Detailed information for compound 865707

Basic information

Technical information
  • TDR Targets ID: 865707
  • Name: N-[(2-chloro-7-methylquinolin-3-yl)methyliden eamino]-3,4-dimethoxybenzamide
  • MW: 383.828 | Formula: C20H18ClN3O3
  • H donors: 1 H acceptors: 2 LogP: 4.37 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1OC)C(=O)N/N=C/c1cc2ccc(cc2nc1Cl)C
  • InChi: 1S/C20H18ClN3O3/c1-12-4-5-13-9-15(19(21)23-16(13)8-12)11-22-24-20(25)14-6-7-17(26-2)18(10-14)27-3/h4-11H,1-3H3,(H,24,25)/b22-11+
  • InChiKey: RUOHSKPQCMOBDZ-SSDVNMTOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(2-chloro-7-methyl-3-quinolyl)methyleneamino]-3,4-dimethoxy-benzamide
  • N-[(2-chloro-7-methyl-3-quinolyl)methyleneamino]-3,4-dimethoxybenzamide
  • N-[(2-chloro-7-methyl-quinolin-3-yl)methylideneamino]-3,4-dimethoxy-benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0024 0.0666 0.5
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3205 0.2934
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0666 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0384 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0384 0.2642
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0384 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0384 0.3665
Giardia lamblia DINP protein human, muc B family 0.0019 0.0384 0.5
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0666 1
Brugia malayi TAR-binding protein 0.0064 0.3205 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0384 0.3665
Loa Loa (eye worm) hypothetical protein 0.0024 0.0666 0.1313
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0384 0.0347
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0666 0.1001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0384 1
Echinococcus granulosus tar DNA binding protein 0.0064 0.3205 0.2934
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0384 1
Trypanosoma brucei unspecified product 0.0019 0.0384 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0384 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0666 1
Brugia malayi RNA binding protein 0.0064 0.3205 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0384 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0384 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0384 0.0347
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0384 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0384 0.5
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0666 0.5
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0666 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0384 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3205 0.2934
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0282 0.139
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0666 0.5
Mycobacterium ulcerans hypothetical protein 0.0024 0.0666 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0666 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0282 0.5
Loa Loa (eye worm) RNA binding protein 0.0064 0.3205 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0384 0.5
Loa Loa (eye worm) TAR-binding protein 0.0064 0.3205 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0666 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0282 0.5
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0384 0.5
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0666 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0666 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0384 0.2642
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0666 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3205 0.2934
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0666 0.1001
Loa Loa (eye worm) hypothetical protein 0.0024 0.0666 0.1313
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0384 0.5
Schistosoma mansoni hypothetical protein 0.0171 1 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0282 0.5
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0666 1
Echinococcus multilocularis tar DNA binding protein 0.0064 0.3205 0.2934
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0666 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0666 0.1313
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0666 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.3205 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0384 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0384 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0666 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0384 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0666 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0384 0.5
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0666 0.1001
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0384 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0384 0.5
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3205 0.2934
Schistosoma mansoni tar DNA-binding protein 0.0064 0.3205 0.2934
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0666 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0384 1
Schistosoma mansoni hypothetical protein 0.0171 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0384 1
Echinococcus multilocularis geminin 0.0171 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.3205 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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