Detailed information for compound 849052

Basic information

Technical information
  • TDR Targets ID: 849052
  • Name: N-[4-bromo-2-(2-chlorobenzoyl)phenyl]-4-piper idin-1-ylsulfonylbenzamide
  • MW: 561.875 | Formula: C25H22BrClN2O4S
  • H donors: 1 H acceptors: 4 LogP: 5.96 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 2
  • SMILES: Brc1ccc(c(c1)C(=O)c1ccccc1Cl)NC(=O)c1ccc(cc1)S(=O)(=O)N1CCCCC1
  • InChi: 1S/C25H22BrClN2O4S/c26-18-10-13-23(21(16-18)24(30)20-6-2-3-7-22(20)27)28-25(31)17-8-11-19(12-9-17)34(32,33)29-14-4-1-5-15-29/h2-3,6-13,16H,1,4-5,14-15H2,(H,28,31)
  • InChiKey: DPKYRRYLTHMMHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[4-bromo-2-(2-chlorobenzoyl)phenyl]-4-(1-piperidylsulfonyl)benzamide
  • N-[4-bromo-2-[(2-chlorophenyl)-oxomethyl]phenyl]-4-(1-piperidylsulfonyl)benzamide
  • N-[4-bromo-2-(2-chlorobenzoyl)phenyl]-4-piperidinosulfonyl-benzamide
  • N-[4-bromo-2-(2-chlorophenyl)carbonyl-phenyl]-4-piperidin-1-ylsulfonyl-benzamide
  • ZINC02026292
  • EU-0034182
  • Oprea1_097447

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis poly(ADP ribose) glycohydrolase 0.0316 0.9361 1
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0643 0.0686
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0009 0.0007
Entamoeba histolytica hypothetical protein 0.0038 0.0864 0.0646
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.3654 0.3904
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.004
Brugia malayi nuclear receptor NHR-88 0.001 0.0009 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0277 0.03
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0002 0.0002
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.1146 0.1144
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1775 0.1894
Schistosoma mansoni ap endonuclease 0.0019 0.0277 0.0294
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.1154 0.1233
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0676 0.0721
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0038 0.0038
Mycobacterium tuberculosis Conserved hypothetical protein 0.0177 0.5124 0.637
Schistosoma mansoni hypothetical protein 0.0054 0.1342 0.1432
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.1713 0.183
Schistosoma mansoni hypothetical protein 0.0031 0.0643 0.0684
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0009 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0048 0.1154 0.1231
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.3654 0.3902
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0009 0.0007
Brugia malayi Carboxylesterase family protein 0.0011 0.0038 0.0038
Echinococcus granulosus phd:f box containing protein 0.001 0.0002 0.0002
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0009 0.0009
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.1146 0.1144
Onchocerca volvulus 0.0027 0.0529 0.1018
Loa Loa (eye worm) carboxylesterase 0.0011 0.0038 0.004
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.2846 0.3039
Loa Loa (eye worm) hypothetical protein 0.0066 0.1713 0.183
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0277 0.4294
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.0004
Schistosoma mansoni hypothetical protein 0.018 0.5193 0.5547
Brugia malayi Carboxylesterase family protein 0.0066 0.1713 0.1828
Brugia malayi intermediate filament protein 0.0027 0.0529 0.0563
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.4573 0.4572
Loa Loa (eye worm) carboxylesterase 0.0066 0.1713 0.183
Echinococcus multilocularis peregrin 0.0031 0.0643 0.0686
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0277 0.0294
Schistosoma mansoni coup transcription factor 0.001 0.0009 0.0007
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0316 0.9361 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.1713 0.1828
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.1013 0.1082
Schistosoma mansoni acetylcholinesterase 0.0011 0.0038 0.0038
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0159 0.4573 0.4572
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.004
Schistosoma mansoni hypothetical protein 0.0048 0.1154 0.1231
Trypanosoma brucei poly(ADP-ribose) glycohydrolase, putative 0.0316 0.9361 0.9361
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.4304 0.4597
Mycobacterium tuberculosis Probable oxidoreductase 0.0272 0.8023 1
Onchocerca volvulus 0.0011 0.0038 0.0057
Brugia malayi MH2 domain containing protein 0.0117 0.3271 0.3493
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0305 0.0324
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0009 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0009
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0006 0.0004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0009 0.0007
Schistosoma mansoni intermediate filament proteins 0.0027 0.0529 0.0563
Onchocerca volvulus 0.0054 0.1342 0.261
Entamoeba histolytica hypothetical protein 0.0141 0.4002 0.41
Echinococcus multilocularis cpg binding protein 0.0034 0.0732 0.0782
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0009 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0066 0.0993
