Detailed information for compound 86526

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 340.592 | Formula: C14H8Cl3N3O
  • H donors: 2 H acceptors: 3 LogP: 4.84 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)c1n[nH]c(n1)c1ccc(c(c1)Cl)Cl)O
  • InChi: 1S/C14H8Cl3N3O/c15-8-2-4-12(21)9(6-8)14-18-13(19-20-14)7-1-3-10(16)11(17)5-7/h1-6,21H,(H,18,19,20)
  • InChiKey: XOXJCBKCQFJVLA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0028
Trypanosoma cruzi polo-like protein kinase, putative 0.0113 0.0395 0.1662
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0009 0.0039
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0331 0.094
Echinococcus multilocularis peregrin 0.0063 0.0191 0.0194
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0395 0.208
Echinococcus multilocularis phd:f box containing protein 0.002 0.0014 0.0014
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0449 0.1784 0.1776
Trichomonas vaginalis penicillin-binding protein, putative 0.0382 0.1506 0.7927
Trypanosoma cruzi hypothetical protein, conserved 0.0382 0.1506 0.6333
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.007
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0449 0.1784 0.1776
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0025 0.0034 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.007
Onchocerca volvulus 0.0089 0.0298 0.1343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0314 0.1652
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.0111 0.0148
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0023 0.0027 0.0176
Echinococcus granulosus chromobox protein 1 0.0072 0.0226 0.0301
Schistosoma mansoni smad1 5 8 and 0.0036 0.0077 0.0102
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0197 0.0829
Plasmodium vivax thioredoxin reductase, putative 0.0177 0.0661 0.439
Plasmodium falciparum glutathione reductase 0.0177 0.0661 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0869 0.3518 0.4674
Onchocerca volvulus 0.0032 0.006 0.0271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0197 0.0819
Toxoplasma gondii ABC1 family protein 0.0382 0.1506 1
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0025 0.0034 0.0045
Echinococcus granulosus thioredoxin glutathione reductase 0.0179 0.0668 0.0887
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Schistosoma mansoni kinase 0.0057 0.0166 0.0221
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0492 0.0653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0235 0.1239
Trichomonas vaginalis D-aminoacylase, putative 0.0382 0.1506 0.7927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0216 0.1134
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0023 0.0027 0.014
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0025 0.0034 0.0034
Brugia malayi jmjC domain containing protein 0.0207 0.0786 0.2235
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0061 0.0183 0.0771
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0023 0.0027 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0059 0.0309
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0191 0.0679
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0026 0.0035 0.0036
Schistosoma mansoni DNA polymerase eta 0.0019 0.0009 0.0012
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0009 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0159 0.0839
Schistosoma mansoni cpg binding protein 0.0094 0.0319 0.0424
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0024 0.0028 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0028
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0018 0.0003 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0159 0.0839
Loa Loa (eye worm) hypothetical protein 0.0018 0.0003 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.016 0.0843
Loa Loa (eye worm) hypothetical protein 0.0382 0.1506 0.534
Schistosoma mansoni smad1 5 8 and 0.0036 0.0077 0.0102
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.0111 0.0467
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0017 0.009
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0063 0.0417
Loa Loa (eye worm) hypothetical protein 0.0062 0.0185 0.0657
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0111 0.0585
Schistosoma mansoni ferritin light chain 0.0028 0.0044 0.0058
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0021 0.0015 0.0102
Echinococcus granulosus dna polymerase kappa 0.0019 0.0009 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.007
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0395 0.208
Leishmania major hypothetical protein, conserved 0.0382 0.1506 0.6333
Loa Loa (eye worm) nuclear factor I 0.002 0.0011 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.007
Schistosoma mansoni patched 1 0.0042 0.0102 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0683 0.3596
Brugia malayi exodeoxyribonuclease III family protein 0.0116 0.0409 0.1162
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0472 0.0627
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0059 0.0247
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0028 0.0106
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0061 0.0183 0.0761
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0235 0.1239
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0023 0.0027 0.0035
Schistosoma mansoni phd/f-box containing protein 0.002 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0109 0.0378 0.1341
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0023 0.0027 0.014
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0096 0.0432
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0587 0.2354 0.3127
Brugia malayi serine/threonine-protein kinase plk-2 0.0113 0.0395 0.1123
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0061 0.0183 0.0761
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0197 0.0819
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0014 0.0051
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0023 0.0027 0.0035
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0116 0.0409 0.2671
Leishmania major cathepsin L-like protease 0.0065 0.0197 0.0829
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0093 0.0314 0.0892
Brugia malayi RNA, U transporter 1 0.0091 0.0308 0.0875
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0177 0.0661 0.0653
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0025 0.0034 0.0179
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0168 0.0223
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0221 0.0844 0.0854
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0869 0.3518 0.3558
Echinococcus multilocularis snurportin 1 0.0343 0.1349 0.1364
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0038 0.0198
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0031 0.0059 0.0059
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.0261 0.1099
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.0111 0.0112
Loa Loa (eye worm) hypothetical protein 0.0048 0.0127 0.0451
Echinococcus multilocularis lysine specific demethylase 5A 0.0077 0.0246 0.0249
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0023 0.0027 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0048 0.025
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0009 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0216 0.1134
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0025 0.0034 0.0045
