Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | calcium transporting ATPase type 2C member | 0.0104 | 0.0573 | 0.0585 |
Trichomonas vaginalis | cation-transporting ATPase fungi, putative | 0.0095 | 0.049 | 0.8167 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.0095 | 0.049 | 0.8425 |
Echinococcus multilocularis | nervana 2 | 0.0445 | 0.3517 | 0.5469 |
Entamoeba histolytica | plasma membrane calcium ion-transporting ATPase, putative | 0.0061 | 0.0202 | 0.2984 |
Loa Loa (eye worm) | hypothetical protein | 0.0184 | 0.1261 | 0.2918 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0104 | 0.0573 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.432 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0538 | 0.432 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0104 | 0.0573 | 1 |
Brugia malayi | calcium ATPase | 0.0053 | 0.0127 | 0.0587 |
Onchocerca volvulus | 0.0538 | 0.432 | 1 | |
Echinococcus multilocularis | Ca2+ transporting ATPase plasma membrane | 0.0104 | 0.0573 | 0.0585 |
Toxoplasma gondii | P-type ATPase4, putative | 0.0104 | 0.0573 | 1 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8425 |
Toxoplasma gondii | sarco/endoplasmic reticulum Ca2+-ATPase | 0.0104 | 0.0573 | 1 |
Schistosoma mansoni | ATPase | 0.0095 | 0.049 | 0.0773 |
Plasmodium vivax | calcium-transporting ATPase, putative | 0.0104 | 0.0573 | 0.5 |
Schistosoma mansoni | calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) | 0.0104 | 0.0573 | 0.0907 |
Brugia malayi | calcium ATPase | 0.0052 | 0.0118 | 0.0543 |
Leishmania major | P-type ATPase, putative | 0.0104 | 0.0573 | 1 |
Echinococcus multilocularis | Na+:K+ ATPase alpha subunit | 0.0274 | 0.2044 | 0.3024 |
Onchocerca volvulus | 0.0445 | 0.3517 | 0.6596 | |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 1 | 0.0095 | 0.049 | 0.8167 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1195 | 1 | 1 |
Echinococcus granulosus | sarco:endoplasmic reticulum calcium ATPase | 0.0095 | 0.049 | 0.0447 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0139 | 0.0872 | 0.108 |
Schistosoma mansoni | plasma membrane calcium-transporting atpase | 0.0104 | 0.0573 | 0.0907 |
Schistosoma mansoni | transmemberane protein | 0.0538 | 0.432 | 0.6912 |
Toxoplasma gondii | calcium-translocating P-type ATPase, PMCA-type protein | 0.0095 | 0.049 | 0.8167 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.1514 | 0.3504 |
Loa Loa (eye worm) | calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0066 | 0.0246 | 0.0569 |
Schistosoma mansoni | na+/k+ atpase alpha subunit | 0.0274 | 0.2044 | 0.3263 |
Echinococcus multilocularis | plasma membrane calcium transporting ATPase | 0.0104 | 0.0573 | 0.0585 |
Echinococcus granulosus | nervana 2 | 0.0538 | 0.432 | 0.6803 |
Mycobacterium leprae | Isocitrate lyase | 0.056 | 0.4513 | 0.3443 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0163 | 0.0763 |
Brugia malayi | Membrane calcium atpase protein 3 | 0.0104 | 0.0573 | 0.2778 |
Echinococcus granulosus | Ca2 transporting ATPase plasma membrane | 0.0104 | 0.0573 | 0.0585 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0163 | 0.0763 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0052 | 0.0118 | 0.1409 |
Echinococcus multilocularis | calcium transporting atpase | 0.0104 | 0.0573 | 0.0585 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8425 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0538 | 0.432 | 0.6803 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase 2 | 0.0095 | 0.049 | 0.8167 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1195 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0163 | 0.0378 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0052 | 0.0118 | 0.1409 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0131 | 0.0804 | 0.186 |
