Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0963 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0043 | 0.0239 | 0.0239 |
Mycobacterium ulcerans | oxidoreductase | 0.0109 | 0.0943 | 0.0788 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0478 | 0.4852 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0368 | 0.369 | 0.3582 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0178 | 0.0178 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0963 | 1 | 1 |
Mycobacterium ulcerans | flavodoxin reductase Hmp | 0.0109 | 0.0943 | 0.0788 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0963 | 1 | 1 |
Chlamydia trachomatis | Na(+)-translocating NADH-quinone reductase subunit F | 0.0109 | 0.0943 | 0.1548 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0109 | 0.0943 | 0.0943 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0109 | 0.0943 | 0.0943 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma cruzi | oxidoreductase-protein, putative | 0.0109 | 0.0943 | 0.0788 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0963 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0043 | 0.0239 | 0.0239 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0368 | 0.369 | 0.3555 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0478 | 0.4852 | 1 |
Trypanosoma brucei | nitrate reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Leishmania major | NADH-dependent fumarate reductase-like protein | 0.0109 | 0.0943 | 0.0788 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0368 | 0.369 | 0.3555 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0368 | 0.369 | 0.5 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0595 | 0.6091 | 0.6091 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0963 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0036 | 0.0168 | 0.0168 |
Mycobacterium ulcerans | monooxygenase | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0043 | 0.0239 | 0.0239 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.0168 | 0.0168 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0478 | 0.4852 | 0.4852 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0368 | 0.369 | 0.3033 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0109 | 0.0943 | 0.0943 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma cruzi | reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Giardia lamblia | Hypothetical protein | 0.0854 | 0.8838 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.006 | 0.042 | 0.042 |
Leishmania major | cytochrome P450 reductase, putative | 0.0854 | 0.8838 | 0.8818 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0368 | 0.369 | 0.3033 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0485 | 0.4929 | 0.4929 |
Echinococcus multilocularis | methionine synthase reductase | 0.0595 | 0.6091 | 0.6091 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0281 | 0.0281 |
Brugia malayi | flavodoxin family protein | 0.0368 | 0.369 | 0.369 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0109 | 0.0943 | 0.0943 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0963 | 1 | 1 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0109 | 0.0943 | 0.0788 |
Mycobacterium ulcerans | flavodoxin oxidoreductase | 0.0109 | 0.0943 | 0.0788 |
Leishmania major | oxidoreductase-like protein | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Treponema pallidum | flavodoxin | 0.0368 | 0.369 | 1 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0368 | 0.369 | 0.5 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.0168 | 0.0168 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0109 | 0.0943 | 0.0788 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0854 | 0.8838 | 0.8717 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0368 | 0.369 | 0.369 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0963 | 1 | 1 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Brugia malayi | FAD binding domain containing protein | 0.0963 | 1 | 1 |
Brugia malayi | diaphorase | 0.0109 | 0.0943 | 0.0943 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0109 | 0.0943 | 0.5 |
Leishmania major | nitrate reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.0168 | 0.0168 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0854 | 0.8838 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0595 | 0.6091 | 0.6091 |
Loa Loa (eye worm) | hypothetical protein | 0.0963 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0963 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0963 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0963 | 1 | 1 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0109 | 0.0943 | 0.0943 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0963 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.0168 | 0.0168 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0047 | 0.0281 | 0.0281 |
Schistosoma mansoni | cytochrome B5 | 0.0109 | 0.0943 | 0.0943 |
Onchocerca volvulus | 0.0109 | 0.0943 | 1 | |
Trypanosoma brucei | oxidoreductase-protein, putative | 0.0109 | 0.0943 | 0.0788 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0109 | 0.0943 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0963 | 1 | 1 |
Trypanosoma brucei | NADH-cytochrome b5 reductase-like protein | 0.0109 | 0.0943 | 0.0788 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0109 | 0.0943 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0854 | 0.8838 | 0.8814 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0368 | 0.369 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0963 | 1 | 1 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0109 | 0.0943 | 0.5 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Leishmania major | hypothetical protein, conserved | 0.0368 | 0.369 | 0.3582 |
Brugia malayi | FAD binding domain containing protein | 0.0595 | 0.6091 | 0.6091 |
Loa Loa (eye worm) | diaphorase | 0.0109 | 0.0943 | 0.0943 |
Leishmania major | NADH-dependent fumarate reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0368 | 0.369 | 0.3555 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0109 | 0.0943 | 0.0943 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0368 | 0.369 | 0.3582 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0109 | 0.0943 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0368 | 0.369 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0043 | 0.0239 | 0.0239 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0109 | 0.0943 | 0.0943 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0963 | 1 | 1 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0368 | 0.369 | 0.3555 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0368 | 0.369 | 0.5 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0368 | 0.369 | 0.3582 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0963 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0368 | 0.369 | 0.3033 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0368 | 0.369 | 0.3582 |
Trypanosoma cruzi | nitrate reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Leishmania major | reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Chlamydia trachomatis | sulfite reductase | 0.0595 | 0.6091 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0963 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0963 | 1 | 1 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0109 | 0.0943 | 0.0943 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0595 | 0.6091 | 0.6091 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Leishmania major | p450 reductase, putative | 0.0963 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.006 | 0.042 | 0.042 |
Mycobacterium ulcerans | oxygenase | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0109 | 0.0943 | 0.0788 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0963 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0963 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.