Detailed information for compound 864713

Basic information

Technical information
  • TDR Targets ID: 864713
  • Name: N-[(4-chlorophenyl)methyl]-1-propylbenzimidaz ol-2-amine
  • MW: 299.798 | Formula: C17H18ClN3
  • H donors: 1 H acceptors: 1 LogP: 4.71 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCn1c(NCc2ccc(cc2)Cl)nc2c1cccc2
  • InChi: 1S/C17H18ClN3/c1-2-11-21-16-6-4-3-5-15(16)20-17(21)19-12-13-7-9-14(18)10-8-13/h3-10H,2,11-12H2,1H3,(H,19,20)
  • InChiKey: NAAFTAUAGAMTRF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-chlorophenyl)methyl]-1-propyl-benzimidazol-2-amine
  • N-[(4-chlorophenyl)methyl]-1-propyl-2-benzimidazolamine
  • (4-chlorobenzyl)-(1-propylbenzimidazol-2-yl)amine
  • AE-848/42278596

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0048 0.0036
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.006
Echinococcus granulosus Smad4 0.0008 0.0027 0.0017
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0012 0.0014
Echinococcus granulosus tumor protein p63 0.0328 0.4124 0.4821
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0373 0.2635
Toxoplasma gondii TIM10 family protein, putative 0.0046 0.0519 0.7649
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0451 0.0514
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.004 0.0444 0.052
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1674 0.1664
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0051 0.0039
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0051 0.0039
Mycobacterium ulcerans lipase LipD 0.0035 0.0373 0.0496
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0319 0.0307
Leishmania major UDP-galactopyranose mutase 0.004 0.0444 0.6484
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.022 0.0286
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.0018
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0048 0.071
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0373 0.0423
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0051 0.0046
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0519 0.7649
Schistosoma mansoni hypothetical protein 0.004 0.0432 0.0492
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0051 0.0046
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0534 0.6769 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.022 0.3123
Onchocerca volvulus 0.001 0.0051 0.0372
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.022 0.0286
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0451 0.0528
Leishmania major hypothetical protein, conserved 0.0035 0.0373 0.5417
Echinococcus multilocularis acetylcholinesterase 0.0673 0.8541 0.8539
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0319 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0051 0.006
Brugia malayi MH2 domain containing protein 0.0008 0.0027 0.0031
Entamoeba histolytica hypothetical protein 0.001 0.0048 0.0315
Mycobacterium tuberculosis Conserved protein 0.0035 0.0373 0.0551
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0012 0.0237
Loa Loa (eye worm) hypothetical protein 0.0229 0.2864 0.3353
Mycobacterium tuberculosis Conserved protein 0.0035 0.0373 0.0551
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.022 0.0286
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0051 0.006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.022 0.183
Mycobacterium leprae Probable lipase LipE 0.0035 0.0373 0.8354
Brugia malayi hypothetical protein 0.0036 0.0381 0.0446
Brugia malayi MH2 domain containing protein 0.0116 0.1409 0.165
Schistosoma mansoni patched 1 0.0041 0.0451 0.0514
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0012 0.0018
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0012 0.0018
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0048 0.0049
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0429 0.8274
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0046 0.0519 0.0608
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.022 0.3123
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0012 0.0018
Treponema pallidum DNA ligase (lig) 0.001 0.0048 0.5
Trichomonas vaginalis spcc417.12 protein, putative 0.0114 0.1381 1
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0048 0.0928
Brugia malayi Carboxylesterase family protein 0.0114 0.1381 0.1617
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0056
Loa Loa (eye worm) hypothetical protein 0.004 0.0444 0.052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0051 0.0039
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1149 0.1333
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0051 0.006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0171
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1409 0.165
Loa Loa (eye worm) hypothetical protein 0.004 0.0444 0.052
Brugia malayi Carboxylesterase family protein 0.0114 0.1381 0.1617
Loa Loa (eye worm) hypothetical protein 0.0031 0.0319 0.0373
Schistosoma mansoni smad1 5 8 and 0.0008 0.0027 0.0017
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0519 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0373 0.0496
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0056
Brugia malayi follicle stimulating hormone receptor 0.0225 0.2803 0.3282
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0051 0.0039
Schistosoma mansoni hypothetical protein 0.004 0.0432 0.0492
Chlamydia trachomatis protoporphyrinogen oxidase 0.004 0.0444 1
Schistosoma mansoni hypothetical protein 0.004 0.0432 0.0492
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0146 0.2812
Echinococcus granulosus expressed conserved protein 0.009 0.1075 0.1246
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1149 0.1138
