Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Smad1 | 0.001 | 0.0004 | 0.0004 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0042 | 0.0056 | 0.1114 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0814 | 0.1285 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.0025 | 0.0098 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.0045 | 0.0353 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0046 | 0.0358 |
Leishmania major | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.0056 | 0.022 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.0074 | 0.0074 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.001 | 0.0004 | 0.0001 |
Loa Loa (eye worm) | histone methyltransferase | 0.0012 | 0.0007 | 0.0007 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.161 | 0.2553 | 1 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.161 | 0.2553 | 1 |
Leishmania major | fatty acid elongase, putative | 0.161 | 0.2553 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.161 | 0.2553 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.028 | 0.0435 | 0.8729 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0074 | 0.0576 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0025 | 0.0025 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Schistosoma mansoni | smad | 0.001 | 0.0004 | 0.0031 |
Brugia malayi | GNS1/SUR4 family protein | 0.161 | 0.2553 | 0.2553 |
Trichomonas vaginalis | glutaminase, putative | 0.032 | 0.0498 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0042 | 0.0056 | 0.0408 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.0056 | 0.022 |
Leishmania major | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.0025 | 0.0195 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0036 | 0.0046 | 0.018 |
Schistosoma mansoni | hypothetical protein | 0.0479 | 0.0751 | 0.5843 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0004 | 0.0004 |
Brugia malayi | fatty acid elongation protein 3 | 0.0401 | 0.0628 | 0.0628 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0814 | 0.1285 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0042 | 0.0056 | 0.022 |
Loa Loa (eye worm) | inositol-1 | 0.0042 | 0.0056 | 0.0056 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.001 | 0.0004 | 0.0032 |
Echinococcus granulosus | dnaJ subfamily B | 0.0479 | 0.0751 | 0.583 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0025 | 0.0025 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0046 | 0.0358 |
Schistosoma mansoni | fatty acid acyl transferase-related | 0.0419 | 0.0656 | 0.5102 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.001 | 0.0004 | 0.0031 |
Trypanosoma brucei | Fatty acid elongase | 0.0401 | 0.0628 | 0.246 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.0025 | 0.0164 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0004 | 0.0031 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0056 | 0.0434 |
Schistosoma mansoni | Smad4 | 0.001 | 0.0004 | 0.0031 |
Onchocerca volvulus | 0.028 | 0.0435 | 0.6702 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Brugia malayi | fatty acid elongation protein 3 | 0.0401 | 0.0628 | 0.0628 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0401 | 0.0628 | 0.0628 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0042 | 0.0056 | 0.1114 |
Leishmania major | fatty acid elongase, putative | 0.161 | 0.2553 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0025 | 0.0025 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.0401 | 0.0628 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0401 | 0.0628 | 0.4888 |
Leishmania major | fatty acid elongase, putative | 0.0419 | 0.0656 | 0.2568 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0042 | 0.0056 | 0.0408 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0042 | 0.0056 | 0.1114 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.161 | 0.2553 | 1 |
Brugia malayi | Fatty acid elongation protein 3 | 0.161 | 0.2553 | 0.2553 |
Trypanosoma brucei | Fatty acid elongase | 0.161 | 0.2553 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0025 | 0.0502 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0038 | 0.0049 | 0.5 |
Leishmania major | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Leishmania major | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Trypanosoma brucei | Long chain fatty acyl elongase | 0.0419 | 0.0656 | 0.2568 |
Brugia malayi | MH2 domain containing protein | 0.0141 | 0.0213 | 0.0213 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0141 | 0.0213 | 0.0213 |
Toxoplasma gondii | fatty acid elongase | 0.0419 | 0.0656 | 0.2568 |
Leishmania major | fatty acid elongase, putative | 0.161 | 0.2553 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.161 | 0.2553 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.0025 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0141 | 0.0213 | 0.0213 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0401 | 0.0628 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0056 | 0.0404 |
Loa Loa (eye worm) | glutaminase | 0.032 | 0.0498 | 0.0498 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0814 | 0.1285 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.0401 | 0.0628 | 0.0628 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.0025 | 0.0164 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0419 | 0.0656 | 0.2568 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0401 | 0.0628 | 0.0628 |
Plasmodium falciparum | long chain polyunsaturated fatty acid elongation enzyme, putative | 0.0419 | 0.0656 | 0.2568 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0025 | 0.0098 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0004 | 0.0001 |
Leishmania major | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.161 | 0.2553 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0004 | 0.0031 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.0074 | 0.0074 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.0025 | 0.0098 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0401 | 0.0628 | 0.4872 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0025 | 0.0098 |
Echinococcus granulosus | cpg binding protein | 0.0036 | 0.0045 | 0.0322 |
Schistosoma mansoni | glutaminase | 0.032 | 0.0498 | 0.3876 |
Loa Loa (eye worm) | ELO-9 protein | 0.0401 | 0.0628 | 0.0628 |
Trypanosoma brucei | unspecified product | 0.0016 | 0.0014 | 0.0054 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0004 | 0.0031 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.0025 | 0.0164 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.0014 | 0.0054 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0012 | 0.0007 | 0.0007 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.0025 | 0.0485 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.0025 | 0.0098 |
