Detailed information for compound 849221

Basic information

Technical information
  • TDR Targets ID: 849221
  • Name: N-[(4-methoxyphenyl)methylideneamino]-2-pyrid in-2-ylsulfanylacetamide
  • MW: 301.364 | Formula: C15H15N3O2S
  • H donors: 1 H acceptors: 2 LogP: 2.65 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C=NNC(=O)CSc1ccccn1
  • InChi: 1S/C15H15N3O2S/c1-20-13-7-5-12(6-8-13)10-17-18-14(19)11-21-15-4-2-3-9-16-15/h2-10H,11H2,1H3,(H,18,19)/b17-10+
  • InChiKey: ALQYBMCOAPVMSK-LICLKQGHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-methoxyphenyl)methyleneamino]-2-(2-pyridylsulfanyl)acetamide
  • N-[(4-methoxyphenyl)methyleneamino]-2-(2-pyridylthio)acetamide
  • N-[(4-methoxybenzylidene)amino]-2-(2-pyridylthio)acetamide
  • N-[(4-methoxyphenyl)methylideneamino]-2-pyridin-2-ylsulfanyl-ethanamide
  • STOCK2S-80657

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) fibroinase 0.0281 0.1977 0.1977
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.1977 0.3751
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.1039 0.1039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.1977 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0324 0.0616
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0381 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0725 0.527 1
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.0812 0.0812
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0182 0.0182
Echinococcus granulosus cathepsin L cysteine protease 0.0155 0.1039 0.1948
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0037 0.004
Onchocerca volvulus 0.0039 0.0182 0.0921
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0083
Plasmodium vivax glutathione reductase, putative 0.0049 0.0252 0.1203
Entamoeba histolytica cysteine proteinase, putative 0.0155 0.1039 0.5254
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0016 0.0002
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.1977 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0047 0.0156
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0047 0.0156
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.1977 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0579 0.1072
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Giardia lamblia Cathepsin L precursor 0.0068 0.0399 0.2026
Echinococcus granulosus bloom syndrome protein 0.002 0.0037 0.004
Plasmodium falciparum serine repeat antigen 4 0.0068 0.0399 0.1952
Entamoeba histolytica cysteine proteinase 1, putative 0.0155 0.1039 0.5254
Brugia malayi cathepsin L precursor 0.0068 0.0399 0.0399
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0283 0.0283
Brugia malayi MH2 domain containing protein 0.0124 0.0812 0.0812
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0381 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0068 0.0399 0.2026
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.1977 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.1977 1
Plasmodium falciparum serine repeat antigen 5 0.0068 0.0399 0.1952
Leishmania major hypothetical protein, conserved 0.0039 0.0182 0.0921
Brugia malayi Cathepsin L-like precursor 0.0195 0.1337 0.1337
Entamoeba histolytica cysteine protease, putative 0.0068 0.0399 0.2018
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0063 0.0119
Echinococcus multilocularis geminin 0.0184 0.1259 0.1987
Toxoplasma gondii cathepsin CPC2 0.0068 0.0399 0.1952
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0271 0.1906 0.9638
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0725 0.527 1
Brugia malayi Cathepsin L-like precursor 0.0086 0.0531 0.0531
Schistosoma mansoni cathepsin s 0.0086 0.0531 0.0981
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0037 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.1977 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0252 0.1361
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0016 0.5
Echinococcus multilocularis cathepsin b 0.0725 0.527 0.84
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0324 0.1631
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0016 0.0016
Giardia lamblia Cathepsin L precursor 0.0068 0.0399 0.2026
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0037 0.0103
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0176 0.0257
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0725 0.527 1
Plasmodium vivax vivapain-2 0.0281 0.1977 1
Plasmodium falciparum serine repeat antigen 9 0.0068 0.0399 0.1952
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0399 0.2018
Giardia lamblia Cathepsin B precursor 0.0271 0.1906 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.1977 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0015 0.0015
Mycobacterium ulcerans lipase LipD 0.0039 0.0182 0.4543
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0068 0.0399 0.1952
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.1977 1
Onchocerca volvulus 0.0281 0.1977 1
Brugia malayi Thioredoxin reductase 0.0049 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0068 0.0399 0.0399
Brugia malayi hypothetical protein 0.0052 0.0279 0.0279
Schistosoma mansoni cathepsin F (C01 family) 0.0281 0.1977 0.3733
Brugia malayi fibroinase precursor 0.0068 0.0399 0.0399
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0183 0.0927