Echinococcus granulosus para nitrobenzyl esterase 0.0114 0.1381 0.1605
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0171
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0429 0.8274
Loa Loa (eye worm) hypothetical protein 0.0035 0.0373 0.0437
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.006
Mycobacterium tuberculosis Conserved protein 0.0035 0.0373 0.0551
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0373 1
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0039 0.0429 0.6329
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.006
Loa Loa (eye worm) hypothetical protein 0.0114 0.1381 0.1617
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0373 0.0551
Echinococcus multilocularis acetylcholinesterase 0.0673 0.8541 0.8539
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0429 0.0503
Trypanosoma cruzi UDP-galactopyranose mutase 0.004 0.0444 1
Brugia malayi nuclear hormone receptor 0.001 0.0051 0.006
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0048 0.0262
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.005 0.0569 0.0666
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0373 0.0437
Brugia malayi Carboxylesterase family protein 0.0114 0.1381 0.1617
Echinococcus multilocularis lysine specific histone demethylase 1A 0.004 0.0444 0.0432
Brugia malayi Carboxylesterase family protein 0.0673 0.8541 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0012 0.0181
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.2803 0.3282
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0027 0.0031
Brugia malayi hypothetical protein 0.004 0.0444 0.052
Echinococcus granulosus nuclear factor of activated T cells 5 0.03 0.3768 0.4404
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0319 0.2307
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0048 0.0262
Loa Loa (eye worm) hypothetical protein 0.0035 0.0373 0.0437
Plasmodium vivax hypothetical protein, conserved 0.004 0.0444 0.856
Echinococcus granulosus carboxylesterase 5A 0.0673 0.8541 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0114 0.1381 0.2041
Echinococcus granulosus Ankyrin 0.0031 0.032 0.0361
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0373 0.0423
Echinococcus multilocularis para nitrobenzyl esterase 0.0114 0.1381 0.1371
Schistosoma mansoni microtubule-associated protein tau 0.067 0.8499 0.9951
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0051 0.006
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0051 0.0046
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0051 0.0039
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0373 0.8354
Onchocerca volvulus 0.0007 0.0012 0.0089
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0014
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0051 0.0039
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0678 0.0781
Echinococcus multilocularis expressed protein 0.0046 0.0519 0.0507
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.054 0.0619
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0048 0.0928
Brugia malayi AMP-binding enzyme family protein 0.0023 0.022 0.0258
Brugia malayi amine oxidase, flavin-containing family protein 0.004 0.0444 0.052
Echinococcus multilocularis 0.004 0.0444 0.0432
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0012 0.0237
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0444 0.052
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1149 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0373 0.0437
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0114 0.1381 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0051 0.006
Schistosoma mansoni hypothetical protein 0.0039 0.0429 0.0489
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0134 0.0197
Plasmodium falciparum protoporphyrinogen oxidase 0.004 0.0444 0.856
Loa Loa (eye worm) hypothetical protein 0.0023 0.022 0.0258
Onchocerca volvulus 0.0048 0.054 0.3911
Echinococcus multilocularis nibrin 0.001 0.0048 0.0036
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0027 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0373 0.0437
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1409 0.165
Onchocerca volvulus 0.0023 0.022 0.1595
Schistosoma mansoni neuroligin 3 (S09 family) 0.0114 0.1381 0.1605
Echinococcus granulosus lysine specific histone demethylase 1A 0.004 0.0444 0.0506
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0056
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.022 0.0286
Trichomonas vaginalis esterase, putative 0.0035 0.0373 0.2635
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0014
Schistosoma mansoni smad1 5 8 and 0.0008 0.0027 0.0017
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.0444 0.0656
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0525 0.0615
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0678 0.0781
Brugia malayi steroid hormone receptor 0.001 0.0051 0.006
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.022 0.183
Loa Loa (eye worm) hypothetical protein 0.0048 0.054 0.0633
Loa Loa (eye worm) carboxylesterase 0.0114 0.1381 0.1617
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0114 0.1381 0.1605
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0048 0.0262
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0678 0.0667
Brugia malayi AMP-binding enzyme family protein 0.0023 0.022 0.0258
Echinococcus granulosus acetylcholinesterase 0.0673 0.8541 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0373 0.0551
Schistosoma mansoni topbp1 0.001 0.0048 0.0042
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0678 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0048 0.0262
Loa Loa (eye worm) hypothetical protein 0.0031 0.032 0.0375
