TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 356.462 | Formula: C20H28N4O2
H donors: 1 H acceptors: 2 LogP: 3.08 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCC(n1c(=O)n(c2c1cccc2)C(=O)NC1CC2CCC(C1)N2C)C
InChi: 1S/C20H28N4O2/c1-4-13(2)23-17-7-5-6-8-18(17)24(20(23)26)19(25)21-14-11-15-9-10-16(12-14)22(15)3/h5-8,13-16H,4,9-12H2,1-3H3,(H,21,25)
InChiKey: MCGFTDIDSXDGDC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0042	0.0317	0.3028
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0102	0.0881	0.0881
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0125	0.0125
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.0918	0.8918
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0538	0.0538
Trichomonas vaginalis	glutathione reductase, putative	0.0016	0.0072	0.0812
Brugia malayi	Importin beta-1 subunit	0.01	0.0864	0.1541
Brugia malayi	RNA binding protein	0.0065	0.0538	0.096
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0028	0.0051
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0042	0.0317	0.3663
Schistosoma mansoni	coup transcription factor	0.0022	0.0125	0.0125
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0125	0.0224
Echinococcus granulosus	lamin	0.0028	0.0188	0.0188
Plasmodium vivax	importin-beta 2, putative	0.01	0.0864	1
Echinococcus multilocularis	nuclear receptor nhr 48	0.001	0.0017	0.0017
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0042	0.0317	0.0317
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0125	0.0125
Schistosoma mansoni	cpg binding protein	0.003	0.0201	0.0201
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0072	0.1043
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0183	0.0183
Schistosoma mansoni	BC026374 protein (S09 family)	0.0102	0.0881	0.0881
Brugia malayi	hypothetical protein	0.0011	0.0028	0.0051
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.1029	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.0357	0.4136
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0028	0.0028
Schistosoma mansoni	nuclear receptor	0.001	0.0017	0.0017
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0031	0.0056
Onchocerca volvulus		0.0102	0.0881	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0072	0.1043
Echinococcus granulosus	translational activator gcn1	0.0019	0.0099	0.0099
Echinococcus multilocularis	importin subunit beta 1	0.01	0.0864	0.0864
Trypanosoma brucei	Importin-beta N-terminal domain/HEAT-like repeat, putative	0.0019	0.0099	0.114
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0102	0.0881	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0881	0.0881
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017
Echinococcus granulosus	transportin 1	0.0019	0.0099	0.0099
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0538	0.0538
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0072	0.1043
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.001	0.0017	0.0017
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0081	0.0686	0.7784
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0602	0.5606	0.5606
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0125	0.0224
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0028
Plasmodium falciparum	importin beta, putative	0.01	0.0864	1
Toxoplasma gondii	exonuclease III APE	0.0042	0.0317	0.3663
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0125	0.0125
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0102	0.0881	0.8556
Loa Loa (eye worm)	nuclear hormone receptor	0.001	0.0017	0.0017
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0602	0.5606	0.5606
Echinococcus granulosus	BC026374 protein S09 family	0.0102	0.0881	0.0881
Schistosoma mansoni	cpg binding protein	0.0028	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0188	0.0188
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.001	0.0017	0.0017
Loa Loa (eye worm)	nuclear receptor NHR-67	0.001	0.0017	0.0017
Trypanosoma brucei	ULK family serine/threonine-protein kinase, putative	0.0019	0.0099	0.114
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.016	0.1433	0.1433
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0017	0.0017
Brugia malayi	Carboxylesterase family protein	0.0102	0.0881	0.1571
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0125	0.0224
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0125	0.0125
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.005	0.039	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0881	0.0881
Onchocerca volvulus		0.001	0.0017	0.0191
Entamoeba histolytica	HEAT repeat domain containing protein	0.0019	0.0099	0.1437
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0125	0.0125
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0042	0.0317	0.3076
Brugia malayi	nuclear receptor NHR-67	0.001	0.0017	0.003
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.0357	0.0357
Loa Loa (eye worm)	carboxylesterase	0.0602	0.5606	0.5606
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0538	0.0538
Schistosoma mansoni	lamin	0.0028	0.0188	0.0188
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0186	0.0186
Brugia malayi	nuclear hormone receptor	0.0022	0.0125	0.0224
Brugia malayi	conserved hypotetical protein	0.001	0.0017	0.003
Schistosoma mansoni	importin-beta 2	0.0019	0.0099	0.0099
Trichomonas vaginalis	importin beta-1, putative	0.0081	0.0686	0.7784
Onchocerca volvulus		0.0102	0.0881	1
Loa Loa (eye worm)	importin-beta domain-containing protein	0.0019	0.0099	0.0099
Brugia malayi	nuclear hormone receptor family member nhr-6	0.001	0.0017	0.003
Echinococcus granulosus	carboxylesterase 5A	0.0602	0.5606	0.5606
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.016	0.1433	0.1433
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0028
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0016	0.0072	0.1043
Echinococcus granulosus	cpg binding protein	0.003	0.0201	0.0201
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0042	0.0317	0.0317
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0881	0.0881
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0016	0.0072	0.1043
Plasmodium vivax	glutathione reductase, putative	0.0046	0.0357	0.4136
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0125	0.0125
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0423	0.4899
