TDR Targets

Basic information

Technical information

TDR Targets ID: 848781
Name: 2-(2-chlorophenyl)sulfanyl-N-(2-morpholin-4-y lethyl)quinoline-4-carboxamide
MW: 427.947 | Formula: C22H22ClN3O2S
H donors: 1 H acceptors: 2 LogP: 4.16 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cc(Sc2ccccc2Cl)nc2c1cccc2)NCCN1CCOCC1
InChi: 1S/C22H22ClN3O2S/c23-18-6-2-4-8-20(18)29-21-15-17(16-5-1-3-7-19(16)25-21)22(27)24-9-10-26-11-13-28-14-12-26/h1-8,15H,9-14H2,(H,24,27)
InChiKey: ICWUJZGHYABIQC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2-chlorophenyl)sulfanyl-N-(2-morpholinoethyl)quinoline-4-carboxamide
2-[(2-chlorophenyl)thio]-N-(2-morpholinoethyl)-4-quinolinecarboxamide
2-[(2-chlorophenyl)thio]-N-(2-morpholinoethyl)cinchoninamide
2-[(2-chlorophenyl)thio]-N-(2-morpholin-4-ylethyl)quinoline-4-carboxamide
MLS000586259
SMR000204622

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, beta, acid	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	Get druggable targets OG5_129423	All targets in OG5_129423
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	O-Glycosyl hydrolase family 30 protein	Get druggable targets OG5_129423	All targets in OG5_129423
Onchocerca volvulus	Glucosylceramidase homolog	Get druggable targets OG5_129423	All targets in OG5_129423
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Trichomonas vaginalis	glucosylceramidase, putative	Get druggable targets OG5_129423	All targets in OG5_129423
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cathepsin L-like protease	0.1751	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.1172	0.6633	0.5946
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1751	1	1
Giardia lamblia	Cysteine protease	0.0323	0.1694	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1751	1	1
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0323	0.1694	0.5
Giardia lamblia	Cathepsin B precursor	0.0323	0.1694	0.5
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0003	0.0003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1751	1	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1751	1	1
Loa Loa (eye worm)	hypothetical protein	0.1751	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.1172	0.6633	0.5946
Loa Loa (eye worm)	hypothetical protein	0.0579	0.3181	0.3181
Plasmodium vivax	unspecified product	0.0579	0.3181	0.1791
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0323	0.1694	0.1691
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0323	0.1694	0.0767
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0323	0.1694	0.1691
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0902	0.5061	0.451
Onchocerca volvulus		0.1172	0.6633	0.6631
Brugia malayi	cathepsin B-like cysteine proteinase	0.0323	0.1694	0.1691
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0902	0.5061	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.1172	0.6633	0.6631
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0323	0.1694	0.1691
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0902	0.5061	0.4054
Giardia lamblia	Cathepsin B precursor	0.0323	0.1694	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1751	1	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0902	0.5061	0.4054
Onchocerca volvulus	Cathepsin L homolog	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1751	1	1
Loa Loa (eye worm)	hypothetical protein	0.0323	0.1694	0.1694
Onchocerca volvulus	Cathepsin F homolog	0.1751	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0323	0.1694	0.1691
Schistosoma mansoni	cathepsin F (C01 family)	0.1751	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1751	1	1
Onchocerca volvulus		0.1751	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0323	0.1694	0.1691
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Giardia lamblia	Hypothetical protein	0.0323	0.1694	0.5
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0323	0.1694	0.1691
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0323	0.1694	0.0767
Onchocerca volvulus		0.1751	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0323	0.1694	0.0767
Echinococcus multilocularis	cathepsin L cysteine protease	0.1751	1	1
Giardia lamblia	Cathepsin L-like protease	0.0323	0.1694	0.5
Loa Loa (eye worm)	hypothetical protein	0.0579	0.3181	0.3181
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.1628	0.0693
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0323	0.1694	0.1691
Plasmodium vivax	vivapain-3	0.0902	0.5061	0.4054
Plasmodium vivax	vivapain-2	0.1751	1	1
Brugia malayi	Cathepsin L-like precursor	0.1172	0.6633	0.6631
Echinococcus granulosus	cathepsin L	0.0902	0.5061	0.5059
Giardia lamblia	Cathepsin L precursor	0.0323	0.1694	0.5
Echinococcus multilocularis	cathepsin L cysteine protease	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1751	1	1
Leishmania major	cathepsin L-like protease	0.1751	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0323	0.1694	0.0767
Brugia malayi	cathepsin L-like precursor	0.1172	0.6633	0.6631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0323	0.1694	0.0767
Echinococcus granulosus	cathepsin b	0.0323	0.1694	0.1691
Echinococcus granulosus	cysteine protease	0.0902	0.5061	0.5059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0902	0.5061	0.451
Echinococcus granulosus	cathepsin L cysteine protease	0.0902	0.5061	0.5059
Giardia lamblia	Cysteine protease	0.0323	0.1694	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0902	0.5061	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0323	0.1694	0.1691