Brugia malayi latrophilin 2 splice variant baaae 0.0478 0.1906 0.5416
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0111 0.0457
Schistosoma mansoni ran 0.0024 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0121
Plasmodium vivax ataxin-2 like protein, putative 0.008 0.0261 0.1736
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0023 0.0027 0.0094
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0113 0.0395 0.04
Schistosoma mansoni protein phosphatase 2C 0.002 0.0014 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0382 0.1506 0.2001
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0226 0.1191
Schistosoma mansoni jumonji domain containing protein 0.002 0.0014 0.0019
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0009 0.0048
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0197 0.0829
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0028
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0025 0.0034 0.0045
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0113 0.0395 0.0525
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0061 0.0183 0.0771
Echinococcus multilocularis PHD finger protein rhinoceros 0.0063 0.0191 0.0194
Mycobacterium ulcerans bacterioferritin BfrB 0.0028 0.0044 0.0232
Echinococcus multilocularis chromobox protein 1 0.0072 0.0226 0.0229
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0023 0.0027 0.0076
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0051
Echinococcus granulosus expressed protein 0.0025 0.0034 0.0045
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0221 0.0844 0.0854
Brugia malayi hypothetical protein 0.0052 0.0144 0.0409
Schistosoma mansoni hypothetical protein 0.0221 0.0844 0.1122
Echinococcus multilocularis expressed protein 0.0028 0.0044 0.0044
Trichomonas vaginalis ferritin, putative 0.0028 0.0044 0.0231
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0023 0.0027 0.0112
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0023 0.0027 0.0112
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0023 0.0027 0.0094
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0038 0.0198
Plasmodium falciparum thioredoxin reductase 0.0177 0.0661 1
Schistosoma mansoni chromobox protein 0.0072 0.0226 0.0301
Brugia malayi jmjC domain containing protein 0.002 0.0014 0.0041
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0093 0.0314 0.0892
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0062 0.0326
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0003 0.0013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.028 0.1089 0.4577
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0061 0.0183 0.1217
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0038 0.0158
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0113 0.0395 0.1401
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0419 0.1662 0.5893
Schistosoma mansoni hypothetical protein 0.0023 0.0027 0.0035
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0023 0.0027 0.0402
Brugia malayi MH1 domain containing protein 0.002 0.0011 0.0032
Entamoeba histolytica serine/threonine protein kinase, putative 0.0113 0.0395 0.1123
Brugia malayi AF-10 protein 0.0021 0.0015 0.0044
Schistosoma mansoni hypothetical protein 0.0221 0.0844 0.1122
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0062 0.0326
Giardia lamblia PHD finger protein 15 0.0063 0.0191 0.4557
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0343 0.1349 0.4783
Toxoplasma gondii TIM10 family protein, putative 0.0056 0.0162 0.1077
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0131 0.0472 0.0627
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0587 0.2354 0.3127
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0014 0.0019
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0028 0.0463
Mycobacterium tuberculosis Probable reductase 0.0404 0.1598 0.159
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0116 0.0409 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0031 0.0059 0.0247
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0062 0.0326
Plasmodium falciparum phd finger protein, putative 0.0063 0.0191 0.2895
Onchocerca volvulus 0.0025 0.0034 0.0153
Toxoplasma gondii thioredoxin reductase 0.0177 0.0661 0.439
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0093 0.0314 0.0892
Schistosoma mansoni jumonji domain containing protein 0.0165 0.061 0.0811
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0111 0.0585
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0197 0.0819
Loa Loa (eye worm) hypothetical protein 0.0555 0.2223 0.7882
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0015 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.007
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0038 0.0251
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0472 0.3091
Echinococcus granulosus phd:f box containing protein 0.002 0.0014 0.0019
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0027 0.0101
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0131 0.0472 0.1984
Brugia malayi hypothetical protein 0.0025 0.0034 0.0097
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0116 0.0409 0.172
Plasmodium vivax JmjC domain containing protein 0.002 0.0014 0.0095
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0061 0.0183 0.1163
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0031 0.0059 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0235 0.1239
Brugia malayi MH1 domain containing protein 0.0036 0.0077 0.0218
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0645 0.3393
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0025 0.0034 0.0045
Trichomonas vaginalis ap endonuclease, putative 0.0116 0.0409 0.2152
Trichomonas vaginalis set domain proteins, putative 0.0477 0.19 1
Schistosoma mansoni hypothetical protein 0.1839 0.7527 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0176
Schistosoma mansoni hypothetical protein 0.0221 0.0844 0.1122
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0009 0.0012
Echinococcus multilocularis protein patched 0.0042 0.0102 0.0103
Schistosoma mansoni ferritin 0.0028 0.0044 0.0058
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0009 0.0033
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0023 0.0027 0.0112
Echinococcus granulosus beta LACTamase domain containing family member 0.0382 0.1506 0.2001
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0093 0.0314 0.1311
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0025 0.0034 0.0179
Echinococcus granulosus jumonji domain containing protein 0.0088 0.0294 0.039
Schistosoma mansoni importin beta-1 0.0032 0.0063 0.0083
Brugia malayi Importin beta-1 subunit 0.0032 0.0063 0.0178
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0274 0.1153
Echinococcus granulosus ferritin 0.0028 0.0044 0.0058
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0031 0.0031
Loa Loa (eye worm) histone methyltransferase 0.003 0.0053 0.0188
Schistosoma mansoni cript-related 0.0023 0.0027 0.0035
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0025 0.0034 0.0097
Brugia malayi hypothetical protein 0.008 0.0261 0.0743
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0063 0.0191 0.0254
Trichomonas vaginalis D-aminoacylase, putative 0.0382 0.1506 0.7927
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0023 0.0027 0.0112
Echinococcus multilocularis synaptojanin 1 0.0023 0.0027 0.0027
