TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 409.48 | Formula: C19H31N5O5
H donors: 3 H acceptors: 6 LogP: 0.09 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OC1C(OCCCCCCn2cnc3c2ncnc3N(C)C)OC(C(C1O)O)C
InChi: 1S/C19H31N5O5/c1-12-14(25)15(26)16(27)19(29-12)28-9-7-5-4-6-8-24-11-22-13-17(23(2)3)20-10-21-18(13)24/h10-12,14-16,19,25-27H,4-9H2,1-3H3
InChiKey: CCRGCIDFEWLDFM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	polo-like protein kinase	0.0112	0.2978	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0512	0.1001
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1476	0.1476
Mycobacterium tuberculosis	Probable lipase LipD	0.0043	0.1016	0.083
Echinococcus granulosus	sterol regulatory element binding protein	0.0048	0.1169	0.1285
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0007	0.0002	0.0002
Mycobacterium tuberculosis	Probable esterase LipL	0.0043	0.1016	0.083
Onchocerca volvulus		0.0007	0.0002	0.0005
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0007	0.0012	0.0035
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1016	0.083
Loa Loa (eye worm)	beta-lactamase	0.0043	0.1016	0.1016
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1016	0.083
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0019	0.0352	0.3468
Brugia malayi	Importin beta-1 subunit	0.0031	0.0677	0.0677
Trypanosoma brucei	hypothetical protein, conserved	0.0043	0.1016	0.2839
Echinococcus granulosus	GPCR family 2	0.0018	0.0316	0.0346
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0002	0.0002
Brugia malayi	Tyrosine-protein kinase abl-1	0.0007	0.0002	0.0002
Schistosoma mansoni	ran	0.0023	0.0447	0.049
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0007	0.0002	0.0002
Loa Loa (eye worm)	SH2 domain-containing protein	0.0007	0.0002	0.0002
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0447	0.0447
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0677	0.6659
Brugia malayi	hypothetical protein	0.028	0.7744	0.7744
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0043	0.1016	1
Brugia malayi	T-complex protein 1, beta subunit	0.0026	0.0537	0.0537
Brugia malayi	T-complex protein 1, beta subunit	0.0026	0.0537	0.0537
Schistosoma mansoni	ap endonuclease	0.0022	0.0426	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0002	0.0002
Loa Loa (eye worm)	TK protein kinase	0.0007	0.0002	0.0002
Trypanosoma cruzi	polo-like protein kinase, putative	0.0112	0.2978	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0272	0.7528	1
Echinococcus multilocularis	protein patched	0.0048	0.1169	0.1285
Leishmania major	hypothetical protein, conserved	0.0043	0.1016	0.2839
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1377	0.4157
Schistosoma mansoni	hypothetical protein	0.0018	0.0316	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2981	0.2981
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0007	0.0002	0.0002
Schistosoma mansoni	DNA helicase recq1	0.0012	0.014	0.0152
Echinococcus multilocularis	Niemann Pick C1 protein	0.0112	0.2981	0.328
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Brugia malayi	CHE-14 protein	0.0048	0.1169	0.1169
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.1016	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.016	0.4343	0.4779
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1016	0.1016
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0677	0.1601
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0426	0.5
Echinococcus granulosus	geminin	0.0197	0.5383	0.5925
Entamoeba histolytica	recQ family helicase, putative	0.0015	0.0238	0.0792
Brugia malayi	SH2 domain containing protein	0.0007	0.0002	0.0002
Entamoeba histolytica	T-complex protein 1 beta subunit, putative	0.0026	0.0537	0.1796
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0002	0.0002
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0019	0.0346	0.3405
Brugia malayi	SH2 domain containing protein	0.0007	0.0002	0.0002
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.0012	0.014	0.0152
Onchocerca volvulus	Huntingtin homolog	0.0145	0.3919	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.014	0.1379
Loa Loa (eye worm)	hypothetical protein	0.0177	0.4821	0.4821
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0046	0.112	0.1231
