Detailed information for compound 864534

Basic information

Technical information
  • TDR Targets ID: 864534
  • Name: E596-0880
  • MW: 496.6 | Formula: C25H29FN6O2S
  • H donors: 0 H acceptors: 4 LogP: 3.64 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cn1c2nnc(n2c2c(c1=O)scc2)CCCC(=O)N1CCN(CC1)c1ccc(cc1)F)C
  • InChi: 1S/C25H29FN6O2S/c1-17(2)16-31-24(34)23-20(10-15-35-23)32-21(27-28-25(31)32)4-3-5-22(33)30-13-11-29(12-14-30)19-8-6-18(26)7-9-19/h6-10,15,17H,3-5,11-14,16H2,1-2H3
  • InChiKey: VFCHPGXNLRROSP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NCGC00123340-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis protein kinase c eta type 0.0031 0.0086 0.0084
Trypanosoma brucei histone-lysine n-methyltransferase 0.0066 0.0289 0.0463
Echinococcus multilocularis somatostatin receptor 0.062 0.348 0.3479
Schistosoma mansoni integrin alpha-ps 0.0064 0.0278 0.0387
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0115 0.0185
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0036 0.0115 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0032 0.003
Brugia malayi Dopamine receptor 0.062 0.348 0.3703
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0069 0.0309 0.0431
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0115 0.0183
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0104
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.1097 0.6221 1
Echinococcus granulosus Rac GTPase activating protein 1 0.0031 0.0086 0.0118
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0055 0.0224 0.0237
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.1097 0.6221 1
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0333 0.0464
Leishmania major C-8 sterol isomerase-like protein 0.0436 0.2416 0.3883
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0087
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0344 0.1891 0.3038
Echinococcus multilocularis serine:threonine protein kinase N2 0.0073 0.0333 0.0332
Trichomonas vaginalis AGC family protein kinase 0.0078 0.0358 0.0573
Echinococcus multilocularis G protein coupled receptor 139 0.062 0.348 0.3479
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0036 0.0115 0.0159
Echinococcus multilocularis calcium dependent protein kinase 0.0045 0.0171 0.017
Entamoeba histolytica protein kinase 2, putative 0.0052 0.0211 0.034
Loa Loa (eye worm) intermediate filament protein 0.003 0.0085 0.0086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.062 0.348 0.4847
Echinococcus granulosus lamin 0.003 0.0085 0.0116
Toxoplasma gondii AGC kinase 0.0452 0.2509 0.4034
Brugia malayi hypothetical protein 0.0054 0.0219 0.0232
Echinococcus multilocularis histone h3 methyltransferase 0.0519 0.2895 0.2894
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0436 0.2416 0.3883
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0312 0.1705 0.274
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0641 0.3596 0.578
Leishmania major trypanothione reductase 0.0046 0.0173 0.0277
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0189 0.1 0.1605
Loa Loa (eye worm) hypothetical protein 0.0044 0.0165 0.0171
Leishmania major protein kinase A catalytic subunit isoform 1 0.0452 0.2509 0.4033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0032 0.0043
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0428 0.0594
Toxoplasma gondii hypothetical protein 0.0066 0.0289 0.0465
Schistosoma mansoni protein arginine n-methyltransferase 0.0068 0.0303 0.0422
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0141 0.0225
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Loa Loa (eye worm) hypothetical protein 0.004 0.0141 0.0147
Echinococcus multilocularis alpha 1A adrenergic receptor 0.062 0.348 0.3479
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0215 0.1146 0.1216
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0606 0.0972
Entamoeba histolytica hypothetical protein 0.0044 0.0165 0.0265
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0115 0.0183
Brugia malayi gonadotropin-releasing hormone receptor 2 0.062 0.348 0.3703
Brugia malayi hypothetical protein 0.0081 0.0377 0.04
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus granulosus tm gpcr rhodopsin 0.062 0.348 0.4846
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0032 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.062 0.348 0.4847
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0088
Loa Loa (eye worm) AGC/AKT protein kinase 0.0121 0.0606 0.0642
Loa Loa (eye worm) hypothetical protein 0.0049 0.0193 0.0202
Echinococcus granulosus high affinity choline transporter 1 0.0411 0.2276 0.3169
Schistosoma mansoni lamin 0.003 0.0085 0.0118
Schistosoma mansoni neuropeptide receptor 0.062 0.348 0.4847
Loa Loa (eye worm) latrophilin receptor protein 2 0.0087 0.0411 0.0434
Schistosoma mansoni coup transcription factor 0.0021 0.0032 0.0045
Trichomonas vaginalis adenosylhomocysteinase, putative 0.1097 0.6221 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0053 0.0218 0.023
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0033 0.0031
Echinococcus multilocularis regulator of G protein signaling 3 0.0044 0.0165 0.0163
Schistosoma mansoni Smad4 0.0042 0.0151 0.021
Echinococcus multilocularis axis inhibition protein axin 0.0044 0.0165 0.0163
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0138 0.0704 0.0703
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0219 0.035
Echinococcus granulosus bloom syndrome protein 0.0074 0.0338 0.0469
Trypanosoma brucei trypanothione reductase 0.0046 0.0173 0.0277
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0068 0.0303 0.0487
Loa Loa (eye worm) Smad1 0.0042 0.0151 0.0157
Brugia malayi MH1 domain containing protein 0.0042 0.0151 0.0159
Leishmania major DNA polymerase eta, putative 0.004 0.0141 0.0225
Echinococcus multilocularis thyroid hormone receptor alpha 0.0163 0.0847 0.0846
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0073 0.0333 0.0332
Brugia malayi hypothetical protein 0.0044 0.0165 0.0174
Schistosoma mansoni DNA polymerase eta 0.004 0.0141 0.0197
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0141 0.0225
Schistosoma mansoni adenosylhomocysteinase 0.1097 0.6221 0.8665
Schistosoma mansoni protein kinase 0.0055 0.0224 0.0312
Loa Loa (eye worm) hypothetical protein 0.0436 0.2416 0.2569
Loa Loa (eye worm) hypothetical protein 0.023 0.1232 0.1308
Brugia malayi Dopamine receptor protein 2 0.062 0.348 0.3703
Brugia malayi ORL1-like opioid receptor 0.062 0.348 0.3703
Echinococcus granulosus smad 0.0042 0.0151 0.0208
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0001 0.5
Schistosoma mansoni protein kinase 0.0055 0.0224 0.0312
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0049 0.0066
Echinococcus granulosus protein kinase c epsilon type 0.011 0.0545 0.0757
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0036 0.0115 0.0161
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.062 0.348 0.4847
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0606 0.0972
Brugia malayi MH2 domain containing protein 0.0019 0.0018 0.0017
Echinococcus granulosus Protein kinase C brain isozyme 0.0309 0.1691 0.2354
Loa Loa (eye worm) RecQ helicase 0.0074 0.0338 0.0356
Schistosoma mansoni retinoic acid receptor RXR 0.0149 0.0769 0.1071
Brugia malayi MAP kinase sur-1 0.0128 0.0648 0.0688
Brugia malayi nuclear hormone receptor 0.0021 0.0032 0.0033
Schistosoma mansoni zinc finger protein 0.0025 0.0057 0.0079
Entamoeba histolytica hypothetical protein 0.0031 0.0086 0.0138
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0032 0.0033
Brugia malayi hypothetical protein 0.062 0.348 0.3703
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0224 0.0312
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0081 0.0377 0.0524
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0086 0.0119
Loa Loa (eye worm) PXA domain-containing protein 0.0044 0.0165 0.0171
Schistosoma mansoni amine GPCR 0.062 0.348 0.4847
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.005 0.0199 0.0318
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0219 0.035
Schistosoma mansoni biogenic amine (5HT) receptor 0.062 0.348 0.4847
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0648 0.104
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0173 0.024
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0036 0.0115 0.0183
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0141 0.0225
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0018 0.0017
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0045 0.0171 0.0236
Echinococcus granulosus protein arginine methyltransferase 0.0121 0.0607 0.0844
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0032 0.0045
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0031 0.0086 0.0118
Trypanosoma cruzi ISWI complex protein 0.0018 0.0016 0.0024
Schistosoma mansoni diacylglycerol kinase theta 0.0031 0.0086 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0309 0.1691 0.2356
Brugia malayi hypothetical protein 0.062 0.348 0.3703
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0018 0.0016
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0189 0.1 0.1605
