 0.8225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0096 0.1478 0.1478
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0083 0.0089
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0726 0.0775
Brugia malayi nuclear receptor NHR-88 0.0041 0.0494 0.0494
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1934 0.7564
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0134 0.2173 0.8496
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0083 0.0089
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0248 0.097
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0083 0.0089
Schistosoma mansoni hypothetical protein 0.0531 0.9372 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1449 0.1546
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0158 0.0616
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1449 0.1449
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0915 0.0977
Brugia malayi steroid hormone receptor 0.0096 0.1478 0.1478
Loa Loa (eye worm) hypothetical protein 0.0208 0.352 0.352
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0915 0.3579
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0382 0.0407
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0083 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0096 0.1478 0.1478
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0083 0.0089
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0494 0.039
Loa Loa (eye worm) hypothetical protein 0.0054 0.0726 0.0726
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0083 0.0089
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0096 0.1478 0.1577
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.017 0.0181
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0039 0.0459 0.049
Toxoplasma gondii Erv1 / Alr family protein 0.0039 0.0459 0.8643
Echinococcus granulosus expressed protein 0.0365 0.6371 0.6798
Brugia malayi RNA binding protein 0.0062 0.0868 0.0868
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0868 0.0926
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.0459 0.1794
Echinococcus multilocularis acetylcholinesterase 0.0285 0.4918 0.5248
Brugia malayi Steroid receptor seven-up type 2 0.0096 0.1478 0.1478
Brugia malayi Augmenter of liver regeneration 0.0039 0.0459 0.0459
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0109 0.0182
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0083 0.0089
Brugia malayi Nuclear hormone receptor-like 1 0.0096 0.1478 0.1478
Brugia malayi PXA domain containing protein 0.0019 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0096 0.1478 0.1478
Schistosoma mansoni hypothetical protein 0.004 0.0466 0.0497
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0048 0.0617 0.3787
Loa Loa (eye worm) acetylcholinesterase 1 0.0285 0.4918 0.4918
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.017 0.0181
Brugia malayi EGF-like domain containing protein 0.0024 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0096 0.1478 0.1478
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0131 0.2123 0.8225
Echinococcus granulosus carboxylesterase 5A 0.0285 0.4918 0.5248
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0083 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1449 0.1546
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0134 0.2173 0.8429
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0155 0.2557 1
Echinococcus multilocularis pikachurin 0.0024 0.017 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0096 0.1478 0.1478
Loa Loa (eye worm) hypothetical protein 0.0024 0.017 0.017
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0051 0.0661 0.0706
Schistosoma mansoni hypothetical protein 0.0142 0.2325 0.2481
Echinococcus multilocularis sterol regulatory element binding protein 0.0097 0.1494 0.1594
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0109 0.0732
Loa Loa (eye worm) RNA binding protein 0.0062 0.0868 0.0868
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0868 0.0868
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0158 0.0616
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0096 0.1478 0.1577
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0494 0.0494
Schistosoma mansoni retinoic acid receptor RXR 0.0096 0.1478 0.1577
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0155 0.2557 1
Mycobacterium ulcerans oxidoreductase 0.0121 0.1934 0.7455
Loa Loa (eye worm) hypothetical protein 0.0134 0.2173 0.2173
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0083 0.0083
Schistosoma mansoni nuclear hormone receptor 0.0096 0.1478 0.1577
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1491 0.1591
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.04 0.0426
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.04 0.1563
Schistosoma mansoni neuroligin 3 (S09 family) 0.0048 0.0617 0.0659
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0472 0.1846
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0083 0.0083
Brugia malayi nuclear receptor RXR 0.0041 0.0494 0.0494
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0938 0.1001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0096 0.1478 0.1478
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0083 0.0089
Loa Loa (eye worm) DR-78 0.0041 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0031 0.0306 0.0306
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0083 0.0089
