Detailed information for compound 863574

Basic information

Technical information
  • TDR Targets ID: 863574
  • Name: N-[(4-chlorophenyl)methyl]-5-[(4-methylphenyl )methylsulfinylmethyl]furan-2-carboxamide
  • MW: 401.906 | Formula: C21H20ClNO3S
  • H donors: 1 H acceptors: 2 LogP: 3.77 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CS(=O)Cc1ccc(o1)C(=O)NCc1ccc(cc1)Cl
  • InChi: 1S/C21H20ClNO3S/c1-15-2-4-17(5-3-15)13-27(25)14-19-10-11-20(26-19)21(24)23-12-16-6-8-18(22)9-7-16/h2-11H,12-14H2,1H3,(H,23,24)
  • InChiKey: WXGKFPFTDLHRQW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-chlorophenyl)methyl]-5-[(4-methylphenyl)methylsulfinylmethyl]-2-furancarboxamide
  • N-(4-chlorobenzyl)-5-[(4-methylbenzyl)sulfinylmethyl]-2-furamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica DNA topoisomerase II, putative 0.0616 0.0852 0.3682
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0023 0.0023
Mycobacterium ulcerans lipase LipD 0.008 0.0077 0.0464
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.004 0.0168
Onchocerca volvulus Huntingtin homolog 0.0142 0.0165 0.0999
Treponema pallidum fructose-bisphosphate aldolase 0.1624 0.2314 1
Trypanosoma brucei hypothetical protein, conserved 0.008 0.0077 0.0648
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0036 0.0012 0.0073
Onchocerca volvulus 0.1171 0.1657 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Plasmodium falciparum DNA gyrase subunit A 0.0132 0.0152 0.1303
Loa Loa (eye worm) hypothetical protein 0.0044 0.0024 0.0024
Mycobacterium leprae cell division protein FtsZ 0.035 0.0467 0.4209
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0036 0.0012 0.0073
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.003 0.003
Mycobacterium ulcerans glutaminase 0.0313 0.0414 0.2501
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0099 0.0104 0.0888
Leishmania major hypothetical protein, conserved 0.008 0.0077 0.0666
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0032 0.0007 0.0041
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0017 0.0126
Echinococcus multilocularis neuroligin 0.1171 0.1657 0.1655
Giardia lamblia Pms1-like protein 0.0032 0.0007 0.0012
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.016 0.0192 0.173
Toxoplasma gondii ThiF family protein 0.0037 0.0013 0.0098
Schistosoma mansoni survival motor neuron protein 0.0164 0.0198 0.0191
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0032 0.0007 0.0041
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0007 0.0029
Leishmania major DNA polymerase eta, putative 0.0043 0.0023 0.0197
Echinococcus multilocularis transfer RNA-Lys 0.0081 0.0078 0.0076
Plasmodium vivax DNA gyrase subunit A, putative 0.0132 0.0152 0.1303
Schistosoma mansoni tsg101-related 0.0067 0.0057 0.0051
Trichomonas vaginalis receptor histidine kinase, putative 0.0032 0.0007 0.0023
Echinococcus multilocularis muscleblind protein 1 0.0333 0.0443 0.0442
Loa Loa (eye worm) hypothetical protein 0.1171 0.1657 0.1657
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0017 0.0066
Onchocerca volvulus Huntingtin homolog 0.0142 0.0165 0.0999
Loa Loa (eye worm) hypothetical protein 0.6929 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0048 0.003 0.003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0021 0.0019
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0048 0.003 0.0028
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0425 0.0577 0.0577
Trypanosoma brucei heat shock protein, putative 0.0032 0.0007 0.004
Leishmania major protein kinase, putative 0.0029 0.0003 0.0024
Toxoplasma gondii RNA-directed DNA polymerase 0.0099 0.0104 0.0882
Schistosoma mansoni gliotactin 0.1171 0.1657 0.1651
Brugia malayi hypothetical protein 0.0029 0.0002 0.0002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.001 0.007
Loa Loa (eye worm) hypothetical protein 0.0046 0.0027 0.0027
Schistosoma mansoni lamin 0.0089 0.009 0.0083
Giardia lamblia DINP protein human, muc B family 0.0043 0.0023 0.0081
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0017 0.0066
Brugia malayi Intermediate filament tail domain containing protein 0.0089 0.009 0.009
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0023 0.0178
Leishmania major DNA polymerase kappa, putative 0.0043 0.0023 0.0197
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0036 0.0012 0.0073
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.0082 0.0082
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0033 0.0008 0.003
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0036 0.0012 0.0073
Leishmania major DNA topoisomerase III, putative 0.0033 0.0008 0.0073
Brugia malayi Cytochrome P450 family protein 0.0036 0.0012 0.0012
Loa Loa (eye worm) Ulp1 protease 0.0077 0.0071 0.0071
Brugia malayi Carboxylesterase family protein 0.1171 0.1657 0.1657
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0032 0.0007 0.0061
Schistosoma mansoni inositol monophosphatase 0.0125 0.0142 0.0135
Trichomonas vaginalis DNA topoisomerase II, putative 0.0616 0.0852 0.3678
Brugia malayi ThiF family protein 0.0037 0.0013 0.0013
Onchocerca volvulus 0.0034 0.001 0.0062
Leishmania major cytochrome p450-like protein 0.0084 0.0082 0.0714
Loa Loa (eye worm) hypothetical protein 0.008 0.0077 0.0077
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0004 0.0015
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0077 0.0326
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0004 0.0021
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0036 0.0012 0.0073
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0032 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.008 0.0077 0.0077
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0043 0.0023 0.0021
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Brugia malayi RNA binding protein 0.0068 0.0059 0.0059
Schistosoma mansoni inositol monophosphatase 0.0125 0.0142 0.0135
Trichomonas vaginalis penicillin-binding protein, putative 0.008 0.0077 0.0326
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.004 0.0337
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0416 0.0563 0.3399
Echinococcus multilocularis geminin 0.0378 0.0509 0.0507
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0016 0.0015
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0023 0.0184
Toxoplasma gondii DNA topoisomerase family protein 0.0033 0.0008 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0023 0.0178
Mycobacterium tuberculosis Conserved protein 0.008 0.0077 0.0464
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0033 0.0008 0.006
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0012 0.0012
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0016 0.0015
Echinococcus granulosus muscleblind protein 0.0333 0.0443 0.0442
Trypanosoma brucei unspecified product 0.0043 0.0023 0.0178
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Echinococcus granulosus intermediate filament protein 0.0089 0.009 0.0088
Plasmodium vivax ubiquitin activating enzyme, putative 0.0056 0.0041 0.0337
Trypanosoma cruzi DNA topoisomerase II, putative 0.0582 0.0804 0.6969
Brugia malayi Inositol-1 0.0125 0.0142 0.0142