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0149 0.0769 0.1069
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0066 0.0289 0.0463
Schistosoma mansoni hypothetical protein 0.062 0.348 0.4847
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0087 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0165 0.0263
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0511 0.0819
Schistosoma mansoni hypothetical protein 0.1263 0.718 1
Schistosoma mansoni serine/threonine protein kinase 0.0452 0.2509 0.3495
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0077 0.0076
Trichomonas vaginalis DNA helicase recq1, putative 0.0074 0.0338 0.0541
Brugia malayi hypothetical protein 0.016 0.0831 0.0883
Entamoeba histolytica diacylglycerol kinase, putative 0.0031 0.0086 0.0138
Onchocerca volvulus 0.0035 0.0111 0.0268
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0141 0.0225
Schistosoma mansoni vav2 0.0035 0.0111 0.0154
Schistosoma mansoni rhodopsin-like orphan GPCR 0.062 0.348 0.4847
Echinococcus multilocularis tachykinin peptides receptor 99D 0.062 0.348 0.3479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.062 0.348 0.4847
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0151 0.0157
Entamoeba histolytica protein kinase, putative 0.0073 0.0333 0.0535
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.004 0.0139 0.0191
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0121 0.0607 0.0974
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0055 0.0224 0.0361
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0049 0.0047
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0045 0.0171 0.017
Echinococcus granulosus regulator of G protein signaling 3 0.0044 0.0165 0.0228
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0085 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0165 0.0263
Plasmodium falciparum calcium-dependent protein kinase 3 0.0055 0.0224 0.0359
Brugia malayi Bromodomain containing protein 0.0046 0.0176 0.0186
Loa Loa (eye worm) hypothetical protein 0.0044 0.0165 0.0171
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0001 0.5
Echinococcus granulosus regulator of G protein signaling 7 0.0044 0.0165 0.0228
Loa Loa (eye worm) adenosylhomocysteinase 0.1097 0.6221 0.662
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0428 0.0596
Echinococcus granulosus beta-adrenergic receptor kinase 0.0053 0.0218 0.0301
Schistosoma mansoni hypothetical protein 0.062 0.348 0.4847
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0452 0.2509 0.4033
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Brugia malayi Regulator of G protein signaling domain containing protein 0.0044 0.0165 0.0174
Onchocerca volvulus 0.062 0.348 1
Echinococcus multilocularis neuropeptide receptor 0.062 0.348 0.3479
Echinococcus multilocularis rac serine:threonine kinase 0.0057 0.0236 0.0235
Brugia malayi Smad1 0.0042 0.0151 0.0159
Echinococcus multilocularis fmrfamide receptor 0.062 0.348 0.3479
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0165 0.0263
Echinococcus multilocularis nervana 2 0.0043 0.0158 0.0157
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0648 0.104
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0117 0.0581 0.0615
Schistosoma mansoni adenosylhomocysteinase 0.0679 0.3815 0.5314
Schistosoma mansoni hypothetical protein 0.0018 0.0016 0.0023
Echinococcus multilocularis serine threonine protein kinase 0.0279 0.1515 0.1514
Schistosoma mansoni biogenic amine (5HT) receptor 0.062 0.348 0.4847
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0068 0.0303 0.042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.062 0.348 0.4847
Brugia malayi PXA domain containing protein 0.0044 0.0165 0.0174
Echinococcus granulosus G protein coupled receptor 139 0.062 0.348 0.4846
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0018 0.0023
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.062 0.348 0.3479
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0036 0.0115 0.0183
Entamoeba histolytica hypothetical protein 0.0189 0.1 0.1607
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.062 0.348 0.3479
Brugia malayi AKH receptor 0.062 0.348 0.3703
Schistosoma mansoni opsin-like receptor 0.062 0.348 0.4847
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0001 0.0002
Trichomonas vaginalis AGC family protein kinase 0.0452 0.2509 0.4033
Echinococcus granulosus N chimaerin 0.0031 0.0086 0.0118
Echinococcus granulosus dro:myosuppressin receptor 0.062 0.348 0.4846
Leishmania major arginine N-methyltransferase, type I 0.0068 0.0303 0.0485
Echinococcus granulosus myotubularin protein 13 0.0035 0.0111 0.0152
Loa Loa (eye worm) TYRA-2 protein 0.062 0.348 0.3701
Echinococcus multilocularis regulator of G protein signaling 7 0.0044 0.0165 0.0163
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.062 0.348 0.3703
Echinococcus multilocularis g protein coupled receptor 0.062 0.348 0.3479
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0031 0.0086 0.0119
Brugia malayi Protein kinase domain containing protein 0.0961 0.544 0.5789
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0036 0.0115 0.0183
Trichomonas vaginalis CAMK family protein kinase 0.0055 0.0224 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0032 0.0033
Echinococcus multilocularis nervana 2 0.0043 0.0158 0.0157
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0141 0.0225
Schistosoma mansoni rac gtpase activating protein 0.0031 0.0086 0.0119
Loa Loa (eye worm) neuropeptide F receptor 0.062 0.348 0.3701
Echinococcus multilocularis mitogen activated protein kinase 0.0128 0.0648 0.0647
Echinococcus multilocularis cpg binding protein 0.0036 0.012 0.0119
Brugia malayi TAR-binding protein 0.0129 0.0652 0.0692
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.062 0.348 0.4847
Loa Loa (eye worm) hypothetical protein 0.0108 0.0531 0.0561
Schistosoma mansoni biogenic amine receptor 0.062 0.348 0.4847
Plasmodium vivax calcium-dependent protein kinase, putative 0.0055 0.0224 0.0359
Echinococcus granulosus serotonin receptor 0.062 0.348 0.4846
Echinococcus granulosus neuropeptide receptor 0.062 0.348 0.4846
Echinococcus multilocularis regulator of G protein signaling 3 0.0044 0.0165 0.0163
Giardia lamblia Kinase, CMGC MAPK 0.0128 0.0648 0.2579
Plasmodium falciparum adenosylhomocysteinase 0.1097 0.6221 1
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0018 0.0023
Echinococcus granulosus intermediate filament protein 0.003 0.0085 0.0116
Schistosoma mansoni growth hormone secretagogue receptor 0.062 0.348 0.4847
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Schistosoma mansoni alpha-1 adrenergic receptor 0.062 0.348 0.4847
Onchocerca volvulus 0.062 0.348 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0428 0.0596
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0652 0.0908
Brugia malayi regulator of G-protein signaling rgs-7 0.0044 0.0165 0.0174
Schistosoma mansoni hypothetical protein 0.0087 0.0411 0.0573
Brugia malayi PHD-finger family protein 0.0032 0.0094 0.0098
Brugia malayi hypothetical protein 0.062 0.348 0.3703
Brugia malayi ecdysteroid receptor 0.0021 0.0032 0.0033
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0141 0.0225
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0032 0.0045
Echinococcus granulosus serine:threonine protein kinase N2 0.0073 0.0333 0.0462
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0087
Echinococcus multilocularis dna polymerase eta 0.004 0.0141 0.014
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0029 0.004
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0128 0.0648 0.0686
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0001 0.0002
Echinococcus granulosus nervana 2 0.0043 0.0158 0.0219
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0066 0.0289 0.0463
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.062 0.348 0.4847
Loa Loa (eye worm) integrin alpha pat-2 0.0141 0.0722 0.0765
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0128 0.0648 0.104
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0032 0.003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0114
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0053 0.0218 0.0228
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0141 0.0225
Schistosoma mansoni neuropeptide f receptor 76f 0.062 0.348 0.4847
Schistosoma mansoni Smad4 0.0019 0.0018 0.0025
Brugia malayi Protein kinase c protein 2 0.0245 0.1321 0.1405
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0032 0.0031
Onchocerca volvulus 0.0315 0.1723 0.4927
Brugia malayi RE15519p 0.062 0.348 0.3703
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0055 0.0224 0.0361
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.0309 0.0431
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0053 0.0218 0.0228
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0333 0.0464
Echinococcus multilocularis neuropeptide receptor 0.062 0.348 0.3479
Schistosoma mansoni intermediate filament proteins 0.003 0.0085 0.0118
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0066 0.0289 0.0463
Echinococcus multilocularis neuropeptides capa receptor 0.062 0.348 0.3479
