TDR Targets

Basic information

Technical information

TDR Targets ID: 848529
Name: N-(3,4-dimethylphenyl)-2-[3-[(4-methylphenyl) methyl]-4-oxopteridin-2-yl]sulfanylacetamide
MW: 445.537 | Formula: C24H23N5O2S
H donors: 1 H acceptors: 4 LogP: 3.84 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc(c(c1)C)C)CSc1nc2nccnc2c(=O)n1Cc1ccc(cc1)C
InChi: 1S/C24H23N5O2S/c1-15-4-7-18(8-5-15)13-29-23(31)21-22(26-11-10-25-21)28-24(29)32-14-20(30)27-19-9-6-16(2)17(3)12-19/h4-12H,13-14H2,1-3H3,(H,27,30)
InChiKey: RITQOKBNTNFGOR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3,4-dimethylphenyl)-2-[3-[(4-methylphenyl)methyl]-4-oxo-pteridin-2-yl]sulfanyl-acetamide
N-(3,4-dimethylphenyl)-2-[[3-[(4-methylphenyl)methyl]-4-oxo-2-pteridinyl]thio]acetamide
N-(3,4-dimethylphenyl)-2-[[4-keto-3-(4-methylbenzyl)pteridin-2-yl]thio]acetamide
N-(3,4-dimethylphenyl)-2-[3-[(4-methylphenyl)methyl]-4-oxo-pteridin-2-yl]sulfanyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0077	0.0077
Echinococcus granulosus	neutral amino acid transporter A	0.1312	1	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0166	0.1109	0.4283
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0431	0.0431
Trichomonas vaginalis	D-aminoacylase, putative	0.0078	0.0431	0.2208
Brugia malayi	follicle stimulating hormone receptor	0.0491	0.3632	0.3632
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0108	0.0297
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0037	0.0108	0.0874
Echinococcus multilocularis	geminin	0.0185	0.126	0.126
Echinococcus granulosus	thioredoxin glutathione reductase	0.0042	0.0148	0.0148
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0582	0.4334	0.4334
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0056	0.0257	0.0257
Brugia malayi	Importin beta-1 subunit	0.0033	0.0083	0.0083
Mycobacterium ulcerans	hypothetical protein	0.0184	0.1254	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0049	0.0205	0.0685
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0078	0.0431	0.0291
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0183	0.0183
Schistosoma mansoni	hypothetical protein	0.0185	0.126	0.126
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0077	0.0077
Trichomonas vaginalis	D-aminoacylase, putative	0.0078	0.0431	0.2208
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0165	0.1106	0.1106
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0083	0.0562
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0132	0.0847	0.3248
Echinococcus granulosus	neutral amino acid transporter A	0.1312	1	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0108	0.0413
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0108	0.0413
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0431	0.0291
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0037	0.0014
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0083	0.1158
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0083	0.0083
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0183	0.0183
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.035	0.2539	1
Schistosoma mansoni	survival motor neuron protein	0.0056	0.0257	0.0257
Trichomonas vaginalis	penicillin-binding protein, putative	0.0078	0.0431	0.2208
Trichomonas vaginalis	esterase, putative	0.0078	0.0431	0.2208
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0183	0.0183
Mycobacterium tuberculosis	Probable lipase LipE	0.0078	0.0431	0.0291
Mycobacterium tuberculosis	Probable hydrolase	0.0078	0.0431	0.0291
Echinococcus multilocularis	muscleblind protein 1	0.0152	0.0999	0.0999
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0165	0.1106	0.1106
Echinococcus multilocularis	tumor protein p63	0.0369	0.2688	0.2688
Echinococcus granulosus	excitatory amino acid transporter 3	0.1312	1	1
Leishmania major	trypanothione reductase	0.0041	0.0144	0.0441
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0037	0.0014
Echinococcus multilocularis	snurportin 1	0.0357	0.2591	0.2591
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0042	0.0148	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0431	0.0431
Trypanosoma brucei	trypanothione reductase	0.0041	0.0144	0.0428
Brugia malayi	hypothetical protein	0.0028	0.0037	0.0037