Echinococcus multilocularis tar DNA binding protein 0.0129 0.3654 0.3904
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0009 0.0009
Echinococcus granulosus GPCR family 2 0.0048 0.1154 0.1233
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0676 0.044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0007
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0009 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0009 0.0009
Brugia malayi ecdysteroid receptor 0.001 0.0009 0.0007
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0643 0.0684
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0316 0.9361 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.001 0.0006 0.0004
Onchocerca volvulus 0.0011 0.0038 0.0057
Onchocerca volvulus 0.0032 0.0677 0.1307
Brugia malayi nuclear hormone receptor 0.001 0.0009 0.0007
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0277 0.5
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0002 0.0002
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0038 0.004
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0676 0.0675
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.1553 0.1657
Echinococcus multilocularis lamin dm0 0.0027 0.0529 0.0565
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.4304 0.4596
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0002 0.0002
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0101 0.2794 0.2985
Echinococcus granulosus polyADP ribose glycohydrolase 0.0316 0.9361 1
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3654 0.3902
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.004
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0841 0.0899
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0864 0.0923
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0009 0.0009
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0038 0.0038
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0009 0.0007
Brugia malayi steroid hormone receptor 0.001 0.0009 0.0007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0009
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0009 0.0009
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.1154 0.1231
Loa Loa (eye worm) hypothetical protein 0.0066 0.1713 0.183
Loa Loa (eye worm) hypothetical protein 0.0151 0.4304 0.4597
Brugia malayi Carboxylesterase family protein 0.0066 0.1713 0.1828
Loa Loa (eye worm) TAR-binding protein 0.0129 0.3654 0.3904
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.1649 0.1762
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0009 0.0009
Schistosoma mansoni survival motor neuron protein 0.0054 0.1342 0.1432
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0676 0.0675
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.1713 0.183
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0277 0.0275
Brugia malayi hypothetical protein 0.0264 0.7764 0.8294
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0277 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0009
Echinococcus granulosus geminin 0.018 0.5193 0.5548
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0002 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.1146 0.1144
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0277 0.0275
Onchocerca volvulus 0.0011 0.0038 0.0057
Echinococcus granulosus lamin dm0 0.0027 0.0529 0.0565
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0101 0.2794 0.2985
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0277 0.3615
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0009 0.0007
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0643 0.0686
Loa Loa (eye worm) hypothetical protein 0.0053 0.1318 0.1408
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0009 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3654 0.3902
Echinococcus granulosus peregrin 0.0031 0.0643 0.0686
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0277 0.4294
Loa Loa (eye worm) hypothetical protein 0.0013 0.0083 0.0089
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0009 0.0007
Brugia malayi jmjC domain containing protein 0.0039 0.0897 0.0957
Brugia malayi N-terminal motif family protein 0.0177 0.5119 0.5467
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0002 0.0002
Schistosoma mansoni gliotactin 0.0011 0.0038 0.0038
Schistosoma mansoni lamin 0.0027 0.0529 0.0563
Schistosoma mansoni hypothetical protein 0.0103 0.2846 0.3039
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.004
Schistosoma mansoni thyroid hormone receptor 0.001 0.0009 0.0007
Echinococcus multilocularis expressed protein 0.0033 0.07 0.0748
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0249 0.0264
Loa Loa (eye worm) hypothetical protein 0.0012 0.0062 0.0066
Brugia malayi PHD-finger family protein 0.0031 0.0643 0.0684
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0002
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0038 0.0038
Echinococcus granulosus survival motor neuron protein 1 0.0264 0.7764 0.8294
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0009 0.0007
Entamoeba histolytica poly(ADP-ribose) glycohydrolase, putative 0.0141 0.4002 0.41