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0027 0.0017
Schistosoma mansoni smad1 5 8 and 0.0008 0.0027 0.0017
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0051 0.0046
Brugia malayi MH1 domain containing protein 0.0008 0.0027 0.0031
Onchocerca volvulus 0.001 0.0048 0.0348
Mycobacterium ulcerans carboxylesterase, LipT 0.0114 0.1381 0.1882
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0051 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0051 0.006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2784 0.4112
Schistosoma mansoni amine oxidase 0.004 0.0444 0.0506
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0048 0.0262
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.022 0.4817
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0051 0.006
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0146 0.2812
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.2864 0.2855
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0051 0.006
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0429 0.0503
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0451 0.0514
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0114 0.1381 0.1605
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0051 0.006
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.022 0.0325
Brugia malayi beta-lactamase 0.0035 0.0373 0.0437
Echinococcus multilocularis BC026374 protein (S09 family) 0.0114 0.1381 0.1371
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0373 0.0423
Echinococcus granulosus nibrin 0.001 0.0048 0.0042
Echinococcus granulosus FTZ F1 alpha 0.001 0.0051 0.0046
Echinococcus multilocularis protoporphyrinogen oxidase 0.004 0.0444 0.0432
Echinococcus multilocularis expressed conserved protein 0.009 0.1075 0.1064
Mycobacterium ulcerans hypothetical protein 0.0023 0.022 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0051 0.006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0373 0.0361
Loa Loa (eye worm) hypothetical protein 0.0673 0.8541 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0114 0.1381 0.2041
Schistosoma mansoni coup transcription factor 0.001 0.0051 0.0046
Loa Loa (eye worm) carboxylesterase 0.0114 0.1381 0.1617
Echinococcus granulosus smad 0.0008 0.0027 0.0017
Brugia malayi beta-lactamase family protein 0.0035 0.0373 0.0437
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0012 0.0018
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0673 0.8541 1
Echinococcus multilocularis tumor protein p63 0.0328 0.4124 0.4116
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0048 0.0042
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0146 0.0215
Mycobacterium tuberculosis Carboxylesterase LipT 0.0114 0.1381 0.2041
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.004 0.0444 0.856
Onchocerca volvulus 0.0114 0.1381 1
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0048 0.071
Mycobacterium ulcerans protoporphyrinogen oxidase 0.004 0.0444 0.0594
Brugia malayi hypothetical protein 0.001 0.0048 0.0056
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0373 0.0496
Schistosoma mansoni survival motor neuron protein 0.0047 0.0525 0.0601
Echinococcus multilocularis microtubule associated protein 2 0.067 0.8499 0.8497
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0373 0.0551
Mycobacterium ulcerans oxidoreductase 0.004 0.0444 0.0594
Mycobacterium tuberculosis Possible oxidoreductase 0.004 0.0444 0.0656
Giardia lamblia Replication factor C, subunit 1 0.001 0.0048 0.5
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0048 0.083
Brugia malayi Death domain containing protein 0.0031 0.0319 0.0373
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0171
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.0018
Brugia malayi MH2 domain containing protein 0.0008 0.0027 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0678 0.0916
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0039 0.0429 0.0418
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0373 0.719
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0051 0.006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0051 0.006
Schistosoma mansoni hypothetical protein 0.0031 0.0319 0.0359
Brugia malayi Carboxylesterase family protein 0.0114 0.1381 0.1617
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0373 0.0551
Plasmodium vivax hypothetical protein, conserved 0.004 0.0444 0.856
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0146 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0051 0.006
Schistosoma mansoni Smad4 0.0008 0.0027 0.0017
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0048 0.0056
Echinococcus granulosus replication factor c subunit 1 0.001 0.0048 0.0042
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0451 0.0439
Schistosoma mansoni netrin receptor unc5 0.0031 0.0319 0.0359
Echinococcus granulosus BC026374 protein S09 family 0.0114 0.1381 0.1605
Brugia malayi CHE-14 protein 0.0041 0.0451 0.0528
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0048 0.083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0051 0.006
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0319 0.0359
Brugia malayi hypothetical protein 0.0114 0.1381 0.1617
Loa Loa (eye worm) hypothetical protein 0.004 0.0444 0.052
Schistosoma mansoni DNA ligase IV 0.001 0.0048 0.0042
Brugia malayi Protein kinase domain containing protein 0.0031 0.0319 0.0373
Schistosoma mansoni hypothetical protein 0.0047 0.0525 0.0601
Schistosoma mansoni nuclear hormone receptor 0.001 0.0051 0.0046
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0051 0.0039
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0678 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0114 0.1381 0.1371