Brugia malayi Carboxylesterase family protein 0.1171 0.1657 0.1657
Loa Loa (eye worm) hypothetical protein 0.0041 0.002 0.002
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0125 0.0142 0.2856
Echinococcus multilocularis heat shock protein 0.0032 0.0007 0.0005
Trichomonas vaginalis receptor histidine kinase, putative 0.0032 0.0007 0.0023
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0032 0.0007 0.0041
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0514 0.0705 0.4253
Onchocerca volvulus 0.0048 0.003 0.0179
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0077 0.0071 0.0071
Mycobacterium leprae Possible regulatory protein 0.0028 0.0002 0.0014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0023 0.0184
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1171 0.1657 0.1651
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0125 0.0142 0.1215
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Echinococcus granulosus heat shock protein 0.0032 0.0007 0.0005
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0004 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0044 0.0044
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0359 0.048 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0048 0.003 0.003
Echinococcus granulosus p2X purinoceptor 4 0.0136 0.0157 0.0156
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0036 0.0012 0.0073
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0023 0.0021
Brugia malayi Cell division protein ftsZ 0.0168 0.0204 0.0204
Echinococcus granulosus single minded 2 0.0081 0.0078 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0119 0.0509
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0032 0.0007 0.0046
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0032 0.0007 0.0023
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0032 0.0007 0.0041
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0125 0.0142 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0048 0.003 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1624 0.2314 1
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0059 0.0058
Mycobacterium ulcerans beta-lactamase 0.008 0.0077 0.0464
Trypanosoma brucei heat shock protein, putative 0.0032 0.0007 0.004
Chlamydia trachomatis DNA gyrase subunit A 0.0132 0.0152 0.3045
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Mycobacterium tuberculosis Conserved protein 0.008 0.0077 0.0464
Schistosoma mansoni intermediate filament proteins 0.0089 0.009 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0119 0.0509
Loa Loa (eye worm) hypoxia-induced factor 1 0.0339 0.0451 0.0451
Schistosoma mansoni hypothetical protein 0.0378 0.0509 0.0502
Toxoplasma gondii hypothetical protein 0.0056 0.0041 0.0337
Echinococcus granulosus microtubule associated protein 2 0.3087 0.4433 0.4432
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0036 0.0012 0.0073
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0017 0.0015
Echinococcus granulosus dna polymerase eta 0.0043 0.0023 0.0021
Brugia malayi Cytochrome P450 family protein 0.0084 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0053 0.0037 0.0035
Brugia malayi Probable DNA topoisomerase II 0.0616 0.0852 0.0852
Trypanosoma brucei unspecified product 0.003 0.0003 0.001
Brugia malayi bHLH-PAS transcription factor 0.0081 0.0078 0.0078
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0043 0.0023 0.0021
Trypanosoma brucei developmentally regulated phosphoprotein 0.0032 0.0007 0.004
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.1171 0.1657 0.1655
Brugia malayi Steroid receptor seven-up type 2 0.0048 0.003 0.003
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0036 0.0012 0.0073
Loa Loa (eye worm) hypothetical protein 0.008 0.0077 0.0077
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0036 0.0012 0.0073
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.0119 0.1022
Entamoeba histolytica Flap nuclease, putative 0.003 0.0004 0.0017
Trichomonas vaginalis inositol monophosphatase, putative 0.0125 0.0142 0.0608
Plasmodium vivax topoisomerase I, putative 0.0823 0.1153 1
Plasmodium falciparum DNA topoisomerase 2 0.0616 0.0852 0.7386
Echinococcus multilocularis sentrin specific protease 8 0.0077 0.0071 0.007
Onchocerca volvulus 0.1171 0.1657 1
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0125 0.0142 0.0857
Onchocerca volvulus 0.1171 0.1657 1
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0036 0.0012 0.0073
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0032 0.0007 0.004
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0099 0.0104 0.0888
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0007 0.0023
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0089 0.009 0.009
Brugia malayi ecdysteroid receptor 0.0048 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0048 0.003 0.003
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0032 0.0007 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0077 0.0654
Echinococcus granulosus acetylcholinesterase 0.6929 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.003 0.0028
Brugia malayi beta-lactamase 0.008 0.0077 0.0077
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0691 0.0961 0.8335
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0036 0.0012 0.0073
Mycobacterium leprae conserved hypothetical protein 0.008 0.0077 0.0692
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.035 0.0467 0.9723
Brugia malayi hypoxia-induced factor 1 0.0339 0.0451 0.0451
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0032 0.0007 0.0041
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0359 0.048 0.29
Schistosoma mansoni kinase 0.0056 0.0041 0.0035
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.008 0.0077 0.0464
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0175 0.0214 0.0214
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0032 0.0007 0.0023
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0007 0.0046
Loa Loa (eye worm) hypothetical protein 0.0367 0.0492 0.0492
Schistosoma mansoni ubiquitin-activating enzyme E1b 0.0037 0.0013 0.0007
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0616 0.0852 0.0851
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0077 0.007
Mycobacterium tuberculosis Probable two component sensor kinase 0.0032 0.0007 0.0041
Schistosoma mansoni bromodomain containing protein 0.0068 0.0059 0.0052
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0023 0.0178
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0004 0.0004
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0004 0.0015
Trichomonas vaginalis Sentrin-specific protease, putative 0.0077 0.0071 0.0303
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0021 0.0019
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.004 0.035
Echinococcus granulosus serine:threonine protein kinase PLK1 0.011 0.0119 0.0118
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0036 0.0012 0.0073
Brugia malayi Flap endonuclease-1 0.003 0.0004 0.0004
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.004 0.0039
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.004 0.0039
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1171 0.1657 0.1651