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.1414	0.1414
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0112	0.2978	1
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0426	0.0688
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0677	0.0743
Schistosoma mansoni	ran	0.0023	0.0447	0.049
Schistosoma mansoni	hypothetical protein	0.0018	0.0316	0.0346
Schistosoma mansoni	survival motor neuron protein	0.0057	0.1426	0.1568
Schistosoma mansoni	hypothetical protein	0.0327	0.9085	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.1016	0.1116
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0426	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.1016	0.2839
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0007	0.0002	0.0002
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.0012	0.014	0.2071
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0112	0.2978	0.3276
Schistosoma mansoni	DNA helicase recq5	0.0012	0.014	0.0152
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0112	0.2978	0.2978
Mycobacterium ulcerans	esterase/lipase LipP	0.0043	0.1016	1
Brugia malayi	beta-lactamase family protein	0.0043	0.1016	0.1016
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0007	0.0002	0.0002
Onchocerca volvulus		0.0007	0.0002	0.0005
Brugia malayi	RhoGAP domain containing protein	0.0007	0.0002	0.0002
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0316	0.0346
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0447	0.0763
Trichomonas vaginalis	CAMK family protein kinase	0.0112	0.2978	1
Plasmodium falciparum	T-complex protein 1 subunit beta	0.0026	0.0537	0.7939
Schistosoma mansoni	hypothetical protein	0.0039	0.0906	0.0995
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0007	0.0002	0.0002
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0677	0.1601
Schistosoma mansoni	ap endonuclease	0.0022	0.0426	0.0467
Schistosoma mansoni	kinase	0.0057	0.1419	0.156
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0012	0.014	0.014
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0426	0.0688
Echinococcus granulosus	bloom syndrome protein	0.0028	0.0613	0.0673
Onchocerca volvulus		0.0043	0.1016	0.2592
Entamoeba histolytica	protein kinase, putative	0.0007	0.0012	0.0035
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0043	0.1016	0.083
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0007	0.0002	0.0002
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0048	0.1169	0.1169
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.0012	0.014	0.0152
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.1016	0.2839
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0007	0.0002	0.0002
Brugia malayi	RNA, U transporter 1	0.0087	0.2279	0.2279
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1016	0.1016
Brugia malayi	SH2 domain containing protein	0.0007	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Trichomonas vaginalis	chaperonin-60kD, ch60, putative	0.0026	0.0537	0.1092
Trichomonas vaginalis	CAMK family protein kinase	0.0055	0.1377	0.4157
Schistosoma mansoni	serine/threonine protein kinase	0.0112	0.2978	0.3276
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0007	0.0002	0.0002
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0512	0.1001
Brugia malayi	Tensin	0.0007	0.0002	0.0002
Echinococcus granulosus	muscleblind protein	0.0177	0.4821	0.5306
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.1414	0.1414
Brugia malayi	Variant SH3 domain containing protein	0.0007	0.0002	0.0002
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1016	0.2839
Loa Loa (eye worm)	RecQ helicase	0.0028	0.0613	0.0613
Toxoplasma gondii	t-complex protein beta subunit	0.0026	0.0537	0.5287
Trichomonas vaginalis	CAMK family protein kinase	0.0112	0.2978	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0426	0.0467
Schistosoma mansoni	hypothetical protein	0.0197	0.5383	0.5925
Echinococcus multilocularis	muscleblind protein 1	0.0177	0.4821	0.5306
Echinococcus granulosus	snurportin 1	0.0327	0.9085	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0426	0.4197
Loa Loa (eye worm)	SH2 domain-containing protein	0.0007	0.0002	0.0002
Schistosoma mansoni	hypothetical protein	0.0018	0.0316	0.0346
