Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Escherichia coli | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 0.5 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0389 | 0.5 | 0.5 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 0.5 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 0.5 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2 uM | Inhibition of cellular growth against mouse (L1210) deficient in thymidine kinase. | ChEMBL. | 2066965 |
IC50 (functional) | = 2 uM | Compound was tested for the the inhibition of mouse L1210 leukemia cell growth | ChEMBL. | 1548676 |
IC50 (functional) | = 2 uM | Inhibition of cellular growth against mouse (L1210) deficient in thymidine kinase. | ChEMBL. | 2066965 |
IC50 (functional) | = 2 uM | Compound was tested for the the inhibition of mouse L1210 leukemia cell growth | ChEMBL. | 1548676 |
IC50 (functional) | = 3.9 uM | Inhibition of cellular growth against human (CCRF-CEM) leukemias (ATCC) deficient in thymidine kinase. | ChEMBL. | 2066965 |
IC50 (functional) | = 3.9 uM | Compound was tested for the the inhibition of human CCRF-CEM leukemia cell growth | ChEMBL. | 1548676 |
IC50 (functional) | = 3.9 uM | Inhibition of cellular growth against human (CCRF-CEM) leukemias (ATCC) deficient in thymidine kinase. | ChEMBL. | 2066965 |
IC50 (functional) | = 3.9 uM | Compound was tested for the the inhibition of human CCRF-CEM leukemia cell growth | ChEMBL. | 1548676 |
IC50 (functional) | > 5 uM | Inhibition of cellular growth against human adenocarcinoma (GC3/M TK-) deficient in thymidine kinase | ChEMBL. | 2066965 |
IC50 (functional) | > 5 uM | Compound was tested for the the inhibition of thymidine kinase deficient human adenocarcinoma GC3M(-) cell growth | ChEMBL. | 1548676 |
Ki (binding) | = 0.0131 uM | Inhibition of human Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Ki (binding) | = 0.0131 uM | Inhibition of human Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Ki (binding) | = 0.031 uM | Inhibition of human Thymidylate synthase (Ki) | ChEMBL. | 2066965 |
Ki (binding) | = 0.031 uM | Inhibition of human Thymidylate synthase (Ki) | ChEMBL. | 2066965 |
Ki (binding) | = 0.043 uM | Inhibition of Thymidylate synthase of E. coli (Ki) | ChEMBL. | 2066965 |
Ki (binding) | = 0.043 uM | Inhibition of Escherichia coli Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Ki (binding) | = 0.043 uM | Inhibition of Thymidylate synthase of E. coli (Ki) | ChEMBL. | 2066965 |
Ki (binding) | = 0.043 uM | Inhibition of Escherichia coli Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Kii (binding) | = 0.043 uM | Inhibition of human Thymidylate synthase (Kii) | ChEMBL. | 2066965 |
Kii (binding) | = 0.043 uM | Inhibition of human Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Kii (binding) | = 0.043 uM | Inhibition of human Thymidylate synthase (Kii) | ChEMBL. | 2066965 |
Kii (binding) | = 0.043 uM | Inhibition of human Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Kii (binding) | = 0.48 uM | Inhibition of Thymidylate synthase of E. coli (Kii) | ChEMBL. | 2066965 |
Kii (binding) | = 0.48 uM | Inhibition of Escherichia coli Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Kii (binding) | = 0.48 uM | Inhibition of Thymidylate synthase of E. coli (Kii) | ChEMBL. | 2066965 |
Kii (binding) | = 0.48 uM | Inhibition of Escherichia coli Thymidylate synthase (TS) | ChEMBL. | 1548676 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 1548676 | |
Homo sapiens | ChEMBL23 | 1548676 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.