Trypanosoma cruzi | calcium-transporting ATPase, putative | 0.0066 | 0.0246 | 0.3812 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1195 | 1 | 1 |
Trypanosoma cruzi | Calcium ATPase SERCA-like | 0.0095 | 0.049 | 0.8425 |
Schistosoma mansoni | ATPase | 0.0095 | 0.049 | 0.0773 |
Trypanosoma brucei | calcium-translocating P-type ATPase | 0.0104 | 0.0573 | 1 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase | 0.0104 | 0.0573 | 0.0585 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1195 | 1 | 1 |
Echinococcus granulosus | calcium transporting ATPase type 2C member | 0.0104 | 0.0573 | 0.0585 |
Trypanosoma cruzi | plasma-membrane proton-efflux P-type ATPase, putative | 0.0052 | 0.0118 | 0.1409 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0538 | 0.432 | 0.6912 |
Trypanosoma cruzi | P-type H+-ATPase, putative | 0.0052 | 0.0118 | 0.1409 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0538 | 0.432 | 0.6912 |
Loa Loa (eye worm) | sodium potassium adenosine triphosphatase | 0.0052 | 0.0118 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.049 | 0.1134 |
Leishmania major | calcium-translocating P-type ATPase | 0.0095 | 0.049 | 0.8167 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0131 | 0.0804 | 0.186 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.2044 | 0.473 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0538 | 0.432 | 0.6803 |
Echinococcus multilocularis | sodium:potassium transporting ATPase subunit | 0.0538 | 0.432 | 0.6803 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0445 | 0.3517 | 0.5469 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0538 | 0.432 | 0.6803 |
Loa Loa (eye worm) | Na,K-ATPase alpha subunit | 0.0274 | 0.2044 | 0.473 |
Echinococcus multilocularis | sarco:endoplasmic reticulum calcium ATPase | 0.0095 | 0.049 | 0.0447 |
Entamoeba histolytica | plasma membrane calcium ion-transporting ATPase, putative | 0.0053 | 0.0127 | 0.1575 |
Brugia malayi | MH2 domain containing protein | 0.0131 | 0.0804 | 0.3909 |
Echinococcus multilocularis | Tetracycline resistance leader peptide, TetL | 0.0104 | 0.0573 | 0.0585 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.0968 | 0.1539 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha chain, putative | 0.0236 | 0.1716 | 0.839 |
Mycobacterium ulcerans | metal cation-transporting p-type ATPase F, CtpF | 0.0104 | 0.0573 | 0.0418 |
Leishmania major | calcium-transporting ATPase, putative | 0.0104 | 0.0573 | 1 |
Leishmania major | calcium motive p-type ATPase, putative | 0.0104 | 0.0573 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1195 | 1 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0761 | 0.6247 | 1 |
Plasmodium falciparum | non-SERCA-type Ca2+ -transporting P-ATPase | 0.0104 | 0.0573 | 0.5 |
Brugia malayi | Na,K-ATPase alpha subunit | 0.0274 | 0.2044 | 1 |
Brugia malayi | E1-E2 ATPase family protein | 0.0061 | 0.0202 | 0.0953 |
Echinococcus multilocularis | nervana 2 | 0.0538 | 0.432 | 0.6803 |
Echinococcus granulosus | nervana 2 | 0.0445 | 0.3517 | 0.5469 |
Plasmodium falciparum | calcium-transporting ATPase | 0.0104 | 0.0573 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.015 | 0.0968 | 0.124 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Loa Loa (eye worm) | E1-E2 ATPase | 0.0052 | 0.0118 | 0.0274 |
Echinococcus granulosus | nervana 2 | 0.0538 | 0.432 | 0.6803 |
Loa Loa (eye worm) | calcium ATPase | 0.0053 | 0.0127 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.1142 | 0.2644 |
Schistosoma mansoni | calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) | 0.0104 | 0.0573 | 0.0907 |
Echinococcus granulosus | Na:K ATPase alpha subunit | 0.0274 | 0.2044 | 0.3024 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0246 | 0.0569 |