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0083 0.0089
Schistosoma mansoni inositol monophosphatase 0.0042 0.0514 0.0548
Schistosoma mansoni lamin 0.0026 0.0222 0.0237
Echinococcus multilocularis geminin 0.0531 0.9372 1
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0131 0.2123 0.8225
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0096 0.1478 0.1577
Brugia malayi hypothetical protein 0.0054 0.0726 0.0726
Schistosoma mansoni hypothetical protein 0.0066 0.0938 0.1001
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0134 0.2173 0.2318
Echinococcus granulosus GPCR family 2 0.0066 0.0938 0.1001
Loa Loa (eye worm) carboxylesterase 0.0048 0.0617 0.0617
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0131 0.2123 0.8225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0096 0.1478 0.1478
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0083 0.0089
Brugia malayi nuclear hormone receptor 0.0096 0.1478 0.1478
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.5756 0.5756
Schistosoma mansoni hypothetical protein 0.0066 0.0938 0.1001
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0109 0.5
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0083 0.0089
Echinococcus granulosus thyroid hormone receptor alpha 0.0041 0.0494 0.0527
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0248 0.3975
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0153 0.2519 0.2687
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0037 0.0146
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0039 0.0459 0.1794
Brugia malayi follicle stimulating hormone receptor 0.0227 0.3856 0.3856
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0131 0.2123 0.8301
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0054 0.0726 0.0775
Onchocerca volvulus 0.0041 0.0494 0.039
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Brugia malayi hypothetical protein 0.0035 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0306 0.1197
Echinococcus granulosus ecdysone induced protein 78C 0.0096 0.1478 0.1577
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0158 0.0168
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0054 0.0726 0.0775
Leishmania major DNA polymerase kappa, putative 0.0021 0.0117 0.0458
Echinococcus multilocularis expressed conserved protein 0.0091 0.1385 0.1478
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0158 0.1384
Loa Loa (eye worm) hypothetical protein 0.0026 0.0213 0.0213
Mycobacterium ulcerans carboxylesterase, LipT 0.0048 0.0617 0.2076
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0131 0.2123 0.8301
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.04 0.2243
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.04 0.0426
Leishmania major GTP-binding protein, putative 0.0023 0.0158 0.0616
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0355 0.1388
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0096 0.1478 0.1577
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0514 0.1653
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0134 0.2173 0.2318
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0083
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0054 0.0726 0.0775
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Brugia malayi Carboxylesterase family protein 0.0048 0.0617 0.0617
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0295 0.1153
Onchocerca volvulus 0.0048 0.0617 0.0566
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0083 0.0089
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0109 0.0116
Brugia malayi polk-prov protein 0.003 0.0295 0.0295
Loa Loa (eye worm) hypothetical protein 0.0051 0.0662 0.0662
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0915 0.0915
Schistosoma mansoni hypothetical protein 0.0035 0.0382 0.0407
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0041 0.0494 0.0494
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.04 0.0426
Schistosoma mansoni intermediate filament proteins 0.0026 0.0222 0.0237
Echinococcus multilocularis neuroligin 0.0048 0.0617 0.0659
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0158 0.0616
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0155 0.2557 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0868 0.0926
Echinococcus granulosus Nuclear hormone receptor HR96 0.0041 0.0494 0.0527
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0109 0.0182
Loa Loa (eye worm) hypothetical protein 0.0024 0.017 0.017
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0134 0.2173 0.8496
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0868 0.0926
Schistosoma mansoni thyroid hormone receptor 0.0096 0.1478 0.1577
Brugia malayi nuclear hormone receptor 0.0041 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0054 0.0726 0.0726
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0514 0.0548
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0472 0.2757
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0109 0.0427
Brugia malayi Carboxylesterase family protein 0.0048 0.0617 0.0617
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0083 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0472 0.1846
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0433 0.1693
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0514 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0039 0.0459 0.1794