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0426	0.0688
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0447	0.4401
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0112	0.2981	1
Onchocerca volvulus		0.0007	0.0002	0.0005
Echinococcus granulosus	chaperonin containing TCP1 subunit 2 beta	0.0026	0.0537	0.0589
Brugia malayi	SH2 domain containing protein	0.0007	0.0002	0.0002
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0007	0.0002	0.0005
Loa Loa (eye worm)	T-complex protein 1	0.0026	0.0537	0.0537
Loa Loa (eye worm)	SH2 domain-containing protein	0.0007	0.0002	0.0002
Brugia malayi	hypothetical protein	0.0007	0.0002	0.0002
Brugia malayi	beta-lactamase family protein	0.0043	0.1016	0.1016
Echinococcus granulosus	expressed conserved protein	0.0105	0.2789	0.3068
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0316	0.0316
Schistosoma mansoni	blooms syndrome DNA helicase	0.0022	0.0444	0.0486
Loa Loa (eye worm)	hypothetical protein	0.0145	0.3919	0.3919
Loa Loa (eye worm)	SRC-1	0.0007	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1016	0.1016
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.014	0.014
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0026	0.0537	0.0589
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0043	0.1016	0.1116
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0043	0.1016	0.083
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0002	0.0002
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0426	0.6302
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0112	0.2978	0.7598
Brugia malayi	SH2 domain containing protein	0.0007	0.0002	0.0002
Schistosoma mansoni	importin beta-1	0.0031	0.0677	0.0743
Mycobacterium ulcerans	hypothetical protein	0.0043	0.1016	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0316	0.0316
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0112	0.2978	0.999
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0026	0.0537	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Onchocerca volvulus		0.0007	0.0002	0.0005
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.1414	0.1414
Brugia malayi	SH2 domain containing protein	0.0007	0.0002	0.0002
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0512	0.1001
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0447	0.049
Trichomonas vaginalis	DNA helicase recq1, putative	0.0028	0.0613	0.137
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.1169	0.3399
Onchocerca volvulus		0.0007	0.0002	0.0005
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0002	0.0002
Brugia malayi	Niemann-Pick C1 protein precursor	0.0112	0.2981	0.2981
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0043	0.1016	0.1116
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0002	0.0002
Trichomonas vaginalis	CAMK family protein kinase	0.0112	0.2978	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0007	0.0012	0.0011
Echinococcus multilocularis	snurportin 1	0.0327	0.9085	1
Schistosoma mansoni	hypothetical protein	0.0018	0.0316	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Brugia malayi	beta-lactamase	0.0043	0.1016	0.1016
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.0012	0.014	0.0152
Mycobacterium tuberculosis	Probable lipase LipE	0.0043	0.1016	0.083
Brugia malayi	SRC-1	0.0007	0.0002	0.0002
Onchocerca volvulus		0.0007	0.0002	0.0005
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0043	0.1016	0.1016
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0057	0.1426	0.1426
Trichomonas vaginalis	CAMK family protein kinase	0.0112	0.2978	1
Schistosoma mansoni	hypothetical protein	0.0057	0.1426	0.1568
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0426	0.0688
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0447	0.6609
Echinococcus granulosus	survival motor neuron protein 1	0.028	0.7744	0.8524
Echinococcus granulosus	Protein patched homolog 1	0.0048	0.1169	0.1285
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1016	0.1016
Brugia malayi	SH2 domain containing protein	0.0007	0.0002	0.0002
Giardia lamblia	TCP-1 chaperonin subunit beta	0.0026	0.0537	0.1399
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0316	0.0346
Trichomonas vaginalis	CAMK family protein kinase	0.0112	0.2978	1
