Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | orotate phosphoribosyltransferase | 0.0104173 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0834847 | 0.355637 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0834847 | 0.355637 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) | 0.215872 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0834847 | 0.355637 | 1 |
Toxoplasma gondii | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase | 0.0178471 | 0.0361627 | 0.101684 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.039716 | 0.142604 | 0.333176 |
Echinococcus granulosus | thymidylate synthase | 0.0834847 | 0.355637 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0834847 | 0.355637 | 1 |
Plasmodium vivax | orotidine 5'-phosphate decarboxylase, putative | 0.0178471 | 0.0361627 | 0.101684 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0834847 | 0.355637 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.039716 | 0.142604 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.039716 | 0.142604 | 0.142604 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0834847 | 0.355637 | 0.355637 |
Brugia malayi | hypothetical protein | 0.039716 | 0.142604 | 0.318061 |
Brugia malayi | thymidylate synthase | 0.0834847 | 0.355637 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0834847 | 0.355637 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0834847 | 0.355637 | 0.355637 |
Loa Loa (eye worm) | thymidylate synthase | 0.0834847 | 0.355637 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0834847 | 0.355637 | 1 |
Mycobacterium leprae | Probable orotidine 5'-phosphate decarboxylase PyrF (OMP decarboxylase) (OMPDCase) (OMPdecase) | 0.0178471 | 0.0361627 | 0.0361627 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.215872 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0834847 | 0.355637 | 0.355637 |
Trypanosoma cruzi | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.019302 | 0.0432439 | 0.0221651 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0834847 | 0.355637 | 1 |
Onchocerca volvulus | 0.0834847 | 0.355637 | 0.5 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.215872 | 1 | 1 |
Trypanosoma cruzi | orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative | 0.019302 | 0.0432439 | 0.0221651 |
Plasmodium falciparum | orotidine 5'-phosphate decarboxylase | 0.0178471 | 0.0361627 | 0.101684 |
Mycobacterium ulcerans | orotidine 5'-phosphate decarboxylase | 0.0178471 | 0.0361627 | 0.0361627 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.2 uM | Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | 1.203 uM | ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
EC50 (functional) | = 5.8 uM | Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | Saint Jude. | 20485428 |
EC50 (functional) | 5.8042 uM | ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye | ChEMBL. | 20485428 |
Percent growth inhibition (functional) | = 92 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by YOYO-3 red dye | Saint Jude. | 20485428 |
Percent growth inhibition (functional) | = 114.4 % | Plasmodium falciparum 3D7 % growth inhibition at 7uM as measured by SYBR green dye | Saint Jude. | 20485428 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 20485428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.