Mycobacterium tuberculosis	Probable dehydrogenase	0.0094	0.0555	0.0417
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0132	0.0847	0.0713
Brugia malayi	beta-lactamase family protein	0.0078	0.0431	0.0431
Plasmodium falciparum	glutathione reductase	0.0041	0.0144	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0083	0.0182
Brugia malayi	Muscleblind-like protein	0.0152	0.0999	0.0999
Echinococcus multilocularis	neutral amino acid transporter A	0.1312	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0078	0.0431	0.1573
Brugia malayi	Pre-SET motif family protein	0.0228	0.1588	0.1588
Echinococcus multilocularis	excitatory amino acid transporter 2	0.1312	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0431	0.1584
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0083	0.0083
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	0.1312	1	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0078	0.0431	0.0291
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0105	0.0637	0.05
Entamoeba histolytica	hypothetical protein	0.0083	0.0471	1
Plasmodium vivax	hypothetical protein, conserved	0.0078	0.0431	1
Schistosoma mansoni	transcription factor LCR-F1	0.0083	0.0471	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0077	0.0077
Trypanosoma cruzi	hypothetical protein, conserved	0.0078	0.0431	0.1584
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0183	0.0183
Loa Loa (eye worm)	thioredoxin reductase	0.0041	0.0144	0.0144
Brugia malayi	beta-lactamase	0.0078	0.0431	0.0431
Echinococcus granulosus	excitatory amino acid transporter 2	0.1312	1	1
Onchocerca volvulus		0.0078	0.0431	0.0431
Onchocerca volvulus		0.0096	0.0565	0.0565
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0108	0.0413
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0105	0.0637	0.05
Plasmodium falciparum	thioredoxin reductase	0.0041	0.0144	1
Echinococcus granulosus	geminin	0.0185	0.126	0.126
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0108	0.0413
Plasmodium falciparum	importin beta, putative	0.0033	0.0083	0.4258
Schistosoma mansoni	aldehyde dehydrogenase	0.0132	0.0847	0.0847
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.006	0.0289	0.1018
Echinococcus multilocularis	neuropeptide s receptor	0.054	0.4008	0.4008
Entamoeba histolytica	hypothetical protein	0.0083	0.0471	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0077	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0431	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0274	0.195	0.195
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0094	0.0555	0.0417
Trypanosoma cruzi	trypanothione reductase, putative	0.0041	0.0144	0.0441
Trichomonas vaginalis	D-aminoacylase, putative	0.0078	0.0431	0.2208
Trypanosoma brucei	glucosidase, putative	0.0037	0.0108	0.0283
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0166	0.1109	0.4291
Echinococcus multilocularis	neuropeptide receptor A26	0.054	0.4008	0.4008
Chlamydia trachomatis	glutamate symporter	0.1312	1	1
Echinococcus granulosus	snurportin 1	0.0357	0.2591	0.2591
Schistosoma mansoni	alpha-glucosidase	0.0142	0.0927	0.0927
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0037	0.0108	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0037	0.0037
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0077	0.0077
Echinococcus multilocularis	survival motor neuron protein 1	0.0274	0.195	0.195
Onchocerca volvulus		0.0259	0.1832	0.1832
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0078	0.0431	0.0431
Echinococcus multilocularis	neutral amino acid transporter A	0.1312	1	1
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0037	0.0108	0.0413
Leishmania major	hypothetical protein, conserved	0.0028	0.0037	0.0014
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0078	0.0431	0.0431
Loa Loa (eye worm)	beta-lactamase	0.0078	0.0431	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0999	0.0999
Mycobacterium tuberculosis	Probable oxidoreductase	0.0105	0.0637	0.05
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0105	0.0637	1
Loa Loa (eye worm)	excitatory amino acid transporter	0.1312	1	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0078	0.0431	0.0291
Brugia malayi	MH2 domain containing protein	0.0121	0.0763	0.0763