Brugia malayi nuclear hormone receptor 0.0048 0.003 0.003
Schistosoma mansoni thyroid hormone receptor 0.0048 0.003 0.0023
Schistosoma mansoni retinoic acid receptor RXR 0.0048 0.003 0.0023
Brugia malayi kinase, mitochondrial precursor 0.0032 0.0007 0.0007
Brugia malayi hypothetical protein 0.0142 0.0165 0.0165
Entamoeba histolytica hypothetical protein 0.0042 0.0021 0.0089
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0017 0.0072
Echinococcus granulosus neuroligin 0.1171 0.1657 0.1655
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0032 0.0007 0.0005
Trypanosoma brucei protein kinase, putative 0.0055 0.004 0.0332
Echinococcus multilocularis inositol monophosphatase 1 0.0125 0.0142 0.0141
Brugia malayi jmjC domain containing protein 0.0065 0.0055 0.0055
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0033 0.0008 0.0054
Plasmodium falciparum DNA gyrase subunit B 0.0359 0.048 0.4155
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0032 0.0007 0.0041
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0125 0.0142 0.1232
Echinococcus granulosus p2X purinoceptor 4 0.0136 0.0157 0.0156
Plasmodium falciparum DNA topoisomerase 3, putative 0.0033 0.0008 0.0054
Mycobacterium tuberculosis Conserved protein 0.008 0.0077 0.0464
Loa Loa (eye worm) hypothetical protein 0.0042 0.002 0.002
Trypanosoma brucei unspecified product 0.003 0.0003 0.001
Mycobacterium tuberculosis Probable lipase LipD 0.008 0.0077 0.0464
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0055 0.0054
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0037 0.003
Trypanosoma brucei glucosidase, putative 0.0039 0.0017 0.0126
Loa Loa (eye worm) hypothetical protein 0.0088 0.0088 0.0088
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.004 0.004
Giardia lamblia DNA topoisomerase II 0.0583 0.0806 0.3471
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0794 0.111 0.6701
Trichomonas vaginalis esterase, putative 0.008 0.0077 0.0326
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0007 0.004
Trypanosoma brucei heat shock protein, putative 0.0032 0.0007 0.004
Leishmania major telomerase reverse transcriptase, putative 0.0099 0.0104 0.09
Treponema pallidum cell division protein FtsZ 0.035 0.0467 0.1996
Loa Loa (eye worm) DNA topoisomerase III 0.0033 0.0008 0.0008
Schistosoma mansoni DNA topoisomerase type I 0.0823 0.1153 0.1147
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.008 0.0077 0.0464
Mycobacterium leprae Probable lipase LipE 0.008 0.0077 0.0692
Echinococcus multilocularis musashi 0.0089 0.009 0.0088
Mycobacterium tuberculosis Carboxylesterase LipT 0.1171 0.1657 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0425 0.0577 0.4993
Loa Loa (eye worm) hypothetical protein 0.1171 0.1657 0.1657
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0112 0.0123 0.0742
Plasmodium vivax telomerase reverse transcriptase, putative 0.0613 0.0848 0.7353
Echinococcus granulosus family S9 non peptidase ue S09 family 0.1171 0.1657 0.1655
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0032 0.0007 0.0023
Onchocerca volvulus 0.0081 0.0078 0.0469
Toxoplasma gondii ABC1 family protein 0.008 0.0077 0.0648
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0036 0.0012 0.0073
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0043 0.0023 0.0137
Echinococcus granulosus neuropeptide receptor A26 0.0554 0.0764 0.0762
Loa Loa (eye worm) hypothetical protein 0.0417 0.0564 0.0564
Echinococcus granulosus lamin dm0 0.0089 0.009 0.0088
Brugia malayi glutaminase DH11.1 0.0313 0.0414 0.0414
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.0309 0.0309
Schistosoma mansoni hypothetical protein 0.0164 0.0198 0.0191
Trypanosoma cruzi hypothetical protein 0.0077 0.0071 0.0608
Loa Loa (eye worm) hypothetical protein 0.025 0.0323 0.0323
Giardia lamblia DNA topoisomerase III 0.0033 0.0008 0.002
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.115 0.1627 0.7032
Loa Loa (eye worm) hypothetical protein 0.0417 0.0564 0.0564
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0037 0.003
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0036 0.0012 0.0073
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.004 0.0168
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0037 0.0035
Echinococcus granulosus lysosomal alpha glucosidase 0.0175 0.0214 0.0213
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0048 0.003 0.0028
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.008 0.0077 0.0464
Plasmodium falciparum heat shock protein 90 0.0032 0.0007 0.004
Trypanosoma brucei heat shock protein, putative 0.0032 0.0007 0.004
Loa Loa (eye worm) hypothetical protein 0.0053 0.0037 0.0037
Brugia malayi Bromodomain containing protein 0.0081 0.0077 0.0077
Schistosoma mansoni hypothetical protein 0.0286 0.0374 0.0368
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0048 0.003 0.0028
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0033 0.0008 0.0002
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.004 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0119 0.0112
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Loa Loa (eye worm) hypothetical protein 0.1171 0.1657 0.1657
Loa Loa (eye worm) CYP4Cod1 0.0084 0.0082 0.0082
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0036 0.0012 0.0073
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0032 0.0007 0.0023
Onchocerca volvulus Bile acid receptor homolog 0.0048 0.003 0.0179
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0012 0.0092
Schistosoma mansoni RAR-like nuclear receptor 0.0048 0.003 0.0023
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0032 0.0007 0.0005
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0055 0.0055
Entamoeba histolytica hypothetical protein 0.0042 0.0021 0.0089
Loa Loa (eye worm) hypothetical protein 0.0058 0.0044 0.0044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0037 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0048 0.003 0.003
Schistosoma mansoni alpha-glucosidase 0.0151 0.0179 0.0172
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1624 0.2314 1
Echinococcus granulosus cytochrome P450 2K1 0.0036 0.0012 0.0011
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0017 0.0066
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0048 0.003 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.001 0.0004
Trypanosoma brucei DNA topoisomerase III, putative 0.0033 0.0008 0.0054
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0023 0.0092
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0416 0.0563 0.3399
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0023 0.0021
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0032 0.0007 0.0041
Onchocerca volvulus 0.0089 0.009 0.0543
Leishmania major hypothetical protein, conserved 0.0029 0.0002 0.0019
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0033 0.0008 0.0007
Mycobacterium ulcerans DNA gyrase subunit A 0.0132 0.0152 0.0918
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0007 0.004
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0037 0.0035
Echinococcus multilocularis heat shock protein 90 0.0032 0.0007 0.0005
