Detailed information for compound 865845

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 379.499 | Formula: C22H29N5O
  • H donors: 1 H acceptors: 1 LogP: 2.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc(cc1)C=NNC(=O)CN1CCN(CC1)Cc1ccccc1)C
  • InChi: 1S/C22H29N5O/c1-25(2)21-10-8-19(9-11-21)16-23-24-22(28)18-27-14-12-26(13-15-27)17-20-6-4-3-5-7-20/h3-11,16H,12-15,17-18H2,1-2H3,(H,24,28)/b23-16-
  • InChiKey: BLSXTOICUDKZNR-KQWNVCNZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii thioredoxin reductase 0.0077 0.1266 1
Brugia malayi hypothetical protein 0.0029 0.027 0.0398
Loa Loa (eye worm) hypothetical protein 0.0062 0.0957 0.0939
Plasmodium falciparum glutathione reductase 0.0027 0.0214 0.1559
Schistosoma mansoni coup transcription factor 0.0062 0.0957 0.1616
Loa Loa (eye worm) hypothetical protein 0.0061 0.0921 0.0903
Trypanosoma brucei trypanothione reductase 0.0077 0.1266 1
Loa Loa (eye worm) hypothetical protein 0.0449 0.9026 0.9024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0062 0.0957 0.1616
Trichomonas vaginalis set domain proteins, putative 0.0235 0.4564 0.8737
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.5193 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0027 0.0214 0.2202
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.027 0.0189
Loa Loa (eye worm) hypothetical protein 0.0038 0.045 0.0431
Loa Loa (eye worm) glutathione reductase 0.0077 0.1266 0.1249
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0143 0.1394
Loa Loa (eye worm) RNA binding protein 0.0138 0.2533 0.2519
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.027 0.0189
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0957 0.2516
Brugia malayi TAR-binding protein 0.0138 0.2533 0.4812
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0143 0.1394
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0033 0.0344 0.0438
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.1038 0.1895
Schistosoma mansoni nuclear receptor 0.0029 0.027 0.0121
Brugia malayi ecdysone receptor 0.0029 0.027 0.0398
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0062 0.0957 0.2516
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0902 0.6742
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0653 0.451
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0902 0.191
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0143 0.1394
Brugia malayi hypothetical protein 0.0029 0.027 0.0398
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0061 0.0921 0.1537
Brugia malayi hydrolase, alpha/beta fold family protein 0.0246 0.4791 0.9216
Mycobacterium tuberculosis Probable oxidoreductase 0.0196 0.3738 0.7911
Onchocerca volvulus 0.0029 0.027 0.0129
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0143 0.1394
Onchocerca volvulus Phospholipase A2 homolog 0.0449 0.9026 0.9012
Echinococcus multilocularis GPCR, family 2 0.0066 0.1038 0.2789
Leishmania major trypanothione reductase 0.0077 0.1266 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0196 0.3738 0.7911
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.045 0.0473
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0062 0.0957 0.0939
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0062 0.0957 0.0939
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0902 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0599 0.1302
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0902 0.233
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0062 0.0957 0.1616
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0077 0.1266 0.268
Schistosoma mansoni tar DNA-binding protein 0.0138 0.2533 0.5045
Brugia malayi nuclear hormone receptor 0.0062 0.0957 0.1738
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0275 0.0206
Mycobacterium tuberculosis Conserved protein 0.0038 0.045 0.0952
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0062 0.0957 0.1738
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.027 0.0189
Plasmodium falciparum thioredoxin reductase 0.0027 0.0214 0.1559
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0523 0.0504
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0214 0.058
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0027 0.0214 0.0635
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0123
Schistosoma mansoni hypothetical protein 0.0066 0.1038 0.1791
Trypanosoma cruzi trypanothione reductase, putative 0.0027 0.0214 0.058
Brugia malayi Nuclear hormone receptor E75 0.0029 0.027 0.0398
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0062 0.0957 0.2516
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.1038 0.2789
Echinococcus multilocularis Peptidase C54 0.0061 0.0921 0.2393
Echinococcus granulosus FTZ F1 alpha 0.0062 0.0957 0.2516
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0062 0.0957 0.2516
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0275 0.0132
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0266 0.5193 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.045 0.4871
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0653 0.451
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0143 0.0302
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0599 0.0837
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0143 0.015
Echinococcus granulosus cysteine protease atg4b 0.0061 0.0921 0.2393
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0902 0.6761
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.2448 0.2433
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0214 0.058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.027 0.0189