Leishmania major importin beta-1 subunit, putative 0.0026 0.0038 0.0158
Schistosoma mansoni hypothetical protein 0.0036 0.0079 0.0104
Plasmodium falciparum thioredoxin reductase 0.0061 0.0183 0.2772
Loa Loa (eye worm) Smad1 0.0036 0.0077 0.0272
Schistosoma mansoni hypothetical protein 0.1839 0.7527 1
Echinococcus multilocularis traf and tnf receptor associated protein 0.0023 0.0027 0.0027
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0025 0.0034 0.0121
Mycobacterium tuberculosis Probable dehydrogenase 0.0404 0.1598 0.159
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0394
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0028 0.0098
Brugia malayi jmjC domain containing protein 0.0082 0.0267 0.076
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0023 0.0027 0.0112
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0587 0.2354 0.6691
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0061 0.0183 0.1163
Schistosoma mansoni synaptojanin 0.0023 0.0027 0.0035
Echinococcus multilocularis mothers against decapentaplegic 5 0.0036 0.0077 0.0078
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0009 0.0009
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0025 0.0034 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0033 0.0173
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0027 0.0112
Schistosoma mansoni hypothetical protein 0.004 0.0096 0.0127
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0009 0.0026
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0025 0.0034 0.0045
Echinococcus multilocularis thioredoxin glutathione reductase 0.0179 0.0668 0.0675
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0492 0.0653
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0503 0.0668
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0111 0.0467
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0048 0.0127 0.0844
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0027 0.0112
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.0014 0.0216
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0093 0.0314 0.0318
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0028 0.0184
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.0645 0.2901
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0025 0.0034 0.0045
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.0111 0.0148
Trichomonas vaginalis glutathione reductase, putative 0.0061 0.0183 0.0964
Loa Loa (eye worm) transcription factor SMAD2 0.0522 0.2086 0.7397
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0185 0.0246
Schistosoma mansoni hypothetical protein 0.0478 0.1906 0.2532
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0683 0.3596
Toxoplasma gondii hypothetical protein 0.0096 0.0325 0.2156
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0109 0.0489
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0023 0.0027 0.0402
Echinococcus granulosus cpg binding protein 0.0094 0.0319 0.0424
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0056 0.0162 0.2453
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0014 0.0051
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0025 0.0034 0.0045
Brugia malayi chromobox protein homolog 3 0.004 0.0096 0.0273
Trichomonas vaginalis D-aminoacylase, putative 0.0382 0.1506 0.7927
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0197 0.0819
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0003 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0179 0.0943
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0061 0.0183 0.1163
Plasmodium falciparum importin beta, putative 0.0032 0.0063 0.0949
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.007
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0111 0.0148
Leishmania major mitochondrial DNA polymerase beta 0.0593 0.2378 1
Brugia malayi MH2 domain containing protein 0.0036 0.0077 0.0218
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0044 0.0111 0.2551
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0031 0.0059 0.0078
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0404 0.1598 0.159
Brugia malayi hypothetical protein 0.0043 0.0108 0.0307
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0197 0.0829
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0025 0.0034 0.0097
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0031 0.0031
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0176
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0025 0.0034 0.0179
Loa Loa (eye worm) hypothetical protein 0.0026 0.0036 0.0129
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0492 0.0653
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0014 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0188 0.0987
Onchocerca volvulus Phospholipase A2 homolog 0.0101 0.0347 0.1563
Leishmania major trypanothione reductase 0.0177 0.0661 0.278
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0009 0.0026
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0009 0.0026
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0036 0.0077 0.0102
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0062 0.0326
Toxoplasma gondii histone lysine methyltransferase SET1 0.0171 0.0637 0.4232
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0018 0.0003 0.0011
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0061 0.0183 0.0771
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0053 0.007
Schistosoma mansoni ran 0.0024 0.0028 0.0037
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0191 0.1271
Echinococcus multilocularis expressed conserved protein 0.0091 0.0306 0.031
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0645 0.3393
Echinococcus granulosus mothers against decapentaplegic 5 0.0036 0.0077 0.0102
Echinococcus multilocularis smad 0.0036 0.0077 0.0078
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0009 0.0048
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0009 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0197 0.0829
Echinococcus multilocularis ferritin 0.0028 0.0044 0.0044
Schistosoma mansoni ferritin 0.0028 0.0044 0.0058
Brugia malayi Bromodomain containing protein 0.0063 0.0191 0.0544
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0404 0.1598 0.893
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0102 0.0536
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0061 0.0183 0.0185
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0331 0.094
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0023 0.0027 0.014
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Entamoeba histolytica hypothetical protein 0.0869 0.3518 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0028 0.0419
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0033
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0174 0.0731
Loa Loa (eye worm) hypothetical protein 0.0382 0.1506 0.534
Brugia malayi TAR-binding protein 0.0136 0.0492 0.1397
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0048 0.0127 0.0844
Trypanosoma cruzi target of rapamycin kinase 3 0.0074 0.0236 0.0991
Schistosoma mansoni hypothetical protein 0.004 0.0096 0.0127
Schistosoma mansoni neutral sphingomyelinase 0.0023 0.0027 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0235 0.1239
Loa Loa (eye worm) MH1 domain-containing protein 0.0036 0.0077 0.0272
Onchocerca volvulus 0.015 0.0548 0.2467
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0137 0.0722