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0324 0.8444
Plasmodium falciparum serine repeat antigen 7 0.0068 0.0399 0.1952
Leishmania major hypothetical protein, conserved 0.0052 0.0279 0.1413
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0252 0.0479
Onchocerca volvulus 0.0281 0.1977 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0068 0.0399 0.0399
Brugia malayi cathepsin L-like precursor 0.0195 0.1337 0.1337
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0037 0.004
Echinococcus granulosus cathepsin L cysteine proteinase 0.0281 0.1977 0.3733
Echinococcus granulosus cathepsin l1 0.0281 0.1977 0.3733
Loa Loa (eye worm) hypothetical protein 0.0068 0.0399 0.0399
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0155 0.1039 0.1971
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0725 0.527 1
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0381 0.0696
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0068 0.0399 0.1952
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0579 0.0901
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0068 0.0399 0.2018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0083
Brugia malayi Papain family cysteine protease containing protein 0.0068 0.0399 0.0399
Trichomonas vaginalis ran, putative 0.0021 0.0047 0.0237
Plasmodium vivax serine-repeat antigen (SERA) 0.0068 0.0399 0.1952
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0182 0.4543
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0177 0.1207 0.1207
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0015 0.0015
Entamoeba histolytica cysteine protease, putative 0.0068 0.0399 0.2018
Brugia malayi Inositol-1 0.0038 0.0176 0.0176
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0182 0.0956
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0182 0.0956
Schistosoma mansoni cathepsin F (C01 family) 0.0195 0.1337 0.2516
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0016 0.0083
Echinococcus granulosus cathepsin l1 0.0195 0.1337 0.2516
Brugia malayi Cathepsin L-like precursor 0.0281 0.1977 0.1977
Brugia malayi beta-lactamase family protein 0.0039 0.0182 0.0182
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0155 0.1039 0.1948
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0183 0.0348
Loa Loa (eye worm) hypothetical protein 0.0039 0.0182 0.0182
Onchocerca volvulus 0.0281 0.1977 1
Loa Loa (eye worm) ctsf protein 0.0281 0.1977 0.1977
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0176 0.0334
Entamoeba histolytica cysteine protease, putative 0.0068 0.0399 0.2018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0037
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0063 0.0317
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.1977 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0037 0.0185
Loa Loa (eye worm) cathepsin B 0.0271 0.1906 0.1906
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0037 0.0185
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0068 0.0399 0.1952
Entamoeba histolytica cysteine proteinase, putative 0.0155 0.1039 0.5254
Schistosoma mansoni cathepsin C 0.0068 0.0399 0.073
Loa Loa (eye worm) hypothetical protein 0.0039 0.0182 0.0182
Onchocerca volvulus 0.0068 0.0399 0.2018
Brugia malayi Glycosyl hydrolases family 31 protein 0.0177 0.1207 0.1207
Schistosoma mansoni cathepsin S (C01 family) 0.0068 0.0399 0.073
Brugia malayi Cathepsin L-like precursor 0.0281 0.1977 0.1977
Trypanosoma brucei glucosidase, putative 0.0039 0.0183 0.0927
Brugia malayi hypothetical protein 0.0034 0.0142 0.0142
Brugia malayi cathepsin F-like cysteine proteinase 0.0086 0.0531 0.0531
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0068 0.0399 0.0399
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0183 0.0851
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0399 0.2018
Echinococcus multilocularis cathepsin L 0.0068 0.0399 0.0613
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0068 0.0399 0.2026
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0715 0.403
Toxoplasma gondii preprocathepsin c precursor, putative 0.0068 0.0399 0.1952
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0579 0.0579
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0579 0.1072
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0176 0.4377
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0182 0.0345
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0279 0.1342
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0068 0.0399 0.2018
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0103 0.052
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0252 0.0252
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0176 0.089
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0324 0.1641
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0715 0.403
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0807 0.456
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0183 0.0927
Trypanosoma cruzi cysteine peptidase, putative 0.0155 0.1039 0.1971
Entamoeba histolytica cysteine proteinase, putative 0.0155 0.1039 0.5254
Plasmodium falciparum serine repeat antigen 8 0.0068 0.0399 0.1952
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0182 0.0317