Brugia malayi Thioredoxin reductase 0.0046 0.0173 0.0183
Echinococcus multilocularis protein kinase c iota type 0.0104 0.0509 0.0507
Echinococcus granulosus methyltransferase protein 5 0.0068 0.0303 0.042
Echinococcus granulosus Glutaredoxin protein 5 0.0043 0.0158 0.0219
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0032 0.0045
Entamoeba histolytica protein kinase, putative 0.0061 0.0261 0.0419
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.0641 0.3596 0.3825
Echinococcus granulosus geminin 0.1263 0.718 1
Loa Loa (eye worm) AGC/NDR protein kinase 0.0073 0.0333 0.0351
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.0519 0.2895 0.308
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0022 0.0034 0.0053
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Brugia malayi hypothetical protein 0.0189 0.1 0.1063
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0138 0.0221
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0151 0.0208
Loa Loa (eye worm) RGS-3 protein 0.0044 0.0165 0.0171
Schistosoma mansoni smad1 5 8 and 0.0042 0.0151 0.021
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0452 0.2509 0.2508
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0077 0.0106
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.062 0.348 0.4846
Schistosoma mansoni protein kinase 0.0055 0.0224 0.0312
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0218 0.0303
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Schistosoma mansoni serine/threonine kinase 0.0073 0.0333 0.0464
Onchocerca volvulus 0.0037 0.0122 0.0302
Brugia malayi protein kinase C3,putative 0.004 0.0139 0.0146
Echinococcus granulosus mitogen activated protein kinase 0.0128 0.0648 0.0901
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus multilocularis adenosylhomocysteinase 0.1097 0.6221 0.6221
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0333 0.0533
Loa Loa (eye worm) hypothetical protein 0.0411 0.2276 0.242
Loa Loa (eye worm) neuropeptide F receptor 0.062 0.348 0.3701
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0165 0.0263
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0165 0.0263
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0066 0.0289 0.0463
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0652 0.0908
Echinococcus multilocularis rhodopsin orphan GPCR 0.062 0.348 0.3479
Schistosoma mansoni hypothetical protein 0.0024 0.0049 0.0068
Echinococcus multilocularis solute carrier family 5 0.0045 0.0171 0.017
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0648 0.104
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.062 0.348 0.4846
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0032 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.007 0.011
Brugia malayi intermediate filament protein 0.003 0.0085 0.0089
Brugia malayi Pleckstrin Homology Domain 0.0035 0.0111 0.0116
Loa Loa (eye worm) hypothetical protein 0.0044 0.0165 0.0171
Brugia malayi Carm1-pending protein 0.0068 0.0303 0.0321
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0032 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0141 0.0225
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0031 0.0086 0.0087
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0139 0.0193
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.062 0.348 0.3479
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0141 0.0149
Brugia malayi Cam kinase protein 1 0.0055 0.0224 0.0237
Onchocerca volvulus 0.062 0.348 1
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0606 0.0972
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0218 0.0303
Loa Loa (eye worm) transcription factor SMAD2 0.0614 0.3444 0.3663
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0044 0.0165 0.0229
Schistosoma mansoni hypothetical protein 0.0068 0.0303 0.0422
Leishmania major hypothetical protein, conserved 0.0066 0.0289 0.0463
Plasmodium vivax SET domain protein, putative 0.0069 0.0309 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0032 0.0033
Schistosoma mansoni serine/threonine protein kinase 0.011 0.0545 0.0759
Schistosoma mansoni neuropeptide receptor 0.062 0.348 0.4847
Echinococcus multilocularis zinc finger protein 0.0025 0.0057 0.0055
Echinococcus granulosus 7tm_1 domain containing protein 0.062 0.348 0.4846
Loa Loa (eye worm) RNA binding protein 0.0129 0.0652 0.069
Echinococcus multilocularis Rac GTPase activating protein 1 0.0031 0.0086 0.0084
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0031 0.0086 0.0087
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0452 0.2509 0.3494
Echinococcus multilocularis Regulator of G protein signaling 20 0.0044 0.0165 0.0163
Leishmania major DNA polymerase kappa, putative 0.004 0.0141 0.0225
Loa Loa (eye worm) AGC/PKA protein kinase 0.0452 0.2509 0.2668
Echinococcus multilocularis fmrfamide receptor 0.062 0.348 0.3479
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.062 0.348 0.3479
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0044 0.0165 0.0229
Brugia malayi C1-like domain containing protein 0.004 0.0139 0.0146
Schistosoma mansoni histone J3 methyltransferase 0.0519 0.2895 0.4032
Brugia malayi RNA binding protein 0.0129 0.0652 0.0692
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0096 0.0098
Schistosoma mansoni atypical protein kinase C 0.0104 0.0509 0.0708
Loa Loa (eye worm) G-protein coupled receptor 0.062 0.348 0.3701
Loa Loa (eye worm) melatonin receptor type 1A 0.062 0.348 0.3701
Schistosoma mansoni unc-13 (munc13) 0.0041 0.0147 0.0205
Brugia malayi Ras association domain family 1 isoform A 0.0031 0.0086 0.009
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0029 0.0038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0087
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Brugia malayi G protein-coupled receptor F59B2.13 0.062 0.348 0.3703
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0001 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0141 0.0225
Schistosoma mansoni protein kinase C 0.0037 0.0122 0.017
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0068 0.0303 0.0485
Schistosoma mansoni smad1 5 8 and 0.0042 0.0151 0.021
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0121 0.0607 0.0606
Onchocerca volvulus 0.0306 0.1671 0.4774
Brugia malayi diacylglycerol kinase 0.0031 0.0086 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.003
Onchocerca volvulus 0.003 0.0085 0.0193
Echinococcus multilocularis GPCR, family 2 0.0087 0.0411 0.041
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0032 0.0033
Echinococcus multilocularis isocitrate dehydrogenase 0.0036 0.0115 0.0114
Schistosoma mansoni hypothetical protein 0.0031 0.0086 0.012
Echinococcus multilocularis raf serine:threonine protein kinase 0.0031 0.0086 0.0084
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0087 0.0091
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0128 0.0648 0.104
Onchocerca volvulus 0.0031 0.0086 0.0197
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0138 0.0221
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0141 0.0195
Trypanosoma brucei unspecified product 0.0028 0.007 0.011
Onchocerca volvulus 0.0035 0.0113 0.0276
Echinococcus granulosus 7TM GPCR rhodopsin 0.062 0.348 0.4846
Brugia malayi nuclear receptor NHR-88 0.0021 0.0032 0.0033
Schistosoma mansoni neuropeptide F-like receptor 0.062 0.348 0.4847
Echinococcus multilocularis tar DNA binding protein 0.0129 0.0652 0.065
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Brugia malayi Pre-SET motif family protein 0.0479 0.2668 0.2839
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0032 0.0033
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0086 0.009
Brugia malayi Protein kinase domain containing protein 0.0073 0.0333 0.0353
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.1097 0.6221 1
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0055 0.0224 0.0359
Echinococcus granulosus biogenic amine 5HT receptor 0.062 0.348 0.4846
Brugia malayi p70 ribosomal S6 kinase beta 0.0117 0.0581 0.0617
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0452 0.2509 0.4033
Loa Loa (eye worm) raf kinase 0.0031 0.0086 0.0087
Echinococcus multilocularis neuropeptide Y receptor 0.062 0.348 0.3479
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0141 0.0225
Brugia malayi G-protein coupled receptor 0.062 0.348 0.3703
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0141 0.0225
Echinococcus multilocularis integrin alpha ps 0.0031 0.0086 0.0085
Brugia malayi hypothetical protein 0.062 0.348 0.3703
Schistosoma mansoni smad 0.0042 0.0151 0.021
Brugia malayi hypothetical protein 0.062 0.348 0.3703
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus multilocularis unc 13 (munc13) 0.0037 0.0122 0.0121
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0141 0.0225
Schistosoma mansoni hypothetical protein 0.0031 0.0086 0.0119
Giardia lamblia Kinase, AGC PKA 0.0052 0.0211 0.0838
Echinococcus multilocularis myotubularin protein 13 0.0035 0.0111 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0032 0.003
Brugia malayi Sodium:solute symporter family protein 0.0045 0.0171 0.0181
