Detailed information for compound 848378

Basic information

Technical information
  • TDR Targets ID: 848378
  • Name: 5-acetyl-N-(4-chlorophenyl)-2,4-dimethyl-1H-p yrrole-3-carboxamide
  • MW: 290.745 | Formula: C15H15ClN2O2
  • H donors: 2 H acceptors: 2 LogP: 2.78 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)NC(=O)c1c(C)[nH]c(c1C)C(=O)C
  • InChi: 1S/C15H15ClN2O2/c1-8-13(9(2)17-14(8)10(3)19)15(20)18-12-6-4-11(16)5-7-12/h4-7,17H,1-3H3,(H,18,20)
  • InChiKey: UDURVZYCMXKPNI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chlorophenyl)-5-ethanoyl-2,4-dimethyl-1H-pyrrole-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lipoxygenase 0.002 0.0152 0.055
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0152 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0152 0.0511
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0152 0.0549
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0032 0.0297 0.1076
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0152 0.0511
Brugia malayi Doublecortin family protein 0.002 0.0152 0.0511
Onchocerca volvulus Huntingtin homolog 0.024 0.2972 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0511
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0152 0.0511
Echinococcus multilocularis lamin 0.0028 0.0247 0.0247
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0297 0.0297
Schistosoma mansoni nuclear receptor 0.001 0.0015 0.0055
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1169 0.3933
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0152 0.0511
Onchocerca volvulus 0.0112 0.1324 0.4426
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0152 0.055
Brugia malayi nuclear receptor RXR 0.0011 0.003 0.01
Schistosoma mansoni nuclear hormone receptor 0.001 0.0015 0.0055
Echinococcus multilocularis thymidylate synthase 0.0112 0.1324 0.1324
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0152 0.0152
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0152 0.0152
Brugia malayi tailless protein 0.001 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0511
Schistosoma mansoni hypothetical protein 0.0031 0.0297 0.1073
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Schistosoma mansoni hypothetical protein 0.0031 0.0297 0.1073
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0006 0.002
Onchocerca volvulus 0.0028 0.0247 0.0784
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0152 0.0511
Schistosoma mansoni lamin 0.0028 0.0247 0.0894
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0152 0.0549
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0152 0.0511
Loa Loa (eye worm) DR-78 0.001 0.0015 0.0051
Schistosoma mansoni polycystin 1-related 0.002 0.0152 0.055
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0152 0.0549
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0297 0.0999
Brugia malayi MH2 domain containing protein 0.0122 0.146 0.4912
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0225 0.2783 1
Schistosoma mansoni hypothetical protein 0.0173 0.2117 0.7655
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0152 0.0549
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.01
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0225 0.2783 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0297 0.0999
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.003 0.01
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0511
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0152 0.0549
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0074 0.0846 0.0846
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0152 0.0549
Brugia malayi dihydrofolate reductase family protein 0.0224 0.2765 0.9305
Schistosoma mansoni hypothetical protein 0.002 0.0152 0.055
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0511
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0015 0.0055
Loa Loa (eye worm) hypothetical protein 0.0027 0.0241 0.081
Echinococcus granulosus FTZ F1 alpha 0.002 0.0152 0.0549
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0511
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0224 0.2765 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0015 0.0055
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Toxoplasma gondii transporter, cation channel family protein 0.0016 0.0093 0.0089
Brugia malayi hypothetical protein 0.024 0.2972 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0152 0.0462
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0015 0.0015
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0152 0.0549
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0224 0.2765 1
Echinococcus multilocularis RUN 0.002 0.0152 0.0152
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0511
Loa Loa (eye worm) thymidylate synthase 0.0112 0.1324 0.4455
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.0013 0.0058 0.0194
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0152 0.0511
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0152 0.0152
Brugia malayi nuclear hormone receptor 0.001 0.0015 0.0051
Brugia malayi hypothetical protein 0.0053 0.0574 0.1931
Schistosoma mansoni hypothetical protein 0.0031 0.0297 0.1073
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0152 0.0511
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0015 0.0015
Echinococcus granulosus RUN 0.002 0.0152 0.055
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.146 0.4912
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.01
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0112 0.1324 0.4788
Brugia malayi nuclear receptor NHR-88 0.002 0.0152 0.0511
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0152 0.0152
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0152 0.0549
Echinococcus granulosus cpg binding protein 0.003 0.0278 0.1005
Brugia malayi nuclear receptor NHR-88 0.001 0.0015 0.0051