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0063	0.0113
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0125	0.0125
Trichomonas vaginalis	mercuric reductase, putative	0.0016	0.0072	0.0812
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0042	0.0317	0.8107
Brugia malayi	nuclear hormone receptor family member odr-7	0.001	0.0017	0.003
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.1067	1	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0125	0.0125
Schistosoma mansoni	ran	0.005	0.039	0.039
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0125	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0028
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0031	0.0056
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0125	0.0125
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.016	0.1433	0.1433
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.0918	0.8918
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.0357	0.5214
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.005	0.039	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.005	0.039	0.039
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0125	0.0224
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.016	0.1433	0.1433
Treponema pallidum	NADH oxidase	0.0016	0.0072	0.226
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0125	0.0125
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0125	0.0125
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0017	0.0017
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0072	0.1043
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0125	0.1424
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.005	0.039	0.4519
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0016	0.0072	0.1043
Echinococcus multilocularis	lamin dm0	0.0028	0.0188	0.0188
Brugia malayi	Thioredoxin reductase	0.0046	0.0357	0.0638
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0102	0.0881	0.0881
Brugia malayi	nuclear receptor RXR	0.001	0.0017	0.003
Schistosoma mansoni	acetylcholinesterase	0.0102	0.0881	0.0881
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.001	0.0017	0.0017
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0016	0.0072	0.0828
Toxoplasma gondii	HEAT repeat-containing protein	0.0019	0.0099	0.114
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0125	0.0224
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0072	0.0828
Brugia malayi	nuclear hormone receptor	0.001	0.0017	0.003
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.1029	1
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0188	0.0188
Leishmania major	hypothetical protein, conserved	0.0019	0.0099	0.1437
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0186	0.0331
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.005	0.039	0.039
Onchocerca volvulus		0.0028	0.0188	0.2133
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.0918	0.8918
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0125	0.0125
Echinococcus granulosus	intermediate filament protein	0.0028	0.0188	0.0188
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0002	0.0002
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0016	0.0072	0.0072
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0188	0.0188
Brugia malayi	intermediate filament protein	0.0028	0.0188	0.0335
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0538	0.0538
Echinococcus multilocularis	snurportin 1	0.1067	1	1
Leishmania major	trypanothione reductase	0.0046	0.0357	0.5214
Echinococcus multilocularis	lamin	0.0028	0.0188	0.0188
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.0028	0.0028
Onchocerca volvulus		0.0028	0.0186	0.2108
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0017	0.0017
Echinococcus multilocularis	neuroligin	0.0102	0.0881	0.0881
Echinococcus multilocularis	musashi	0.0028	0.0188	0.0188
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0125	0.1424
Schistosoma mansoni	ran	0.005	0.039	0.039
Brugia malayi	ecdysteroid receptor	0.0022	0.0125	0.0224
Mycobacterium tuberculosis	Probable reductase	0.0106	0.0918	0.8918
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.0357	0.0357
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.0918	0.8918
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.001	0.0017	0.0017
Echinococcus granulosus	importin 5	0.0019	0.0099	0.0099
Brugia malayi	hypothetical protein	0.0011	0.0028	0.0051
Loa Loa (eye worm)	hypothetical protein	0.01	0.0864	0.0864
Toxoplasma gondii	HEAT repeat-containing protein	0.01	0.0864	1
Onchocerca volvulus		0.0102	0.0881	1
Plasmodium falciparum	transportin	0.0019	0.0099	0.114
Trypanosoma brucei	importin beta-1 subunit, putative	0.01	0.0864	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0072	0.1043
Plasmodium falciparum	thioredoxin reductase	0.0046	0.0357	0.4136
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.005	0.039	0.4519
Plasmodium falciparum	glutathione reductase	0.0046	0.0357	0.4136
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0016	0.0072	0.0828
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.1029	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0017	0.0017
Brugia malayi	nuclear receptor RXR	0.0011	0.0028	0.0051
Leishmania major	importin beta-1 subunit, putative	0.0081	0.0686	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.005	0.039	0.4519
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0538	0.0538
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0016	0.0072	0.0695
Trichomonas vaginalis	hypothetical protein	0.0019	0.0099	0.1118
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0042	0.0317	0.4618
Echinococcus multilocularis	cpg binding protein	0.003	0.0201	0.0201
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0001	0.0002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.016	0.1433	0.1433
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0125	0.0224
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0042	0.0317	0.4618
Echinococcus granulosus	acetylcholinesterase	0.0602	0.5606	0.5606
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.1029	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0102	0.0881	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0125	0.0125
Schistosoma mansoni	cpg binding protein	0.003	0.0201	0.0201
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0063	0.0063