Plasmodium vivax | P-type ATPase4, putative | 0.0104 | 0.0573 | 0.5 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0104 | 0.0573 | 1 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Schistosoma mansoni | sodium/potassium-dependent atpase beta subunit | 0.0445 | 0.3517 | 0.5624 |
Schistosoma mansoni | lipoxygenase | 0.0063 | 0.0221 | 0.0341 |
Echinococcus granulosus | plasma membrane calcium transporting ATPase 2 | 0.0104 | 0.0573 | 0.0585 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0538 | 0.432 | 0.6803 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Brugia malayi | Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type | 0.0104 | 0.0573 | 0.2778 |
Leishmania major | vacuolar-type Ca2 -ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Schistosoma mansoni | hypothetical protein | 0.0139 | 0.0872 | 0.1385 |
Mycobacterium ulcerans | metal cation transporter p-type ATPase a | 0.0265 | 0.196 | 0.1827 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Brugia malayi | Sodium/potassium-transporting ATPase alpha-3 chain, putative | 0.0052 | 0.0118 | 0.0543 |
Schistosoma mansoni | calcium-transporting atpase 2 (atpase 2) | 0.0104 | 0.0573 | 0.0907 |
Entamoeba histolytica | Plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8425 |
Brugia malayi | haloacid dehalogenase-like hydrolase family protein | 0.0053 | 0.0127 | 0.0587 |
Loa Loa (eye worm) | sodium/potassium-transporting ATPase subunit alpha | 0.0236 | 0.1716 | 0.3971 |
Brugia malayi | Probable calcium-transporting ATPase KIAA0703 | 0.0066 | 0.0246 | 0.1168 |
Giardia lamblia | Potassium-transporting ATPase alpha chain 1 | 0.0274 | 0.2044 | 1 |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 0.0095 | 0.049 | 0.8425 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0761 | 0.6247 | 1 |
Trypanosoma cruzi | calcium-translocating P-type ATPase, putative | 0.0052 | 0.0118 | 0.1409 |
Trypanosoma brucei | calcium motive p-type ATPase, putative | 0.0104 | 0.0573 | 1 |
Schistosoma mansoni | sodium / potassium ATPase beta chain | 0.0445 | 0.3517 | 0.5624 |
Trypanosoma cruzi | calcium motive p-type ATPase, putative | 0.0104 | 0.0573 | 1 |
Trypanosoma brucei | calcium-transporting ATPase, putative | 0.0066 | 0.0246 | 0.2797 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0445 | 0.3517 | 0.5469 |
Schistosoma mansoni | Na+/K+ transporting ATPase subunit alpha | 0.0274 | 0.2044 | 0.3263 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0163 | 0.0378 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0761 | 0.6247 | 1 |
Echinococcus granulosus | calcium transporting atpase | 0.0104 | 0.0573 | 0.0585 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.0968 | 0.1539 |
Echinococcus granulosus | nervana 2 | 0.0445 | 0.3517 | 0.5469 |
Trichomonas vaginalis | cation-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Entamoeba histolytica | calcium-transporting P-type ATPase, putative | 0.0104 | 0.0573 | 1 |
Trypanosoma brucei | vacuolar-type Ca2+-ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Echinococcus multilocularis | nervana 2 | 0.0538 | 0.432 | 0.6803 |
Toxoplasma gondii | plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 | 0.0104 | 0.0573 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0139 | 0.0872 | 0.108 |
Schistosoma mansoni | plasma membrane calcium-transporting atpase | 0.0104 | 0.0573 | 0.0907 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0118 | 0.0274 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0008 | 0.0018 |
Echinococcus multilocularis | nervana 2 | 0.0445 | 0.3517 | 0.5469 |
Echinococcus granulosus | sodium:potassium transporting ATPase subunit | 0.0538 | 0.432 | 0.6803 |
Trichomonas vaginalis | plasma membrane calcium-transporting ATPase, putative | 0.0095 | 0.049 | 0.8167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.