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0152 0.0549
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0297 0.1073
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0225 0.2783 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0618 0.2234
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0064 0.0232
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.146 0.4912
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0152 0.0511
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.0074 0.0846 0.2847
Onchocerca volvulus 0.002 0.0152 0.0463
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0231
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.003 0.01
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0074 0.0846 0.0846
Brugia malayi hypothetical protein 0.002 0.0152 0.0511
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0247 0.0832
Schistosoma mansoni dihydrofolate reductase 0.0224 0.2765 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0152 0.0511
Loa Loa (eye worm) doublecortin family protein 0.002 0.0152 0.0511
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Schistosoma mansoni cpg binding protein 0.0028 0.0257 0.093
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0013 0.0058 0.0194
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0152 0.0511
Echinococcus granulosus dihydrofolate reductase 0.0224 0.2765 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0225 0.2783 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Echinococcus granulosus voltage dependent calcium channel 0.0074 0.0846 0.306
Schistosoma mansoni voltage-gated cation channel 0.0074 0.0846 0.306
Brugia malayi ecdysteroid receptor 0.002 0.0152 0.0511
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0152 0.0549
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0004 0.0015
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0083 0.0279
Echinococcus multilocularis musashi 0.0028 0.0247 0.0247
Echinococcus granulosus thymidylate synthase 0.0112 0.1324 0.4788
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.003 0.003
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0152 0.0152
Loa Loa (eye worm) calcium channel 0.0074 0.0846 0.2847
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0015 0.0055
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0152 0.055
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0152 0.0511
Echinococcus multilocularis cpg binding protein 0.003 0.0278 0.0278
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0257 0.0865
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0152 0.0511
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0297 0.0999
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0152 0.0511
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0583 0.1893
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0152 0.0511
Schistosoma mansoni zinc finger protein 0.001 0.0015 0.0055
Schistosoma mansoni rab6-interacting 0.002 0.0152 0.055
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0015 0.0055
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0021
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0074 0.0846 0.306
Onchocerca volvulus 0.002 0.0152 0.0462
Brugia malayi thymidylate synthase 0.0112 0.1324 0.4455
Schistosoma mansoni nuclear receptor 0.001 0.0015 0.0055
Echinococcus multilocularis lamin dm0 0.0028 0.0247 0.0247
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Echinococcus multilocularis voltage dependent calcium channel 0.0074 0.0846 0.0846
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0053 0.0574 0.0437
Brugia malayi hypothetical protein 0.001 0.0015 0.0051
Schistosoma mansoni cpg binding protein 0.003 0.0278 0.1005
Brugia malayi hypothetical protein 0.0011 0.003 0.01
Loa Loa (eye worm) hypothetical protein 0.024 0.2972 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0247 0.0832
Brugia malayi hypothetical protein 0.001 0.0015 0.0051
Brugia malayi Dihydrofolate reductase 0.0224 0.2765 0.9305
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0152 0.0511
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0015 0.0051
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0074 0.0846 0.0846
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0152 0.0549
Brugia malayi Nuclear hormone receptor E75 0.001 0.0015 0.0051
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0297 0.0999
Schistosoma mansoni lamin 0.0028 0.0247 0.0894
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0765 0.2575
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.003 0.01
Loa Loa (eye worm) hypothetical protein 0.024 0.2972 1
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0224 0.2765 1
Loa Loa (eye worm) dihydrofolate reductase 0.0224 0.2765 0.9305
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0074 0.0846 0.306
Schistosoma mansoni loxhd1 0.002 0.0152 0.055
Schistosoma mansoni thyroid hormone receptor 0.002 0.0152 0.0549
Loa Loa (eye worm) hypothetical protein 0.0016 0.0093 0.0312
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0152 0.0511
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0152 0.0152
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0665 0.2404
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0015 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0152 0.0511
Brugia malayi nuclear receptor RXR 0.001 0.0015 0.0051
Schistosoma mansoni nuclear hormone receptor 0.001 0.0015 0.0055
Brugia malayi Nuclear hormone receptor E75 0.001 0.0015 0.0051
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0112 0.1324 0.3423
Schistosoma mansoni thyroid hormone receptor 0.002 0.0152 0.0549
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0152 0.055
Brugia malayi conserved hypotetical protein 0.001 0.0015 0.0051
Brugia malayi CXXC zinc finger family protein 0.0028 0.0257 0.0865
Echinococcus granulosus geminin 0.0173 0.2117 0.7655