Schistosoma mansoni inositol monophosphatase 0.0038 0.0176 0.0306
Mycobacterium tuberculosis Probable reductase 0.0111 0.0715 0.403
Echinococcus granulosus geminin 0.0184 0.1259 0.2366
Brugia malayi RNA, U transporter 1 0.0081 0.0493 0.0493
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.1207 0.1905
Loa Loa (eye worm) glutathione reductase 0.0049 0.0252 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0068 0.0399 0.073
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0281 0.1977 1
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0182 0.0956
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0068 0.0399 0.1952
Trypanosoma cruzi major cysteine proteinase, putative 0.0068 0.0399 0.0757
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0068 0.0399 0.073
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0068 0.0399 0.2018
Entamoeba histolytica cysteine proteinase, putative 0.0195 0.1337 0.6764
Onchocerca volvulus 0.0039 0.0182 0.0921
Giardia lamblia Hypothetical protein 0.0068 0.0399 0.2026
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0016 0.0083
Echinococcus granulosus importin subunit beta 1 0.0028 0.0103 0.0166
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0068 0.0399 0.073
Leishmania major cathepsin L-like protease 0.0281 0.1977 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0068 0.0399 0.1952
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0183 0.0927
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0037 0.0034
Brugia malayi Importin beta-1 subunit 0.0028 0.0103 0.0103
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0324 0.1778
Loa Loa (eye worm) hypothetical protein 0.0068 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0281 0.1977 0.1977
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0155 0.1039 0.1948
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0016 0.0002
Loa Loa (eye worm) hypothetical protein 0.0725 0.527 0.527
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155 0.1039 0.5254
Echinococcus granulosus cathepsin L 0.0155 0.1039 0.1948
Schistosoma mansoni ran 0.0021 0.0047 0.006
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.1977 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0182 0.0182
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0016 0.0083
Onchocerca volvulus 0.0195 0.1337 0.6764
Loa Loa (eye worm) hypothetical protein 0.0195 0.1337 0.1337
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0176 0.089
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0016 0.0083
Leishmania major importin beta-1 subunit, putative 0.0023 0.0063 0.0317
Loa Loa (eye worm) hypothetical protein 0.0039 0.0182 0.0182
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0279 0.1342
Brugia malayi beta-lactamase 0.0039 0.0182 0.0182
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Entamoeba histolytica recQ family helicase, putative 0.002 0.0037 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Schistosoma mansoni hypothetical protein 0.0184 0.1259 0.2366
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0381 0.1928
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0399 0.2018
Leishmania major GTP-binding protein, putative 0.0021 0.0047 0.0237
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0279 0.1342
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0807 0.456
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0279 0.053
Trypanosoma brucei cysteine peptidase C (CPC) 0.0271 0.1906 0.9638
Plasmodium falciparum importin beta, putative 0.0028 0.0103 0.0441
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Brugia malayi Papain family cysteine protease containing protein 0.0068 0.0399 0.0399
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0183 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0399 0.2018
Leishmania major cathepsin L-like protease 0.0281 0.1977 1
Giardia lamblia Cathepsin L precursor 0.0068 0.0399 0.2026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0281 0.1977 0.3733
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0715 0.403
Brugia malayi Papain family cysteine protease containing protein 0.0068 0.0399 0.0399
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0324 0.1571
Entamoeba histolytica Ran family GTPase 0.0021 0.0047 0.0237
Leishmania major cathepsin L-like protease 0.0281 0.1977 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0047 0.0089
Leishmania major cathepsin L-like protease 0.0281 0.1977 1
Onchocerca volvulus Cathepsin F homolog 0.0281 0.1977 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.0103 0.0441
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0176 0.089
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0381 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0047 0.0156
Echinococcus multilocularis cathepsin L cysteine protease 0.0281 0.1977 0.3136
Mycobacterium tuberculosis Conserved protein 0.0039 0.0182 0.0956
Plasmodium vivax vivapain-1 0.0155 0.1039 0.5215
Leishmania major cathepsin L-like protease 0.0281 0.1977 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0037 0.0069
Plasmodium falciparum serine repeat antigen 2 0.0068 0.0399 0.1952
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Schistosoma mansoni hypothetical protein 0.0184 0.1259 0.2366
Plasmodium falciparum serine repeat antigen 3 0.0068 0.0399 0.1952