Trichomonas vaginalis	CAMK family protein kinase	0.0112	0.2978	1
Trichomonas vaginalis	esterase, putative	0.0043	0.1016	0.2839
Onchocerca volvulus		0.0007	0.0002	0.0005
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0426	0.1425
Echinococcus multilocularis	chaperonin containing TCP1, subunit 2 (beta)	0.0026	0.0537	0.0589
Loa Loa (eye worm)	hypothetical protein	0.0145	0.3919	0.3919
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0002	0.0002
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0426	0.0467
Leishmania major	T-complex protein 1, beta subunit, putative	0.0026	0.0537	0.1092
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0002	0.0002
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0043	0.1016	0.083
Brugia malayi	Bloom's syndrome protein homolog	0.0028	0.0613	0.0613
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.0012	0.014	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1016	0.1016
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0447	0.4401
Echinococcus multilocularis	muscleblind protein	0.0177	0.4821	0.5306
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0677	0.0677
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0426	0.0426
Trichomonas vaginalis	DNA helicase recq, putative	0.0028	0.0613	0.137
Trichomonas vaginalis	CAMK family protein kinase	0.0112	0.2978	1
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Schistosoma mansoni	chaperonin containing t-complex protein 1 beta subunit tcpb	0.0026	0.0537	0.0589
Brugia malayi	Variant SH3 domain containing protein	0.0007	0.0002	0.0002
Echinococcus multilocularis	expressed conserved protein	0.0105	0.2789	0.3068
Loa Loa (eye worm)	hypothetical protein	0.028	0.7744	0.7744
Echinococcus granulosus	Niemann Pick C1 protein	0.016	0.4343	0.4779
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1016	0.2839
Toxoplasma gondii	exonuclease III APE	0.0022	0.0426	0.4197
Onchocerca volvulus		0.0007	0.0002	0.0005
Loa Loa (eye worm)	STAT protein	0.0359	1	1
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.0012	0.014	0.014
Loa Loa (eye worm)	hypothetical protein	0.0177	0.4821	0.4821
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0447	0.0763
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Mycobacterium leprae	conserved hypothetical protein	0.0043	0.1016	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0007	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0906	0.0906
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0677	0.6659
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0316	0.0346
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.014	0.014
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0002	0.0002
Onchocerca volvulus		0.0043	0.1016	0.2592
Trichomonas vaginalis	D-aminoacylase, putative	0.0043	0.1016	0.2839
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0906	0.0906
Echinococcus granulosus	Niemann Pick C1 protein	0.0112	0.2981	0.328
Brugia malayi	protein-tyrosine kinase	0.0007	0.0002	0.0002
Brugia malayi	Muscleblind-like protein	0.0177	0.4821	0.4821
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0426	0.0688
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0677	0.0743
Onchocerca volvulus		0.0057	0.1426	0.3639
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0002	0.0002
Schistosoma mansoni	patched 1	0.0048	0.1169	0.1285
Mycobacterium leprae	Probable lipase LipE	0.0043	0.1016	0.5
Onchocerca volvulus		0.0007	0.0002	0.0005
Loa Loa (eye worm)	TK/ABL protein kinase	0.0007	0.0002	0.0002
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0512	0.1001
Trichomonas vaginalis	penicillin-binding protein, putative	0.0043	0.1016	0.2839
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0512	0.1001
Brugia malayi	serine/threonine-protein kinase plk-2	0.0112	0.2978	0.2978
Brugia malayi	SH2 domain containing protein	0.0007	0.0002	0.0002
Onchocerca volvulus		0.0007	0.0002	0.0005
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0316	0.0316
Entamoeba histolytica	Ran family GTPase	0.0023	0.0447	0.1494
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0007	0.0002	0.0005
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0447	0.049
Onchocerca volvulus	Huntingtin homolog	0.0145	0.3919	1
Mycobacterium ulcerans	beta-lactamase	0.0043	0.1016	1