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0002	0.0002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0602	0.5606	0.5606
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0049	0.0049
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0125	0.0125
Mycobacterium ulcerans	carboxylesterase, LipT	0.0102	0.0881	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0042	0.0317	0.4618
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0125	0.0125
Echinococcus granulosus	para nitrobenzyl esterase	0.0102	0.0881	0.0881
Echinococcus granulosus	acetylcholinesterase	0.0602	0.5606	0.5606
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0125	0.0125
Echinococcus granulosus	importin subunit beta 1	0.01	0.0864	0.0864
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0072	0.1043
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.0357	0.3473
Echinococcus granulosus	lamin dm0	0.0028	0.0188	0.0188
Trichomonas vaginalis	spcc417.12 protein, putative	0.0102	0.0881	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0102	0.0881	0.0881
Loa Loa (eye worm)	DR-78	0.001	0.0017	0.0017
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0538	0.0538
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0125	0.0224
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.005	0.039	0.5696
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0125	0.0125
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0538	0.096
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0028	0.0051
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.0357	0.0357
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0125	0.0125
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.005	0.039	0.5696
Echinococcus granulosus	thyroid hormone receptor alpha	0.001	0.0017	0.0017
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0081	0.0686	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0016	0.0072	0.1043
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.0028	0.0028
Schistosoma mansoni	ap endonuclease	0.0042	0.0317	0.0317
Schistosoma mansoni	ap endonuclease	0.0042	0.0317	0.0317
Echinococcus multilocularis	carboxylesterase 5A	0.0602	0.5606	0.5606
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0017	0.003
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0538	0.0538
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0049	0.0049
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0125	0.0125
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0016	0.0072	0.0828
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0016	0.0072	0.0828
Schistosoma mansoni	lamin	0.0028	0.0188	0.0188
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0072	0.1043
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0125	0.0125
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0042	0.0317	0.3663
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0017	0.0017
Schistosoma mansoni	nuclear receptor	0.001	0.0017	0.0017
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0125	0.0125
Schistosoma mansoni	gliotactin	0.0102	0.0881	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0881	0.0881
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0102	0.0881	0.0881
Brugia malayi	TAR-binding protein	0.0065	0.0538	0.096
Brugia malayi	ecdysone receptor	0.001	0.0017	0.003
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0125	0.0224
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0125	0.0125
Brugia malayi	kap beta 3 protein	0.0019	0.0099	0.0176
Plasmodium vivax	transportin, putative	0.0019	0.0099	0.114
Brugia malayi	Carboxylesterase family protein	0.0102	0.0881	0.1571
Echinococcus multilocularis	acetylcholinesterase	0.0602	0.5606	0.5606
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0484	0.0484
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0016	0.0072	0.0828
Trichomonas vaginalis	ran, putative	0.005	0.039	0.4434
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.016	0.1433	0.1433
Brugia malayi	glutathione reductase	0.0046	0.0357	0.0638
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0125	0.0224
Brugia malayi	Carboxylesterase family protein	0.0602	0.5606	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0028
Loa Loa (eye worm)	carboxylesterase	0.0102	0.0881	0.0881
Brugia malayi	Carboxylesterase family protein	0.0102	0.0881	0.1571
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.0072	0.1832
Plasmodium falciparum	glutathione reductase	0.0016	0.0072	0.0828
Brugia malayi	nuclear receptor NHR-88	0.001	0.0017	0.003
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0017	0.0191
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.016	0.1433	0.1433
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0002	0.0002
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0125	0.0125
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0011	0.0028	0.0028
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0125	0.0125
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0042	0.0317	0.4618
Echinococcus multilocularis	importin 5	0.0019	0.0099	0.0099
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0016	0.0072	0.0828
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0125	0.0224
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0042	0.0317	0.3663
Brugia malayi	steroid hormone receptor	0.0022	0.0125	0.0224
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0125	0.0125
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0102	0.0881	0.8556
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0102	0.0881	0.1571
Echinococcus granulosus	nuclear receptor nhr 48	0.001	0.0017	0.0017
Brugia malayi	RNA, U transporter 1	0.0284	0.2605	0.4647
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0125	0.0125
Schistosoma mansoni	importin beta-1	0.01	0.0864	0.0864
Brugia malayi	orphan nuclear receptor NR2E1	0.001	0.0017	0.003
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0016	0.0072	0.0072
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0017	0.0017
Schistosoma mansoni	nuclear receptor nhr-48	0.001	0.0017	0.0017
Onchocerca volvulus		0.0102	0.0881	1
Schistosoma mansoni	hypothetical protein	0.1067	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0125	0.0125
Onchocerca volvulus		0.0022	0.0125	0.1424
Entamoeba histolytica	hypothetical protein	0.0081	0.0686	1
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.005	0.039	0.4519
