Detailed information for compound 864961

Basic information

Technical information
  • TDR Targets ID: 864961
  • Name: 2-[(2-fluorophenyl)methylsulfanyl]-N-(2-metho xyphenyl)-5-methyl-7-pyridin-2-yl-1,7-dihydro -[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxami de
  • MW: 502.563 | Formula: C26H23FN6O2S
  • H donors: 2 H acceptors: 4 LogP: 4.42 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccccc1NC(=O)C1=C(C)Nc2n(C1c1ccccn1)nc(n2)SCc1ccccc1F
  • InChi: 1S/C26H23FN6O2S/c1-16-22(24(34)30-19-11-5-6-13-21(19)35-2)23(20-12-7-8-14-28-20)33-25(29-16)31-26(32-33)36-15-17-9-3-4-10-18(17)27/h3-14,23H,15H2,1-2H3,(H,30,34)(H,29,31,32)
  • InChiKey: XRXFWNJXVVNSNO-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(2-fluorophenyl)methylsulfanyl]-N-(2-methoxyphenyl)-5-methyl-7-(2-pyridyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide
  • 2-[(2-fluorophenyl)methylthio]-N-(2-methoxyphenyl)-5-methyl-7-(2-pyridyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide
  • 2-[(2-fluorobenzyl)thio]-N-(2-methoxyphenyl)-5-methyl-7-(2-pyridyl)-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide
  • Oprea1_440715

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.0029
Brugia malayi serine/threonine-protein kinase plk-2 0.03 0.6632 1
Treponema pallidum hypothetical protein 0.0238 0.524 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0083 0.0083
Trypanosoma cruzi galactokinase, putative 0.022 0.4818 0.7266
Trichomonas vaginalis CAMK family protein kinase 0.03 0.6632 1
Plasmodium vivax glutathione reductase, putative 0.0075 0.1543 0.4971
Echinococcus multilocularis geminin 0.0172 0.3735 0.3735
Trypanosoma brucei polo-like protein kinase 0.03 0.6632 1
Trypanosoma cruzi galactokinase-like protein, putative 0.022 0.4818 0.7266
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.03 0.6632 0.6632
Chlamydia trachomatis DNA topoisomerase I 0.001 0.0079 0.0196
Echinococcus multilocularis cpg binding protein 0.0036 0.0661 0.0661
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0433 0.0826
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0433 0.0652
Mycobacterium tuberculosis Probable homoserine kinase ThrB 0.004 0.0749 0.1309
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.03 0.6632 1
Echinococcus granulosus cpg binding protein 0.0036 0.0661 0.0661
Treponema pallidum galactokinase 0.022 0.4818 0.9195
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.008 0.0121
Leishmania major galactokinase-like protein 0.026 0.5724 0.8631
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.0433 0.0652
Echinococcus granulosus N acetylgalactosamine kinase 0.0132 0.284 0.284
Mycobacterium tuberculosis Probable dehydrogenase 0.0171 0.3721 0.65
Brugia malayi SWIB/MDM2 domain containing protein 0.001 0.0079 0.0119
Trypanosoma brucei mevalonate diphosphate decarboxylase 0.004 0.0749 0.113
Brugia malayi glutathione reductase 0.0075 0.1543 0.2327
Schistosoma mansoni kinase 0.0152 0.3294 0.4966
Trichomonas vaginalis galactokinase, putative 0.0054 0.1074 0.162
Giardia lamblia Mevalonate kinase 0.0094 0.198 0.2985
Trypanosoma brucei trypanothione reductase 0.0075 0.1543 0.2327
Trichomonas vaginalis glutathione reductase, putative 0.0026 0.0433 0.0652
Echinococcus granulosus geminin 0.0172 0.3735 0.3735
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.001 0.0079 0.0277
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0083 0.0125
Mycobacterium ulcerans galactokinase 0.026 0.5724 1
Mycobacterium tuberculosis Probable oxidoreductase 0.019 0.4153 0.7256
Trichomonas vaginalis galactokinase, putative 0.004 0.0749 0.113
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.0433 0.0652
Echinococcus multilocularis diphosphomevalonate decarboxylase 0.004 0.0749 0.0749
Leishmania major fucose kinase, putative 0.004 0.0749 0.113
Trypanosoma cruzi trypanothione reductase, putative 0.0075 0.1543 0.2327
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.0029
Brugia malayi hypothetical protein 0.0229 0.5037 0.7596
Echinococcus multilocularis thioredoxin glutathione reductase 0.0076 0.1566 0.1566
Echinococcus granulosus SWI:SNF matrix associated 0.001 0.0079 0.0079
Trypanosoma brucei phosphomevalonate kinase protein, putative 0.0094 0.198 0.2985
Echinococcus granulosus Upstream activation factor subunit UAF30 0.001 0.0079 0.0079
Plasmodium falciparum glutathione reductase 0.0026 0.0433 0.1394
Schistosoma mansoni hypothetical protein 0.001 0.0079 0.0119
Giardia lamblia Diphosphomevalonate decarboxylase 0.004 0.0749 0.113