Echinococcus granulosus Niemann Pick C1 protein 0.0193 0.3242 0.3459
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0131 0.2123 0.8301
Loa Loa (eye worm) hypothetical protein 0.0096 0.1491 0.1491
Brugia malayi hypothetical protein 0.0018 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.004 0.0466 0.0497
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0131 0.2123 0.8225
Brugia malayi nuclear receptor NHR-88 0.0096 0.1478 0.1478
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0131 0.2123 0.8225
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0041 0.0494 0.039
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.04 0.0426
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0131 0.2123 0.8225
Loa Loa (eye worm) hypothetical protein 0.0285 0.4918 0.4918
Schistosoma mansoni lamin 0.0026 0.0222 0.0237
Schistosoma mansoni hypothetical protein 0.0066 0.0938 0.1001
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0083 0.0089
Loa Loa (eye worm) hypothetical protein 0.0048 0.0617 0.0617
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0494 0.0527
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0131 0.2123 0.8225
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0306 0.4871
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0248 0.097
Loa Loa (eye worm) hypothetical protein 0.0048 0.0617 0.0617
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1449 0.1546
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0131 0.2123 0.8225
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0134 0.2173 0.8496
Schistosoma mansoni nuclear receptor 0.0041 0.0494 0.0527
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0248 0.3435
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0083 0.0089
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0063 0.0883 0.567
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0039 0.0459 1
Loa Loa (eye worm) hypothetical protein 0.0411 0.7206 0.7206
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.1494 1
Brugia malayi Carboxylesterase family protein 0.0048 0.0617 0.0617
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0041 0.0494 0.0527
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0158 0.0158
Echinococcus granulosus neuroligin 0.0048 0.0617 0.0659
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.0617 0.0659
Brugia malayi Nuclear hormone receptor E75 0.0041 0.0494 0.0494
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0155 0.2557 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0096 0.1478 0.1577
Schistosoma mansoni patched 1 0.0097 0.1494 0.1594
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0514 0.3052
Entamoeba histolytica hypothetical protein 0.0019 0.0083 0.0559
Schistosoma mansoni BC026374 protein (S09 family) 0.0048 0.0617 0.0659
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0096 0.1478 0.1478
Loa Loa (eye worm) DnaJ domain-containing protein 0.007 0.1021 0.1021
Echinococcus granulosus expressed conserved protein 0.0091 0.1385 0.1478
Schistosoma mansoni ran 0.0023 0.0158 0.0168
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1491 0.1491
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.04 0.1563
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0868 0.0926
Schistosoma mansoni hypothetical protein 0.004 0.0466 0.0497
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0472 0.1846
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.0617 0.0659
Echinococcus multilocularis protein patched 0.0097 0.1494 0.1594
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.3856 0.3856
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0131 0.2123 0.8225
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0131 0.2123 0.8301
Onchocerca volvulus 0.0048 0.0617 0.0566
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.02 0.0825
Brugia malayi Carboxylesterase family protein 0.0048 0.0617 0.0617
Loa Loa (eye worm) hypothetical protein 0.0096 0.1478 0.1478
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0868 0.0868
Loa Loa (eye worm) hypothetical protein 0.0041 0.0494 0.0494
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0131 0.2123 0.8225
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0131 0.2123 0.8225
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0208 0.352 0.352
Brugia malayi Carboxylesterase family protein 0.0285 0.4918 0.4918
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0083 0.0089
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0295 0.1153
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.017 0.017
Brugia malayi nuclear hormone receptor family member odr-7 0.0041 0.0494 0.0494
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1491 0.1591
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0472 0.1846
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0048 0.0617 0.0659
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0422 0.045
Echinococcus multilocularis FTZ F1 alpha 0.0096 0.1478 0.1577
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0083 0.0083
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.0617 0.0659
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0117 0.0458
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.04 0.3755
Mycobacterium leprae putative cytochrome p450 0.0131 0.2123 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0868 0.0868

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.