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0579 0.1072
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0281 0.1977 0.1977
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0183 0.0927
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.1977 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0579 0.0901
Plasmodium vivax serine-repeat antigen (SERA) 0.0068 0.0399 0.1952
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.1977 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0016 0.0083
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0146 0.0749
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0271 0.1906 0.3616
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0324 0.1641
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0271 0.1906 0.3597
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0399 0.2018
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0324 0.0588
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0182 0.0956
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0068 0.0399 0.0399
Giardia lamblia Cathepsin B precursor 0.0271 0.1906 1
Giardia lamblia Cathepsin B precursor 0.0068 0.0399 0.2026
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0281 0.1977 0.3136
Loa Loa (eye worm) hypothetical protein 0.0086 0.0531 0.0531
Schistosoma mansoni hypothetical protein 0.0023 0.0065 0.0095
Brugia malayi Cathepsin L-like precursor 0.0281 0.1977 0.1977
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0324 0.0616
Toxoplasma gondii cathepsin CPC1 0.0068 0.0399 0.1952
Onchocerca volvulus Cathepsin L homolog 0.0068 0.0399 0.2018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.1977 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0031
Loa Loa (eye worm) inositol-1 0.0038 0.0176 0.0176
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0037 0.0107
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0324 0.1641
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0279 0.1413
Giardia lamblia Cathepsin B precursor 0.0068 0.0399 0.2026
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0016 0.0031
Entamoeba histolytica cysteine proteinase, putative 0.0281 0.1977 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0183 0.0927
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0281 0.1977 0.1977
Echinococcus granulosus cathepsin b 0.0725 0.527 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.1337 0.1337
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.0812 0.0812
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.1977 1
Toxoplasma gondii cathepsin CPL 0.0281 0.1977 1
Brugia malayi glutathione reductase 0.0049 0.0252 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0068 0.0399 0.2018
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0047 0.0162
Brugia malayi cathepsin L-like cysteine proteinase 0.0068 0.0399 0.0399
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0579 0.1072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0031
Plasmodium falciparum thioredoxin reductase 0.0049 0.0252 0.1203
Loa Loa (eye worm) hypothetical protein 0.0039 0.0182 0.0182
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0068 0.0399 0.0399
Toxoplasma gondii ABC1 family protein 0.0039 0.0182 0.0845
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0037 0.0185
Mycobacterium tuberculosis Conserved protein 0.0039 0.0182 0.0956
Giardia lamblia Cathepsin B precursor 0.0068 0.0399 0.2026
Onchocerca volvulus 0.0281 0.1977 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0381 0.0696
Giardia lamblia Cysteine protease 0.0068 0.0399 0.2026
Entamoeba histolytica cysteine protease, putative 0.0068 0.0399 0.2018
Schistosoma mansoni ap endonuclease 0.0058 0.0324 0.0588
Onchocerca volvulus 0.0281 0.1977 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0068 0.0399 0.2018
Loa Loa (eye worm) POT family protein 0.0042 0.0206 0.0206
Brugia malayi Cathepsin L-like precursor 0.0281 0.1977 0.1977
Onchocerca volvulus 0.0281 0.1977 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0399 0.0399
Brugia malayi Papain family cysteine protease containing protein 0.0155 0.1039 0.1039
Entamoeba histolytica cysteine protease, putative 0.0281 0.1977 1
Plasmodium vivax unspecified product 0.0086 0.0531 0.2625
Onchocerca volvulus 0.0039 0.0182 0.0921
Schistosoma mansoni alpha-glucosidase 0.0153 0.1024 0.192
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0031
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0068 0.0399 0.1952
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Giardia lamblia Encystation-specific protease 0.0068 0.0399 0.2026
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0068 0.0399 0.1952
Loa Loa (eye worm) hypothetical protein 0.0068 0.0399 0.0399
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0068 0.0399 0.073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.1977 1
Giardia lamblia Cysteine protease 0.0068 0.0399 0.2026
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0182 0.0544
Loa Loa (eye worm) hypothetical protein 0.0086 0.0531 0.0531
Echinococcus multilocularis snurportin 1 0.0304 0.2149 0.3411
Brugia malayi Cathepsin L-like precursor 0.0281 0.1977 0.1977
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0068 0.0399 0.073