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus granulosus tm gpcr rhodopsin 0.062 0.348 0.4846
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.062 0.348 0.3701
Brugia malayi MH1 domain containing protein 0.0023 0.0043 0.0045
Trichomonas vaginalis set domain proteins, putative 0.0545 0.3049 0.49
Schistosoma mansoni biogenic amine (dopamine) receptor 0.062 0.348 0.4847
Leishmania major S-adenosylmethionine decarboxylase 0.0641 0.3596 0.578
Giardia lamblia Kinase, AGC PKA 0.0452 0.2509 1
Schistosoma mansoni amine GPCR 0.062 0.348 0.4847
Trypanosoma brucei C-8 sterol isomerase, putative 0.0436 0.2416 0.3883
Echinococcus granulosus rhodopsin orphan GPCR 0.062 0.348 0.4846
Echinococcus granulosus zinc finger protein 0.0025 0.0057 0.0077
Loa Loa (eye worm) hypothetical protein 0.0044 0.0165 0.0171
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0037 0.0122 0.0121
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0036 0.0115 0.0183
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.062 0.348 0.4847
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.062 0.348 0.4847
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0452 0.2509 0.4033
Echinococcus granulosus Regulator of G protein signaling 20 0.0044 0.0165 0.0228
Onchocerca volvulus 0.062 0.348 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0032 0.0045
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0018 0.0015
Echinococcus granulosus dna polymerase eta 0.004 0.0141 0.0195
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0452 0.2509 0.4033
Echinococcus granulosus rhodopsin orphan GPCR 0.062 0.348 0.4846
Echinococcus granulosus Smad4 0.0042 0.0151 0.0208
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus granulosus cpg binding protein 0.0036 0.012 0.0165
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0032 0.0043
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0064 0.028 0.0448
Echinococcus granulosus expressed protein 0.0861 0.4867 0.6779
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0073 0.0333 0.0332
Echinococcus multilocularis rhodopsin orphan GPCR 0.062 0.348 0.3479
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0044 0.0165 0.0228
Brugia malayi Calcitonin receptor-like protein seb-1 0.0275 0.1494 0.1589
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0052 0.0211 0.0338
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0031 0.0086 0.0087
Loa Loa (eye worm) hypothetical protein 0.0059 0.0251 0.0264
Schistosoma mansoni neuropeptide receptor 0.062 0.348 0.4847
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0121 0.0607 0.0974
Echinococcus granulosus g-protein coupled receptor 0.062 0.348 0.4846
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0141 0.0225
Trypanosoma brucei unspecified product 0.004 0.0141 0.0225
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus granulosus calcium dependent protein kinase 0.0045 0.0171 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0032 0.0033
Brugia malayi Bromodomain containing protein 0.0092 0.0442 0.0469
Echinococcus granulosus lamin dm0 0.003 0.0085 0.0116
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0333 0.0464
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0121 0.0607 0.0846
Entamoeba histolytica protein kinase, putative 0.0117 0.0581 0.0934
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0652 0.0908
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0032 0.0045
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0068 0.0303 0.0485
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus multilocularis bloom syndrome protein 0.0074 0.0338 0.0336
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0087 0.0411 0.0571
Onchocerca volvulus 0.062 0.348 1
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0219 0.0352
Schistosoma mansoni axis inhibition protein axin 0.0044 0.0165 0.0229
Loa Loa (eye worm) hypothetical protein 0.0031 0.0087 0.0088
Schistosoma mansoni DNA helicase recq5 0.0031 0.0087 0.0121
Echinococcus multilocularis rhodopsin orphan GPCR 0.062 0.348 0.3479
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0044 0.0165 0.0163
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0032 0.0043
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.003
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0121 0.0607 0.0976
Echinococcus granulosus neuropeptide receptor A26 0.062 0.348 0.4846
Echinococcus granulosus regulator of G protein signaling 7 0.0044 0.0165 0.0228
Echinococcus multilocularis N chimaerin 0.0031 0.0086 0.0084
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0031 0.0087 0.0085
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.004 0.0139 0.0137
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0185 0.0257
Brugia malayi hypoxia-induced factor 1 0.0148 0.076 0.0807
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0511 0.0819
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0085 0.0089
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0068 0.0303 0.0485
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0442 0.2456 0.342
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.062 0.348 0.4846
Entamoeba histolytica hypothetical protein 0.0081 0.0377 0.0607
Echinococcus multilocularis orexin receptor type 2 0.062 0.348 0.3479
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0087 0.0091
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0113 0.0112
Brugia malayi isocitrate dehydrogenase 0.0036 0.0115 0.0121
Loa Loa (eye worm) hypothetical protein 0.0188 0.0993 0.1054
Brugia malayi Hr1 repeat family protein 0.0073 0.0333 0.0353
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0032 0.0042
Schistosoma mansoni unc-13 (munc13) 0.0037 0.0122 0.017
Loa Loa (eye worm) hypothetical protein 0.0275 0.1494 0.1587
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.062 0.348 0.3479
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0151 0.021
Leishmania major histone-lysine N-methyltransferase, putative 0.0066 0.0289 0.0463
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0165 0.0229
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.062 0.348 0.3701
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.007 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0111 0.0114
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0087 0.0411 0.0571
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0073 0.0333 0.0332
Brugia malayi putative neuropeptide receptor 0.062 0.348 0.3703
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0139 0.0193
Brugia malayi diacylglycerol kinase 0.0031 0.0086 0.009
Onchocerca volvulus 0.0021 0.0032 0.0042
Loa Loa (eye worm) TAR-binding protein 0.0129 0.0652 0.069
Loa Loa (eye worm) isocitrate dehydrogenase 0.0036 0.0115 0.0119
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0055 0.0224 0.0223
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0087 0.0411 0.0436
Schistosoma mansoni Smad4 0.0019 0.0018 0.0025
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0141 0.0225
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0128 0.0648 0.1042
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.0641 0.3596 0.5008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.062 0.348 0.4846
Echinococcus multilocularis g protein coupled receptor 0.062 0.348 0.3479
Leishmania major hypothetical protein, conserved 0.0054 0.0219 0.035
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0189 0.1 0.1605
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0055 0.0224 0.0223
Entamoeba histolytica protein kinase, putative 0.0121 0.0606 0.0974
Echinococcus granulosus rhodopsin orphan GPCR 0.062 0.348 0.4846
Echinococcus granulosus fmrfamide receptor 0.062 0.348 0.4846
Brugia malayi Latrophilin receptor protein 2 0.0087 0.0411 0.0436
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0219 0.035
Echinococcus granulosus Diacylglycerol kinase theta 0.0031 0.0086 0.0118
Echinococcus multilocularis musashi 0.003 0.0085 0.0083
Entamoeba histolytica hypothetical protein 0.0081 0.0377 0.0607
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0141 0.014
Brugia malayi PXA domain containing protein 0.0044 0.0165 0.0174
Brugia malayi hypothetical protein 0.062 0.348 0.3703
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0173 0.0277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0032 0.003
Schistosoma mansoni hypothetical protein 0.1263 0.718 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.1191 0.1264
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0336 0.0466
Trypanosoma cruzi ISWI complex protein 0.0018 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.003 0.0081 0.0083
Echinococcus granulosus integrin alpha 3 0.0031 0.0086 0.0118
Loa Loa (eye worm) hypothetical protein 0.0055 0.0224 0.0235
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0151 0.0208
Schistosoma mansoni hypothetical protein 0.0087 0.0411 0.0573
Trypanosoma brucei protein kinase, putative 0.0128 0.0648 0.104
Leishmania major protein kinase, putative 0.0022 0.0034 0.0053
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.062 0.348 0.4847
Echinococcus granulosus unc 13 munc13 0.0037 0.0122 0.0168