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0093 0.0314 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0137 0.0721
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0014 0.0019
Trypanosoma cruzi mitochondrial protein 99, putative 0.0023 0.0027 0.0112
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0028 0.0079
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0023 0.0027 0.0076
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0382 0.1506 0.1498
Toxoplasma gondii LsmAD domain-containing protein 0.008 0.0261 0.1736
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0062 0.0326
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0094
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0039 0.0089 0.0366
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0472 0.3091
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0593 0.2378 1
Loa Loa (eye worm) G protein alpha subunit 3 0.0025 0.0034 0.0121
Brugia malayi CCR4 0.0024 0.0028 0.008
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.0111 0.0316
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0061 0.0183 0.0771
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0038 0.0198
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0048 0.0127 0.1922
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0061 0.0183 0.0771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0059 0.0309
Schistosoma mansoni hypothetical protein 0.0221 0.0844 0.1122
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0027 0.0112
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0102 0.0361
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0063 0.0254
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0027 0.0112
Echinococcus granulosus traf and tnf receptor associated protein 0.0023 0.0027 0.0035
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0083 0.0274 0.1143
Leishmania major hypothetical protein, conserved 0.0023 0.0027 0.0112
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0116 0.0409 0.04
Trypanosoma brucei unspecified product 0.0019 0.0009 0.0028
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.007
Echinococcus multilocularis protein dispatched 1 0.0048 0.0126 0.0128
Toxoplasma gondii non-specific serine/threonine protein kinase 0.002 0.0011 0.0072
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0102 0.0103
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0048 0.0127 0.0361
Brugia malayi Latrophilin receptor protein 2 0.0221 0.0844 0.24
Echinococcus granulosus snurportin 1 0.0343 0.1349 0.1792
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0121
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0028 0.0116
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0593 0.2378 1
Brugia malayi Pre-SET motif family protein 0.0062 0.0185 0.0526
Schistosoma mansoni cpg binding protein 0.0094 0.0319 0.0424
Onchocerca volvulus Putative neutral sphingomyelinase 0.0023 0.0027 0.012
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0023 0.0027 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0059 0.0309
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0025 0.0034 0.0179
Echinococcus granulosus expressed protein 0.0028 0.0044 0.0058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0587 0.2354 0.3127
Mycobacterium ulcerans aldehyde dehydrogenase 0.0131 0.0472 0.3091
Giardia lamblia NADH oxidase lateral transfer candidate 0.0061 0.0183 0.4354
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0094
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0056 0.0162 0.0215
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0023 0.0027 0.014
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0003 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0395 0.208
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0003 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0116 0.0409 0.172
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0027 0.0176
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0191 0.0721 0.0958
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0014 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0395 0.208
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0226 0.1191
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0183 0.0771
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0009 0.0012
Schistosoma mansoni ferritin 0.0028 0.0044 0.0058
Echinococcus granulosus chromobox protein 1 0.0072 0.0226 0.0301
Echinococcus granulosus lysine specific demethylase 5A 0.0082 0.0267 0.0355
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0056 0.0162 0.1077
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0048 0.0127 0.0361
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0121
Toxoplasma gondii target of rapamycin (TOR), putative 0.0069 0.0216 0.1431
Plasmodium falciparum DNase I-like protein, putative 0.0023 0.0027 0.0402
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.028 0.1089 0.4572
Loa Loa (eye worm) beta-lactamase 0.0382 0.1506 0.534
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0009 0.0039
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0094
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0023 0.0027 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0314 0.1652
Loa Loa (eye worm) thioredoxin reductase 0.0177 0.0661 0.2344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0197 0.0819
Loa Loa (eye worm) CXXC zinc finger family protein 0.0089 0.0298 0.1058
Mycobacterium ulcerans esterase/lipase LipP 0.0382 0.1506 1
Leishmania major cathepsin L-like protease 0.0065 0.0197 0.0829
Trypanosoma brucei polo-like protein kinase 0.0113 0.0395 0.1653
Mycobacterium tuberculosis Conserved hypothetical protein 0.0312 0.1219 0.1211
Brugia malayi Phospholipase A2 family protein 0.0555 0.2223 0.6318
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0221 0.0844 0.24
Brugia malayi MH2 domain containing protein 0.0522 0.2086 0.5929
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0028 0.0044 0.0035
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0121
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0897 0.3182
Loa Loa (eye worm) hypothetical protein 0.0221 0.0844 0.2994
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0023 0.0027 0.0101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0587 0.2354 0.2381
Onchocerca volvulus 0.0074 0.0234 0.1051
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0003 0.0011
Leishmania major cathepsin L-like protease 0.0065 0.0197 0.0829
Schistosoma mansoni cpg binding protein 0.0089 0.0298 0.0397
Loa Loa (eye worm) RNA binding protein 0.0136 0.0492 0.1743
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0645 0.3393
Toxoplasma gondii FATC domain-containing protein 0.0018 0.0003 0.0017
Toxoplasma gondii aldehyde dehydrogenase 0.0131 0.0472 0.3133
Echinococcus multilocularis GPCR, family 2 0.0221 0.0844 0.0854
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0185 0.123
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0023 0.0027 0.0112
Trichomonas vaginalis esterase, putative 0.0382 0.1506 0.7927
Brugia malayi RNA binding protein 0.0136 0.0492 0.1397
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0137 0.0721
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0094
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0048 0.0127 0.0361
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0061 0.0183 0.3816
