Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0259 | 0.0288 | 0.0291 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.1024 | 0.5508 | 0.6249 |
Brugia malayi | diacylglycerol kinase | 0.0227 | 0.0065 | 0.0039 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.1024 | 0.5508 | 0.6249 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0481 | 0.1804 | 0.2021 |
Brugia malayi | RhoGAP domain containing protein | 0.0227 | 0.0065 | 0.0039 |
Schistosoma mansoni | rac gtpase activating protein | 0.0227 | 0.0065 | 0.0037 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0222 | 0.0033 | 0.5 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0232 | 0.0098 | 0.0066 |
Echinococcus multilocularis | N chimaerin | 0.0227 | 0.0065 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0065 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0065 | 0.0033 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0227 | 0.0065 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1506 | 0.8795 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0227 | 0.0065 | 1 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0259 | 0.0288 | 0.0291 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.1061 | 0.5764 | 0.575 |
Trichomonas vaginalis | AGC family protein kinase | 0.0222 | 0.0033 | 1 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0232 | 0.0098 | 0.0078 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0065 | 0.0033 |
Schistosoma mansoni | vav2 | 0.0227 | 0.0065 | 0.0037 |
Brugia malayi | RasGEF domain containing protein | 0.1454 | 0.8441 | 1 |
Echinococcus granulosus | N chimaerin | 0.0227 | 0.0065 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0065 | 0.0033 |
Echinococcus multilocularis | protein kinase c eta type | 0.0227 | 0.0065 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0065 | 0.0033 |
Trichomonas vaginalis | AGC family protein kinase | 0.0222 | 0.0033 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1506 | 0.8795 | 1 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0227 | 0.0065 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0232 | 0.0098 | 0.0075 |
Brugia malayi | C1-like domain containing protein | 0.0232 | 0.0098 | 0.0078 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.1024 | 0.5508 | 0.6249 |
Schistosoma mansoni | unc-13 (munc13) | 0.0259 | 0.0288 | 0.0291 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0232 | 0.0098 | 0.0075 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0227 | 0.0065 | 0.0033 |
Trichomonas vaginalis | AGC family protein kinase | 0.0222 | 0.0033 | 1 |
Brugia malayi | Pleckstrin Homology Domain | 0.0227 | 0.0065 | 0.0039 |
Schistosoma mansoni | unc-13 (munc13) | 0.0259 | 0.0288 | 0.0291 |
Loa Loa (eye worm) | Ras association domain family 1 isoform A | 0.0227 | 0.0065 | 0.0033 |
Echinococcus granulosus | protein kinase c eta type | 0.0227 | 0.0065 | 0.0037 |
Echinococcus granulosus | unc 13 munc13 | 0.0259 | 0.0288 | 0.0291 |
Trichomonas vaginalis | AGC family protein kinase | 0.0222 | 0.0033 | 1 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0227 | 0.0065 | 0.0037 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0227 | 0.0065 | 0.0037 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0227 | 0.0065 | 0.0037 |
Brugia malayi | RhoGAP domain containing protein | 0.0227 | 0.0065 | 0.0039 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0065 | 0.0033 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0227 | 0.0065 | 0.0033 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0232 | 0.0098 | 0.0066 |
Brugia malayi | protein kinase C II. | 0.0481 | 0.1804 | 0.2106 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0259 | 0.0288 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0065 | 0.0033 |
Schistosoma mansoni | protein kinase C mu | 0.0232 | 0.0098 | 0.0075 |
Schistosoma mansoni | protein kinase C | 0.0259 | 0.0288 | 0.0291 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0227 | 0.0065 | 0.0037 |
Echinococcus granulosus | Diacylglycerol kinase theta | 0.0227 | 0.0065 | 0.0037 |
Brugia malayi | RhoGEF domain containing protein | 0.0227 | 0.0065 | 0.0039 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0481 | 0.1804 | 0.2021 |
Brugia malayi | Ras association domain family 1 isoform A | 0.0227 | 0.0065 | 0.0039 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0232 | 0.0098 | 0.0075 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0227 | 0.0065 | 0.0037 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0227 | 0.0065 | 0.0037 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0227 | 0.0065 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0065 | 0.0033 |
Loa Loa (eye worm) | hypothetical protein | 0.1024 | 0.5508 | 0.5494 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0065 | 0.0033 |
Trichomonas vaginalis | AGC family protein kinase | 0.0222 | 0.0033 | 1 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0227 | 0.0065 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0227 | 0.0065 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0227 | 0.0065 | 0.0037 |
Trichomonas vaginalis | AGC family protein kinase | 0.0222 | 0.0033 | 1 |
Brugia malayi | protein kinase C3,putative | 0.0232 | 0.0098 | 0.0078 |
Schistosoma mansoni | atypical protein kinase C | 0.0449 | 0.1581 | 0.1767 |
Toxoplasma gondii | diacylglycerol kinase, putative | 0.0227 | 0.0065 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0222 | 0.0033 | 1 |
Echinococcus multilocularis | Diacylglycerol kinase theta | 0.0227 | 0.0065 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.1251 | 0.7057 | 0.7047 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.1506 | 0.8795 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.1279 | 0.7247 | 0.8233 |
Brugia malayi | Protein kinase c protein 2 | 0.1288 | 0.7312 | 0.8658 |
Echinococcus granulosus | protein kinase C gamma type | 0.1279 | 0.7247 | 0.8233 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.0288 | 0.0256 |
Onchocerca volvulus | 0.0259 | 0.0288 | 1 | |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0227 | 0.0065 | 0.0037 |
Trichomonas vaginalis | AGC family protein kinase | 0.0222 | 0.0033 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0222 | 0.0033 | 1 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0227 | 0.0065 | 0.0037 |
Trichomonas vaginalis | AGC family protein kinase | 0.0222 | 0.0033 | 1 |
Brugia malayi | diacylglycerol kinase | 0.0227 | 0.0065 | 0.0039 |
Trichomonas vaginalis | AGC family protein kinase | 0.0222 | 0.0033 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.0065 | 0.0033 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0481 | 0.1804 | 0.2021 |
Schistosoma mansoni | protein kinase C mu | 0.0227 | 0.0065 | 0.0037 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0481 | 0.1804 | 0.1777 |
Echinococcus granulosus | protein kinase c iota type | 0.0449 | 0.1581 | 0.1767 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0227 | 0.0065 | 0.0037 |
Brugia malayi | Protein kinase domain containing protein | 0.0232 | 0.0098 | 0.0078 |
Echinococcus multilocularis | protein kinase c iota type | 0.0449 | 0.1581 | 0.1767 |
Loa Loa (eye worm) | raf kinase | 0.0227 | 0.0065 | 0.0033 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0232 | 0.0098 | 0.0075 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.1506 | 0.8795 | 1 |
Echinococcus granulosus | myotubularin protein 13 | 0.0227 | 0.0065 | 0.0037 |
Brugia malayi | Variant SH3 domain containing protein | 0.0227 | 0.0065 | 0.0039 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.