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.4022 0.7716
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.5193 1
Brugia malayi Steroid receptor seven-up type 2 0.0062 0.0957 0.1738
Schistosoma mansoni retinoic acid receptor RXR 0.0062 0.0957 0.1616
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0062 0.0957 0.0826
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0902 1
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.027 0.0189
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0252 0.0129
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.057 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.057 0.4415
Echinococcus multilocularis thioredoxin glutathione reductase 0.0078 0.1288 0.3635
Loa Loa (eye worm) hypothetical protein 0.0033 0.0344 0.0324
Schistosoma mansoni hypothetical protein 0.0168 0.3167 0.6424
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.045 0.0798
Onchocerca volvulus 0.003 0.0275 0.0134
Loa Loa (eye worm) hypothetical protein 0.0062 0.0957 0.0939
Loa Loa (eye worm) hypothetical protein 0.0062 0.0957 0.0939
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0027 0.0214 0.2202
Loa Loa (eye worm) beta-lactamase 0.0038 0.045 0.0431
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0027 0.0214 0.1559
Brugia malayi CHE-14 protein 0.0042 0.0523 0.0892
Plasmodium falciparum glutathione reductase 0.0077 0.1266 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0027 0.0214 0.1559
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0176 0.3328 0.7044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0957 0.2516
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.0921 0.1419
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0214 0.0635
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.045 0.0473
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0143 0.1394
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.045 0.0512
Echinococcus multilocularis protein dispatched 1 0.0047 0.0646 0.1462
Schistosoma mansoni nuclear hormone receptor 0.0029 0.027 0.0121
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0027 0.0214 0.058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0599 0.0837
Plasmodium vivax glutathione reductase, putative 0.0077 0.1266 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.1038 0.102
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0062 0.0957 0.2516
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.1038 0.2789
Brugia malayi nuclear receptor NHR-67 0.0029 0.027 0.0398
Entamoeba histolytica peptidase, C54 family 0.0024 0.0149 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0062 0.0957 0.0939
Schistosoma mansoni hypothetical protein 0.004 0.0492 0.0604
Loa Loa (eye worm) steroid hormone receptor 0.0062 0.0957 0.0939
Echinococcus multilocularis geminin 0.0168 0.3167 1
Trypanosoma cruzi trypanothione reductase, putative 0.0077 0.1266 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0653 0.5081
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0653 0.0881
Schistosoma mansoni hypothetical protein 0.0066 0.1038 0.1791
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.4022 0.401
Loa Loa (eye worm) hypothetical protein 0.0062 0.0957 0.0939
Loa Loa (eye worm) hypothetical protein 0.0095 0.1629 0.1612
Toxoplasma gondii NADPH-glutathione reductase 0.0027 0.0214 0.058
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.0921 0.1419
Loa Loa (eye worm) hypothetical protein 0.0062 0.0957 0.0939
Echinococcus multilocularis FTZ F1 alpha 0.0062 0.0957 0.2516
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.045 0.0748
Brugia malayi tailless protein 0.0029 0.027 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0062 0.0957 0.1738
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0957 0.1616
Brugia malayi MH2 domain containing protein 0.0134 0.2448 0.4646
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0062 0.0957 0.1738
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.3485 0.6569
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.2951 0.9266
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3289 0.6176
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0062 0.0957 0.2516
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.045 0.4871
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.3485 0.6569
Mycobacterium ulcerans lipase LipD 0.0038 0.045 0.4871
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.5193 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1676 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0062 0.0957 0.1738
Echinococcus multilocularis thyroid hormone receptor alpha 0.0062 0.0957 0.2516
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.057 0.2785
Echinococcus multilocularis ecdysone induced protein 78C 0.0062 0.0957 0.2516
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.0921 0.6926
Brugia malayi hypothetical protein 0.0033 0.0344 0.0541
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3289 0.6176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0214 0.058
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0143 0.0302
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0344 0.0541
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0062 0.0957 0.1616
Schistosoma mansoni steroid hormone receptor ad4bp 0.0062 0.0957 0.1616
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3289 0.6176
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0957 0.1738
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.0921 0.1419
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0266 0.5193 0.5184