Toxoplasma gondii DNA topoisomerase 2, putative 0.0616 0.0852 0.7386
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0037 0.003
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0416 0.0563 0.3399
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0036 0.0012 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1624 0.2314 1
Trichomonas vaginalis hypothetical protein 0.0039 0.0017 0.0067
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0007 0.0023
Trypanosoma brucei polo-like protein kinase 0.011 0.0119 0.1017
Plasmodium falciparum endoplasmin, putative 0.0032 0.0007 0.004
Echinococcus multilocularis dna polymerase eta 0.0043 0.0023 0.0021
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0059 0.0059
Echinococcus granulosus flap endonuclease 1 0.003 0.0004 0.0002
Schistosoma mansoni nuclear hormone receptor 0.0048 0.003 0.0023
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1624 0.2314 1
Trichomonas vaginalis protein kinase inhibitor, putative 0.0066 0.0056 0.0235
Brugia malayi photoreceptor-specific nuclear receptor 0.0048 0.003 0.003
Echinococcus granulosus FTZ F1 alpha 0.0048 0.003 0.0028
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0048 0.003 0.0028
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0048 0.003 0.0023
Echinococcus granulosus dna polymerase kappa 0.0043 0.0023 0.0021
Schistosoma mansoni BC026374 protein (S09 family) 0.1171 0.1657 0.1651
Plasmodium vivax hypothetical protein, conserved 0.008 0.0077 0.0648
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0033 0.0008 0.0076
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0017 0.0066
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.0214 0.0213
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0017 0.0132
Mycobacterium leprae Conserved hypothetical protein 0.0036 0.0012 0.0109
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0036 0.0012 0.0073
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0032 0.0007 0.0041
Mycobacterium ulcerans DNA gyrase subunit B 0.0359 0.048 0.29
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0002 0.0013
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0004 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0059 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0119 0.0509
Mycobacterium ulcerans two component sensor kinase MprB 0.0032 0.0007 0.0041
Echinococcus multilocularis ecdysone induced protein 78C 0.0048 0.003 0.0028
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Entamoeba histolytica deoxycytidyl transferase, putative 0.0043 0.0023 0.0098
Loa Loa (eye worm) glutaminase 2 0.0313 0.0414 0.0414
Schistosoma mansoni hypothetical protein 0.0066 0.0056 0.0049
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0077 0.0326
Loa Loa (eye worm) intermediate filament protein 0.0089 0.009 0.009
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0036 0.0012 0.0086
Loa Loa (eye worm) glutaminase 0.0313 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Brugia malayi nuclear receptor NHR-88 0.0048 0.003 0.003
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0003 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0003 0.001
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0023 0.0178
Loa Loa (eye worm) hypothetical protein 0.008 0.0077 0.0077
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0012 0.0092
Echinococcus multilocularis para nitrobenzyl esterase 0.1171 0.1657 0.1655
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0021 0.0014
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0008 0.0007
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0077 0.0071 0.0309
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0052 0.0051
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0048 0.003 0.0023
Brugia malayi Cytochrome P450 family protein 0.0036 0.0012 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0119 0.0509
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0033 0.0008 0.0008
Toxoplasma gondii cytochrome p450 superfamily protein 0.0036 0.0012 0.0086
Onchocerca volvulus 0.0028 0.0002 0.0009
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.6929 1 1
Echinococcus granulosus BC026374 protein S09 family 0.1171 0.1657 0.1655
Echinococcus granulosus SUMO activating enzyme subunit 1 0.0056 0.0041 0.004
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0048 0.003 0.0028
Entamoeba histolytica hypothetical protein 0.0042 0.0021 0.0089
Brugia malayi Carboxylesterase family protein 0.6929 1 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0059 0.0052
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0048 0.003 0.0179
Plasmodium vivax SET domain protein, putative 0.0034 0.001 0.007
Loa Loa (eye worm) hypothetical protein 0.0039 0.0017 0.0017
Trypanosoma cruzi DNA topoisomerase III, putative 0.0033 0.0008 0.006
Loa Loa (eye worm) hypothetical protein 0.0089 0.009 0.009
Brugia malayi Carboxylesterase family protein 0.1171 0.1657 0.1657
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0036 0.0012 0.0073
Echinococcus multilocularis FTZ F1 alpha 0.0048 0.003 0.0028
Brugia malayi Carboxylesterase family protein 0.1171 0.1657 0.1657
Echinococcus granulosus dnaJ subfamily C 6 0.0066 0.0056 0.0054
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0033 0.0008 0.0035
Onchocerca volvulus Protein ultraspiracle homolog 0.0048 0.003 0.0179
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0029 0.0003 0.0011
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0036 0.0012 0.0073
Schistosoma mansoni hypothetical protein 0.0039 0.0017 0.0011
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0359 0.048 0.2053
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0048 0.003 0.0028
Leishmania major cytochrome p450-like protein 0.0036 0.0012 0.0105
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0033 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.025 0.0323 0.0323
Echinococcus multilocularis X box binding protein 1 0.0286 0.0374 0.0373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0037 0.003
Brugia malayi cytoplasmic intermediate filament protein 0.0048 0.003 0.003
Leishmania major DNA topoisomerase 1A 0.0033 0.0008 0.0073
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0036 0.0012 0.0073
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0059 0.0052
Schistosoma mansoni glutaminase 0.0313 0.0414 0.0408
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0036 0.0012 0.0073
Mycobacterium leprae Probable two-component sensor kinase 0.0032 0.0007 0.0061
Onchocerca volvulus Serine\/threonine kinase homolog 0.011 0.0119 0.0719
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.1171 0.1657 0.7157
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1171 0.1657 1
Chlamydia trachomatis DNA gyrase subunit B 0.0359 0.048 1
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0119 0.0509
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0059 0.0052
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.011 0.0119 0.0118
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0032 0.0007 0.004
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.004 0.0337
Schistosoma mansoni thyroid hormone receptor 0.0048 0.003 0.0023
