Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0275 | 0.0275 |
Trypanosoma brucei | NADH-cytochrome b5 reductase-like protein | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Brugia malayi | diaphorase | 0.0057 | 0.0806 | 0.0806 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma cruzi | p450 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma brucei | NADH-dependent fumarate reductase | 0.0057 | 0.0806 | 0.0806 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0057 | 0.0806 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0501 | 1 | 1 |
Loa Loa (eye worm) | diaphorase | 0.0057 | 0.0806 | 0.0806 |
Leishmania major | p450 reductase, putative | 0.0501 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0045 | 0.0564 | 0.0564 |
Mycobacterium ulcerans | oxidoreductase | 0.0057 | 0.0806 | 0.0806 |
Leishmania major | oxidoreductase-like protein | 0.0057 | 0.0806 | 0.0806 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0501 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0192 | 0.3595 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0045 | 0.0564 | 0.0564 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0018 | 0 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0249 | 0.4774 | 1 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0036 | 0.0374 | 0.0374 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Brugia malayi | Cytochrome b5-like Heme/Steroid binding domain containing protein | 0.0057 | 0.0806 | 0.0806 |
Brugia malayi | FAD binding domain containing protein | 0.0309 | 0.6032 | 0.6032 |
Trypanosoma brucei | oxidoreductase-protein, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0192 | 0.3595 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0036 | 0.0374 | 0.0374 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0192 | 0.3595 | 0.338 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0249 | 0.4774 | 1 |
Toxoplasma gondii | NADH-cytochrome b5 reductase 1, putative | 0.0057 | 0.0806 | 0.1689 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0501 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0045 | 0.0564 | 0.0564 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0192 | 0.3595 | 0.3595 |
Leishmania major | hypothetical protein, conserved | 0.0192 | 0.3595 | 0.3595 |
Echinococcus multilocularis | methionine synthase reductase | 0.0309 | 0.6032 | 0.6032 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0036 | 0.0374 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0191 | 0.0191 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0252 | 0.4853 | 0.4853 |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.0782 | 0.0782 |
Mycobacterium leprae | putative cytochrome p450 | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0444 | 0.8821 | 0.8781 |
Echinococcus multilocularis | cytochrome b5 reductase 4 | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0192 | 0.3595 | 0.3595 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0249 | 0.4774 | 0.4774 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0444 | 0.8821 | 1 |
Trypanosoma cruzi | nitrate reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0501 | 1 | 1 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0045 | 0.0564 | 0.0564 |
Leishmania major | cytochrome p450-like protein | 0.0045 | 0.0564 | 0.0564 |
Trypanosoma cruzi | reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0057 | 0.0806 | 0.0806 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0039 | 0.0443 | 0.0443 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0057 | 0.0806 | 1 |
Mycobacterium ulcerans | oxygenase | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0045 | 0.0564 | 0.0564 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0444 | 0.8821 | 0.8717 |
Trypanosoma brucei | nitrate reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0192 | 0.3595 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0192 | 0.3595 | 0.5 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Mycobacterium ulcerans | monooxygenase | 0.0057 | 0.0806 | 0.0806 |
Leishmania major | NADH-dependent fumarate reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0501 | 1 | 1 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma brucei | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Brugia malayi | Cytochrome P450 family protein | 0.0045 | 0.0564 | 0.0564 |
Echinococcus multilocularis | NADH cytochrome b5 reductase 3 | 0.0057 | 0.0806 | 0.0806 |
Treponema pallidum | flavodoxin | 0.0192 | 0.3595 | 1 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0309 | 0.6032 | 0.6032 |
Giardia lamblia | Hypothetical protein | 0.0444 | 0.8821 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0045 | 0.0564 | 0.0564 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0501 | 1 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0036 | 0.0374 | 0.0374 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0057 | 0.0806 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0501 | 1 | 1 |
Brugia malayi | flavodoxin family protein | 0.0192 | 0.3595 | 0.3595 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Leishmania major | nitrate reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma brucei | NADH-dependent fumarate reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Echinococcus granulosus | cytochrome b5 reductase 4 | 0.0057 | 0.0806 | 0.0806 |
Mycobacterium ulcerans | flavodoxin oxidoreductase | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0501 | 1 | 1 |
Schistosoma mansoni | NADH-cytochrome B5 reductase | 0.0057 | 0.0806 | 0.0806 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0057 | 0.0806 | 1 |
Onchocerca volvulus | 0.0057 | 0.0806 | 0.5 | |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0501 | 1 | 1 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0045 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.0782 | 0.0782 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0501 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0501 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0501 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0501 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0045 | 0.0564 | 0.0564 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0057 | 0.0806 | 0.0806 |
Leishmania major | cytochrome-b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Plasmodium vivax | hypothetical protein, conserved | 0.0192 | 0.3595 | 0.3033 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0501 | 1 | 1 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0192 | 0.3595 | 0.3033 |
Chlamydia trachomatis | sulfite reductase | 0.0309 | 0.6032 | 1 |
Toxoplasma gondii | ferredoxin NADP+ oxidoreductase FNR | 0.0057 | 0.0806 | 0.1689 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0501 | 1 | 1 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0192 | 0.3595 | 0.3595 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0192 | 0.3595 | 0.338 |
Echinococcus granulosus | NADH cytochrome b5 reductase 3 | 0.0057 | 0.0806 | 0.0806 |
Loa Loa (eye worm) | cytochrome b5 reductase 4 | 0.0057 | 0.0806 | 0.0806 |
Leishmania major | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0057 | 0.0806 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0192 | 0.3595 | 0.5 |
Leishmania major | cytochrome P450 reductase, putative | 0.0444 | 0.8821 | 0.8821 |
Mycobacterium ulcerans | flavodoxin reductase Hmp | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma cruzi | NADH-cytochrome b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0501 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0501 | 1 | 1 |
Trypanosoma cruzi | cytochrome-b5 reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Trypanosoma cruzi | NADH-dependent fumarate reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0501 | 1 | 1 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0501 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0309 | 0.6032 | 0.6032 |
Leishmania major | NADH-dependent fumarate reductase-like protein | 0.0057 | 0.0806 | 0.0806 |
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 1 | 1 |
Leishmania major | reductase, putative | 0.0057 | 0.0806 | 0.0806 |
Schistosoma mansoni | cytochrome B5 | 0.0057 | 0.0806 | 0.0806 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0309 | 0.6032 | 0.6032 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0501 | 1 | 1 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0192 | 0.3595 | 0.3033 |
Trypanosoma cruzi | oxidoreductase-protein, putative | 0.0057 | 0.0806 | 0.0806 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0192 | 0.3595 | 0.3595 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0192 | 0.3595 | 0.3595 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0192 | 0.3595 | 0.338 |
Trichomonas vaginalis | NADPH cytochrome P450, putative | 0.0192 | 0.3595 | 0.338 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.