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0094	0.0555	0.0417
Treponema pallidum	glutamate transporter	0.0582	0.4334	0.5
Mycobacterium tuberculosis	Probable lipase LipD	0.0078	0.0431	0.0291
Schistosoma mansoni	alpha glucosidase	0.0037	0.0108	0.0108
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	0.1312	1	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0037	0.0108	0.0413
Echinococcus granulosus	neutral alpha glucosidase AB	0.0037	0.0108	0.0108
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0183	0.0183
Toxoplasma gondii	aldehyde dehydrogenase	0.0132	0.0847	1
Entamoeba histolytica	hypothetical protein	0.0083	0.0471	1
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0431	0.0291
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0183	0.0183
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0094	0.0555	0.0417
Entamoeba histolytica	hypothetical protein	0.0083	0.0471	1
Plasmodium vivax	glutathione reductase, putative	0.0041	0.0144	0.2719
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0108	0.0297
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0049	0.0205	0.0685
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0078	0.0431	0.0431
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0357	0.2591	0.2591
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0491	0.3632	0.3632
Echinococcus multilocularis	muscleblind protein	0.0152	0.0999	0.0999
Toxoplasma gondii	thioredoxin reductase	0.0041	0.0144	0.1321
Toxoplasma gondii	ABC1 family protein	0.0078	0.0431	0.4857
Loa Loa (eye worm)	hypothetical protein	0.0152	0.0999	0.0999
Loa Loa (eye worm)	transcription factor SMAD2	0.0121	0.0763	0.0763
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0132	0.0847	0.5062
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0077	0.0077
Echinococcus granulosus	lysosomal alpha glucosidase	0.0165	0.1106	0.1106
Echinococcus granulosus	Excitatory amino acid transporter	0.1312	1	1
Schistosoma mansoni	hypothetical protein	0.0083	0.0471	0.0471
Trichomonas vaginalis	set domain proteins, putative	0.0259	0.1832	1
Brugia malayi	beta-lactamase family protein	0.0078	0.0431	0.0431
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0077	0.0077
Onchocerca volvulus		0.0054	0.0243	0.0243
Echinococcus multilocularis	neutral amino acid transporter A	0.1312	1	1
Echinococcus granulosus	sodium:dicarboxylate symporter	0.1312	1	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0166	0.1109	0.4291
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.1312	1	1
Schistosoma mansoni	importin beta-1	0.0033	0.0083	0.0083
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0049	0.0205	0.0685
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0083	0.0471	0.0471
Echinococcus granulosus	excitatory amino acid transporter 2	0.1312	1	1
Brugia malayi	glutathione reductase	0.0041	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0431	0.0431
Brugia malayi	hypothetical protein	0.0083	0.0471	0.0471
Loa Loa (eye worm)	MH2 domain-containing protein	0.0121	0.0763	0.0763
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0165	0.1106	0.1106
Leishmania major	hypothetical protein, conserved	0.0078	0.0431	0.1584
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.05	0.3703	0.3611
Echinococcus granulosus	tumor protein p63	0.0369	0.2688	0.2688
Mycobacterium tuberculosis	Probable reductase	0.0094	0.0555	0.0417
Schistosoma mansoni	hypothetical protein	0.0357	0.2591	0.2591
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0049	0.0205	0.0672
Echinococcus multilocularis	excitatory amino acid transporter 2	0.1312	1	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0067	0.0067
Schistosoma mansoni	alpha-glucosidase	0.0142	0.0927	0.0927
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0582	0.4334	0.4334
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0037	0.0108	0.0108
Echinococcus granulosus	Excitatory amino acid transporter	0.1312	1	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0228	0.1588	0.1588
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0132	0.0847	0.5062
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0183	0.0183
Plasmodium vivax	SET domain protein, putative	0.0033	0.0077	0.1001