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.0029
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.0433 0.0652
Plasmodium vivax hypothetical protein, conserved 0.001 0.0079 0.0254
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.0433 0.0756
Mycobacterium ulcerans homoserine kinase 0.0094 0.198 0.3459
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.001 0.0079 0.0277
Trypanosoma cruzi mevalonate kinase, putative 0.0094 0.198 0.2985
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.1484 0.2238
Brugia malayi brahma associated protein 60 kDa 0.001 0.0079 0.0119
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.0433 0.0652
Brugia malayi mevalonate kinase family protein 0.0094 0.198 0.2985
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.004 0.0749 0.113
Schistosoma mansoni cpg binding protein 0.0036 0.0661 0.0997
Treponema pallidum NADH oxidase 0.0026 0.0433 0.0826
Trichomonas vaginalis CAMK family protein kinase 0.03 0.6632 1
Schistosoma mansoni hypothetical protein 0.001 0.0079 0.0119
Mycobacterium ulcerans hypothetical protein 0.0108 0.2281 0.3985
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.001 0.0079 0.0079
Echinococcus multilocularis SWI:SNF matrix associated 0.001 0.0079 0.0079
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0036 0.0036
Trypanosoma cruzi homoserine kinase 0.0094 0.198 0.2985
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0433 0.0652
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0026 0.0433 0.1394
Giardia lamblia Kinase, PLK 0.03 0.6632 1
Schistosoma mansoni galactokinase 0.0132 0.284 0.4282
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0617 0.0931
Leishmania major fucose kinase, putative 0.004 0.0749 0.113
Echinococcus granulosus diphosphomevalonate decarboxylase 0.004 0.0749 0.0749
Loa Loa (eye worm) hypothetical protein 0.0104 0.2203 0.3322
Leishmania major mevalonate kinase, putative 0.0094 0.198 0.2985
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.0029
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.0433 0.0433
Trichomonas vaginalis CAMK family protein kinase 0.0148 0.3204 0.4831
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0433 0.0652
Wolbachia endosymbiont of Brugia malayi 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0238 0.524 1
Loa Loa (eye worm) glutathione reductase 0.0075 0.1543 0.2327
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0019 0.0029
Schistosoma mansoni hypothetical protein 0.0172 0.3735 0.5633
Trypanosoma cruzi galactokinase, putative 0.026 0.5724 0.8631
Trichomonas vaginalis CAMK family protein kinase 0.03 0.6632 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0036 0.0036
Leishmania major homoserine kinase, putative 0.0094 0.198 0.2985
Mycobacterium leprae Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 0.0238 0.524 1
Echinococcus multilocularis transcription factor eb 0.0105 0.2214 0.2214
Schistosoma mansoni hypothetical protein 0.0047 0.0903 0.1362
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0433 0.0652
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0.0433 0.1079
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0903 0.1362
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.0433 0.0652
Trichomonas vaginalis galactokinase, putative 0.0132 0.284 0.4282
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0433 0.0652
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.001 0.0079 0.0254
Trichomonas vaginalis galactokinase, putative 0.0132 0.284 0.4282
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0433 0.0652
Echinococcus multilocularis neuropeptide receptor A26 0.0448 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0171 0.3721 0.65
Trypanosoma cruzi fucose kinase, putative 0.0054 0.1074 0.162
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.0433 0.0756
Loa Loa (eye worm) hypothetical protein 0.0229 0.5037 0.7596
Echinococcus multilocularis SWI:SNF matrix associated 0.001 0.0079 0.0079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0433 0.0652
Plasmodium vivax 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative 0.0144 0.3104 1
Echinococcus granulosus neuropeptide receptor A26 0.0448 1 1
Trichomonas vaginalis galactokinase, putative 0.0132 0.284 0.4282
Echinococcus granulosus thioredoxin glutathione reductase 0.0076 0.1566 0.1566
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.0029
Toxoplasma gondii GHMP kinase, N-terminal domain-containing protein 0.0132 0.284 1