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0056 0.0041 0.0034
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0036 0.0012 0.0073
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0048 0.003 0.0028
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0616 0.0852 0.0852
Mycobacterium tuberculosis Probable esterase LipL 0.008 0.0077 0.0464
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.008 0.0077 0.0077
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0112 0.0123 0.1108
Schistosoma mansoni hypothetical protein 0.0036 0.0012 0.0005
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0007 0.0012
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0032 0.0007 0.0041
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0007 0.004
Echinococcus granulosus sumo-activating enzyme subunit 2 0.0037 0.0013 0.0012
Brugia malayi hypothetical protein 0.0803 0.1124 0.1124
Brugia malayi jmjC domain containing protein 0.0063 0.0052 0.0052
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0036 0.0012 0.0073
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.0119 0.1022
Trypanosoma brucei DNA topoisomerase III, putative 0.0033 0.0008 0.0054
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0036 0.0012 0.0073
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.008 0.0077 0.0077
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0033 0.0008 0.0002
Brugia malayi beta-lactamase family protein 0.008 0.0077 0.0077
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0023 0.0137
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0099 0.0104 0.0626
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0119 0.0509
Mycobacterium leprae putative cytochrome p450 0.0036 0.0012 0.0109
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0077 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0023 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0048 0.003 0.003
Brugia malayi hypothetical protein 0.008 0.0077 0.0077
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.004 0.0039
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0032 0.0007 0.0041
Loa Loa (eye worm) acetylcholinesterase 1 0.6929 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1624 0.2314 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0043 0.0023 0.0016
Schistosoma mansoni P2X receptor subunit 0.0136 0.0157 0.0151
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.004 0.0337
Plasmodium vivax DNA gyrase subunit B, putative 0.0359 0.048 0.4155
Leishmania major ubiquitin-activating enzyme-like protein 0.0037 0.0013 0.0116
Plasmodium vivax DNA topoisomerase 3, putative 0.0033 0.0008 0.0054
Trypanosoma brucei ubiquitin-activating enzyme E1, putative 0.0037 0.0013 0.0098
Brugia malayi DNA topoisomerase III 0.0033 0.0008 0.0008
Trichomonas vaginalis glutaminase, putative 0.0313 0.0414 0.1785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1624 0.2314 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0043 0.0023 0.0016
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0052 0.0051
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.1171 0.1657 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0017 0.0072
Entamoeba histolytica serine/threonine protein kinase, putative 0.011 0.0119 0.0515
Echinococcus multilocularis muscleblind protein 0.0333 0.0443 0.0442
Giardia lamblia DNA repair protein RAD52 0.115 0.1627 0.7027
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0036 0.0012 0.0105
Mycobacterium ulcerans putative regultory protein 0.0032 0.0007 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0048 0.003 0.003
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.004 0.035
Brugia malayi Bromodomain containing protein 0.0041 0.002 0.002
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0028 0.0002 0.0002
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0616 0.0852 0.0852
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0048 0.003 0.0023
Loa Loa (eye worm) hypothetical protein 0.008 0.0077 0.0077
Echinococcus granulosus survival motor neuron protein 1 0.0803 0.1124 0.1122
Echinococcus granulosus DNA topoisomerase 1 0.0823 0.1153 0.1152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.003 0.0028
Mycobacterium ulcerans putative regulatory protein 0.0081 0.0078 0.0469
Mycobacterium ulcerans esterase/lipase LipP 0.008 0.0077 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0048 0.003 0.003
Brugia malayi cytochrome P450 0.0036 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0142 0.0165 0.0165
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0359 0.048 0.4155
Treponema pallidum DNA topoisomerase I (topA) 0.0033 0.0008 0.0007
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0582 0.0804 0.6967
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0048 0.003 0.003
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0036 0.0012 0.0073
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0007 0.0046
Echinococcus multilocularis p2X purinoceptor 4 0.0136 0.0157 0.0156
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0023 0.0184
Loa Loa (eye worm) hypothetical protein 0.1171 0.1657 0.1657
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0023 0.0023
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.011 0.0119 0.1034
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0059 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0053 0.0037 0.003
Brugia malayi heat shock protein 90 0.0032 0.0007 0.0007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0023 0.0184
Loa Loa (eye worm) hypothetical protein 0.0028 0.0002 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0125 0.0142 0.0608
Brugia malayi Glycosyl hydrolases family 31 protein 0.0175 0.0214 0.0214
Loa Loa (eye worm) carboxylesterase 0.1171 0.1657 0.1657
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0029 0.0003 0.0011
Mycobacterium tuberculosis Conserved protein 0.0032 0.0007 0.0041
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0048 0.003 0.0023
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0017 0.0015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0048 0.003 0.0023
Mycobacterium tuberculosis Possible two component sensor kinase 0.0032 0.0007 0.0041
Mycobacterium tuberculosis Probable conserved lipoprotein 0.008 0.0077 0.0464
Echinococcus granulosus beta LACTamase domain containing family member 0.008 0.0077 0.0075
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0007 0.004
Schistosoma mansoni tsg101-related 0.0067 0.0057 0.0051
Brugia malayi Pre-SET motif family protein 0.0034 0.001 0.001
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0023 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0003 0.001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0556 0.0767 0.0767
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0077 0.0071 0.0303
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0077 0.0654
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0048 0.003 0.003
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1171 0.1657 0.1651
Mycobacterium tuberculosis Probable lipase LipE 0.008 0.0077 0.0464
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0033 0.0008 0.006