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0125	0.0125
Loa Loa (eye worm)	carboxylesterase	0.0102	0.0881	0.0881
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017
Entamoeba histolytica	Ran family GTPase	0.005	0.039	0.5696
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0011	0.0028	0.0028
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0016	0.0072	0.1043
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.005	0.039	0.039
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0881	0.0881
Brugia malayi	tailless protein	0.001	0.0017	0.003
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.001	0.0017	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0125	0.0224
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0188	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0881	0.0881
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0042	0.0317	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0044	0.0044
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0125	0.0224
Echinococcus multilocularis	translational activator gcn1	0.0019	0.0099	0.0099
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0049	0.0049
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.001	0.0017	0.0017
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0125	0.0125
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0044	0.0044
Trichomonas vaginalis	ap endonuclease, putative	0.0042	0.0317	0.3595
Leishmania major	GTP-binding protein, putative	0.005	0.039	0.5696
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0125	0.0224
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0125	0.0125
Toxoplasma gondii	thioredoxin reductase	0.0046	0.0357	0.4136
Loa Loa (eye worm)	glutathione reductase	0.0046	0.0357	0.0357
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0102	0.0881	0.0881
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0125	0.0224
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0081	0.0686	0.7784
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0102	0.0881	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0016	0.0072	0.0828
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0017	0.0017
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.0072	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0125	0.0125
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0538	0.0538
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.001	0.0017	0.003
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.001	0.0017	0.0191
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0016	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0881	0.0881
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0016	0.0072	0.1043
Onchocerca volvulus		0.0028	0.0188	0.2133
Brugia malayi	Carboxylesterase family protein	0.0602	0.5606	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0016	0.0072	0.0828
Schistosoma mansoni	zinc finger protein	0.001	0.0017	0.0017
Echinococcus granulosus	neuroligin	0.0102	0.0881	0.0881
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0538	0.0538
Brugia malayi	Carboxylesterase family protein	0.0102	0.0881	0.1571
Plasmodium falciparum	thioredoxin reductase	0.0016	0.0072	0.0828
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0125	0.0125
Brugia malayi	exodeoxyribonuclease III family protein	0.0042	0.0317	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0125	0.0125
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0042	0.0317	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0102	0.0881	0.0881
Echinococcus multilocularis	acetylcholinesterase	0.0602	0.5606	0.5606
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0125	0.0224
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.016	0.1433	0.2557
Loa Loa (eye worm)	acetylcholinesterase 1	0.0602	0.5606	0.5606
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017
Brugia malayi	hypothetical protein	0.001	0.0017	0.003
Toxoplasma gondii	NADPH-glutathione reductase	0.0016	0.0072	0.0828
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0102	0.0881	0.8556
Loa Loa (eye worm)	kap beta 3 protein	0.0019	0.0099	0.0099
Trichomonas vaginalis	ap endonuclease, putative	0.0042	0.0317	0.3595
Trypanosoma brucei	trypanothione reductase	0.0046	0.0357	0.4136
Onchocerca volvulus		0.001	0.0017	0.0191
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0125	0.0125
Toxoplasma gondii	HEAT repeat-containing protein	0.0019	0.0099	0.114
Echinococcus multilocularis	transportin 1	0.0019	0.0099	0.0099
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0188	0.0188
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0125	0.0125
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0017	0.003
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0125	0.0125
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.0918	0.8918
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0125	0.0224
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.016	0.1433	0.1433
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0028	0.0028
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0538	0.0538
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0125	0.0125
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0072	0.0128
Brugia malayi	hypothetical protein	0.001	0.0017	0.003
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0042	0.0317	0.0317
Onchocerca volvulus		0.0102	0.0881	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0125	0.0224
Trypanosoma brucei	importin beta-1 subunit, putative	0.01	0.0864	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0125	0.0125
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0017

Activities

Activity type	Activity value	Assay description	Source	Reference
Relaxation (functional)	= 8.8 %	Antagonistic activity by ability to block serotonin induced relaxation (mediated by activation of 5-hydroxytryptamine 4 receptor) in carbamylcholine (10e-6 M) contracted esophagus at a concentration of 10e-6 M.	ChEMBL.	9599243
Relaxation (functional)	= 8.8 %	Antagonistic activity by ability to block serotonin induced relaxation (mediated by activation of 5-hydroxytryptamine 4 receptor) in carbamylcholine (10e-6 M) contracted esophagus at a concentration of 10e-6 M.	ChEMBL.	9599243

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 86027