Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lamin | 0.0033 | 0.117 | 0.1135 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.117 | 0.1236 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.117 | 0.1236 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.117 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.117 | 0.1236 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.9182 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.117 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.113 | 0.9658 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.117 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.9182 | 0.9178 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.117 | 1 |
Onchocerca volvulus | 0.0033 | 0.117 | 0.5 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0156 | 0.1333 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.004 | 0.0342 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.117 | 0.1135 |
Onchocerca volvulus | 0.0033 | 0.117 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.117 | 0.1135 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.117 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.9182 | 0.9073 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.