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0039 0.0163
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.004 0.0332
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0048 0.003 0.003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0037 0.0035
Echinococcus granulosus sentrin specific protease 8 0.0077 0.0071 0.007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.003 0.0028
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0064 0.0053 0.0052
Brugia malayi hypothetical protein 0.0042 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0048 0.003 0.003
Schistosoma mansoni P2X receptor subunit 0.0136 0.0157 0.0151
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0794 0.111 1
Echinococcus multilocularis carboxylesterase 5A 0.6929 1 1
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0036 0.0012 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0023 0.0178
Loa Loa (eye worm) hypothetical protein 0.1171 0.1657 0.1657
Brugia malayi TAR-binding protein 0.0068 0.0059 0.0059
Loa Loa (eye worm) carboxylesterase 0.1171 0.1657 0.1657
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Mycobacterium leprae Probable two component sensor kinase MprB 0.0032 0.0007 0.0061
Brugia malayi DNA topoisomerase I 0.0823 0.1153 0.1153
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0036 0.0012 0.0073
Loa Loa (eye worm) beta-lactamase 0.008 0.0077 0.0077
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0007 0.0046
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0077 0.0071 0.0303
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1624 0.2314 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0077 0.0077
Trypanosoma cruzi DNA topoisomerase III, putative 0.0033 0.0008 0.006
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0007 0.0046
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0055 0.0048
Plasmodium falciparum flap endonuclease 1 0.003 0.0004 0.0015
Mycobacterium ulcerans DNA topoisomerase I 0.0033 0.0008 0.0051
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0023 0.0178
Brugia malayi Endoplasmin precursor 0.0032 0.0007 0.0007
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0023 0.0178
Loa Loa (eye worm) hypothetical protein 0.0042 0.002 0.002
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0007 0.0046
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.008 0.0077 0.007
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0032 0.0007 0.0041
Loa Loa (eye worm) inositol-1 0.0125 0.0142 0.0142
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.006 0.0048 0.0838
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0032 0.0007 0.0041
Echinococcus multilocularis 0.0036 0.0012 0.0011
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0052 0.0045
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0048 0.003 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.001 0.0004
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0032 0.0007 0.0046
Schistosoma mansoni P2X receptor subunit 0.0136 0.0157 0.0151
Trichomonas vaginalis sensor histidine kinase, putative 0.0032 0.0007 0.0023
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0036 0.0012 0.0073
Echinococcus granulosus neuropeptide s receptor 0.0554 0.0764 0.0762
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1624 0.2314 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0036 0.0012 0.0073
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0048 0.003 0.003
Plasmodium falciparum SUMO-activating enzyme subunit 1 0.0056 0.0041 0.0337
Trypanosoma cruzi cytochrome P450, putative 0.0084 0.0082 0.0702
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0937 0.1318 0.1317
Echinococcus granulosus tar DNA binding protein 0.0068 0.0059 0.0058
Echinococcus granulosus heat shock protein 90 0.0032 0.0007 0.0005
Trypanosoma brucei heat shock protein, putative 0.0032 0.0007 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0023 0.0178
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0077 0.0071 0.0303
Brugia malayi hypothetical protein 0.1171 0.1657 0.1657
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0023 0.0178
Echinococcus granulosus acetylcholinesterase 0.6929 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0044 0.0044
Loa Loa (eye worm) endoplasmin 0.0032 0.0007 0.0007
Schistosoma mansoni P2X receptor subunit 0.0136 0.0157 0.0151
Echinococcus granulosus histone lysine methyltransferase setb 0.0053 0.0037 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0036 0.0012 0.0073
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0164 0.0198 0.0198
Echinococcus multilocularis lamin 0.0089 0.009 0.0088
Trypanosoma brucei DNA topoisomerase IA, putative 0.0033 0.0008 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.004 0.0034
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0036 0.0012 0.0073
Giardia lamblia DNA topoisomerase III 0.0033 0.0008 0.002
Trypanosoma cruzi cytochrome P450, putative 0.0084 0.0082 0.0702
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0023 0.0184
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0125 0.0142 0.122
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0029 0.0003 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0017 0.0132
Echinococcus multilocularis neuropeptide s receptor 0.0554 0.0764 0.0762
Plasmodium vivax DNA topoisomerase II, putative 0.0616 0.0852 0.7386
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0023 0.0178
Chlamydia trachomatis DNA gyrase subunit A 0.0132 0.0152 0.3045
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0036 0.0012 0.0073
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.004 0.0168
Onchocerca volvulus 0.0089 0.009 0.0543
Leishmania major DNA topoisomerase III, putative 0.0033 0.0008 0.0073
Loa Loa (eye worm) hypothetical protein 0.0803 0.1124 0.1124
Leishmania major DNA topoisomerase ii 0.0582 0.0804 0.6973
Loa Loa (eye worm) cytochrome P450 0.0036 0.0012 0.0012
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0032 0.0007 0.0041
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0425 0.0577 0.4996
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.003 0.0028
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0055 0.004 0.0171
Loa Loa (eye worm) hypothetical protein 0.0085 0.0083 0.0083
Schistosoma mansoni DNA topoisomerase type I 0.0823 0.1153 0.1147
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0048 0.003 0.0028
Echinococcus granulosus para nitrobenzyl esterase 0.1171 0.1657 0.1655
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0036 0.0012 0.0073
Onchocerca volvulus 0.0274 0.0357 0.2154
Echinococcus multilocularis DNA topoisomerase 1 0.0823 0.1153 0.1152
Brugia malayi GRF zinc finger family protein 0.0033 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0333 0.0443 0.0443
Echinococcus granulosus carboxylesterase 5A 0.6929 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0007 0.0046
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0036 0.0012 0.0073
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0037 0.0037
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0007 0.0029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0048 0.003 0.0023
