Detailed information for compound 864563

Basic information

Technical information
  • TDR Targets ID: 864563
  • Name: ZINC05043175
  • MW: 364.358 | Formula: C18H16N6O3
  • H donors: 1 H acceptors: 4 LogP: 2.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)c1noc(n1)c1nnn(c1N)c1ccccc1OC
  • InChi: 1S/C18H16N6O3/c1-25-12-9-7-11(8-10-12)17-20-18(27-22-17)15-16(19)24(23-21-15)13-5-3-4-6-14(13)26-2/h3-10H,19H2,1-2H3
  • InChiKey: XHZRMBMDDRSVRI-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0058 0.0155 0.3921
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0058 0.0155 0.0556
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0058 0.0155 0.3921
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0058 0.0155 0.3921
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 0.3921
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0186 0.0667
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0058 0.0155 0.0556
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0186 0.0667
Echinococcus granulosus geminin 0.0344 0.1665 0.7029
Plasmodium falciparum glutathione reductase 0.0096 0.0356 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0155 0.3921
Echinococcus multilocularis dna polymerase kappa 0.004 0.0059 0.0142
Brugia malayi MH2 domain containing protein 0.0243 0.1128 0.5442
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0025 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0025 0.0094
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 0.3921
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0041 0.0066
Brugia malayi RNA binding protein 0.0064 0.0186 0.0792
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Loa Loa (eye worm) hypothetical protein 0.005 0.0114 0.036
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Echinococcus multilocularis geminin 0.0344 0.1665 0.7029
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0186 0.0689
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0059 0.1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0219 0.1005 0.1377
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1383 0.7139 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0058 0.0155 0.3921
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0476 0.2358 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0025 0.0108
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0543 0.2711 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0244 0.1134 0.1558
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.004 0.0059 0.3772
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0058 0.0155 0.3921
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Brugia malayi glutathione reductase 0.0096 0.0356 0.1633
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0059 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0058 0.0155 0.3921
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0196 0.516
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0058 0.0155 0.064
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0058 0.0155 0.3921
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0058 0.0155 0.0535
Echinococcus granulosus dna polymerase eta 0.0066 0.0196 0.0732
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0058 0.0155 0.064
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0058 0.0155 1
Plasmodium falciparum phosphodiesterase gamma, putative 0.0058 0.0155 0.3921
Trichomonas vaginalis DNA polymerase eta, putative 0.004 0.0059 0.3772
Echinococcus granulosus dna polymerase kappa 0.004 0.0059 0.0142
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0476 0.2358 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0196 0.516
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Leishmania major hypothetical protein, conserved 0.0058 0.0155 0.3921
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0058 0.0155 0.064
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.0059 0.0119
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0058 0.0155 0.0556
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0244 0.1134 0.1558
Loa Loa (eye worm) RNA binding protein 0.0064 0.0186 0.0667
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0186 0.0792
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0058 0.0155 0.0556
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0058 0.0155 0.0556
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 0.3921
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0244 0.1134 0.1558
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0543 0.2711 0.2693
Mycobacterium ulcerans DNA polymerase IV 0.004 0.0059 0.0033
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Schistosoma mansoni hypothetical protein 0.0344 0.1665 0.7029
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 0.3921
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0058 0.0155 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0476 0.2358 0.8695
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0058 0.0155 0.0556
Giardia lamblia hypothetical protein 0.0058 0.0155 0.0658
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0058 0.0155 0.3921
Brugia malayi TAR-binding protein 0.0064 0.0186 0.0792
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0058 0.0155 0.3921
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.0059 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0058 0.0155 0.3921
Toxoplasma gondii thioredoxin reductase 0.0096 0.0356 0.1314
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.004 0.0059 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0186 0.0689
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0418 0.2052 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0196 0.0842
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 0.3921
Leishmania major DNA polymerase eta, putative 0.0066 0.0196 0.516
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0025 0.1639
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.1
Loa Loa (eye worm) hypothetical protein 0.0476 0.2358 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0058 0.0155 0.0556
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Echinococcus multilocularis dna polymerase eta 0.0066 0.0196 0.0732
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.0059 0.0142
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0058 0.0155 0.0556
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0058 0.0155 0.0556
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0058 0.0155 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0058 0.0155 0.0556
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Loa Loa (eye worm) glutathione reductase 0.0096 0.0356 0.1399
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0543 0.2711 0.2782
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0155 0.3921
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0356 1
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0155 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0058 0.0155 0.064
Leishmania major DNA polymerase eta, putative 0.0038 0.0052 0.0813
