Detailed information for compound 848349

Basic information

Technical information
  • TDR Targets ID: 848349
  • Name: 2-chloro-N-[5-[ethyl-(4-methylphenyl)sulfamoy l]-1,3,4-thiadiazol-2-yl]benzamide
  • MW: 436.936 | Formula: C18H17ClN4O3S2
  • H donors: 1 H acceptors: 5 LogP: 3.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1nnc(s1)NC(=O)c1ccccc1Cl)c1ccc(cc1)C
  • InChi: 1S/C18H17ClN4O3S2/c1-3-23(13-10-8-12(2)9-11-13)28(25,26)18-22-21-17(27-18)20-16(24)14-6-4-5-7-15(14)19/h4-11H,3H2,1-2H3,(H,20,21,24)
  • InChiKey: XSJXXEHYTRULPX-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium ulcerans aminopeptidase N PepN 0.0219 0.0399 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0219 0.0399 0.0399
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0219 0.0399 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0219 0.0399 0.0399
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0219 0.0399 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0214 0.0386 0.0386
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0219 0.0399 0.0399
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0196 0.0342 0.0342
Onchocerca volvulus 0.0219 0.0399 0.5
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0219 0.0399 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0214 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0219 0.0399 0.0399
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0219 0.0399 0.5
Loa Loa (eye worm) leukotriene A4 hydrolase 0.4131 1 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0219 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.017 0.0278 0.0278
Mycobacterium ulcerans aminopeptidase N PepN 0.0219 0.0399 0.5
Trypanosoma cruzi aminopeptidase, putative 0.0219 0.0399 0.5
Trypanosoma cruzi aminopeptidase, putative 0.0219 0.0399 0.5
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0219 0.0399 0.5
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0219 0.0399 0.5
Entamoeba histolytica aminopeptidase, putative 0.0219 0.0399 0.5
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0219 0.0399 0.0399
Toxoplasma gondii aminopeptidase N protein 0.0219 0.0399 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0219 0.0399 0.0399
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.4131 1 1
Echinococcus multilocularis aminopeptidase N 0.0219 0.0399 0.0399
Brugia malayi Peptidase family M1 containing protein 0.0219 0.0399 0.0883
Loa Loa (eye worm) hypothetical protein 0.0219 0.0399 0.0399
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0219 0.0399 0.0399
Loa Loa (eye worm) peptidase family M1 containing protein 0.0219 0.0399 0.0399
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0219 0.0399 0.0399
Echinococcus granulosus aminopeptidase N 0.0219 0.0399 0.0399
Schistosoma mansoni aminopeptidase A (M01 family) 0.0219 0.0399 0.0399
Brugia malayi Peptidase family M1 containing protein 0.0219 0.0399 0.0883
Loa Loa (eye worm) aminopeptidase N 0.0219 0.0399 0.0399
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0219 0.0399 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0219 0.0399 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0196 0.0342 0.0755
Loa Loa (eye worm) hypothetical protein 0.0219 0.0399 0.0399
Trypanosoma cruzi Aminopeptidase M1, putative 0.0219 0.0399 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0219 0.0399 0.0399
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0219 0.0399 0.5
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0219 0.0399 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0219 0.0399 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0219 0.0399 0.0399
Brugia malayi hypothetical protein 0.0219 0.0399 0.0883
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0219 0.0399 0.5
Brugia malayi hypothetical protein 0.0219 0.0399 0.0883
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0219 0.0399 0.5
Onchocerca volvulus 0.0219 0.0399 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0196 0.0342 0.0342
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0219 0.0399 0.0399
Onchocerca volvulus 0.0219 0.0399 0.5
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0196 0.0342 0.0342
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0219 0.0399 0.0399
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0219 0.0399 0.5
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0219 0.0399 0.0399
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0219 0.0399 0.0399
Toxoplasma gondii aminopeptidase N, putative 0.0219 0.0399 0.5
Trypanosoma brucei Aminopeptidase M1, putative 0.0219 0.0399 0.5
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0219 0.0399 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0219 0.0399 0.0399
Trypanosoma brucei Aminopeptidase M1, putative 0.0219 0.0399 0.5
Loa Loa (eye worm) TATA binding protein associated factor 0.0219 0.0399 0.0399
Echinococcus multilocularis leukotriene A 4 hydrolase 0.4131 1 1
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0219 0.0399 0.5
Toxoplasma gondii aminopeptidase n, putative 0.0219 0.0399 0.5
Brugia malayi TATA binding protein associated factor 0.0219 0.0399 0.0883
Brugia malayi hypothetical protein 0.1899 0.4522 1
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0219 0.0399 0.5
Trypanosoma brucei aminopeptidase, putative 0.0219 0.0399 0.5
Brugia malayi Peptidase family M1 containing protein 0.0219 0.0399 0.0883

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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