Echinococcus granulosus neuropeptide Y receptor 0.062 0.348 0.4846
Brugia malayi MH1 domain containing protein 0.0023 0.0043 0.0045
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.076 0.0805
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.0641 0.3596 0.578
Leishmania major protein kinase, putative 0.0055 0.0224 0.0359
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0031 0.0087 0.0085
Echinococcus granulosus hypothetical protein 0.062 0.348 0.4846
Echinococcus granulosus solute carrier family 5 0.0045 0.0171 0.0236
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0087
Echinococcus granulosus sodium:glucose cotransporter 0.0045 0.0171 0.0236
Echinococcus granulosus single minded 2 0.0035 0.0113 0.0156
Brugia malayi Protein kinase domain containing protein 0.0121 0.0606 0.0644
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.062 0.348 0.4846
Echinococcus granulosus adenosylhomocysteinase 0.1097 0.6221 0.8665
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.0648 0.104
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0141 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.003
Schistosoma mansoni single-minded 0.0048 0.0185 0.0257
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0073 0.0333 0.0351
Echinococcus multilocularis serotonin receptor 0.062 0.348 0.3479
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0436 0.2416 0.2571
Brugia malayi A-kinase anchor protein 10, precursor 0.0044 0.0165 0.0174
Echinococcus granulosus histone h3 methyltransferase 0.0519 0.2895 0.4031
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0141 0.0225
Plasmodium falciparum calcium-dependent protein kinase 4 0.0055 0.0224 0.0359
Echinococcus multilocularis biogenic amine (5HT) receptor 0.062 0.348 0.3479
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0142 0.0725 0.1008
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0055 0.0224 0.0359
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.004 0.0139 0.0146
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.062 0.348 0.3479
Schistosoma mansoni smad1 5 8 and 0.0042 0.0151 0.021
Treponema pallidum NADH oxidase 0.0016 0.0001 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0032 0.0033
Loa Loa (eye worm) hypothetical protein 0.009 0.0428 0.0452
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0073 0.0333 0.0351
Echinococcus granulosus dna polymerase kappa 0.004 0.0141 0.0195
Schistosoma mansoni opsin-like receptor 0.062 0.348 0.4847
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0452 0.2509 0.3494
Schistosoma mansoni protein kinase C mu 0.0031 0.0086 0.0119
Entamoeba histolytica hypothetical protein 0.0044 0.0165 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0032 0.0033
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0044 0.0165 0.0263
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0032 0.0033
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0578 0.0927
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.0641 0.3596 0.3827
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0141 0.0225
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0055 0.0224 0.0223
Onchocerca volvulus 0.0069 0.0309 0.0842
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0031 0.0087 0.0137
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0073 0.0333 0.0462
Brugia malayi Regulator of G protein signaling domain containing protein 0.0044 0.0165 0.0174
Loa Loa (eye worm) MH2 domain-containing protein 0.0614 0.3444 0.3663
Loa Loa (eye worm) hypothetical protein 0.0033 0.0102 0.0104
Loa Loa (eye worm) hypothetical protein 0.0452 0.2509 0.2668
Brugia malayi Dopamine receptor protein 1 0.062 0.348 0.3703
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0022 0.0034 0.0053
Entamoeba histolytica hypothetical protein 0.0081 0.0377 0.0607
Echinococcus granulosus integrin alpha ps 0.0031 0.0086 0.0118
Brugia malayi GnHR receptor homolog 0.062 0.348 0.3703
Brugia malayi MH2 domain containing protein 0.0614 0.3444 0.3665
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0652 0.0908
Schistosoma mansoni amine GPCR 0.062 0.348 0.4847
Echinococcus multilocularis beta adrenergic receptor kinase 0.0053 0.0218 0.0216
Schistosoma mansoni bromodomain containing protein 0.0078 0.036 0.0502
Echinococcus granulosus raf serine:threonine protein kinase 0.0031 0.0086 0.0118
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.016 0.0159
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0032 0.0043
Schistosoma mansoni hypothetical protein 0.0142 0.0725 0.101
Loa Loa (eye worm) hypothetical protein 0.0519 0.2895 0.3079
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0333 0.0533
Schistosoma mansoni z-protein (S1r protein) 0.0044 0.0165 0.0229
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0045 0.0171 0.0275
Brugia malayi GH02984p 0.0411 0.2276 0.2421
Entamoeba histolytica hypothetical protein 0.0081 0.0377 0.0607
Loa Loa (eye worm) RasGEF domain-containing protein 0.0031 0.0086 0.0087
Brugia malayi CXXC zinc finger family protein 0.0032 0.0096 0.0101
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0309 0.1691 0.169
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0032 0.0045
Brugia malayi Serotonin receptor 0.062 0.348 0.3703
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0151 0.015
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0068 0.0303 0.0485
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1648 0.9396 1
Brugia malayi Bloom's syndrome protein homolog 0.0074 0.0338 0.0358
Trypanosoma brucei ISWI complex protein 0.0018 0.0016 0.0024
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0293 0.0471
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0173 0.0172
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0128 0.0648 0.104
Echinococcus granulosus alpha 1A adrenergic receptor 0.062 0.348 0.4846
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0032 0.0031
Schistosoma mansoni opsin-like receptor 0.062 0.348 0.4847
Echinococcus multilocularis mitogen activated protein kinase 3 0.0128 0.0648 0.0647
Brugia malayi Serotonin receptor 0.062 0.348 0.3703
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.062 0.348 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0087 0.0411 0.041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0122 0.0126
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0128 0.0648 0.104
Onchocerca volvulus 0.062 0.348 1
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0045 0.0171 0.017
Schistosoma mansoni biogenic amine (dopamine) receptor 0.062 0.348 0.4847
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0066 0.0291 0.0403
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0069 0.0309 0.0497
Schistosoma mansoni hypothetical protein 0.062 0.348 0.4847
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Toxoplasma gondii bicoid-interacting protein BIN3 0.0068 0.0303 0.0487
Echinococcus multilocularis dna polymerase kappa 0.004 0.0141 0.014
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0115 0.0114
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0055 0.0224 0.0223
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0032 0.0045
Onchocerca volvulus 0.062 0.348 1
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Onchocerca volvulus 0.062 0.348 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0055 0.0224 0.0361
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.062 0.348 0.3701
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.0652 0.0692
Entamoeba histolytica hypothetical protein 0.0044 0.0165 0.0265
Leishmania major S-adenosylhomocysteine hydrolase 0.1097 0.6221 1
Echinococcus granulosus NDR protein kinase 0.0073 0.0333 0.0462
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0319 0.0444
Echinococcus multilocularis Smad4 0.0042 0.0151 0.015
Echinococcus granulosus regulator of G protein signaling 3 0.0044 0.0165 0.0228
Echinococcus multilocularis regulator of G protein signaling 7 0.0044 0.0165 0.0163
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0036 0.0115 0.0183
Echinococcus granulosus thyrotropin releasing hormone receptor 0.062 0.348 0.4846
Mycobacterium tuberculosis Probable reductase 0.0104 0.0511 0.0819
Echinococcus granulosus rhodopsin orphan GPCR 0.062 0.348 0.4846
Echinococcus granulosus protein kinase c iota type 0.0104 0.0509 0.0707
Brugia malayi RhoGAP domain containing protein 0.0031 0.0086 0.009
Onchocerca volvulus 0.062 0.348 1
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Loa Loa (eye worm) nuclear factor I 0.0023 0.0043 0.0042
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0052 0.0211 0.021
Schistosoma mansoni amine GPCR 0.062 0.348 0.4847
Brugia malayi hypothetical protein 0.062 0.348 0.3703
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0141 0.0225
Echinococcus granulosus tar DNA binding protein 0.0129 0.0652 0.0906
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0068 0.0303 0.0301
Echinococcus granulosus neuropeptide FF receptor 2 0.062 0.348 0.4846
Schistosoma mansoni myosin xvIII 0.062 0.348 0.4847
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0115 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.0648 0.0903