Brugia malayi Muscleblind-like protein 0.0333 0.0443 0.0443
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1624 0.2314 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0048 0.003 0.003
Schistosoma mansoni alpha-glucosidase 0.0151 0.0179 0.0172
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0032 0.0007 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0007 0.004
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0823 0.1153 1
Loa Loa (eye worm) carboxylesterase 0.6929 1 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0007 0.004
Mycobacterium ulcerans carboxylesterase, LipT 0.1171 0.1657 1
Echinococcus multilocularis rho GTPase activating protein 20 0.0033 0.0008 0.0007
Schistosoma mansoni microtubule-associated protein tau 0.3087 0.4433 0.4429
Onchocerca volvulus 0.0164 0.0198 0.1193
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0039 0.0163
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.001 0.0009
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0007 0.0023
Loa Loa (eye worm) TOPoisomerase family member 0.0616 0.0852 0.0852
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0007 0.0007
Loa Loa (eye worm) ThiF family protein 0.0037 0.0013 0.0013
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0033 0.0008 0.003
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0327 0.0435 0.1878
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0037 0.0037
Echinococcus multilocularis SUMO activating enzyme subunit 2 0.0037 0.0013 0.0012
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0003 0.001
Entamoeba histolytica hypothetical protein 0.0042 0.0021 0.0089
Mycobacterium tuberculosis Conserved hypothetical protein 0.0043 0.0023 0.0137
Loa Loa (eye worm) hypothetical protein 0.0056 0.0041 0.0041
Echinococcus granulosus inositol monophosphatase 1 0.0125 0.0142 0.0141
Leishmania major hypothetical protein, conserved 0.0032 0.0007 0.0059
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0032 0.0007 0.004
Loa Loa (eye worm) hypothetical protein 0.0425 0.0577 0.0577
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0036 0.0012 0.0092
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0032 0.0007 0.0061
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0823 0.1153 1
Plasmodium falciparum topoisomerase I 0.0823 0.1153 1
Schistosoma mansoni lamin 0.0089 0.009 0.0083
Loa Loa (eye worm) hypothetical protein 0.1171 0.1657 0.1657
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0048 0.003 0.003
Brugia malayi Pre-SET motif family protein 0.024 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0085 0.0083 0.0083
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0055 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0048 0.003 0.003
Echinococcus granulosus X box binding protein 1 0.0286 0.0374 0.0373
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0032 0.0007 0.0023
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0048 0.003 0.0023
Echinococcus multilocularis acetylcholinesterase 0.6929 1 1
Chlamydia trachomatis DNA gyrase subunit B 0.0284 0.0371 0.7687
Onchocerca volvulus 0.008 0.0077 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0048 0.003 0.003
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0064 0.0053 0.0052
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0017 0.0066
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0691 0.0961 0.8335
Loa Loa (eye worm) hypothetical protein 0.0217 0.0275 0.0275
Giardia lamblia Fructose-bisphosphate aldolase 0.1624 0.2314 1
Brugia malayi PAS domain containing protein 0.0109 0.0119 0.0119
Loa Loa (eye worm) DnaJ domain-containing protein 0.0066 0.0056 0.0056
Echinococcus multilocularis thyroid hormone receptor alpha 0.0048 0.003 0.0028
Loa Loa (eye worm) steroid hormone receptor 0.0048 0.003 0.003
Giardia lamblia Telomerase catalytic subunit 0.0099 0.0104 0.0432
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0125 0.0142 0.122
Trichomonas vaginalis set domain proteins, putative 0.0274 0.0357 0.1537
Echinococcus multilocularis BC026374 protein (S09 family) 0.1171 0.1657 0.1655
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0043 0.0023 0.0023
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0582 0.0804 0.6967
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0036 0.0012 0.0073
Brugia malayi DNA topoisomerase III beta-1 0.0033 0.0008 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.004 0.0168
Plasmodium falciparum telomerase reverse transcriptase 0.0613 0.0848 0.7353
Schistosoma mansoni DNA polymerase eta 0.0043 0.0023 0.0016
Loa Loa (eye worm) hypothetical protein 0.0076 0.0071 0.0071
Leishmania major DNA topoisomerase IB, large subunit 0.0823 0.1153 1
Brugia malayi DnaJ domain containing protein 0.0066 0.0056 0.0056
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0036 0.0012 0.0073
Schistosoma mansoni hypothetical protein 0.0378 0.0509 0.0502
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0084 0.0082 0.0497
Plasmodium vivax SUMO-activating enzyme subunit 2, putative 0.0037 0.0013 0.0098
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0007 0.004
Schistosoma mansoni DNA topoisomerase II 0.0616 0.0852 0.0846
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0017 0.0017
Echinococcus multilocularis neuropeptide receptor A26 0.0554 0.0764 0.0762
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0048 0.003 0.003
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.004 0.0332
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0032 0.0007 0.0041
Schistosoma mansoni neuroligin 3 (S09 family) 0.1171 0.1657 0.1651
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0032 0.0006 0.0039
Mycobacterium ulcerans hypothetical protein 0.008 0.0077 0.0464
Trypanosoma cruzi ubiquitin-activating enzyme, putative 0.0037 0.0013 0.0103
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Leishmania major protein kinase, putative 0.0029 0.0003 0.0024
Brugia malayi serine/threonine-protein kinase plk-2 0.011 0.0119 0.0119
Brugia malayi hypothetical protein 0.0367 0.0492 0.0492
Giardia lamblia Kinase, PLK 0.011 0.0119 0.0499
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0033 0.0008 0.0007
Trypanosoma brucei cytochrome P450, putative 0.0084 0.0082 0.0696
Brugia malayi Cell division protein ftsZ 0.0173 0.0211 0.0211
Entamoeba histolytica DNA topoisomerase III, putative 0.0033 0.0008 0.0036
Mycobacterium tuberculosis Probable hydrolase 0.008 0.0077 0.0464
Loa Loa (eye worm) cytochrome P450 family protein 0.0084 0.0082 0.0082
Trypanosoma cruzi DNA topoisomerase III, putative 0.0033 0.0008 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0023 0.0178
Trichomonas vaginalis D-aminoacylase, putative 0.008 0.0077 0.0326
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.011 0.0119 0.0119
Plasmodium vivax endoplasmin, putative 0.0032 0.0007 0.004
Echinococcus multilocularis acetylcholinesterase 0.6929 1 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0582 0.0804 0.6969
Echinococcus granulosus p2X purinoceptor 4 0.0136 0.0157 0.0156
Echinococcus multilocularis beta LACTamase domain containing family member 0.008 0.0077 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.011 0.0119 0.0509