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0009 0.0007
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0009 0.0009
Schistosoma mansoni ap endonuclease 0.0019 0.0277 0.0294
Brugia malayi hypothetical protein 0.0011 0.0038 0.0038
Echinococcus multilocularis musashi 0.0027 0.0529 0.0565
Schistosoma mansoni hypothetical protein 0.0048 0.1154 0.1231
Echinococcus granulosus neuroligin 0.0011 0.0038 0.004
Trichomonas vaginalis rotamase, putative 0.0032 0.0676 0.9643
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.001 0.0006 0.0004
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.3271 0.3495
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0009
Entamoeba histolytica hypothetical protein 0.0038 0.0864 0.0646
Loa Loa (eye worm) carboxylesterase 0.0011 0.0038 0.004
Echinococcus multilocularis phd:f box containing protein 0.001 0.0002 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0337 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0009 0.0007
Brugia malayi AF-10 protein 0.001 0.0006 0.0004
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0009 0.0009
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0676 0.0675
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0143 0.0152
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0002 0.0002
Echinococcus multilocularis geminin 0.018 0.5193 0.5548
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.3271 0.3495
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0009 0.0009
Toxoplasma gondii hypothetical protein 0.0054 0.1359 0.145
Brugia malayi TAR-binding protein 0.0129 0.3654 0.3902
Echinococcus granulosus cpg binding protein 0.0034 0.0732 0.0782
Loa Loa (eye worm) RNA binding protein 0.0129 0.3654 0.3904
Echinococcus granulosus jumonji domain containing protein 0.0043 0.1013 0.1082
Schistosoma mansoni cpg binding protein 0.0034 0.0732 0.078
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3654 0.3902
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0143 0.015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Onchocerca volvulus 0.0027 0.0529 0.1018
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1713 0.183
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.4304 0.4596
Brugia malayi Bromodomain containing protein 0.0031 0.0643 0.0684
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0277 0.0275
Brugia malayi Poly 0.0316 0.9361 1
Trichomonas vaginalis rotamase, putative 0.0033 0.07 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0009 0.0007
Echinococcus multilocularis acetylcholinesterase 0.0066 0.1713 0.183
Loa Loa (eye worm) hypothetical protein 0.0031 0.0643 0.0686
Toxoplasma gondii PHD-finger domain-containing protein 0.001 0.0006 0.0004
Echinococcus granulosus FTZ F1 alpha 0.001 0.0009 0.0009
Toxoplasma gondii poly(ADP-ribose) glycohydrolase 0.0141 0.4002 0.4274
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.07 1
Echinococcus granulosus acetylcholinesterase 0.0066 0.1713 0.183
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0643 1
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0316 0.9361 0.9361
Onchocerca volvulus 0.0011 0.0038 0.0057
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0277 0.3615
Plasmodium falciparum phd finger protein, putative 0.0031 0.0643 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0277 0.0296
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0009 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0009 0.0007
Mycobacterium ulcerans hypothetical protein 0.0177 0.5124 0.637
Schistosoma mansoni cpg binding protein 0.0034 0.0732 0.078
Echinococcus granulosus carboxylesterase 5A 0.0066 0.1713 0.183
Echinococcus granulosus intermediate filament protein 0.0027 0.0529 0.0565
Loa Loa (eye worm) hypothetical protein 0.0177 0.5119 0.5468
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3654 0.3902
Echinococcus granulosus tar DNA binding protein 0.0129 0.3654 0.3904
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.07 0.0746
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0277 0.0296
Echinococcus granulosus lamin 0.0027 0.0529 0.0565
Giardia lamblia PHD finger protein 15 0.0031 0.0643 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0009 0.0009
Brugia malayi hypothetical protein 0.0038 0.0864 0.0921
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.1146 0.1144
Echinococcus multilocularis survival motor neuron protein 1 0.0264 0.7764 0.8294
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.1463 0.1461
Schistosoma mansoni cpg binding protein 0.0032 0.0677 0.0721
Loa Loa (eye worm) hypothetical protein 0.0027 0.0529 0.0565
Brugia malayi Carboxylesterase family protein 0.0011 0.0038 0.0038
Brugia malayi RNA binding protein 0.0129 0.3654 0.3902
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0277 0.0275
Echinococcus multilocularis neuroligin 0.0011 0.0038 0.004
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0038 0.0038
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.1154 0.1233
Entamoeba histolytica hypothetical protein 0.0038 0.0864 0.0646
Schistosoma mansoni thyroid hormone receptor 0.001 0.0009 0.0007
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0897 0.0957