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0152 0.0549
Schistosoma mansoni cpg binding protein 0.003 0.0278 0.1005
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0015 0.0055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.003 0.0108
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0074 0.0846 0.306
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0152 0.0511
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0511
Echinococcus multilocularis voltage dependent calcium channel 0.0074 0.0846 0.0846
Brugia malayi nuclear receptor NHR-67 0.001 0.0015 0.0051
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0152 0.0462
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0015 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1169 0.3933
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0152 0.0462
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.01
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0152 0.0549
Brugia malayi steroid hormone receptor 0.002 0.0152 0.0511
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1169 0.3933
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Schistosoma mansoni coup transcription factor 0.002 0.0152 0.0549
Onchocerca volvulus 0.002 0.0152 0.0463
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0152 0.0511
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0015 0.0055
Loa Loa (eye worm) hypothetical protein 0.0014 0.0069 0.0231
Schistosoma mansoni lipoxygenase 0.0056 0.0618 0.2234
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0511
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.0028 0.0247 0.0832
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0015 0.0055
Schistosoma mansoni hypothetical protein 0.0031 0.0297 0.1073
Echinococcus granulosus lamin 0.0028 0.0247 0.0894
Echinococcus multilocularis dihydrofolate reductase 0.0224 0.2765 0.2765
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0152 0.0549
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0152 0.0152
Schistosoma mansoni hypothetical protein 0.0173 0.2117 0.7655
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0152 0.0152
Onchocerca volvulus 0.0028 0.0257 0.0818
Loa Loa (eye worm) hypothetical protein 0.0099 0.1169 0.3933
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0297 0.1073
Brugia malayi ecdysone receptor 0.001 0.0015 0.0051
Echinococcus multilocularis geminin 0.0173 0.2117 0.2117
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0064 0.0064
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0015 0.0015
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0015 0.0051
Schistosoma mansoni nuclear hormone receptor 0.002 0.0152 0.0549
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.01
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0074 0.0846 0.306
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0574 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0152 0.0549
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0152 0.0511
Loa Loa (eye worm) voltage-dependent calcium channel 0.0016 0.0093 0.0312
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0297 0.0297
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0015 0.0051
Chlamydia trachomatis dihydrofolate reductase 0.0224 0.2765 0.5
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0083 0.0279
Echinococcus granulosus intermediate filament protein 0.0028 0.0247 0.0894
Brugia malayi hypothetical protein 0.0011 0.003 0.01
Onchocerca volvulus Huntingtin homolog 0.024 0.2972 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0765 0.2575
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0152 0.0152
Echinococcus granulosus GPCR family 2 0.0031 0.0297 0.1073
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0074 0.0846 0.0846
Schistosoma mansoni hypothetical protein 0.0068 0.0765 0.2767
Brugia malayi nuclear hormone receptor 0.002 0.0152 0.0511
Loa Loa (eye worm) hypothetical protein 0.002 0.0152 0.0511
Schistosoma mansoni intermediate filament proteins 0.0028 0.0247 0.0894
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.003 0.0108
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0152 0.0549
Loa Loa (eye worm) hypothetical protein 0.0013 0.0064 0.0215
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0247 0.0832
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0015 0.0015
Echinococcus granulosus lamin dm0 0.0028 0.0247 0.0894
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0152 0.0152
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0015 0.0055
Echinococcus granulosus voltage dependent calcium channel 0.0016 0.0093 0.0335
Brugia malayi intermediate filament protein 0.0028 0.0247 0.0832
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0225 0.2783 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0152 0.0549
Schistosoma mansoni rab6-interacting 0.002 0.0152 0.055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0152 0.0511
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0152 0.0511
Brugia malayi hypothetical protein 0.002 0.0152 0.0511
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0015 0.0051
Loa Loa (eye worm) hypothetical protein 0.0011 0.003 0.01
Onchocerca volvulus 0.0028 0.0247 0.0784
Echinococcus multilocularis GPCR, family 2 0.0031 0.0297 0.0297
Echinococcus multilocularis sodium channel protein 0.0032 0.0297 0.0297
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0074 0.0846 0.2847
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.003 0.0108
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0225 0.2783 0.5
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0074 0.0846 0.306
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0051
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0015 0.0055

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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