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0023 0.0027 0.014
Schistosoma mansoni synaptojanin 0.0023 0.0027 0.0035
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0009 0.0009
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0185 0.0187
Onchocerca volvulus 0.0382 0.1506 0.6775
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.007
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0059 0.0208
Entamoeba histolytica hypothetical protein 0.0869 0.3518 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0062 0.0326
Onchocerca volvulus 0.0023 0.0027 0.012
Toxoplasma gondii NADPH-glutathione reductase 0.0061 0.0183 0.1217
Schistosoma mansoni hypothetical protein 0.0048 0.0127 0.0169
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0116 0.0409 0.1162
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0025 0.0034 0.0179
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.0274 0.1153
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0131 0.0472 0.0477
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0014 0.006
Entamoeba histolytica protein kinase rad3, putative 0.0018 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.008 0.0261 0.0927
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.014 0.0588
Echinococcus granulosus synaptojanin 1 0.0023 0.0027 0.0035
Schistosoma mansoni GTP-binding protein alpha subunit 0.0025 0.0034 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0113 0.0395 0.0525
Echinococcus multilocularis dna polymerase eta 0.0019 0.0009 0.0009
Echinococcus multilocularis serine protein kinase ATM 0.0018 0.0003 0.0003
Schistosoma mansoni apoferritin-2 0.0028 0.0044 0.0058
Mycobacterium tuberculosis Probable hydrolase 0.0382 0.1506 0.1498
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0031 0.0059 0.0078
Trichomonas vaginalis ap endonuclease, putative 0.0116 0.0409 0.2152
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0025 0.0034 0.0045
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0897 0.255
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0023 0.0027 0.0101
Onchocerca volvulus 0.0382 0.1506 0.6775
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0028 0.0116
Echinococcus multilocularis jumonji domain containing protein 0.0088 0.0294 0.0297
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0056 0.0162 0.0575
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.1019 0.5365
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0023 0.0027 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0028
Leishmania major RNA-editing complex protein MP100, putative 0.0023 0.0027 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0137 0.0721
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0382 0.1506 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0082 0.0267 0.0948
Schistosoma mansoni Smad4 0.0036 0.0077 0.0102
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0079 0.0079
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0221 0.0844 0.1122
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.0492 0.1397
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0404 0.1598 0.159
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0025 0.0034 0.0179
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0023 0.0027 0.0027
Echinococcus granulosus expressed protein 0.0056 0.0162 0.0215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0056 0.0159 0.0839
Entamoeba histolytica hypothetical protein 0.0026 0.0038 0.0107
Echinococcus granulosus TGF beta signal transducer SmadC 0.0036 0.0077 0.0102
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0183 0.0771
Brugia malayi Smad1 0.0036 0.0077 0.0218
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0045 0.0116 0.033
Plasmodium vivax SET domain protein, putative 0.0062 0.0185 0.123
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.0111 0.0316
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0018 0.0003 0.0003
Mycobacterium tuberculosis Conserved protein 0.0382 0.1506 0.1498
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0116 0.0409 0.0414
Echinococcus multilocularis geminin 0.1839 0.7527 0.7612
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0025 0.0034 0.0045
Schistosoma mansoni ferritin 0.0028 0.0044 0.0058
Brugia malayi MH1 domain containing protein 0.002 0.0011 0.0032
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0014 0.0014
Brugia malayi beta-lactamase family protein 0.0382 0.1506 0.4281
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0061 0.0183 0.0771
Brugia malayi Pre-SET motif family protein 0.0419 0.1662 0.4724
Mycobacterium ulcerans lipase LipD 0.0382 0.1506 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0063 0.0191 0.0254
Entamoeba histolytica G protein alpha subunit, putative 0.0025 0.0034 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0185 0.0246
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.07 0.282 0.8016
Brugia malayi jmjC domain containing protein 0.002 0.0014 0.0041
Echinococcus granulosus smad 0.0036 0.0077 0.0102
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0183 0.0771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0059 0.0309
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0014 0.0051
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0039
Leishmania major pantothenate kinase subunit, putative 0.0023 0.0027 0.0112
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0191 0.1271
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0062 0.0326
Mycobacterium tuberculosis Probable exported protein 0.0023 0.0027 0.0017
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0023 0.0027 0.0101
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0014 0.0019
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0074 0.0236 0.0982
Treponema pallidum bacterioferrin (TpF1) 0.0028 0.0044 0.0455
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0031 0.0041
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0061 0.0183 0.0761
Brugia malayi MH2 domain containing protein 0.0036 0.0077 0.0218
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0027 0.0112
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0015 0.0054
Giardia lamblia Kinase, PLK 0.0113 0.0395 0.9656
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0061 0.0183 0.1217
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0176
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0023 0.0027 0.0101
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0116 0.0409 0.1711
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0036 0.0077 0.0078
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0024 0.0028 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.1019 0.5365
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0031 0.0041
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0593 0.2378 1
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.0261 0.3954
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0061 0.0183 0.0521
Loa Loa (eye worm) hypothetical protein 0.0382 0.1506 0.534
Schistosoma mansoni smad 0.0036 0.0077 0.0102
Mycobacterium tuberculosis Conserved protein 0.0382 0.1506 0.1498
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0382 0.1506 0.4281
Echinococcus multilocularis Smad4 0.0036 0.0077 0.0078
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0197 0.0819
Echinococcus granulosus neutral sphingomyelinase 0.0023 0.0027 0.0035
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.0111 0.0585