Brugia malayi Nuclear hormone receptor-like 1 0.0062 0.0957 0.1738
Brugia malayi nuclear receptor NHR-88 0.0029 0.027 0.0398
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0027 0.0214 1
Brugia malayi Pre-SET motif family protein 0.003 0.0275 0.0407
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Schistosoma mansoni tar DNA-binding protein 0.0138 0.2533 0.5045
Treponema pallidum NADH oxidase 0.0027 0.0214 0.5
Brugia malayi acetyltransferase, GNAT family protein 0.0163 0.3046 0.5811
Schistosoma mansoni autophagin-1 (C54 family) 0.0061 0.0921 0.1537
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.2543 0.7887
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0062 0.0957 0.1738
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.045 0.0952
Onchocerca volvulus Glucosylceramidase homolog 0.0174 0.3289 0.3192
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0163 0.3046 0.6159
Echinococcus multilocularis expressed conserved protein 0.0091 0.1554 0.4537
Schistosoma mansoni nuclear hormone receptor 0.0062 0.0957 0.1616
Onchocerca volvulus 0.0029 0.027 0.0129
Brugia malayi Latrophilin receptor protein 2 0.0066 0.1038 0.1895
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0062 0.0957 0.2516
Plasmodium falciparum cysteine protease ATG4, putative 0.0024 0.0149 0.104
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0196 0.3738 0.7911
Schistosoma mansoni hypothetical protein 0.0143 0.2641 0.5278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0275 0.0132
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.045 0.0473
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.045 0.0952
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0027 0.0214 0.058
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.0921 0.1419
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0957 0.1738
Brugia malayi beta-lactamase family protein 0.0038 0.045 0.0748
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0214 0.058
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0214 0.058
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0027 0.0214 0.0635
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.027 0.0189
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.045 0.0952
Brugia malayi beta-lactamase 0.0038 0.045 0.0748
Echinococcus granulosus ecdysone induced protein 78C 0.0062 0.0957 0.2516
Schistosoma mansoni patched 1 0.0042 0.0523 0.0672
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0344 0.0541
Loa Loa (eye worm) hypothetical protein 0.0038 0.045 0.0431
Plasmodium vivax hypothetical protein, conserved 0.0038 0.045 0.3449
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.0496 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.027 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0957 0.1738
Loa Loa (eye worm) hypothetical protein 0.0033 0.0344 0.0324
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.002 0.0042
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0599 0.058
Brugia malayi nuclear receptor RXR 0.0033 0.0344 0.0541
Mycobacterium ulcerans hypothetical protein 0.0023 0.0143 0.1394
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.027 0.0189
Schistosoma mansoni tar DNA-binding protein 0.0138 0.2533 0.5045
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.045 0.0952
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.045 0.2689
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3289 0.6176
Brugia malayi nuclear receptor NHR-88 0.0062 0.0957 0.1738
Loa Loa (eye worm) thioredoxin reductase 0.0077 0.1266 0.1249
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.027 0.0189
Brugia malayi Peptidase family C54 containing protein 0.0061 0.0921 0.1667
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0599 0.1039
Schistosoma mansoni hypothetical protein 0.004 0.0492 0.0604
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0033 0.0344 0.0281
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0062 0.0957 0.1738
Echinococcus multilocularis cysteine protease atg4b 0.0061 0.0921 0.2393
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0062 0.0957 0.1616
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0275 0.0206
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0902 0.1497
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0123
Loa Loa (eye worm) DR-78 0.0029 0.027 0.0251
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.3969 0.3957
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.027 0.0121
Entamoeba histolytica peptidase, C54 family 0.0024 0.0149 0.0043
Onchocerca volvulus 0.0062 0.0957 0.0826
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0653 0.0881
Brugia malayi RNA recognition motif domain containing protein 0.0138 0.2533 0.4812
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0599 0.1302
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.027 0.0251
Plasmodium vivax SET domain protein, putative 0.003 0.0275 0.2046
Loa Loa (eye worm) hypothetical protein 0.0023 0.0143 0.0123
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0902 0.1497
Loa Loa (eye worm) hypothetical protein 0.003 0.0275 0.0256
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.1038 0.2789
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3289 0.6176
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0062 0.0957 0.1738
Echinococcus granulosus Peptidase C54 0.0061 0.0921 0.2393
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0027 0.0214 0.1559
Onchocerca volvulus 0.0038 0.045 0.0311
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.027 0.0189
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0176 0.3328 0.886
