Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | p450 reductase, putative | 0.0175 | 1 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0155 | 0.8717 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0175 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0175 | 1 | 1 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0108 | 0.5684 | 0.5684 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.002 | 0 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0108 | 0.5684 | 0.5684 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0067 | 0.3033 | 0.3033 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0067 | 0.3033 | 0.3033 |
Treponema pallidum | flavodoxin | 0.0067 | 0.3033 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0175 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0175 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0108 | 0.5684 | 0.5684 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0175 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0067 | 0.3033 | 0.3033 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0087 | 0.4316 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0175 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0067 | 0.3033 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0175 | 1 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0067 | 0.3033 | 0.3033 |
Plasmodium vivax | hypothetical protein, conserved | 0.0067 | 0.3033 | 0.3033 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0175 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0175 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0175 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0067 | 0.3033 | 0.3033 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0175 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0175 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0175 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0088 | 0.4402 | 0.4402 |
Leishmania major | cytochrome P450 reductase, putative | 0.0155 | 0.8717 | 0.8717 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0175 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0108 | 0.5684 | 0.5684 |
Chlamydia trachomatis | sulfite reductase | 0.0108 | 0.5684 | 1 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0067 | 0.3033 | 0.3033 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0067 | 0.3033 | 0.5 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0155 | 0.8717 | 0.8717 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0067 | 0.3033 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0155 | 0.8717 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0175 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0067 | 0.3033 | 0.5 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0087 | 0.4316 | 0.4316 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0175 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0175 | 1 | 1 |
Mycobacterium tuberculosis | Possible oxygenase | 0.002 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0067 | 0.3033 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0108 | 0.5684 | 0.5684 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0155 | 0.8717 | 0.8159 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0067 | 0.3033 | 0.3033 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0087 | 0.4316 | 1 |
Onchocerca volvulus | 0.002 | 0 | 0.5 | |
Brugia malayi | flavodoxin family protein | 0.0067 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0067 | 0.3033 | 0.3033 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0175 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0175 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.