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.1977 0.3751
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.1977 1
Entamoeba histolytica cysteine proteinase, putative 0.0155 0.1039 0.5254
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0324 1
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0103
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0068 0.0399 0.2018
Entamoeba histolytica cysteine protease, putative 0.0068 0.0399 0.2018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.1039 0.5254
Onchocerca volvulus Cathepsin L homolog 0.0281 0.1977 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0183 0.0183
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0068 0.0399 0.073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.1977 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0068 0.0399 0.1952
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0271 0.1906 0.9638
Brugia malayi cathepsin Z-like cysteine proteinase 0.0068 0.0399 0.0399
Giardia lamblia Cathepsin L-like protease 0.0068 0.0399 0.2026
Toxoplasma gondii thioredoxin reductase 0.0049 0.0252 0.1203
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0182 0.0845
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0324 1
Schistosoma mansoni cathepsin F (C01 family) 0.0281 0.1977 0.3733
Brugia malayi cathepsin F-like cysteine proteinase 0.0068 0.0399 0.0399
Loa Loa (eye worm) hypothetical protein 0.0036 0.0159 0.0159
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0103 0.052
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0279 0.1342
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.2149 0.2149
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0015
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0183 0.0927
Loa Loa (eye worm) hypothetical protein 0.0086 0.0531 0.0531
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0182 0.0921
Trypanosoma cruzi cysteine peptidase, putative 0.0086 0.0531 0.1008
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0195 0.1337 0.2537
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0176 0.0306
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0182 0.0921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Leishmania major cathepsin L-like protease 0.0281 0.1977 1
Giardia lamblia Cathepsin L precursor 0.0068 0.0399 0.2026
Mycobacterium leprae Probable lipase LipE 0.0039 0.0182 0.0544
Brugia malayi beta-lactamase family protein 0.0039 0.0182 0.0182
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0068 0.0399 0.2018
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0047 0.0237
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0324 0.0324
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.1207 0.1905
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0037 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.1977 0.3751
Giardia lamblia Cathepsin L precursor 0.0068 0.0399 0.2026
Loa Loa (eye worm) cysteine protease 0.0281 0.1977 0.1977
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0281 0.1977 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0068 0.0399 0.0399
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0068 0.0399 0.1952
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0715 0.403
Echinococcus granulosus cysteine protease 0.0155 0.1039 0.1948
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0381 0.0585
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0068 0.0399 0.2018
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0715 0.8609
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0016 0.0031
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0037 0.0037
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0068 0.0399 0.1952
Giardia lamblia Cysteine protease 0.0068 0.0399 0.2026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Onchocerca volvulus 0.0103 0.0652 0.33
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0047 0.0047
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0183 0.0927
Brugia malayi POT family protein 0.0042 0.0206 0.0206
Brugia malayi Papain family cysteine protease containing protein 0.0281 0.1977 0.1977
Plasmodium falciparum cysteine proteinase falcipain 1 0.0155 0.1039 0.5215
Echinococcus multilocularis cathepsin L 0.0155 0.1039 0.1636
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0183 0.0927
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0281 0.1977 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0579 0.0579
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0015 0.0015
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0068 0.0399 0.2026
Plasmodium vivax unspecified product 0.0068 0.0399 0.1952
Onchocerca volvulus 0.0281 0.1977 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0252 0.0379
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0252 0.1203
Loa Loa (eye worm) hypothetical protein 0.0052 0.0279 0.0279
Trypanosoma cruzi cruzipain precursor, putative 0.0281 0.1977 0.3751
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0279 0.053
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0182 0.4543
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0037 0.0185
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0182 0.0317
Schistosoma mansoni cathepsin B (C01 family) 0.0068 0.0399 0.073