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0058 0.0155 0.0556
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0543 0.2711 0.2693
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0114 0.0439
Trypanosoma brucei unspecified product 0.004 0.0059 0.1
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0155 0.3921
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0052 0.0813
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0244 0.1134 0.021
Plasmodium falciparum thioredoxin reductase 0.0096 0.0356 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0058 0.0155 0.0556
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0186 0.0689
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 0.3921
Mycobacterium tuberculosis Probable reductase 0.0219 0.1005 0.1377
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0058 0.0155 0.3921
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0096 0.0356 0.0465
Loa Loa (eye worm) PDE1B protein 0.0058 0.0155 0.0535
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Leishmania major trypanothione reductase 0.0096 0.0356 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.0059 0.0142
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0058 0.0155 0.3921
Trypanosoma brucei trypanothione reductase 0.0096 0.0356 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0096 0.0356 0.1419
Trypanosoma cruzi DNA polymerase kappa, putative 0.004 0.0059 0.1
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0059 0.0047
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.1128 0.4718
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0219 0.1005 0.1377
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0058 0.0155 0.0556
Loa Loa (eye worm) hypothetical protein 0.0058 0.0155 0.0535
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0058 0.0155 0.3921
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0058 0.0155 0.0556
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0186 0.0689
Leishmania major hypothetical protein, conserved 0.0058 0.0155 0.3921
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0114 0.036
Leishmania major DNA polymerase kappa, putative 0.004 0.0059 0.1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0041 0.0066
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0058 0.0155 0.064
Plasmodium vivax thioredoxin reductase, putative 0.0096 0.0356 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 0.3921
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0155 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0476 0.2358 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0219 0.1005 0.1377
Schistosoma mansoni hypothetical protein 0.0034 0.0031 0.0023
Leishmania major cAMP-specific phosphodiesterase, putative 0.0058 0.0155 0.3921
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0418 0.2052 0.8688
Giardia lamblia Hypothetical protein 0.0058 0.0155 0.0658
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1383 0.7139 1
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0025 0.1639
Loa Loa (eye worm) hypothetical protein 0.0058 0.0155 0.0535
Mycobacterium tuberculosis Probable dehydrogenase 0.0219 0.1005 0.1377
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0058 0.0155 0.0556
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0186 0.0689
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0058 0.0155 0.3921
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0041 0.0066
Echinococcus granulosus tar DNA binding protein 0.0064 0.0186 0.0689
Loa Loa (eye worm) hypothetical protein 0.0058 0.0155 0.0535
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.0059 0.0163
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0476 0.2358 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0058 0.0155 0.3921
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1925 1 1
Brugia malayi hypothetical protein 0.0036 0.0041 0.0076
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0058 0.0155 0.0556
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.004 0.0059 0.1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0096 0.0356 0.1419
Plasmodium vivax glutathione reductase, putative 0.0096 0.0356 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0219 0.1005 0.1377
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0058 0.0155 0.0556
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Plasmodium vivax phosphodiesterase gamma, putative 0.0058 0.0155 0.3921
Loa Loa (eye worm) thioredoxin reductase 0.0096 0.0356 0.1399
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0155 0.3921
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0052 0.0193
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0058 0.0155 0.3921
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0058 0.0155 0.0556
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0196 0.0711
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0059 0.1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0058 0.0155 0.0556
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0031 0.0026
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0058 0.0155 0.3921
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0155 1
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0155 0.3921
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0476 0.2358 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0058 0.0155 0.064
Schistosoma mansoni DNA polymerase eta 0.0066 0.0196 0.0732
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0155 0.3921
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0058 0.0155 0.0556
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0476 0.2358 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.1128 0.4718
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.0059 0.0142
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.0059 0.0142
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0418 0.2052 0.8691
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0059 0.1
Brugia malayi Thioredoxin reductase 0.0096 0.0356 0.1633
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0114 0.0439
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0058 0.0155 0.0556
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1
Schistosoma mansoni hypothetical protein 0.0344 0.1665 0.7029
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0058 0.0155 0.0572
Schistosoma mansoni hypothetical protein 0.0036 0.0041 0.0066
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0059 0.1
Giardia lamblia DINP protein human, muc B family 0.004 0.0059 0.0248
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0058 0.0155 0.0556
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0186 0.0689
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0058 0.0155 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0418 0.2052 0.8691
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0058 0.0155 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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