Mycobacterium ulcerans hypothetical protein 0.0038 0.045 0.4871
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0027 0.0214 0.058
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0024 0.0149 0.0059
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0138 0.2533 0.2519
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0061 0.0921 0.1419
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0143 0.015
Loa Loa (eye worm) hypothetical protein 0.0062 0.0957 0.0939
Echinococcus granulosus thioredoxin glutathione reductase 0.0078 0.1288 0.3635
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.045 0.0952
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0275 0.0132
Loa Loa (eye worm) hypothetical protein 0.0066 0.1038 0.102
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0143 0.015
Brugia malayi Pre-SET motif family protein 0.0207 0.3969 0.7612
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0062 0.0957 0.1738
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0523 0.1047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0062 0.0957 0.2516
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1676 0.4952
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0062 0.0957 0.0939
Loa Loa (eye worm) hypothetical protein 0.0209 0.4022 0.401
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0027 0.0214 0.0635
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.027 0.0121
Schistosoma mansoni RAR-like nuclear receptor 0.0062 0.0957 0.1616
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.045 0.0473
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0061 0.0921 0.1537
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.045 0.2689
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1676 0.3141
Brugia malayi nuclear hormone receptor 0.0029 0.027 0.0398
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0214 0.058
Onchocerca volvulus Phospholipase A2 homolog 0.0095 0.1629 0.1508
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0176 0.3328 0.7044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.027 0.0189
Plasmodium falciparum thioredoxin reductase 0.0077 0.1266 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.027 0.0398
Echinococcus granulosus tar DNA binding protein 0.0138 0.2533 0.7854
Echinococcus multilocularis tar DNA binding protein 0.0138 0.2533 0.7854
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0163 0.3046 0.9588
Schistosoma mansoni nuclear receptor 0.0029 0.027 0.0121
Mycobacterium ulcerans beta-lactamase 0.0038 0.045 0.4871
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.045 0.0512
Loa Loa (eye worm) hypothetical protein 0.0033 0.0344 0.0324
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.027 0.0189
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0523 0.1047
Loa Loa (eye worm) hypothetical protein 0.0033 0.0344 0.0324
Loa Loa (eye worm) hypothetical protein 0.0042 0.0523 0.0504
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.027 0.0129
Loa Loa (eye worm) hypothetical protein 0.0038 0.045 0.0431
Brugia malayi Nuclear hormone receptor E75 0.0029 0.027 0.0398
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.4725 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.2641 0.2626
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0062 0.0957 0.0939
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0599 0.1302
Schistosoma mansoni thyroid hormone receptor 0.0062 0.0957 0.1616
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0033 0.0344 0.0324
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3289 0.6176
Mycobacterium tuberculosis Conserved protein 0.0038 0.045 0.0952
Schistosoma mansoni tar DNA-binding protein 0.0138 0.2533 0.5045
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0062 0.0957 0.1616
Brugia malayi nuclear receptor RXR 0.0029 0.027 0.0398
Loa Loa (eye worm) hypothetical protein 0.0062 0.0957 0.0939
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1676 0.4952
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.027 0.0251
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0143 0.1394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0062 0.0957 0.0939
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0027 0.0214 0.1559
Leishmania major hypothetical protein, conserved 0.0038 0.045 0.2732
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0275 0.0132
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0027 0.0214 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0523 0.0621
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.5193 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.045 0.0431
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0902 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0062 0.0957 0.1738
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.027 0.0398
Loa Loa (eye worm) hypothetical protein 0.0038 0.045 0.0431
Trichomonas vaginalis esterase, putative 0.0038 0.045 0.0473
Entamoeba histolytica peptidase, C54 family 0.0024 0.0149 0.0043
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.045 0.0431
Onchocerca volvulus 0.0038 0.045 0.0311
Schistosoma mansoni hypothetical protein 0.004 0.0492 0.0604
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0062 0.0957 0.1738
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0062 0.0957 0.1738
Plasmodium vivax thioredoxin reductase, putative 0.0077 0.1266 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.045 0.2689
Echinococcus granulosus geminin 0.0168 0.3167 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0214 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.3289 0.6176