Brugia malayi	Cathepsin L-like precursor	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0323	0.1694	0.0767
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1751	1	1
Loa Loa (eye worm)	hypothetical protein	0.0323	0.1694	0.1694
Brugia malayi	cathepsin F-like cysteine proteinase	0.0579	0.3181	0.3179
Giardia lamblia	Cathepsin L precursor	0.0323	0.1694	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0902	0.5061	0.5059
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Giardia lamblia	Cathepsin L-like protease	0.0323	0.1694	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Echinococcus granulosus	cathepsin L	0.0323	0.1694	0.1691
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1172	0.6633	0.6257
Trichomonas vaginalis	conserved hypothetical protein	0.0323	0.1694	0.0767
Trypanosoma cruzi	cysteine peptidase, putative	0.0579	0.3181	0.1791
Giardia lamblia	Cathepsin L precursor	0.0323	0.1694	0.5
Leishmania major	cathepsin L-like protease	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0323	0.1694	0.1691
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.1628	0.0693
Onchocerca volvulus		0.0323	0.1694	0.1691
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0003	0.0003
Trichomonas vaginalis	glucosylceramidase, putative	0.0216	0.1068	0.0071
Schistosoma mansoni	cathepsin B (C01 family)	0.0323	0.1694	0.1691
Schistosoma mansoni	cathepsin S (C01 family)	0.0323	0.1694	0.1691
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1751	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0323	0.1694	0.5
Loa Loa (eye worm)	hypothetical protein	0.0323	0.1694	0.1694
Entamoeba histolytica	cysteine protease, putative	0.1751	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1751	1	1
Onchocerca volvulus		0.1751	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0323	0.1694	0.1691
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0323	0.1694	0.1691
Onchocerca volvulus	Glucosylceramidase homolog	0.0205	0.1004	0.1001
Leishmania major	cathepsin L-like protease	0.1751	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0902	0.5061	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1751	1	1
Loa Loa (eye worm)	hypothetical protein	0.0323	0.1694	0.1694
Onchocerca volvulus		0.1751	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.1751	1	1
Loa Loa (eye worm)	hypothetical protein	0.1172	0.6633	0.6633
Giardia lamblia	Cathepsin L precursor	0.0323	0.1694	0.5
Brugia malayi	Cathepsin L-like precursor	0.0579	0.3181	0.3179
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1751	1	1
Leishmania major	cathepsin L-like protease	0.1751	1	1
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0312	0.1628	0.1628
Trichomonas vaginalis	glucosylceramidase, putative	0.0216	0.1068	0.0071
Echinococcus granulosus	cathepsin l1	0.1172	0.6633	0.6631
Brugia malayi	Cathepsin L-like precursor	0.1751	1	1
Loa Loa (eye worm)	cysteine protease	0.1751	1	1
Loa Loa (eye worm)	fibroinase	0.1751	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0323	0.1694	0.1691
Leishmania major	cathepsin L-like protease	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0323	0.1694	0.0767
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1751	1	1
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.1628	0.0693
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0323	0.1694	0.0767
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0902	0.5061	0.5059
Onchocerca volvulus		0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0323	0.1694	0.0767
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.1628	0.0693
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0323	0.1694	0.0767
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Giardia lamblia	Cathepsin B precursor	0.0323	0.1694	0.5
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1172	0.6633	0.6631
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0323	0.1694	0.1691
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1751	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0579	0.3181	0.3181
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1751	1	1
Brugia malayi	Cathepsin L-like precursor	0.1172	0.6633	0.6631
Giardia lamblia	Cysteine protease	0.0323	0.1694	0.5
Giardia lamblia	Hypothetical protein	0.0323	0.1694	0.5
Brugia malayi	Cathepsin L-like precursor	0.1751	1	1
Echinococcus granulosus	cathepsin l1	0.1751	1	1
Plasmodium vivax	vivapain-2	0.1751	1	1
Brugia malayi	fibroinase precursor	0.0323	0.1694	0.1691
Schistosoma mansoni	cathepsin s	0.0579	0.3181	0.3179
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Echinococcus multilocularis	cathepsin b	0.0323	0.1694	0.1691
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Giardia lamblia	Encystation-specific protease	0.0323	0.1694	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1172	0.6633	0.6257
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0323	0.1694	0.0767
Echinococcus multilocularis	cysteine protease	0.1751	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0902	0.5061	0.5059
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0323	0.1694	0.1691
Onchocerca volvulus	Cathepsin L homolog	0.0323	0.1694	0.1691
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1751	1	1
Echinococcus multilocularis	cathepsin L	0.0323	0.1694	0.1691
Echinococcus multilocularis	cysteine protease	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1751	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0323	0.1694	0.1691
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0902	0.5061	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.1628	0.0693