Schistosoma mansoni thyroid hormone receptor 0.001 0.0051 0.0046
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0051 0.0046
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0048 0.0262
Brugia malayi nuclear receptor NHR-88 0.001 0.0051 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0373 0.2635
Schistosoma mansoni Lysine-specific histone demethylase 1 0.004 0.0444 0.0506
Loa Loa (eye worm) hypothetical protein 0.0041 0.0451 0.0528
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0048 0.0056
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0319 0.0359
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0051 0.006
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0373 0.0551
Loa Loa (eye worm) hypothetical protein 0.0114 0.1381 0.1617
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0012 0.0018
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0051 0.0046
Schistosoma mansoni amine oxidase 0.004 0.0444 0.0506
Echinococcus multilocularis Ankyrin 0.0031 0.032 0.0308
Echinococcus granulosus lysine specific histone demethylase 1A 0.004 0.0444 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0051 0.006
Schistosoma mansoni thyroid hormone receptor 0.001 0.0051 0.0046
Mycobacterium ulcerans beta-lactamase 0.0035 0.0373 0.0496
Loa Loa (eye worm) oxidoreductase 0.0007 0.0012 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0051 0.006
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0373 0.2635
Loa Loa (eye worm) acetylcholinesterase 1 0.0673 0.8541 1
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.004 0.0444 0.6548
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0114 0.1381 0.1605
Brugia malayi Carboxylesterase family protein 0.0673 0.8541 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0575 0.7287 1
Onchocerca volvulus 0.0035 0.0373 0.2701
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0012 0.0181
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.004 0.0444 0.0506
Brugia malayi SWIRM domain containing protein 0.004 0.0444 0.052
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.022 0.3123
Loa Loa (eye worm) hypothetical protein 0.0114 0.1381 0.1617
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0134 0.0197
Loa Loa (eye worm) hypothetical protein 0.0039 0.0429 0.0503
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0146 0.2468
Echinococcus granulosus microtubule associated protein 2 0.067 0.8499 0.9951
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0051 0.0046
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0114 0.1381 0.1605
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0051 0.0046
Loa Loa (eye worm) hypothetical protein 0.0023 0.022 0.0258
Plasmodium vivax protoporphyrinogen oxidase, putative 0.004 0.0444 0.856
Loa Loa (eye worm) hypothetical protein 0.0114 0.1381 0.1617
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0056
Echinococcus multilocularis Smad4 0.0008 0.0027 0.0015
Onchocerca volvulus 0.0114 0.1381 1
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0046 0.0519 0.0594
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0051 0.0372
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0046 0.0519 0.0608
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0319 0.0359
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0048 0.083
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0012 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0373 0.2635
Brugia malayi hypothetical protein 0.0229 0.2864 0.3353
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.006
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0027 0.0031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.022 0.0325
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0678 0.1002
Onchocerca volvulus 0.0114 0.1381 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0373 0.55
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.004 0.0444 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0048 0.0262
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0051 0.0046
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0039 0.0429 0.0503
Loa Loa (eye worm) hypothetical protein 0.0023 0.022 0.0258
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.022 0.183
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0051 0.0039
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.022 0.0286
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1674 0.1948
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0373 0.2635
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0048 0.0262
Loa Loa (eye worm) beta-lactamase 0.0035 0.0373 0.0437
Mycobacterium ulcerans monoamine oxidase 0.004 0.0444 0.0594
Onchocerca volvulus 0.0047 0.0525 0.3801
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0373 0.8354
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0051 0.0372
Mycobacterium ulcerans dehydrogenase 0.004 0.0444 0.0594
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0051 0.006
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0046 0.0519 1
Brugia malayi beta-lactamase family protein 0.0035 0.0373 0.0437
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0134 0.0197
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0012 0.0014
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0051 0.006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0678 0.0916
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0451 0.3202
Onchocerca volvulus 0.0007 0.0012 0.0089
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.022 0.4817
Toxoplasma gondii histone lysine-specific demethylase 0.004 0.0444 0.6548