Onchocerca volvulus Alhambra homolog 0.0063 0.0191 0.0861
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0258 0.1357
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Plasmodium vivax glutathione reductase, putative 0.0177 0.0661 0.439
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.1019 0.5365
Loa Loa (eye worm) jmjC domain-containing protein 0.0131 0.047 0.1666
Schistosoma mansoni smad1 5 8 and 0.0036 0.0077 0.0102
Loa Loa (eye worm) hypothetical protein 0.0032 0.006 0.0213
Brugia malayi beta-lactamase 0.0382 0.1506 0.4281
Brugia malayi jmjC domain containing protein 0.002 0.0014 0.0041
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0025 0.0034 0.0045
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0028
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0116 0.0409 0.145
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0053 0.0054
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0045 0.0116 0.033
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0023 0.0027 0.0076
Plasmodium falciparum glutathione reductase 0.0061 0.0183 0.2772
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0337 0.0448
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0492 0.0653
Loa Loa (eye worm) hypothetical protein 0.0478 0.1906 0.6757
Echinococcus granulosus dna polymerase eta 0.0019 0.0009 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0048 0.025
Onchocerca volvulus Serine\/threonine kinase homolog 0.0113 0.0395 0.1778
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0009 0.0039
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0027 0.0101
Brugia malayi G-protein alpha subunit 0.0025 0.0034 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0096 0.0506
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0111 0.0148
Brugia malayi Heterochromatin protein 1 0.0072 0.0226 0.0643
Leishmania major hypothetical protein, conserved 0.0023 0.0027 0.0112
Schistosoma mansoni carbon catabolite repressor protein 0.0023 0.0027 0.0035
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0061 0.0183 0.3816
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0197 0.0819
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0028
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.1019 0.5365
Leishmania major phosphatidylinositol 3-kinase, putative 0.0031 0.0059 0.0247
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0027 0.0112
Loa Loa (eye worm) MH2 domain-containing protein 0.0522 0.2086 0.7397
Echinococcus granulosus peregrin 0.0063 0.0191 0.0254
Loa Loa (eye worm) hypothetical protein 0.0063 0.0191 0.0679
Loa Loa (eye worm) hypothetical protein 0.004 0.0096 0.0341
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0074 0.0234 0.031
Entamoeba histolytica Ran family GTPase 0.0024 0.0028 0.0079
Schistosoma mansoni hypothetical protein 0.0021 0.0015 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0216 0.1134
Trypanosoma cruzi polo-like protein kinase, putative 0.0113 0.0395 0.1662
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0013 0.007
Brugia malayi jmjC domain containing protein 0.002 0.0014 0.0041
Echinococcus multilocularis expressed protein 0.0025 0.0034 0.0034
Echinococcus multilocularis beta LACTamase domain containing family member 0.0382 0.1506 0.1523
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0025 0.0034 0.0045
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0061 0.0183 0.5
Echinococcus multilocularis cpg binding protein 0.0094 0.0319 0.0323
Trypanosoma brucei RNA editing exonuclease 2 0.0023 0.0027 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0235 0.1239
Giardia lamblia Inositol 5-phosphatase 4 0.0023 0.0027 0.0435
Schistosoma mansoni hypothetical protein 0.0063 0.0191 0.0254
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0059 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0003 0.0013
Loa Loa (eye worm) phosphatidylinositol 3 0.0093 0.0314 0.1113
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0027 0.0112
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0093 0.0314 0.1311
Echinococcus granulosus Smad4 0.0036 0.0077 0.0102
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0191 0.1271
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0031 0.0059 0.0236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0157 0.0827
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0011 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0197 0.0819
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0116 0.0409 0.6186
Schistosoma mansoni hypothetical protein 0.0869 0.3518 0.4674
Loa Loa (eye worm) hypothetical protein 0.07 0.282 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0223
Brugia malayi glutathione reductase 0.0177 0.0661 0.1879
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0025 0.0034 0.0034
Brugia malayi F/Y-rich N-terminus family protein 0.005 0.0137 0.0389
Leishmania major hypothetical protein, conserved 0.0023 0.0027 0.0112
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0023 0.0027 0.0094
Loa Loa (eye worm) hypothetical protein 0.015 0.0548 0.1945
Loa Loa (eye worm) pigment dispersing factor receptor c 0.07 0.282 1
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0025 0.0034 0.0034
Onchocerca volvulus 0.0477 0.19 0.8548
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0031 0.0059 0.0247
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0183 0.0771
Schistosoma mansoni fkbp-rapamycin associated protein 0.0018 0.0003 0.0003
Brugia malayi beta-lactamase family protein 0.0382 0.1506 0.4281
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0018 0.0003 0.0007
Echinococcus granulosus serine protein kinase ATM 0.0018 0.0003 0.0003
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0025 0.0034 0.0045
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0331 0.0439
Loa Loa (eye worm) glutathione reductase 0.0177 0.0661 0.2344
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0026 0.0038 0.0572
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0056 0.0162 0.1077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0009 0.0039
Schistosoma mansoni hypothetical protein 0.0343 0.1349 0.1792
Schistosoma mansoni GTP-binding protein alpha subunit 0.0025 0.0034 0.0045
Schistosoma mansoni hypothetical protein 0.004 0.0096 0.0127
Leishmania major hypothetical protein, conserved 0.002 0.0014 0.006
Trichomonas vaginalis penicillin-binding protein, putative 0.0382 0.1506 0.7927
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0449 0.1784 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0185 0.0187
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0176
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0093 0.0314 0.0417
Leishmania major DNA polymerase kappa, putative 0.0019 0.0009 0.0039
Loa Loa (eye worm) hypothetical protein 0.0382 0.1506 0.534
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0018 0.0003 0.0003
Trichomonas vaginalis ran, putative 0.0024 0.0028 0.0146
Plasmodium vivax exodeoxyribonuclease III, putative 0.0023 0.0027 0.0176
Mycobacterium tuberculosis Probable lipase LipD 0.0382 0.1506 0.1498
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0051
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0093 0.0314 0.132
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0074 0.0236 0.0991
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0382 0.1506 0.1498