Brugia malayi CXXC zinc finger family protein 0.0032 0.0677 0.0721
Loa Loa (eye worm) hypothetical protein 0.0048 0.1154 0.1233
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0038 0.0038
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0159 0.4573 0.4572
Onchocerca volvulus Alhambra homolog 0.0031 0.0643 0.124
Echinococcus multilocularis GPCR, family 2 0.0048 0.1154 0.1233
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0009 0.0007
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0098 0.0105
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0002 0.0002
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0277 0.03
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0009 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0009 0.0007
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0643 0.0684
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.004
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.1342 0.1432
Brugia malayi Carboxylesterase family protein 0.0011 0.0038 0.0038
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Onchocerca volvulus 0.0011 0.0038 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0009 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0129 0.3654 0.3902
Trypanosoma cruzi poly(ADP-ribose) glycohydrolase, putative 0.0316 0.9361 0.9361
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0529 0.0563
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0058 0.0062
Entamoeba histolytica hypothetical protein 0.0038 0.0864 0.0646
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0529 0.0565
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0009 0.0007
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0038 0.004
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0038 0.004
Schistosoma mansoni nuclear hormone receptor 0.001 0.0009 0.0007
Loa Loa (eye worm) Poly(ADP-ribose) glycohydrolase 0.0316 0.9361 1
Loa Loa (eye worm) hypothetical protein 0.0264 0.7764 0.8294
Echinococcus granulosus acetylcholinesterase 0.0066 0.1713 0.183
Toxoplasma gondii exonuclease III APE 0.0019 0.0277 0.0294
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0058 0.0062
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0864 0.0921
Schistosoma mansoni rotamase 0.0033 0.07 0.0746
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0277 0.0296
Echinococcus multilocularis lamin 0.0027 0.0529 0.0565
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0897 0.0959
Schistosoma mansoni hypothetical protein 0.0038 0.0864 0.0921
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0643 0.0684
Brugia malayi jmjC domain containing protein 0.0101 0.2794 0.2983
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0529 0.0565
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0038 0.004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0009 0.0007
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0676 0.0675
Brugia malayi PHD-finger family protein 0.0012 0.0062 0.0064
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0038 0.004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0677 0.0723
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0038 0.004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.1154 0.1233
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0337 1 1
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0897 0.0959
Brugia malayi Latrophilin receptor protein 2 0.0048 0.1154 0.1231
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0009 0.0007
Schistosoma mansoni hypothetical protein 0.018 0.5193 0.5547
Schistosoma mansoni lamin 0.0027 0.0529 0.0563
Entamoeba histolytica hypothetical protein 0.0316 0.9361 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0098 0.0105
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.5119 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0643 0.0686
Brugia malayi Carboxylesterase family protein 0.0011 0.0038 0.0038
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0098 0.0105
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0066 0.0993
Loa Loa (eye worm) hypothetical protein 0.0103 0.2846 0.304
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0897 0.0957
Schistosoma mansoni hypothetical protein 0.0048 0.1154 0.1231
Mycobacterium ulcerans short chain dehydrogenase 0.0272 0.8023 1
Schistosoma mansoni poly(ADP-ribose) glycohydrolase 0.0316 0.9361 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0009 0.0007
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.07 0.0748
Schistosoma mansoni jumonji domain containing protein 0.008 0.2157 0.2303
Echinococcus granulosus expressed protein 0.0033 0.07 0.0748
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0337 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0864 0.0923
Loa Loa (eye worm) hypothetical protein 0.0013 0.0083 0.0089
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.1154 0.1233
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.1154 0.1233
Loa Loa (eye worm) hypothetical protein 0.0027 0.0514 0.0549

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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