Leishmania major | long chain polyunsaturated fatty acid elongation enzyme-like protein | 0.0419 | 0.0656 | 0.2568 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.0004 | 0.0004 |
Trypanosoma brucei | unspecified product | 0.0016 | 0.0014 | 0.0054 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0004 | 0.0004 |
Onchocerca volvulus | 0.0401 | 0.0628 | 1 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0056 | 0.0056 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.161 | 0.2553 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0036 | 0.0046 | 0.0328 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.0004 | 0.0004 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0036 | 0.0046 | 0.0358 |
Brugia malayi | Inositol-1 | 0.0042 | 0.0056 | 0.0056 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0074 | 0.0546 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0419 | 0.0656 | 0.5102 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0042 | 0.0056 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0036 | 0.0046 | 0.0328 |
Brugia malayi | CXXC zinc finger family protein | 0.0034 | 0.0042 | 0.0042 |
Plasmodium vivax | elongation of very long chain fatty acids protein 3, putative | 0.0401 | 0.0628 | 0.246 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.0401 | 0.0628 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0073 | 0.0104 | 0.0812 |
Schistosoma mansoni | inositol monophosphatase | 0.0042 | 0.0056 | 0.0438 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.001 | 0.0004 | 0.0001 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.0025 | 0.0164 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.161 | 0.2553 | 1 |
Leishmania major | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0025 | 0.0098 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.161 | 0.2553 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0419 | 0.0656 | 0.5087 |
Onchocerca volvulus | 0.0401 | 0.0628 | 1 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0036 | 0.0046 | 0.0358 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.6285 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.0014 | 0.0054 |
Brugia malayi | glutaminase DH11.1 | 0.032 | 0.0498 | 0.0498 |
Echinococcus multilocularis | cpg binding protein | 0.0036 | 0.0045 | 0.0322 |
Brugia malayi | Pre-SET motif family protein | 0.0246 | 0.0381 | 0.0381 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0034 | 0.0042 | 0.0042 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0025 | 0.0502 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0056 | 0.0404 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0065 | 0.0092 | 0.0361 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0074 | 0.0546 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0042 | 0.0056 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0074 | 0.0576 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.0056 | 0.022 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0056 | 0.9851 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0056 | 0.9851 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0025 | 0.0164 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0056 | 0.9851 |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.0004 | 0.0004 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.0025 | 0.0195 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0246 | 0.0381 | 0.0381 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Onchocerca volvulus | 0.0036 | 0.0046 | 0.0064 | |
Schistosoma mansoni | inositol monophosphatase | 0.0042 | 0.0056 | 0.0438 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.0401 | 0.0628 | 0.0628 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0401 | 0.0628 | 0.246 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.0025 | 0.0098 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.161 | 0.2553 | 0.2553 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0074 | 0.0546 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.0025 | 0.0195 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.0025 | 0.0025 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.0025 | 0.0485 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.0045 | 0.0353 |
Mycobacterium ulcerans | glutaminase | 0.032 | 0.0498 | 1 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.0419 | 0.0656 | 0.5087 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.0025 | 0.0098 |
Loa Loa (eye worm) | glutaminase 2 | 0.032 | 0.0498 | 0.0498 |
Loa Loa (eye worm) | hypothetical protein | 0.0401 | 0.0628 | 0.0628 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.0056 | 0.9851 |
Brugia malayi | Hypothetical 34.1 kDa protein C40H1.4 in chromosome III | 0.0401 | 0.0628 | 0.0628 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0056 | 0.0434 |
Plasmodium vivax | long chain polyunsaturated fatty acid elongation enzyme, putative | 0.0419 | 0.0656 | 0.2568 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0042 | 0.0056 | 0.1129 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0004 | 0.0004 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0074 | 0.0546 |
Trypanosoma brucei | elongation of very long chain fatty acids protein, putative | 0.0419 | 0.0656 | 0.2568 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.0401 | 0.0628 | 0.4872 |
Brugia malayi | fatty acid elongation protein 3 | 0.0401 | 0.0628 | 0.0628 |
Plasmodium vivax | SET domain protein, putative | 0.0036 | 0.0046 | 0.018 |
Trypanosoma brucei | Fatty acid elongase | 0.0401 | 0.0628 | 0.246 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0074 | 0.0576 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0012 | 0.0007 | 0.0026 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0036 | 0.0046 | 0.0328 |
Brugia malayi | Pre-SET motif family protein | 0.0036 | 0.0046 | 0.0046 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0042 | 0.0056 | 0.022 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0025 | 0.0164 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0004 | 0.0001 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.161 | 0.2553 | 0.2553 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0016 | 0.0014 | 0.0054 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0042 | 0.0329 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0419 | 0.0656 | 0.5102 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0012 | 0.0007 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0046 | 0.0046 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.0419 | 0.0656 | 0.2568 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.0401 | 0.0628 | 0.4888 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0479 | 0.0751 | 0.583 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0034 | 0.0043 | 0.0302 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0038 | 0.0049 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0025 | 0.0098 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.