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0062 0.0957 0.2516
Loa Loa (eye worm) hypothetical protein 0.0033 0.0344 0.0324
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0902 0.233
Echinococcus multilocularis protein patched 0.0042 0.0523 0.1047
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.045 0.0952
Onchocerca volvulus Protein ultraspiracle homolog 0.0062 0.0957 0.0826
Echinococcus granulosus expressed conserved protein 0.0091 0.1554 0.4537
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.027 0.0121
Mycobacterium tuberculosis Conserved protein 0.0038 0.045 0.0952
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.2641 0.5022
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0062 0.0957 0.2516
Brugia malayi hypothetical protein 0.0033 0.0344 0.0541
Brugia malayi beta-lactamase family protein 0.0038 0.045 0.0748
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.4022 0.7716
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0176 0.3328 0.7044
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0176 0.3328 0.7044
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0275 0.0206
Loa Loa (eye worm) hypothetical protein 0.0051 0.0718 0.07
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0027 0.0214 0.0453
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0143 0.1394
Brugia malayi Thioredoxin reductase 0.0077 0.1266 0.234
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.5193 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0523 0.1047
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.2543 0.7887
Echinococcus granulosus GPCR family 2 0.0066 0.1038 0.2789
Loa Loa (eye worm) hypothetical protein 0.0097 0.1676 0.166
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.0921 0.6907
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.5193 1
Schistosoma mansoni zinc finger protein 0.0029 0.027 0.0121
Brugia malayi conserved hypotetical protein 0.0029 0.027 0.0398
Brugia malayi ecdysteroid receptor 0.0062 0.0957 0.1738
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0275 0.1123
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.027 0.0398
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.2448 0.2433
Entamoeba histolytica peptidase, C54 family 0.0061 0.0921 0.5072
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1708 0.3249
Mycobacterium tuberculosis Probable reductase 0.0176 0.3328 0.7044
Onchocerca volvulus Bile acid receptor homolog 0.0062 0.0957 0.0826
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0196 0.3738 1
Schistosoma mansoni nuclear hormone receptor 0.0029 0.027 0.0121
Entamoeba histolytica peptidase, C54 family 0.0024 0.0149 0.0043
Schistosoma mansoni hypothetical protein 0.0066 0.1038 0.1791
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0062 0.0957 0.0939
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0027 0.0214 0.2202
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.045 0.0473
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0214 0.058
Loa Loa (eye worm) TAR-binding protein 0.0138 0.2533 0.2519
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0599 0.0837
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0344 0.0281
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.027 0.0251
Schistosoma mansoni hypothetical protein 0.0168 0.3167 0.6424
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0027 0.0214 0.0289
Onchocerca volvulus 0.0038 0.045 0.0311
Schistosoma mansoni hypothetical protein 0.004 0.0492 0.0604
Loa Loa (eye worm) hypothetical protein 0.0029 0.027 0.0251
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0599 0.1302
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.027 0.0189
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0062 0.0957 0.2516
Brugia malayi glutathione reductase 0.0077 0.1266 0.234
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.045 0.0798
Mycobacterium tuberculosis Probable dehydrogenase 0.0176 0.3328 0.7044
Brugia malayi Phospholipase A2 family protein 0.0095 0.1629 0.3048
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0062 0.0957 0.2516
Brugia malayi RNA binding protein 0.0138 0.2533 0.4812
Mycobacterium leprae Probable lipase LipE 0.0038 0.045 0.0854
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.1038 0.2789
Loa Loa (eye worm) hypothetical protein 0.0038 0.045 0.0431
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0027 0.0214 0.5
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0061 0.0921 0.6907
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.045 0.0952
Loa Loa (eye worm) hypothetical protein 0.0062 0.0957 0.0939
Schistosoma mansoni hypothetical protein 0.0066 0.1038 0.1791
Schistosoma mansoni tar DNA-binding protein 0.0138 0.2533 0.5045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0027 0.0214 0.058
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0062 0.0957 0.1616
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0027 0.0214 0.058
Mycobacterium leprae conserved hypothetical protein 0.0038 0.045 0.0854
Loa Loa (eye worm) acetyltransferase 0.0163 0.3046 0.3032
Brugia malayi steroid hormone receptor 0.0062 0.0957 0.1738
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0033 0.0344 0.0438
Toxoplasma gondii ABC1 family protein 0.0038 0.045 0.2689
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0653 0.1486
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.027 0.0398
Onchocerca volvulus 0.0235 0.4564 0.4486

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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