Schistosoma mansoni sodium/solute symporter 0.0045 0.0171 0.0238
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.1097 0.6221 1
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Brugia malayi hypothetical protein 0.062 0.348 0.3703
Echinococcus multilocularis geminin 0.1263 0.718 0.7179
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.016 0.0221
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.062 0.348 0.3703
Echinococcus granulosus allatostatin A receptor 0.062 0.348 0.4846
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.011 0.0545 0.0576
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0032 0.0031
Brugia malayi Melatonin receptor type 1A 0.062 0.348 0.3703
Echinococcus granulosus somatostatin receptor 0.062 0.348 0.4846
Schistosoma mansoni inositol transporter 0.0045 0.0171 0.0238
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0121 0.0607 0.0846
Echinococcus multilocularis Glutaredoxin protein 5 0.0043 0.0158 0.0157
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0113 0.0119
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.1097 0.6221 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0151 0.0157
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Brugia malayi follicle stimulating hormone receptor 0.1648 0.9396 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.062 0.348 0.3479
Trichomonas vaginalis AGC family protein kinase 0.0073 0.0333 0.0533
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0142 0.0725 0.0724
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0068 0.0303 0.0485
Echinococcus multilocularis neuropeptide Y receptor 0.062 0.348 0.3479
Toxoplasma gondii diacylglycerol kinase, putative 0.0031 0.0086 0.0138
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0452 0.2509 0.4033
Schistosoma mansoni lamin 0.003 0.0085 0.0118
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0165 0.0229
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0452 0.2509 0.4033
Loa Loa (eye worm) glutathione reductase 0.0046 0.0173 0.0181
Echinococcus granulosus neuropeptide receptor 0.062 0.348 0.4846
Plasmodium vivax glutathione reductase, putative 0.0046 0.0173 0.0277
Onchocerca volvulus 0.062 0.348 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0141 0.0147
Brugia malayi RhoGAP domain containing protein 0.0031 0.0086 0.009
Trypanosoma brucei DNA polymerase eta, putative 0.004 0.0141 0.0225
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0452 0.2509 0.2508
Schistosoma mansoni biogenic amine receptor 0.062 0.348 0.4847
Entamoeba histolytica PH domain containing protein kinase, putative 0.0057 0.0236 0.038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.062 0.348 0.4847
Onchocerca volvulus 0.062 0.348 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0055 0.0224 0.0359
Echinococcus granulosus sex peptide receptor 0.062 0.348 0.4846
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0055 0.0224 0.0311
Brugia malayi G protein-coupled receptor 0.062 0.348 0.3703
Brugia malayi latrophilin 2 splice variant baaae 0.0188 0.0993 0.1056
Trypanosoma brucei rac serine-threonine kinase, putative 0.0121 0.0606 0.0972
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0087
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0031 0.0086 0.0084
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0073 0.0333 0.0462
Plasmodium falciparum calcium-dependent protein kinase 2 0.0055 0.0224 0.0359
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0029 0.004
Echinococcus multilocularis lamin 0.003 0.0085 0.0083
Echinococcus multilocularis protein arginine methyltransferase 0.0121 0.0607 0.0606
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0641 0.3596 0.578
Leishmania major hypothetical protein, conserved 0.0018 0.0016 0.0024
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0961 0.544 0.5788
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0108 0.0531 0.0563
Brugia malayi protein kinase C II. 0.011 0.0545 0.0579
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0068 0.0303 0.0318
Brugia malayi MH2 domain containing protein 0.0042 0.0151 0.0159
Loa Loa (eye worm) hypothetical protein 0.0189 0.1 0.1061
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0073 0.0333 0.0462
Trichomonas vaginalis DNA helicase recq, putative 0.0074 0.0338 0.0541
Echinococcus granulosus serine/threonine protein kinase 0.0057 0.0236 0.0327
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0141 0.0225
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0141 0.0225
Echinococcus multilocularis serine:threonine protein kinase 38 0.0073 0.0333 0.0332
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0031 0.0086 0.0119
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0032 0.0042
Schistosoma mansoni neuropeptide receptor 0.062 0.348 0.4847
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0032 0.0031
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0022 0.0034 0.0053
Schistosoma mansoni cpg binding protein 0.0032 0.0096 0.0134
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0606 0.0972
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0452 0.2509 0.2508
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0052 0.0211 0.0338
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0052 0.0211 0.0338
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0001 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.062 0.348 0.3479
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0031 0.0087 0.0119
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0275 0.1494 0.1587
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0121 0.0607 0.0974
Toxoplasma gondii adenosylhomocysteinase, putative 0.1097 0.6221 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0022 0.0034 0.0053
Echinococcus granulosus neuropeptide s receptor 0.062 0.348 0.4846
Schistosoma mansoni serine/threonine-protein kinase 0.0057 0.0236 0.0329
Plasmodium falciparum calcium-dependent protein kinase 1 0.0055 0.0224 0.0359
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.062 0.348 0.3703
Onchocerca volvulus 0.062 0.348 1
Echinococcus multilocularis sex peptide receptor 0.062 0.348 0.3479
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0057 0.0236 0.0378
Trypanosoma brucei unspecified product 0.0028 0.007 0.011
Trypanosoma cruzi Protein kinase B 0.0057 0.0236 0.0378
Echinococcus granulosus peptide allatostatin:somatostatin 0.062 0.348 0.4846
Echinococcus granulosus protein kinase c eta type 0.0031 0.0086 0.0118
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0032 0.0042
Echinococcus multilocularis integrin alpha ps 0.0064 0.0278 0.0277
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0141 0.0225
Onchocerca volvulus 0.062 0.348 1
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0452 0.2509 0.267
Schistosoma mansoni hypothetical protein 0.0087 0.0411 0.0573
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0032 0.0033
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0219 0.035
Echinococcus multilocularis RNA directed DNA polymerase 0.0199 0.1056 0.1055
Brugia malayi putative neuropeptide receptor NPR1 0.062 0.348 0.3703
Schistosoma mansoni transcription factor LCR-F1 0.0081 0.0377 0.0526
Brugia malayi Protein arginine N-methyltransferase 0.0068 0.0303 0.0321
Echinococcus multilocularis G-protein coupled receptor, putative 0.062 0.348 0.3479
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0053 0.0053
Toxoplasma gondii AGC kinase 0.0452 0.2509 0.4034
Schistosoma mansoni serine/threonine protein kinase 0.0309 0.1691 0.2356
Echinococcus multilocularis integrin alpha ps 0.0064 0.0278 0.0277
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0032 0.0031
Schistosoma mansoni smad 0.0019 0.0018 0.0025
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0452 0.2509 0.4033
Giardia lamblia Sgs1 DNA helicase, putative 0.0031 0.0087 0.034
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0652 0.0908
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0165 0.0263
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0479 0.2668 0.2837
Schistosoma mansoni rhodopsin-like orphan GPCR 0.062 0.348 0.4847
Echinococcus granulosus integrin alpha ps 0.0064 0.0278 0.0385
Echinococcus multilocularis allatostatin A receptor 0.062 0.348 0.3479
Schistosoma mansoni neuropeptide F-like receptor 0.062 0.348 0.4847
Schistosoma mansoni axis inhibition protein axin 0.0044 0.0165 0.0229
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.062 0.348 0.3479
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0141 0.0225
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0036 0.0115 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0032 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.062 0.348 0.3479
Brugia malayi neuropeptide F receptor 0.062 0.348 0.3703
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.0641 0.3596 0.3595
Echinococcus granulosus nervana 2 0.0043 0.0158 0.0219
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0173 0.0181
Brugia malayi PAS domain containing protein 0.0048 0.0185 0.0195
Onchocerca volvulus Neuropeptide F receptor homolog 0.062 0.348 1
Brugia malayi regulator of G-protein signaling egl-10 0.0044 0.0165 0.0174