Entamoeba histolytica	hypothetical protein	0.0025	0.0512	0.1713
Trichomonas vaginalis	ran, putative	0.0023	0.0447	0.0763
Echinococcus multilocularis	protein dispatched 1	0.0055	0.1362	0.1497
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0327	0.9085	0.9085
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0025	0.0515	0.7618
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0043	0.1016	0.1016
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0447	0.0763
Leishmania major	GTP-binding protein, putative	0.0023	0.0447	0.0763
Brugia malayi	Protein kinase domain containing protein	0.0007	0.0002	0.0002
Trypanosoma brucei	T-complex protein 1, beta subunit, putative	0.0026	0.0537	0.1092
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0447	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Echinococcus granulosus	beta LACTamase domain containing family member	0.0043	0.1016	0.1116
Schistosoma mansoni	hypothetical protein	0.0046	0.112	0.1231
Schistosoma mansoni	hypothetical protein	0.0046	0.112	0.1231
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1414	0.1414
Onchocerca volvulus		0.0007	0.0002	0.0005
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0114	0.303	0.3334
Brugia malayi	SH2 domain containing protein	0.0007	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1016	0.1016
Mycobacterium tuberculosis	Probable hydrolase	0.0043	0.1016	0.083
Giardia lamblia	Kinase, PLK	0.0112	0.2978	1
Toxoplasma gondii	ABC1 family protein	0.0043	0.1016	1
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0112	0.2978	0.3276
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0012	0.014	0.1379
Mycobacterium tuberculosis	Conserved protein	0.0043	0.1016	0.083
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0316	0.0346
Schistosoma mansoni	hypothetical protein	0.0046	0.112	0.1231
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0002	0.0002
Onchocerca volvulus		0.0007	0.0002	0.0005
Echinococcus multilocularis	bloom syndrome protein	0.0028	0.0613	0.0673
Trypanosoma cruzi	T-complex protein 1, beta subunit, putative	0.0026	0.0537	0.1092
Onchocerca volvulus		0.0043	0.1016	0.2592
Trypanosoma cruzi	hypothetical protein, conserved	0.0043	0.1016	0.2839
Mycobacterium ulcerans	lipase LipD	0.0043	0.1016	1
Brugia malayi	hypothetical protein	0.0007	0.0002	0.0002
Brugia malayi	Variant SH3 domain containing protein	0.0007	0.0002	0.0002
Loa Loa (eye worm)	TK/FER protein kinase	0.0007	0.0002	0.0002
Echinococcus multilocularis	geminin	0.0197	0.5383	0.5925
Brugia malayi	Sex muscle abnormal protein 5	0.0007	0.0002	0.0002
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0447	0.1082
Plasmodium falciparum	importin beta, putative	0.0031	0.0677	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0426	0.0688
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1169	0.1169
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0316	0.0346
Echinococcus multilocularis	survival motor neuron protein 1	0.028	0.7744	0.8524
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0426	0.1009
Trypanosoma cruzi	polo-like protein kinase, putative	0.0112	0.2978	1
Trichomonas vaginalis	chaperonin, putative	0.0026	0.0537	0.1092
Brugia malayi	hypothetical protein	0.0145	0.3919	0.3919
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0316	0.0316
Echinococcus multilocularis	sterol regulatory element binding protein	0.0048	0.1169	0.1285
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0426	0.0426
Plasmodium vivax	T-complex protein 1 subunit beta, putative	0.0026	0.0537	0.5287
Schistosoma mansoni	hypothetical protein	0.0197	0.5383	0.5925
Loa Loa (eye worm)	hypothetical protein	0.0143	0.3863	0.3863

Activities

Activity type	Activity value	Assay description	Source	Reference
Concentration (functional)	= 0.00000000001 M	Peak or the range of peak activity relative to positive IL 2 control; Range 10e-12-10e-6	ChEMBL.	9599240
Stimulation (functional)	= 81 %	In vitro Natural Killer cell activity (Activation of murine splenocyte NK cells by its ability to lyze YAC-1 target cells in chromium release assay) relative to interleukin 2 at 10E-4 to 10E-12 M conc; Range 81-80%	ChEMBL.	9599240

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 84907