Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mucolipin 3 | 0.0068 | 0.0767 | 0.1774 |
Brugia malayi | nuclear hormone receptor | 0.0053 | 0.0439 | 0.0439 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0039 | 0.0128 | 0.0296 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0576 | 0.1862 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0039 | 0.0128 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0053 | 0.0439 | 0.0439 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0053 | 0.0439 | 0.1017 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0039 | 0.0128 | 0.0296 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0053 | 0.0439 | 0.0439 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0053 | 0.0439 | 0.1017 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0053 | 0.0439 | 0.1421 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0055 | 0.0478 | 0.1547 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0053 | 0.0439 | 0.0439 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.0478 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0439 | 0.0439 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0084 | 0.0084 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0258 | 0.0598 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0039 | 0.0128 | 0.0128 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.3092 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0037 | 0.0084 | 0.0084 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0053 | 0.0439 | 0.1017 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0258 | 0.0835 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.0478 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0072 | 0.0166 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0576 | 0.1333 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0053 | 0.0439 | 0.1421 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0055 | 0.0478 | 0.1107 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0258 | 0.0835 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0037 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0053 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0053 | 0.0439 | 0.0439 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0053 | 0.0439 | 0.0439 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0055 | 0.0478 | 0.1107 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0258 | 0.0258 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0053 | 0.0439 | 0.1017 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0053 | 0.0439 | 0.1421 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0053 | 0.0439 | 0.0439 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0053 | 0.0439 | 0.0439 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0055 | 0.0478 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0053 | 0.0439 | 0.1421 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0053 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.1537 | 0.1537 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0053 | 0.0439 | 0.0439 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0055 | 0.0478 | 0.7825 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0315 | 0.1018 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0053 | 0.0439 | 0.1421 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0053 | 0.0439 | 0.1017 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0037 | 0.0084 | 0.0195 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0055 | 0.0478 | 0.7825 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0576 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0439 | 0.0439 |
Echinococcus multilocularis | geminin | 0.0175 | 0.3092 | 0.7156 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0403 | 0.8057 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0053 | 0.0439 | 0.1421 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0053 | 0.0439 | 0.1421 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0037 | 0.0084 | 0.0272 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0053 | 0.0439 | 0.0439 |
Onchocerca volvulus | 0.0053 | 0.0439 | 0.0161 | |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0053 | 0.0439 | 0.0439 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0576 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0258 | 0.0598 |
Brugia malayi | steroid hormone receptor | 0.0053 | 0.0439 | 0.0439 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0576 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0231 | 0.4321 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0053 | 0.0439 | 0.0439 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0053 | 0.0439 | 0.1017 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0084 | 0.0084 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0576 | 0.1333 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0053 | 0.0439 | 0.0439 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0053 | 0.0439 | 0.0439 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0128 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0439 | 0.0439 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0039 | 0.0128 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0053 | 0.0439 | 0.1421 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0053 | 0.0439 | 0.1017 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0053 | 0.0439 | 0.0439 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0128 | 0.0413 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0053 | 0.0439 | 0.1017 |
Echinococcus multilocularis | mucolipin 3 | 0.0068 | 0.0767 | 0.1774 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0053 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | mucolipin 1 | 0.0068 | 0.0767 | 0.0767 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0258 | 0.0598 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.1537 | 0.1537 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0439 | 0.0439 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0037 | 0.0084 | 0.0272 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0231 | 0.4321 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0439 | 0.0439 |
Echinococcus granulosus | FTZ F1 alpha | 0.0053 | 0.0439 | 0.1017 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0315 | 0.1018 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0055 | 0.0478 | 0.7825 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0315 | 0.0315 |
Schistosoma mansoni | mucolipin | 0.0062 | 0.0643 | 0.2079 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0072 | 0.0072 |
Brugia malayi | ecdysteroid receptor | 0.0403 | 0.8057 | 0.8057 |
Schistosoma mansoni | mucolipin | 0.0068 | 0.0767 | 0.2479 |
Schistosoma mansoni | coup transcription factor | 0.0053 | 0.0439 | 0.1421 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.3092 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0826 | 0.2671 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0053 | 0.0439 | 0.0439 |
Schistosoma mansoni | thyroid hormone receptor | 0.0053 | 0.0439 | 0.1421 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0053 | 0.0439 | 0.1017 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1537 | 0.1537 |
Trypanosoma brucei | protein kinase, putative | 0.0055 | 0.0478 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0053 | 0.0439 | 0.0439 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0055 | 0.0478 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.1537 | 0.1537 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0053 | 0.0439 | 0.1017 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0576 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0072 | 0.0232 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0053 | 0.0439 | 0.0161 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0053 | 0.0439 | 0.1017 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0258 | 0.0598 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0055 | 0.0478 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0055 | 0.0478 | 0.0478 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0037 | 0.0084 | 0.0195 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0128 | 0.0413 |
Brugia malayi | Coelomocyte uptake defective protein 5 | 0.0068 | 0.0767 | 0.0767 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0492 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0039 | 0.0128 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0053 | 0.0439 | 0.1421 |
Brugia malayi | hypothetical protein | 0.0231 | 0.4321 | 0.4321 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0053 | 0.0439 | 0.1017 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0055 | 0.0478 | 0.1107 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0053 | 0.0439 | 0.0439 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0053 | 0.0439 | 0.1017 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0072 | 0.0166 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0055 | 0.0478 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0258 | 0.0835 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0039 | 0.0128 | 0.0128 |
Brugia malayi | MAP kinase sur-1 | 0.0055 | 0.0478 | 0.0478 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0053 | 0.0439 | 0.0161 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0055 | 0.0478 | 0.1107 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0826 | 0.0826 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.8057 | 0.8057 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0055 | 0.0478 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0576 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0053 | 0.0439 | 0.1017 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0053 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.4321 | 0.4321 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0576 | 0.1862 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0037 | 0.0084 | 0.0084 |
Brugia malayi | nuclear receptor RXR | 0.0037 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0084 | 0.0084 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0258 | 0.0258 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0055 | 0.0478 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0053 | 0.0439 | 0.1017 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0053 | 0.0439 | 0.1421 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0439 | 0.0439 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0055 | 0.0478 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0053 | 0.0439 | 0.0439 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0439 | 0.0439 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0053 | 0.0439 | 0.1017 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0128 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0084 | 0.0084 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0576 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0053 | 0.0439 | 0.1421 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0053 | 0.0439 | 0.0439 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0053 | 0.0439 | 0.0439 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0053 | 0.0439 | 0.0439 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0053 | 0.0439 | 0.1017 |
Echinococcus granulosus | geminin | 0.0175 | 0.3092 | 0.7156 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0072 | 0.0232 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.0826 | 0.0826 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.