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0183 0.0268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0195 0.1337 0.6764
Schistosoma mansoni hypothetical protein 0.0304 0.2149 0.4061
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0715 0.403
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0183 0.0927
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Brugia malayi Cathepsin L-like precursor 0.0281 0.1977 0.1977
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.1362 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0031
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0065 0.0095
Echinococcus granulosus cathepsin L 0.0068 0.0399 0.073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.1977 1
Giardia lamblia Cathepsin B precursor 0.0068 0.0399 0.2026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0086 0.0531 0.0531
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0182 0.0317
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0183 0.032
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0324 0.1641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0399 0.2018
Echinococcus multilocularis cysteine protease 0.0281 0.1977 0.3136
Echinococcus multilocularis cathepsin L cysteine protease 0.0281 0.1977 0.3136
Toxoplasma gondii cathepsin B 0.0271 0.1906 0.9635
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0183 0.0927
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0579 0.1072
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0068 0.0399 0.1952
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0068 0.0399 0.2018
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0176 0.089
Echinococcus multilocularis bloom syndrome protein 0.002 0.0037 0.0034
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0068 0.0399 0.073
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0176 0.0334
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0182 0.0267
Leishmania major cathepsin L-like protease 0.0281 0.1977 1
Schistosoma mansoni DNA helicase recq1 0.002 0.0037 0.004
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0176 0.0814
Loa Loa (eye worm) hypothetical protein 0.0053 0.0283 0.0283
Entamoeba histolytica cysteine protease, putative 0.0068 0.0399 0.2018
Giardia lamblia Cathepsin L precursor 0.0068 0.0399 0.2026
Schistosoma mansoni inositol monophosphatase 0.0038 0.0176 0.0306
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0155 0.1039 0.5254
Mycobacterium ulcerans hypothetical protein 0.0039 0.0182 0.4543
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0037 0.0185
Giardia lamblia Cathepsin B precursor 0.0271 0.1906 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0176 0.5184
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0159 0.0159
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0047 0.0089
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0324 0.0494
Plasmodium falciparum glutathione reductase 0.0049 0.0252 0.1203
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0037 0.0103
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0176 0.089
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0381 0.0696
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0016 0.0083
Loa Loa (eye worm) beta-lactamase 0.0039 0.0182 0.0182
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0182 0.0921
Schistosoma mansoni hypothetical protein 0.0036 0.0159 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0155 0.1039 0.5254
Brugia malayi Cathepsin L-like precursor 0.0195 0.1337 0.1337
Giardia lamblia Cathepsin B precursor 0.0068 0.0399 0.2026
Giardia lamblia Hypothetical protein 0.0068 0.0399 0.2026
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0859 0.6271 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0399 0.0399
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0283 0.0283
Echinococcus granulosus lysosomal alpha glucosidase 0.0177 0.1207 0.2268
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0065 0.008
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0047 0.0047
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0086 0.0531 0.0531
Entamoeba histolytica hypothetical protein 0.0068 0.0399 0.2018
Schistosoma mansoni ran 0.0021 0.0047 0.006
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0252 0.0451
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0068 0.0399 0.1952
Trypanosoma cruzi cruzipain precursor, putative 0.0086 0.0531 0.1008
Trypanosoma cruzi cysteine protease, putative 0.0155 0.1039 0.1971
Trypanosoma cruzi cysteine peptidase, putative 0.0281 0.1977 0.3751
Echinococcus granulosus cathepsin b 0.0725 0.527 1
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0182 0.0956
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0183 0.0927
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0068 0.0399 0.2018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0399 0.2018
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0176 0.089
Plasmodium vivax unspecified product 0.0155 0.1039 0.5215
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0807 0.456
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.1749 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0324 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0807 1