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0025 0.0034 0.0097
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0113 0.0395 0.1662
Onchocerca volvulus 0.0023 0.0027 0.012
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0116 0.0409 1
Trichomonas vaginalis mercuric reductase, putative 0.0061 0.0183 0.0964
Echinococcus multilocularis expressed protein 0.0056 0.0162 0.0164
Echinococcus multilocularis chromobox protein 1 0.0072 0.0226 0.0229
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0061 0.0183 0.0174
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0025 0.0034 0.0097
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0025 0.0034 0.0121
Echinococcus granulosus GPCR family 2 0.0221 0.0844 0.1122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0216 0.1134
Brugia malayi PHD-finger family protein 0.0063 0.0191 0.0544
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0176
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0093 0.0314 0.132
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0028 0.0044 0.0035
Loa Loa (eye worm) hypothetical protein 0.0051 0.0141 0.0499
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0079 0.0104
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0009 0.0039
Mycobacterium ulcerans beta-lactamase 0.0382 0.1506 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0028 0.0028
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0063 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0183 0.0771
Schistosoma mansoni hypothetical protein 0.004 0.0096 0.0127
Leishmania major DNA polymerase eta, putative 0.0019 0.0009 0.0039
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0382 0.1506 0.1498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0216 0.1134
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0274 0.1153
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0061 0.0183 0.2772
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0395 0.208
Trichomonas vaginalis Phospholipase C precursor, putative 0.0023 0.0027 0.014
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0096 0.0506
Mycobacterium tuberculosis Probable esterase LipL 0.0382 0.1506 0.1498
Leishmania major hypothetical protein, conserved 0.008 0.0261 0.1099
Brugia malayi CHE-14 protein 0.0042 0.0102 0.029
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0025 0.0034 0.0179
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0009 0.0028
Treponema pallidum exodeoxyribonuclease (exoA) 0.0116 0.0409 1
Trypanosoma brucei hypothetical protein, conserved 0.0382 0.1506 0.6329
Brugia malayi Thioredoxin reductase 0.0177 0.0661 0.1879
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.016 0.0843
Brugia malayi hypothetical protein 0.0869 0.3518 1
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0025 0.0034 0.0045
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0023 0.0027 0.0101
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0025 0.0034 0.0121
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0093 0.0314 0.0417
Schistosoma mansoni jumonji/arid domain-containing protein 0.0082 0.0267 0.0355
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0645 0.3393
Trypanosoma brucei trypanothione reductase 0.0177 0.0661 0.2772
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0404 0.1598 0.159
Onchocerca volvulus 0.0025 0.0034 0.0153
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0116 0.0409 0.0543
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0207 0.0786 0.1045
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0025 0.0034 0.0097
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0025 0.0034 0.0097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.0116 0.0154
Loa Loa (eye worm) hypothetical protein 0.0382 0.1506 0.534
Brugia malayi Calcitonin receptor-like protein seb-1 0.07 0.282 0.8016
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0185 0.0246
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0109 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0137 0.0722
Brugia malayi CXXC zinc finger family protein 0.0089 0.0298 0.0848
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0382 0.1506 0.2001
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0061 0.0183 0.1217
Schistosoma mansoni ap endonuclease 0.0116 0.0409 0.0543
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.0014 0.0095
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0028 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0028
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0025 0.0034 0.0045
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0023 0.0027 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0587 0.2354 0.3127
Leishmania major GTP-binding protein, putative 0.0024 0.0028 0.0116
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0197 0.0819
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0044 0.0112 0.0459
Toxoplasma gondii exonuclease III APE 0.0116 0.0409 0.2715
Mycobacterium tuberculosis Probable oxidoreductase 0.0449 0.1784 0.1776
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0264 0.1019 0.2898
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0023 0.0027 0.0027
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0093 0.0314 0.132
Mycobacterium ulcerans bacterioferritin BfrA 0.0028 0.0044 0.0232
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0116 0.0409 0.2715
Trypanosoma cruzi trypanothione reductase, putative 0.0177 0.0661 0.278
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0028
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0059 0.0167
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0197 0.0819
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0025 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0382 0.1506 0.534
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0014 0.006
Mycobacterium leprae conserved hypothetical protein 0.0382 0.1506 0.8403
Loa Loa (eye worm) MH2 domain-containing protein 0.0036 0.0077 0.0272
Echinococcus granulosus tar DNA binding protein 0.0136 0.0492 0.0653
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0062 0.0326
Schistosoma mansoni ap endonuclease 0.0116 0.0409 0.0543
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0015 0.0054
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0026 0.0035 0.0047
Treponema pallidum NADH oxidase 0.0061 0.0183 0.4097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0314 0.1652
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0061 0.0183 0.0771
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0587 0.2354 0.2381
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.0111 0.0148
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0109 0.0572
Echinococcus multilocularis tar DNA binding protein 0.0136 0.0492 0.0497
Giardia lamblia GTOR 0.0093 0.0314 0.7624
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0009 0.0028
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0395 0.208
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.0492 0.1743
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.0111 0.0112
Onchocerca volvulus Phospholipase A2 homolog 0.0555 0.2223 1
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0023 0.0027 0.014
Onchocerca volvulus 0.0025 0.0034 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.1019 0.5365
Plasmodium vivax importin-beta 2, putative 0.0032 0.0063 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0137 0.0722