Schistosoma mansoni	cellular tumor antigen P53	0.0054	0.0243	0.0243
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0108	0.1701
Mycobacterium tuberculosis	Probable esterase LipL	0.0078	0.0431	0.0291
Echinococcus granulosus	neuropeptide s receptor	0.054	0.4008	0.4008
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0183	0.0183
Onchocerca volvulus	Excitatory amino acid transporter homolog	0.1312	1	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0078	0.0431	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0083	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0431	0.0431
Mycobacterium tuberculosis	Conserved protein	0.0078	0.0431	0.0291
Echinococcus granulosus	beta LACTamase domain containing family member	0.0078	0.0431	0.0431
Echinococcus multilocularis	Excitatory amino acid transporter	0.1312	1	1
Brugia malayi	RNA, U transporter 1	0.0095	0.0561	0.0561
Trichomonas vaginalis	penicillin-binding protein, putative	0.0078	0.0431	0.2208
Schistosoma mansoni	hypothetical protein	0.0056	0.0257	0.0257
Brugia malayi	Thioredoxin reductase	0.0041	0.0144	0.0144
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0132	0.0847	0.0847
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0077	0.0077
Onchocerca volvulus		0.0056	0.0257	0.0257
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0083	0.0471	0.0471
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	0.1312	1	0.5
Brugia malayi	hypothetical protein	0.0274	0.195	0.195
Loa Loa (eye worm)	glutathione reductase	0.0041	0.0144	0.0144
Schistosoma mansoni	hypothetical protein	0.0185	0.126	0.126
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0183	0.0183
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0094	0.0555	0.6037
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0037	0.0108	0.0413
Echinococcus granulosus	neutral amino acid transporter	0.1312	1	1
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0582	0.4334	0.4334
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.1312	1	1
Brugia malayi	Pre-SET motif family protein	0.0033	0.0077	0.0077
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0077	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0243	0.0243
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0037	0.0108	0.1701
Onchocerca volvulus		0.0078	0.0431	0.0431
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0094	0.0555	0.0417
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0078	0.0431	0.0431
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0108	0.0413
Trypanosoma brucei	importin beta-1 subunit, putative	0.0033	0.0083	0.0182
Onchocerca volvulus		0.0033	0.0077	0.0077
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.035	0.2539	1
Echinococcus multilocularis	Excitatory amino acid transporter	0.1312	1	1
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.035	0.2539	1
Toxoplasma gondii	hypothetical protein	0.0056	0.0261	0.2768
Trichomonas vaginalis	alpha-glucosidase, putative	0.0037	0.0108	0.0413
Plasmodium vivax	thioredoxin reductase, putative	0.0041	0.0144	0.2719
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0184	0.1254	0.1126
Echinococcus granulosus	neuropeptide receptor A26	0.054	0.4008	0.4008
Echinococcus granulosus	muscleblind protein	0.0152	0.0999	0.0999
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0165	0.1106	0.1106
Echinococcus multilocularis	excitatory amino acid transporter 3	0.1312	1	1
Leishmania major	alpha glucosidase II subunit, putative	0.0037	0.0108	0.0297
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0132	0.0847	0.5062
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0431	0.0431
Echinococcus granulosus	survival motor neuron protein 1	0.0274	0.195	0.195
Onchocerca volvulus		0.0078	0.0431	0.0431
Treponema pallidum	glutamate/aspartate transporter	0.0582	0.4334	0.5
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0132	0.0847	0.0847
Schistosoma mansoni	aldehyde dehydrogenase	0.0132	0.0847	0.0847
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0037	0.0108	0.0108
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0582	0.4334	0.4334
Leishmania major	mitochondrial DNA polymerase beta	0.035	0.2539	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 848529