Onchocerca volvulus 0.062 0.348 1
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0068 0.0303 0.0485
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0073 0.0333 0.0351
Brugia malayi Serotonin/octopamine receptor family protein 7 0.062 0.348 0.3703
Schistosoma mansoni DNA helicase recq1 0.0031 0.0087 0.0121
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.004 0.0139 0.0144
Schistosoma mansoni zinc finger protein 0.0018 0.0016 0.0023
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0032 0.0031
Schistosoma mansoni histamine h1 receptor 0.062 0.348 0.4847
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0032 0.0043
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0141 0.0225
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus granulosus rhodopsin orphan GPCR 0.062 0.348 0.4846
Echinococcus granulosus GPCR family 2 0.0087 0.0411 0.0571
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Entamoeba histolytica PH domain containing protein kinase, putative 0.0057 0.0236 0.038
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Brugia malayi hypothetical protein 0.0035 0.0109 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0141 0.0225
Leishmania major hypothetical protein, conserved 0.0066 0.0289 0.0463
Schistosoma mansoni adenosylhomocysteinase 0.0679 0.3815 0.5314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0032 0.003
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0606 0.0972
Echinococcus granulosus rhodopsin orphan GPCR 0.062 0.348 0.4846
Echinococcus multilocularis g-protein coupled receptor 0.062 0.348 0.3479
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0032 0.0043
Echinococcus multilocularis high affinity choline transporter 1 0.0411 0.2276 0.2275
Brugia malayi neuropeptide F receptor 0.062 0.348 0.3703
Loa Loa (eye worm) hypothetical protein 0.0073 0.0333 0.0351
Echinococcus multilocularis integrin alpha 3 0.0031 0.0086 0.0085
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0032 0.0033
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.062 0.348 0.4847
Schistosoma mansoni adenoreceptor 0.062 0.348 0.4847
Brugia malayi MH1 domain containing protein 0.0042 0.0151 0.0159
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0141 0.0225
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.003
Brugia malayi G-protein coupled receptor 0.062 0.348 0.3703
Brugia malayi Isocitrate dehydrogenase 0.0036 0.0115 0.0121
Schistosoma mansoni rhodopsin-like orphan GPCR 0.062 0.348 0.4847
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0333 0.0464
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0138 0.0221
Leishmania major protein kinase A catalytic subunit 0.0452 0.2509 0.4033
Plasmodium falciparum glutathione reductase 0.0046 0.0173 0.0277
Toxoplasma gondii thioredoxin reductase 0.0046 0.0173 0.0279
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0066 0.0289 0.0463
Echinococcus granulosus biogenic amine 5HT receptor 0.062 0.348 0.4846
Onchocerca volvulus 0.003 0.0085 0.0193
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0068 0.0303 0.0487
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0068 0.0303 0.0487
Echinococcus granulosus g protein coupled receptor 0.062 0.348 0.4846
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0065 0.0286 0.0457
Leishmania major protein kinase A catalytic subunit isoform 2 0.0452 0.2509 0.4033
Echinococcus multilocularis rhodopsin orphan GPCR 0.062 0.348 0.3479
Loa Loa (eye worm) hypothetical protein 0.0199 0.1056 0.1121
Schistosoma mansoni serine/threonine protein kinase 0.0315 0.1723 0.2401
Entamoeba histolytica recQ family helicase, putative 0.004 0.0138 0.0223
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0055 0.0224 0.0311
Loa Loa (eye worm) AGC/PKA protein kinase 0.0452 0.2509 0.2668
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.004 0.0138 0.0221
Entamoeba histolytica diacylglycerol kinase, putative 0.0031 0.0086 0.0138
Entamoeba histolytica PH domain containing protein kinase, putative 0.0456 0.2534 0.4074
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.062 0.348 0.4847
Schistosoma mansoni hypothetical protein 0.0025 0.0053 0.0074
Brugia malayi glutathione reductase 0.0046 0.0173 0.0183
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0032 0.003
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.0641 0.3596 0.578
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0452 0.2509 0.4034
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0055 0.0224 0.0235
Schistosoma mansoni protein kinase C mu 0.004 0.0139 0.0193
Onchocerca volvulus 0.062 0.348 1
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0121 0.0607 0.0846
Brugia malayi Adenosylhomocysteinase 0.1097 0.6221 0.6621
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0055 0.0224 0.0235
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0032 0.0045
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.062 0.348 0.3479
Echinococcus multilocularis neuropeptide s receptor 0.062 0.348 0.3479
Echinococcus granulosus orexin receptor type 2 0.062 0.348 0.4846
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0199 0.1056 0.1055
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0428 0.0426
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.1097 0.6221 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.003
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0044 0.0165 0.0229
Loa Loa (eye worm) hypothetical protein 0.003 0.0085 0.0086
Echinococcus granulosus rhodopsin orphan GPCR 0.062 0.348 0.4846
Loa Loa (eye worm) AGC/PKN protein kinase 0.0073 0.0333 0.0351
Loa Loa (eye worm) hypothetical protein 0.0053 0.0217 0.0227
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0141 0.0197
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0087
Loa Loa (eye worm) hypothetical protein 0.0023 0.0043 0.0042
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.003
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0336 0.0334
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0578 0.0927
Brugia malayi MH2 domain containing protein 0.0042 0.0151 0.0159
Schistosoma mansoni diacylglycerol kinase theta 0.0031 0.0086 0.0119
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0128 0.0648 0.104
Brugia malayi hypothetical protein 0.062 0.348 0.3703
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0128 0.0648 0.104
Toxoplasma gondii isocitrate dehydrogenase 0.0036 0.0115 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0218 0.0303
Giardia lamblia DINP protein human, muc B family 0.004 0.0141 0.0559
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.062 0.348 0.3479
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0068 0.0303 0.0301
Echinococcus multilocularis rho associated protein kinase 0.0315 0.1723 0.1722
Echinococcus granulosus RNA directed DNA polymerase 0.0199 0.1056 0.147
Loa Loa (eye worm) hypothetical protein 0.0044 0.0165 0.0171
Brugia malayi Pre-SET motif family protein 0.0069 0.0309 0.0328
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0043 0.0158 0.0157
Plasmodium falciparum calcium-dependent protein kinase 5 0.0055 0.0224 0.0359
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0452 0.2509 0.4033
Echinococcus granulosus axis inhibition protein axin 0.0044 0.0165 0.0228
Echinococcus multilocularis regulator of G protein signaling 0.0044 0.0165 0.0163
Echinococcus granulosus g protein coupled receptor 0.062 0.348 0.4846
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0442 0.2456 0.2455
Schistosoma mansoni amine GPCR 0.062 0.348 0.4847
Schistosoma mansoni serine/threonine protein kinase 0.0452 0.2509 0.3495
Echinococcus granulosus tm gpcr rhodopsin 0.062 0.348 0.4846
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0087 0.0411 0.041
Loa Loa (eye worm) hypothetical protein 0.0044 0.0165 0.0171
Echinococcus multilocularis rhodopsin orphan GPCR 0.062 0.348 0.3479
Brugia malayi steroid hormone receptor 0.0021 0.0032 0.0033
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0055 0.0224 0.0311
Brugia malayi RhoGEF domain containing protein 0.0031 0.0086 0.009
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.062 0.348 0.4847
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0087
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0312 0.1705 0.274
Echinococcus multilocularis dro:myosuppressin receptor 0.062 0.348 0.3479
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0018 0.0016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0032 0.0033
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.062 0.348 0.3701
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0606 0.0972
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0121 0.0607 0.0974
Echinococcus granulosus protein kinase C gamma type 0.0279 0.1515 0.2109
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Brugia malayi Tachykinin-like peptides receptor 99D 0.062 0.348 0.3703
Schistosoma mansoni biogenic amine (dopamine) receptor 0.062 0.348 0.4847
Schistosoma mansoni cpg binding protein 0.0036 0.012 0.0167
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0029 0.0027
Echinococcus multilocularis neuropeptide receptor A26 0.062 0.348 0.3479