Brugia malayi	cathepsin F-like cysteine proteinase	0.0323	0.1694	0.1691
Onchocerca volvulus	Cathepsin L homolog	0.1751	1	1
Giardia lamblia	Cathepsin B precursor	0.0323	0.1694	0.5
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0579	0.3181	0.3179
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1751	1	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0323	0.1694	0.1691
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0323	0.1694	0.0767
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1751	1	1
Leishmania major	cathepsin L-like protease	0.1751	1	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0003	0.0003
Schistosoma mansoni	cathepsin C	0.0323	0.1694	0.1691
Loa Loa (eye worm)	hypothetical protein	0.0323	0.1694	0.1694
Entamoeba histolytica	cysteine proteinase, putative	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0323	0.1694	0.0767
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0312	0.1628	0.1625
Entamoeba histolytica	cysteine proteinase, putative	0.0902	0.5061	0.4054
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0323	0.1694	0.1694
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1751	1	1
Echinococcus multilocularis	cathepsin L	0.0902	0.5061	0.5059
Giardia lamblia	Cathepsin L precursor	0.0323	0.1694	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0323	0.1694	0.0767
Plasmodium vivax	unspecified product	0.0902	0.5061	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1751	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1751	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0902	0.5061	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0902	0.5061	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0323	0.1694	0.1691
Toxoplasma gondii	cathepsin CPL	0.1751	1	1
Brugia malayi	cathepsin L precursor	0.0323	0.1694	0.1691
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0323	0.1694	0.0767
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0323	0.1694	0.1694
Trypanosoma cruzi	cysteine proteinase, putative	0.0902	0.5061	0.4054
Trypanosoma cruzi	cysteine protease, putative	0.0902	0.5061	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Giardia lamblia	Cathepsin B precursor	0.0323	0.1694	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0902	0.5061	0.4054
Giardia lamblia	Cathepsin B precursor	0.0323	0.1694	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.1751	1	1
Giardia lamblia	Cathepsin B precursor	0.0323	0.1694	0.5
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0323	0.1694	0.5
Brugia malayi	Cathepsin L-like precursor	0.1751	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0323	0.1694	0.5
Trypanosoma cruzi	cruzipain precursor, putative	0.0579	0.3181	0.1791
Onchocerca volvulus		0.1751	1	1
Giardia lamblia	Cathepsin B precursor	0.0323	0.1694	0.5
Echinococcus granulosus	cathepsin b	0.0323	0.1694	0.1691
Leishmania major	cathepsin L-like protease	0.1751	1	1
Loa Loa (eye worm)	hypothetical protein	0.0323	0.1694	0.1694
Entamoeba histolytica	cysteine proteinase, putative	0.1751	1	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1751	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1751	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0323	0.1694	0.1691
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0323	0.1694	0.1691
Trypanosoma cruzi	cysteine peptidase, putative	0.1751	1	1
Giardia lamblia	Cathepsin L precursor	0.0323	0.1694	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Giardia lamblia	Cysteine protease	0.0323	0.1694	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Leishmania major	cysteine peptidase A (CPA)	0.1751	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0902	0.5061	0.4054
Loa Loa (eye worm)	hypothetical protein	0.1172	0.6633	0.6633
Trichomonas vaginalis	glucosylceramidase, putative	0.0312	0.1628	0.0693
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0323	0.1694	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0579	0.3181	0.3181
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1751	1	1
Plasmodium vivax	vivapain-1	0.0902	0.5061	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0323	0.1694	0.0767
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0323	0.1694	0.1691
Brugia malayi	Cathepsin L-like precursor	0.1751	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0902	0.5061	0.5059
Onchocerca volvulus		0.1751	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1751	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1751	1	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0902	0.5061	0.5059
Entamoeba histolytica	cysteine proteinase 2	0.0902	0.5061	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0323	0.1694	0.1691
Echinococcus multilocularis	cathepsin b	0.0323	0.1694	0.1691
Loa Loa (eye worm)	cathepsin B	0.0323	0.1694	0.1694
Loa Loa (eye worm)	hypothetical protein	0.0323	0.1694	0.1694
Loa Loa (eye worm)	hypothetical protein	0.1172	0.6633	0.6633
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0323	0.1694	0.0767
Trichomonas vaginalis	conserved hypothetical protein	0.0323	0.1694	0.0767
Trypanosoma cruzi	cysteine peptidase, putative	0.1751	1	1
Entamoeba histolytica	cysteine protease, putative	0.0902	0.5061	0.4054
Loa Loa (eye worm)	ctsf protein	0.1751	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0323	0.1694	0.0767

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 5.6234 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	6.5733 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1371092
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 848781