Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein patched | 0.0055 | 0.3254 | 0.2271 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0133 | 1 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0055 | 0.3254 | 0.3254 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.1272 | 0.1272 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.1272 | 0.1272 |
Brugia malayi | CHE-14 protein | 0.0055 | 0.3254 | 0.3254 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0055 | 0.3254 | 0.2271 |
Schistosoma mansoni | patched 1 | 0.0055 | 0.3254 | 0.2271 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0055 | 0.3254 | 0.2271 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0055 | 0.3254 | 0.2271 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0055 | 0.3254 | 0.2271 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.1272 | 0.1272 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1272 | 0.1272 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0062 | 0.3913 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0055 | 0.3254 | 0.2271 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0133 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0133 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0133 | 1 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0133 | 1 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0133 | 1 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0133 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0133 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.3254 | 0.3254 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0062 | 0.3913 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.1272 | 0.1272 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0062 | 0.3913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1221 | 0.1221 |
Onchocerca volvulus | 0.0032 | 0.1272 | 0.5 | |
Echinococcus multilocularis | protein dispatched 1 | 0.0055 | 0.3254 | 0.2271 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0062 | 0.3913 | 1 |
Onchocerca volvulus | 0.0032 | 0.1272 | 0.5 | |
Echinococcus granulosus | Protein patched homolog 1 | 0.0055 | 0.3254 | 0.2271 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ka (binding) | = 0.13 uM | In vitro binding affinity against human carbonic anhydrase I (hCA-I human cloned isozyme). | ChEMBL. | 10450978 |
Ka (binding) | = 0.13 uM | In vitro binding affinity against human carbonic anhydrase I (hCA-I human cloned isozyme). | ChEMBL. | 10450978 |
Ka (binding) | = 1.6 uM | In vitro inhibitory activity against bovine carbonic anhydrase IV (bCA IV) purified from lung microsomes. | ChEMBL. | 10450978 |
Ka (binding) | = 1.6 uM | In vitro inhibitory activity against bovine carbonic anhydrase IV (bCA IV) purified from lung microsomes. | ChEMBL. | 10450978 |
Ka (binding) | = 8 uM | In vitro binding affinity against human carbonic anhydrase II (hCA-II human cloned isozyme). | ChEMBL. | 10450978 |
Ka (binding) | = 8 uM | In vitro binding affinity against human carbonic anhydrase II (hCA-II human cloned isozyme). | ChEMBL. | 10450978 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.