Entamoeba histolytica hypothetical protein 0.0023 0.0063 0.0317
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0037 0.0034
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0063 0.0317
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0155 0.1039 0.1948
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0725 0.527 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0182 0.0345
Schistosoma mansoni alpha glucosidase 0.0039 0.0183 0.032
Leishmania major trypanothione reductase 0.0049 0.0252 0.1276
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Mycobacterium ulcerans beta-lactamase 0.0039 0.0182 0.4543
Leishmania major cysteine peptidase A (CPA) 0.0281 0.1977 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0281 0.1977 1
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0182 0.0956
Brugia malayi Cathepsin L-like cysteine proteinase 0.0195 0.1337 0.1337
Mycobacterium tuberculosis Conserved protein 0.0039 0.0182 0.0956
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0068 0.0399 0.2018
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0281 0.1977 1
Echinococcus multilocularis cathepsin b 0.0725 0.527 0.84
Entamoeba histolytica cysteine proteinase, putative 0.0281 0.1977 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0037 0.0103
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0182 0.0956
Giardia lamblia Cathepsin L-like protease 0.0068 0.0399 0.2026
Plasmodium falciparum serine repeat antigen 6 0.0068 0.0399 0.1952
Plasmodium vivax vivapain-2 0.0281 0.1977 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0725 0.527 0.527
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0068 0.0399 0.2018
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0281 0.1977 0.3136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0195 0.1337 0.6764
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0103 0.0441
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.1977 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0068 0.0399 0.2018
Trypanosoma cruzi cysteine proteinase, putative 0.0155 0.1039 0.1971
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0047 0.006
Trichomonas vaginalis esterase, putative 0.0039 0.0182 0.0921
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0068 0.0399 0.2026
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0182 0.0921
Loa Loa (eye worm) hypothetical protein 0.0195 0.1337 0.1337
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0182 0.0921
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0103 0.014
Schistosoma mansoni alpha-glucosidase 0.0153 0.1024 0.192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0068 0.0399 0.2018
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0047 0.005
Echinococcus multilocularis cysteine protease 0.0281 0.1977 0.3136
Schistosoma mansoni ap endonuclease 0.0058 0.0324 0.0588
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0381 0.1861
Schistosoma mansoni importin beta-1 0.0028 0.0103 0.0166
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0031
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0068 0.0399 0.073
Toxoplasma gondii exonuclease III APE 0.0058 0.0324 0.1571
Loa Loa (eye worm) hypothetical protein 0.0039 0.0182 0.0182
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0063 0.0317
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0068 0.0399 0.0757
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0016 0.0031
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0016 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.1977 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0182 0.0182
Plasmodium falciparum cysteine proteinase falcipain 3 0.0281 0.1977 1
Onchocerca volvulus Cathepsin L homolog 0.0281 0.1977 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0068 0.0399 0.073
Trypanosoma cruzi cysteine proteinase, putative 0.0155 0.1039 0.1971
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0324 0.1641
Giardia lamblia Cysteine protease 0.0068 0.0399 0.2026
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0068 0.0399 0.1952
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0016 0.0083
Loa Loa (eye worm) RecQ helicase 0.002 0.0037 0.0037
Entamoeba histolytica cysteine proteinase 2 0.0155 0.1039 0.5254
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0183 0.0183
Schistosoma mansoni DNA helicase recq5 0.002 0.0037 0.004
Plasmodium falciparum serine repeat antigen 1 0.0068 0.0399 0.1952
Plasmodium vivax vivapain-3 0.0155 0.1039 0.5215
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0324 0.1571
Echinococcus granulosus snurportin 1 0.0304 0.2149 0.4061
Trypanosoma brucei trypanothione reductase 0.0049 0.0252 0.1276
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0182 0.0921
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0016 0.0002
Entamoeba histolytica cysteine protease, putative 0.0155 0.1039 0.5254
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0037 0.0037
Leishmania major cathepsin L-like protease 0.0281 0.1977 1
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0016 0.0031
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0183 0.0927
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0381 0.2105

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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