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0165 0.0229
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0036 0.0115 0.0114
Echinococcus multilocularis expressed protein 0.0861 0.4867 0.4867
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0031 0.0087 0.0088
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0452 0.2509 0.2508
Entamoeba histolytica protein kinase, putative 0.0055 0.0224 0.036
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0068 0.0303 0.0485
Schistosoma mansoni hypothetical protein 0.062 0.348 0.4847
Schistosoma mansoni rhodopsin-like orphan GPCR 0.062 0.348 0.4847
Schistosoma mansoni adenosylhomocysteinase 0.0679 0.3815 0.5314
Echinococcus multilocularis serotonin receptor 0.062 0.348 0.3479
Schistosoma mansoni peptide (allatostatin)-like receptor 0.062 0.348 0.4847
Echinococcus multilocularis neuropeptide FF receptor 2 0.062 0.348 0.3479
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.062 0.348 0.3479
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0077 0.0108
Brugia malayi hypothetical protein 0.0044 0.0165 0.0174
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0066 0.0289 0.0463
Trichomonas vaginalis AGC family protein kinase 0.0121 0.0606 0.0972
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0113 0.018
Echinococcus granulosus mitogen activated protein kinase 3 0.0128 0.0648 0.0901
Leishmania major protein kinase, putative 0.0022 0.0034 0.0053
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0452 0.2509 0.4033
Echinococcus granulosus protein arginine N methyltransferase 7 0.0068 0.0303 0.042
Schistosoma mansoni thyroid hormone receptor 0.0163 0.0847 0.118
Trypanosoma brucei DNA polymerase kappa, putative 0.0028 0.007 0.011
Loa Loa (eye worm) G-protein coupled receptor 0.062 0.348 0.3701
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0032 0.0033
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0087 0.0139
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0165 0.0229
Echinococcus granulosus axis inhibition protein axin 0.0044 0.0165 0.0228
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0128 0.0648 0.104
Schistosoma mansoni cpg binding protein 0.0036 0.012 0.0167
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Loa Loa (eye worm) hypothetical protein 0.016 0.0831 0.0881
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0032 0.003
Schistosoma mansoni inositol transporter 0.0045 0.0171 0.0238
Loa Loa (eye worm) hypothetical protein 0.062 0.348 0.3701
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0068 0.0303 0.0485
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0044 0.0165 0.0171
Entamoeba histolytica adenosylhomocysteinase, putative 0.1097 0.6221 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0032 0.0033
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0141 0.0225
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0511 0.0819
Echinococcus granulosus protein arginine N methyltransferase 8 0.0121 0.0607 0.0844
Echinococcus multilocularis axis inhibition protein axin 0.0044 0.0165 0.0163
Onchocerca volvulus 0.062 0.348 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0173 0.0277
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0032 0.0043
Loa Loa (eye worm) hypothetical protein 0.0045 0.0171 0.0178
Echinococcus multilocularis serine:threonine protein kinase N2 0.0073 0.0333 0.0332
Echinococcus granulosus neuropeptides capa receptor 0.062 0.348 0.4846
Schistosoma mansoni thyroid hormone receptor 0.0163 0.0847 0.118
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.1097 0.6221 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0219 0.035
Schistosoma mansoni blooms syndrome DNA helicase 0.0059 0.0248 0.0345
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0031 0.0087 0.0119
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.005 0.0196 0.0315
Brugia malayi Protein kinase domain containing protein 0.004 0.0139 0.0146
Brugia malayi larval opioid receptor 0.062 0.348 0.3703
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0045 0.0171 0.017
Leishmania major arginine N-methyltransferase-like protein 0.0121 0.0607 0.0974
Echinococcus multilocularis smad 0.0042 0.0151 0.015
Onchocerca volvulus 0.0545 0.3049 0.8755
Schistosoma mansoni hypothetical protein 0.0081 0.0377 0.0526
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0018 0.0015
Onchocerca volvulus 0.0032 0.0096 0.0226
Entamoeba histolytica PH domain containing protein kinase, putative 0.0456 0.2534 0.4074
Schistosoma mansoni hypothetical protein 0.0087 0.0411 0.0573
Entamoeba histolytica protein kinase, putative 0.0121 0.0606 0.0974
Brugia malayi sulfakinin receptor protein 0.062 0.348 0.3703
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.0652 0.069
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.003
Echinococcus granulosus serine threonine protein kinase nrc 0.0052 0.0211 0.0293
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0032 0.0045
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.1097 0.6221 1
Echinococcus multilocularis neuropeptides capa receptor 0.062 0.348 0.3479
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.003
Onchocerca volvulus 0.0045 0.0171 0.0443
Brugia malayi hypothetical protein 0.062 0.348 0.3703
Echinococcus granulosus sodium:myo inositol cotransporter 0.0045 0.0171 0.0236
Echinococcus granulosus rho-associated protein kinase 1 0.0315 0.1723 0.2399
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0141 0.0197
Loa Loa (eye worm) CAMK/PKD protein kinase 0.004 0.0139 0.0144
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0068 0.0303 0.0485
Plasmodium falciparum thioredoxin reductase 0.0046 0.0173 0.0277
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0081 0.0377 0.0376
Schistosoma mansoni high-affinity choline transporter 0.0411 0.2276 0.317
Loa Loa (eye worm) hypothetical protein 0.0054 0.0219 0.0229
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0069 0.0309 0.0308
Echinococcus granulosus g protein coupled receptor 0.062 0.348 0.4846
Loa Loa (eye worm) hypothetical protein 0.0085 0.0402 0.0424
Echinococcus granulosus tachykinin peptides receptor 99D 0.062 0.348 0.4846
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0141 0.0227
Brugia malayi Integrin alpha pat-2 precursor 0.0064 0.0278 0.0294
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0219 0.035
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0043 0.0158 0.0219
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0055 0.0224 0.0311
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0452 0.2509 0.3494
Echinococcus multilocularis Diacylglycerol kinase theta 0.0031 0.0086 0.0084
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0578 0.0927
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0511 0.0819
Echinococcus multilocularis protein kinase c epsilon type 0.011 0.0545 0.0544
Trichomonas vaginalis adenosylhomocysteinase, putative 0.1097 0.6221 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0333 0.0353
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0189 0.1 0.1607
Schistosoma mansoni biogenic amine receptor 0.062 0.348 0.4847
Schistosoma mansoni serine/threonine protein kinase 0.0452 0.2509 0.3495
Echinococcus multilocularis g protein coupled receptor 0.062 0.348 0.3479
Schistosoma mansoni regulator of G protein signaling 0.0044 0.0165 0.0229
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0511 0.0819
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0275 0.1494 0.1589
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.0641 0.3596 0.578
Echinococcus granulosus neuropeptides capa receptor 0.062 0.348 0.4846
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0578 0.0117
Echinococcus multilocularis rhodopsin orphan GPCR 0.062 0.348 0.3479
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0151 0.015
Echinococcus granulosus neuropeptide Y receptor 0.062 0.348 0.4846
Toxoplasma gondii AGC kinase 0.0117 0.0581 0.0934
Loa Loa (eye worm) hypothetical protein 0.0046 0.0177 0.0184
Echinococcus granulosus sodium:glucose cotransporter 2 0.0045 0.0171 0.0236
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0055 0.0224 0.0359
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0037 0.0122 0.0168
Echinococcus multilocularis lamin dm0 0.003 0.0085 0.0083
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0018 0.0015
Schistosoma mansoni serine/threonine-protein kinase 0.0057 0.0236 0.0329
Schistosoma mansoni adenosylhomocysteinase 0.0679 0.3815 0.5314
Schistosoma mansoni hypothetical protein 0.0188 0.0993 0.1383
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0173 0.0277
Onchocerca volvulus 0.062 0.348 1
Schistosoma mansoni integrin alpha-ps 0.0033 0.0102 0.0141
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0121 0.0607 0.0974
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0052 0.0211 0.0293
Schistosoma mansoni integrin alpha 0.0064 0.0278 0.0387
Loa Loa (eye worm) hypothetical protein 0.0087 0.0411 0.0434
Loa Loa (eye worm) Carm1-pending protein 0.0068 0.0303 0.0318

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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