Schistosoma mansoni ferritin light chain 0.0028 0.0044 0.0058
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.028 0.1089 0.4577
Mycobacterium ulcerans hypothetical protein 0.0382 0.1506 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0061 0.0183 0.0243
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0185 0.0246
Loa Loa (eye worm) latrophilin receptor protein 2 0.0221 0.0844 0.2994
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0025 0.0034 0.0045
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0025 0.0034 0.0097
Trypanosoma brucei PAB1-binding protein , putative 0.008 0.0261 0.109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0157 0.0827
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.0111 0.0467
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0176
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0587 0.2354 0.3127
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0025 0.0034 0.0097
Mycobacterium ulcerans hypothetical protein 0.0312 0.1219 0.8085
Schistosoma mansoni nocturnin 0.0023 0.0027 0.0035
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0264 0.1019 0.3615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0197 0.0819
Toxoplasma gondii histone lysine demethylase JMJD6a 0.002 0.0014 0.0095
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0009 0.0039
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0102 0.0349 0.1469
Loa Loa (eye worm) hypothetical protein 0.0025 0.0034 0.0121
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0331 0.0334
Leishmania major endonuclease/exonuclease protein-like protein 0.0023 0.0027 0.0112
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.0261 0.1099
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0207 0.0786 0.0795
Echinococcus multilocularis neutral sphingomyelinase 0.0023 0.0027 0.0027
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.0261 0.3954
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0492 0.0653
Schistosoma mansoni chromobox protein 0.0072 0.0226 0.0301
Loa Loa (eye worm) hypothetical protein 0.0097 0.0331 0.1173
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0023 0.0027 0.0402
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0226 0.0803
Schistosoma mansoni apoferritin-2 0.0028 0.0044 0.0058
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0061 0.0183 0.0761
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0116 0.0409 0.172
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.1019 0.5365
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2411 0.9888 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0347 0.1232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0216 0.1134
Echinococcus granulosus importin subunit beta 1 0.0032 0.0063 0.0083
Schistosoma mansoni transcription factor LCR-F1 0.0869 0.3518 0.4674
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0028 0.0184
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0048 0.0127 0.0129
Echinococcus multilocularis deoxyribonuclease 1 2 0.0023 0.0027 0.0027
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0014 0.0014
Mycobacterium leprae Probable lipase LipE 0.0382 0.1506 0.8403
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0023 0.0027 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0645 0.3393
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.0111 0.0112
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0587 0.2354 0.8348
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0102 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0645 0.3393
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0404 0.1598 0.159
Schistosoma mansoni aldehyde dehydrogenase 0.0131 0.0472 0.0627
Giardia lamblia hypothetical protein 0.0023 0.0027 0.0435
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0023 0.0122
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0023 0.0027 0.0176
Onchocerca volvulus 0.0382 0.1506 0.6775
Entamoeba histolytica hypothetical protein 0.0869 0.3518 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0131 0.0472 0.0463
Trypanosoma cruzi mitochondrial protein 99, putative 0.0023 0.0027 0.0112
Entamoeba histolytica hypothetical protein 0.0869 0.3518 1
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0023 0.0027 0.0094
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0056 0.0162 0.0461
Entamoeba histolytica hypothetical protein 0.0018 0.0003 0.0007
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0023 0.0027 0.0076
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0025 0.0034 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0382 0.1506 1
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0023 0.0027 0.0402
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0023 0.0027 0.0112
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0025 0.0034 0.0045
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0645 0.3393
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0137 0.0722
Brugia malayi PHD-finger family protein 0.0026 0.0036 0.0103
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0009 0.0028
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0061 0.0183 0.2772
Trichomonas vaginalis CAMK family protein kinase 0.0113 0.0395 0.208
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0063 0.0254
Trichomonas vaginalis helicase, putative 0.002 0.0013 0.007
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.0014 0.0049
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0382 0.1506 0.534
Mycobacterium tuberculosis Probable lipase LipE 0.0382 0.1506 0.1498
Trypanosoma cruzi hypothetical protein, conserved 0.0382 0.1506 0.6333
Echinococcus granulosus expressed conserved protein 0.0091 0.0306 0.0407
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0023 0.0027 0.0076
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0221 0.0844 0.1122
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0014 0.0014
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0061 0.0183 0.0243
Brugia malayi MH1 domain containing protein 0.0036 0.0077 0.0218
Schistosoma mansoni jumonji/arid domain-containing protein 0.0082 0.0267 0.0355
Loa Loa (eye worm) TAR-binding protein 0.0136 0.0492 0.1743
Echinococcus granulosus geminin 0.1839 0.7527 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0503 0.0508
Loa Loa (eye worm) hypothetical protein 0.0042 0.0102 0.0361
Trichomonas vaginalis PIKK family atypical protein kinase 0.0069 0.0216 0.1134
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0102 0.0135
Brugia malayi hypothetical protein 0.015 0.0548 0.1559
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0023 0.0122
Brugia malayi hypothetical protein 0.0043 0.0108 0.0307
Mycobacterium tuberculosis Conserved protein 0.0382 0.1506 0.1498
Trypanosoma cruzi trypanothione reductase, putative 0.0061 0.0183 0.0771
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0025 0.0034 0.0097

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 500 uM Ability to inhibit autophosphorylation of KinA/Sp0F assay ChEMBL. 9873461
IC50 (binding) > 500 uM Ability to inhibit autophosphorylation of KinA/Sp0F assay ChEMBL. 9873461
MIC (functional) > 32 ug ml-1 Minimum inhibitory concentration of the compound was determined for Gram-positive antibacterial activity by using standard MIC broth assay method ChEMBL. 9873461

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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