Trichomonas vaginalis CAMK family protein kinase 0.03 0.6632 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0433 0.0652
Plasmodium falciparum thioredoxin reductase 0.0075 0.1543 0.4971
Loa Loa (eye worm) galactokinase 0.0132 0.284 0.4282
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0433 0.0652
Onchocerca volvulus 0.004 0.0749 0.113
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.0433 0.0756
Echinococcus granulosus galactokinase 0.026 0.5724 0.5724
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0026 0.0433 0.0756
Schistosoma mansoni survival motor neuron protein 0.0047 0.0903 0.1362
Toxoplasma gondii thioredoxin reductase 0.0075 0.1543 0.5434
Trypanosoma cruzi fucose kinase, putative 0.0054 0.1074 0.162
Trichomonas vaginalis CAMK family protein kinase 0.03 0.6632 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.0029
Brugia malayi CXXC zinc finger family protein 0.0034 0.0617 0.0931
Chlamydia trachomatis 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0184 0.401 1
Trichomonas vaginalis CAMK family protein kinase 0.0148 0.3204 0.4831
Mycobacterium leprae PROBABLE HOMOSERINE KINASE THRB 0.004 0.0749 0.143
Leishmania major trypanothione reductase 0.0075 0.1543 0.2327
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.001 0.0079 0.0254
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0026 0.0433 0.1394
Schistosoma mansoni hypothetical protein 0.0172 0.3735 0.5633
Loa Loa (eye worm) hypothetical protein 0.0094 0.198 0.2985
Onchocerca volvulus 0.0047 0.0903 0.1362
Schistosoma mansoni mevalonate kinase 0.0094 0.198 0.2985
Trypanosoma brucei mevalonate kinase, putative 0.0094 0.198 0.2985
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.004 0.0749 0.113
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0171 0.3721 0.65
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.001 0.0079 0.0119
Echinococcus granulosus serine:threonine protein kinase PLK1 0.03 0.6632 0.6632
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0036 0.0036
Mycobacterium ulcerans diphosphomevalonate decarboxylase 0.004 0.0749 0.1309
Trichomonas vaginalis diphosphomevalonate decarboxylase, putative 0.004 0.0749 0.113
Echinococcus multilocularis Mevalonate galactokinase 0.0094 0.198 0.198
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.0029
Mycobacterium tuberculosis Possible D-alpha-D-heptose-7-phosphate kinase HddA 0.0094 0.198 0.3459
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.019 0.4153 0.7256
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.001 0.0079 0.0254
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.03 0.6632 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.0029
Schistosoma mansoni diphosphomevalonate decarboxylase 0.004 0.0749 0.113
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0105 0.2214 0.3339
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0026 0.0433 0.1523
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.0029
Leishmania major mevalonate-diphosphate decarboxylase, putative 0.004 0.0749 0.113
Loa Loa (eye worm) hypothetical protein 0.004 0.0749 0.113
Trichomonas vaginalis CAMK family protein kinase 0.03 0.6632 1
Mycobacterium ulcerans phosphomevalonate kinase 0.0094 0.198 0.3459
Schistosoma mansoni hypothetical protein 0.001 0.0079 0.0119
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0433 0.0652
Onchocerca volvulus Serine\/threonine kinase homolog 0.03 0.6632 1
Echinococcus granulosus transcription factor eb 0.0105 0.2214 0.2214
Echinococcus multilocularis N acetylgalactosamine kinase 0.0132 0.284 0.284
Trichomonas vaginalis helicase, putative 0.0008 0.0019 0.0029
Plasmodium vivax thioredoxin reductase, putative 0.0075 0.1543 0.4971
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0019 0.0276 0.0417
Loa Loa (eye worm) brahma associated protein 0.001 0.0079 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0749 0.113
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.0029
Brugia malayi diphosphomevalonate decarboxylase family protein 0.004 0.0749 0.113
Echinococcus multilocularis galactokinase 0.026 0.5724 0.5724
Echinococcus multilocularis SWI:SNF matrix associated 0.001 0.0079 0.0079
Schistosoma mansoni brg-1 associated factor 0.001 0.0079 0.0119
Mycobacterium ulcerans mevalonate kinase, Erg12 0.0094 0.198 0.3459
Trypanosoma cruzi polo-like protein kinase, putative 0.03 0.6632 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0026 0.0433 0.1394