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0043 0.0023 0.0197
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.6929 1 1
Brugia malayi MAP kinase sur-1 0.0055 0.004 0.004
Echinococcus granulosus lamin 0.0089 0.009 0.0088
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0017 0.0066
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0017 0.0066
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0032 0.0007 0.004
Mycobacterium ulcerans cell division protein FtsZ 0.035 0.0467 0.2821
Onchocerca volvulus 0.1171 0.1657 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0083 0.0083
Entamoeba histolytica hypothetical protein 0.0327 0.0435 0.1878
Schistosoma mansoni cytochrome P450 0.0036 0.0012 0.0005
Echinococcus multilocularis p2X purinoceptor 4 0.0136 0.0157 0.0156
Echinococcus multilocularis microtubule associated protein 2 0.3087 0.4433 0.4432
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0616 0.0852 0.0851
Schistosoma mansoni sumo-1-activating enzyme E1a 0.0051 0.0034 0.0027
Echinococcus granulosus geminin 0.0378 0.0509 0.0507
Plasmodium falciparum SUMO-activating enzyme subunit 2 0.0037 0.0013 0.0098
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0017 0.0066
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0059 0.0059
Brugia malayi steroid hormone receptor 0.0048 0.003 0.003
Brugia malayi intermediate filament protein 0.0089 0.009 0.009
Schistosoma mansoni tsg101-related 0.0055 0.004 0.0033
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0044 0.0044
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0794 0.111 0.6701
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0032 0.0007 0.0005
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0132 0.0152 0.0918
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1624 0.2314 1
Leishmania major cytochrome p450-like protein 0.0036 0.0012 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0036 0.0012 0.0073
Mycobacterium ulcerans two component regulator - sensor kinase 0.0032 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.008 0.0077 0.0077
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0036 0.0012 0.0073
Brugia malayi follicle stimulating hormone receptor 0.0556 0.0767 0.0767
Schistosoma mansoni acetylcholinesterase 0.1171 0.1657 0.1651
Trypanosoma brucei heat shock protein, putative 0.0032 0.0007 0.004
Onchocerca volvulus 0.0101 0.0107 0.0648
Loa Loa (eye worm) hypothetical protein 0.0048 0.0031 0.0031
Echinococcus multilocularis p2X purinoceptor 4 0.0136 0.0157 0.0156
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0132 0.0152 0.063
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0004 0.001
Loa Loa (eye worm) hypothetical protein 0.0333 0.0443 0.0443
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0023 0.0178
Schistosoma mansoni DNA topoisomerase type I 0.0823 0.1153 0.1147
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0017 0.0066
Leishmania major developmentally regulated phosphoprotein-like protein 0.0032 0.0007 0.0059
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.008 0.0077 0.0075
Echinococcus multilocularis lysosomal alpha glucosidase 0.0175 0.0214 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0023 0.0178
Loa Loa (eye worm) hypothetical protein 0.0048 0.003 0.003
Toxoplasma gondii DNA topoisomerase I, putative 0.0823 0.1153 1
Leishmania major heat shock protein 83-1 0.0032 0.0007 0.0059
Schistosoma mansoni hypothetical protein 0.0042 0.0021 0.0014
Echinococcus multilocularis dnaJ subfamily C 6 0.0066 0.0056 0.0054
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0132 0.0152 0.3069
Trypanosoma brucei telomerase reverse transcriptase 0.0099 0.0104 0.0882
Echinococcus multilocularis flap endonuclease 1 0.003 0.0004 0.0002
Trypanosoma brucei DNA topoisomerase ii 0.0691 0.0961 0.8334
Loa Loa (eye worm) hypothetical protein 0.1171 0.1657 0.1657
Onchocerca volvulus 0.1171 0.1657 1
Trypanosoma brucei heat shock protein, putative 0.0032 0.0007 0.004
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0059 0.0052
Echinococcus granulosus hypothetical protein 0.082 0.1149 0.1148
Onchocerca volvulus 0.0033 0.0008 0.0051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0007
Schistosoma mansoni single-minded 0.0109 0.0119 0.0112
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0036 0.0012 0.0073
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0032 0.0007 0.0041
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0132 0.0152 0.1303
Echinococcus multilocularis conserved hypothetical protein 0.0797 0.1116 0.1114
Echinococcus granulosus tumor susceptibility gene 101 protein 0.008 0.0077 0.0075
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0125 0.0142 0.1215
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0017 0.0017
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.004 0.0039
Brugia malayi ThiF family protein 0.0056 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.006 0.0048 0.0041
Onchocerca volvulus 0.008 0.0077 0.0464
Brugia malayi beta-lactamase family protein 0.008 0.0077 0.0077
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0077 0.0071 0.0065
Leishmania major C-8 sterol isomerase-like protein 0.0425 0.0577 0.5002
Schistosoma mansoni alpha glucosidase 0.0039 0.0017 0.001
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0017 0.0145
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0007 0.004
Echinococcus granulosus ecdysone induced protein 78C 0.0048 0.003 0.0028
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0023 0.0021
Schistosoma mansoni aryl hydrocarbon receptor 0.0109 0.0119 0.0112
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.004 0.0337
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0036 0.0012 0.0073
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0023 0.0092
Loa Loa (eye worm) RNA binding protein 0.0068 0.0059 0.0059
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0002 0.0006
Loa Loa (eye worm) DNA topoisomerase I 0.0823 0.1153 0.1153
Trichomonas vaginalis spcc417.12 protein, putative 0.1171 0.1657 0.7157
Onchocerca volvulus 0.008 0.0077 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0048 0.003 0.003
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0002 0.0006
Echinococcus multilocularis lamin dm0 0.0089 0.009 0.0088
Leishmania major mitochondrial DNA topoisomerase II 0.0691 0.0961 0.8337
Brugia malayi Cytochrome P450 family protein 0.0084 0.0082 0.0082
Schistosoma mansoni coup transcription factor 0.0048 0.003 0.0023
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0125 0.0142 0.0614
Echinococcus multilocularis SUMO activating enzyme subunit 1 0.0056 0.0041 0.004
Entamoeba histolytica DNA topoisomerase III, putative 0.0033 0.0008 0.0036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0048 0.003 0.003
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0029 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0142 0.0165 0.0165
Mycobacterium tuberculosis Cell division protein FtsZ 0.035 0.0467 0.2821
Echinococcus multilocularis survival motor neuron protein 1 0.0803 0.1124 0.1122

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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