Echinococcus multilocularis smad 0.0008 0.0027 0.0015
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.0018
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0051 0.0039
Loa Loa (eye worm) hypothetical protein 0.0096 0.1149 0.1345
Echinococcus multilocularis neuroligin 0.0114 0.1381 0.1371
Onchocerca volvulus 0.0007 0.0012 0.0089
Brugia malayi hypothetical protein 0.0036 0.0381 0.0446
Onchocerca volvulus 0.0114 0.1381 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.022 0.0286
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.006
Echinococcus granulosus death domain containing protein 0.0031 0.0319 0.0359
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1168 0.1355
Echinococcus multilocularis protein dispatched 1 0.0047 0.0525 0.0513
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0048 0.083
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0048 0.0262
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.032 0.0361
Schistosoma mansoni acetylcholinesterase 0.0114 0.1381 0.1605
Loa Loa (eye worm) hypothetical protein 0.0114 0.1381 0.1617
Schistosoma mansoni gliotactin 0.0114 0.1381 0.1605
Loa Loa (eye worm) carboxylesterase 0.0673 0.8541 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.022 0.0258
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0027 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0171
Onchocerca volvulus 0.0035 0.0373 0.2701
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0012 0.0014
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0048 0.083
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0051 0.006
Loa Loa (eye worm) hypothetical protein 0.0673 0.8541 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0678 0.0916
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0051 0.0372
Onchocerca volvulus 0.004 0.0444 0.3216
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.004 0.0444 0.856
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0134 0.0197
Onchocerca volvulus 0.0035 0.0373 0.2701
Schistosoma mansoni hypothetical protein 0.004 0.0432 0.0492
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0014
Loa Loa (eye worm) Smad1 0.0008 0.0027 0.0031
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0373 0.0551
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0051 0.006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0051 0.006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0319 0.0373
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0048 0.0315
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.2864 0.3343
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0051 0.0046
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0051 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0051 0.006
Mycobacterium ulcerans hypothetical protein 0.0035 0.0373 0.0496
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0051 0.0046
Brugia malayi Uncoordinated protein 44 0.0031 0.0319 0.0373
Brugia malayi DKFZp564C0469 protein 0.001 0.0048 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0171
Brugia malayi Smad1 0.0008 0.0027 0.0031
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.004 0.0444 0.856
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.022 0.0286
Brugia malayi hypothetical protein 0.001 0.0048 0.0056
Loa Loa (eye worm) hypothetical protein 0.004 0.0444 0.052
Schistosoma mansoni smad 0.0008 0.0027 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0373 0.0437
Echinococcus granulosus acetylcholinesterase 0.0673 0.8541 1
Echinococcus multilocularis protein patched 0.0041 0.0451 0.0439
Schistosoma mansoni topbp1 0.001 0.0048 0.0042
Echinococcus multilocularis nuclear factor of activated T cells 5 0.03 0.3768 0.3761
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0012 0.0181
Echinococcus granulosus expressed protein 0.0046 0.0519 0.0594
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0056
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0027 0.0017
Loa Loa (eye worm) hypothetical protein 0.001 0.0051 0.006
Echinococcus granulosus neuroligin 0.0114 0.1381 0.1605
Brugia malayi topoisomerase 0.001 0.0048 0.0056
Onchocerca volvulus 0.0114 0.1381 1
Onchocerca volvulus 0.0007 0.0012 0.0089
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0027 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0051 0.0046
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0048 0.0993
Brugia malayi ecdysteroid receptor 0.001 0.0051 0.006
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0373 0.0437
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0678 0.0781
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0373 0.0551
Loa Loa (eye worm) hypothetical protein 0.0114 0.1381 0.1617
Echinococcus multilocularis carboxylesterase 5A 0.0673 0.8541 0.8539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0051 0.006
Loa Loa (eye worm) hypothetical protein 0.0114 0.1381 0.1617
Schistosoma mansoni BC026374 protein (S09 family) 0.0114 0.1381 0.1605
Brugia malayi MH1 domain containing protein 0.0008 0.0027 0.0031
Trypanosoma cruzi UDP-galactopyranose mutase 0.004 0.0444 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0373 0.8354
Loa Loa (eye worm) hypothetical protein 0.0035 0.0373 0.0437
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0051 0.0046
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1149 0.1345
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0048 0.5
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0319 0.0307
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0575 0.7287 1
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0048 0.0262

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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