Toxoplasma gondii GHMP kinase, putative 0.0094 0.198 0.6971
Echinococcus multilocularis neuropeptide s receptor 0.0448 1 1
Trichomonas vaginalis galactokinase, putative 0.0132 0.284 0.4282
Mycobacterium tuberculosis Probable 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase IspE (CMK) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 0.0144 0.3104 0.5423
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0083 0.0083
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.1309 0.4609
Trypanosoma cruzi galactokinase, putative 0.026 0.5724 0.8631
Brugia malayi galactokinase family protein 0.0132 0.284 0.4282
Plasmodium falciparum glutathione reductase 0.0075 0.1543 0.4971
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0019 0.0029
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0433 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.0029
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.0433 0.0433
Plasmodium falciparum thioredoxin reductase 0.0026 0.0433 0.1394
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0075 0.1543 0.2696
Echinococcus granulosus Mevalonate galactokinase 0.0094 0.198 0.198
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0079 0.0119
Entamoeba histolytica serine/threonine protein kinase, putative 0.03 0.6632 1
Trichomonas vaginalis mevalonate kinase, putative 0.004 0.0749 0.113
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0171 0.3721 0.71
Brugia malayi brahma associated protein 60 kDa 0.001 0.0079 0.0119
Brugia malayi Thioredoxin reductase 0.0075 0.1543 0.2327
Leishmania major phosphomevalonate kinase protein, putative 0.0094 0.198 0.2985
Trichomonas vaginalis mercuric reductase, putative 0.0026 0.0433 0.0652
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.5037 0.5037
Entamoeba histolytica galactokinase, putative 0.026 0.5724 0.8631
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.0433 0.0652
Giardia lamblia NADH oxidase lateral transfer candidate 0.0026 0.0433 0.0652
Schistosoma mansoni cpg binding protein 0.0036 0.0661 0.0997
Trypanosoma brucei homoserine kinase 0.0094 0.198 0.2985
Mycobacterium ulcerans 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 0.0238 0.524 0.9155
Chlamydia trachomatis SWIB complex protein 0.001 0.0079 0.0196
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0019 0.0276 0.0417
Mycobacterium tuberculosis Probable galactokinase GalK (galactose kinase) 0.026 0.5724 1
Trypanosoma cruzi mevalonate-diphosphate decarboxylase, putative 0.004 0.0749 0.113
Schistosoma mansoni serine/threonine protein kinase 0.03 0.6632 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0433 0.0826
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.0433 0.0652
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0036 0.0054
Mycobacterium tuberculosis Probable reductase 0.0171 0.3721 0.65
Onchocerca volvulus 0.0034 0.0617 0.0931
Plasmodium falciparum 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, putative 0.0144 0.3104 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0036 0.0036
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.019 0.4153 0.7256
Toxoplasma gondii NADPH-glutathione reductase 0.0026 0.0433 0.1523
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0433 0.0652
Trichomonas vaginalis CAMK family protein kinase 0.03 0.6632 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0171 0.3721 0.65
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0019 0.0029
Trypanosoma cruzi homoserine kinase 0.0094 0.198 0.2985
Trypanosoma cruzi polo-like protein kinase, putative 0.03 0.6632 1
Trypanosoma cruzi phosphomevalonate kinase protein, putative 0.004 0.0749 0.113
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.5037 0.5037
Trypanosoma brucei galactokinase-like protein, putative 0.0167 0.3633 0.5478
Trypanosoma brucei mevalonate-diphosphate decarboxylase 0.004 0.0749 0.113
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.019 0.4153 0.7926
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.0029
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0171 0.3721 0.65
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0104 0.2203 0.3322
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0019 0.0029
Schistosoma mansoni cpg binding protein 0.0034 0.0617 0.0931
Onchocerca volvulus 0.001 0.0079 0.0119
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0026 0.0433 0.1394
Loa Loa (eye worm) thioredoxin reductase 0.0075 0.1543 0.2327

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.