TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 506.394 | Formula: C25H24BrN5O2
H donors: 1 H acceptors: 2 LogP: 5.46 Rotable bonds: 5
Rule of 5 violations (Lipinski): 2
SMILES: CN1CCN(CC1)Cn1c(O)c(c2c1ccc(c2)Br)N=NC(=O)c1cccc2c1cccc2
InChi: 1S/C25H24BrN5O2/c1-29-11-13-30(14-12-29)16-31-22-10-9-18(26)15-21(22)23(25(31)33)27-28-24(32)20-8-4-6-17-5-2-3-7-19(17)20/h2-10,15,33H,11-14,16H2,1H3
InChiKey: PIADYOPLHRHTRM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	EGF family domain-containing protein	0.0357	0.272	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0197	0.0231
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Schistosoma mansoni	hypothetical protein	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0197	0.0231
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0357	0.272	0.3183
Echinococcus granulosus	notch	0.0357	0.272	0.3183
Echinococcus multilocularis	survival motor neuron protein 1	0.1005	0.7775	0.7775
Schistosoma mansoni	notch	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Echinococcus granulosus	neurogenic locus protein delta	0.0357	0.272	0.3183
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0102	0.0515
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0357	0.272	0.272
Schistosoma mansoni	hypothetical protein	0.0357	0.272	0.3183
Schistosoma mansoni	hypothetical protein	0.0357	0.272	0.3183
Brugia malayi	Animal haem peroxidase family protein	0.1104	0.8544	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0357	0.272	0.272
Echinococcus multilocularis	Niemann Pick C1 protein	0.0109	0.0788	0.0788
Echinococcus multilocularis	protein jagged 2	0.0357	0.272	0.272
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0093	0.4698
Brugia malayi	Muscle positioning protein 4	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Schistosoma mansoni	survival motor neuron protein	0.0205	0.1538	0.18
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0144	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0144	1
Echinococcus multilocularis	fibropellin Ia	0.0357	0.272	0.272
Onchocerca volvulus	Peroxidasin homolog	0.1104	0.8544	1
Loa Loa (eye worm)	Notch2	0.0357	0.272	0.3183
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0197	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Schistosoma mansoni	hypothetical protein	0.0045	0.0291	0.034
Onchocerca volvulus	Peroxidasin homolog	0.1104	0.8544	1
Onchocerca volvulus	Dual oxidase homolog	0.1104	0.8544	1
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Echinococcus granulosus	expressed conserved protein	0.0102	0.0737	0.0862
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.003	0.017	0.0199
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Brugia malayi	Pre-SET motif family protein	0.0033	0.0197	0.0231
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0109	0.0788	1
Entamoeba histolytica	hypothetical protein	0.003	0.017	0.216
Echinococcus granulosus	Niemann Pick C1 protein	0.0109	0.0788	0.0922
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0102	0.7073
Echinococcus granulosus	protein jagged 2	0.0357	0.272	0.3183
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0144	1
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0304	0.0356
Echinococcus granulosus	neurogenic locus notch protein 4	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0108
Schistosoma mansoni	hypothetical protein	0.0357	0.272	0.3183
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0357	0.272	0.3183
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0304	0.1535
Onchocerca volvulus		0.1104	0.8544	1
Brugia malayi	Peroxidasin	0.1104	0.8544	1
Entamoeba histolytica	hypothetical protein	0.003	0.017	0.216
Echinococcus granulosus	Niemann Pick C1 protein	0.0155	0.1152	0.1348
Onchocerca volvulus		0.0205	0.1538	0.18
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0102	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0357	0.272	0.272
Echinococcus granulosus	protein jagged 2	0.0357	0.272	0.3183
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.003	0.017	0.017
Brugia malayi	Calcium binding EGF domain containing protein	0.0357	0.272	0.3183
Echinococcus granulosus	peroxidasin	0.1104	0.8544	1
Schistosoma mansoni	patched 1	0.0047	0.0304	0.0356
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0205	0.1538	0.18
Echinococcus multilocularis	peroxidasin	0.1104	0.8544	0.8544
Onchocerca volvulus		0.0357	0.272	0.3183
Toxoplasma gondii	exonuclease III APE	0.0021	0.0102	0.0375
Schistosoma mansoni	hypothetical protein	0.0045	0.0291	0.034
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Giardia lamblia	High cysteine protein	0.0357	0.272	1
Schistosoma mansoni	hypothetical protein	0.0357	0.272	0.3183
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0108
Echinococcus multilocularis	protein jagged 1	0.0357	0.272	0.272
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0084	0.5844
Brugia malayi	Animal haem peroxidase family protein	0.1104	0.8544	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0084	0.5844
Echinococcus granulosus	neurogenic locus notch protein	0.0357	0.272	0.3183
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0357	0.272	0.272
Onchocerca volvulus	Peroxidase homolog	0.1104	0.8544	1
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0144	1
Echinococcus multilocularis	neurogenic locus protein delta	0.0357	0.272	0.272
Echinococcus multilocularis	protein patched	0.0047	0.0304	0.0304
Brugia malayi	Animal haem peroxidase family protein	0.1104	0.8544	1
Echinococcus granulosus	protein jagged 1	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Loa Loa (eye worm)	animal heme peroxidase	0.1104	0.8544	1
Schistosoma mansoni	cell polarity protein	0.0357	0.272	0.3183
Schistosoma mansoni	ap endonuclease	0.0021	0.0102	0.0119
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0108
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0093	0.9078
Echinococcus multilocularis	expressed conserved protein	0.0102	0.0737	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0144	0.183
Onchocerca volvulus	Chorion peroxidase homolog	0.1104	0.8544	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0144	0.0169
Onchocerca volvulus		0.0262	0.1981	0.2318
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0084	0.5844
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0102	0.0119
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0197	0.0231
Brugia malayi	Cadherin domain containing protein	0.0357	0.272	0.3183
Brugia malayi	CHE-14 protein	0.0047	0.0304	0.0356
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0093	0.6421
Onchocerca volvulus		0.1104	0.8544	1
Echinococcus granulosus	survival motor neuron protein 1	0.1005	0.7775	0.9099
Brugia malayi	EGF-like domain containing protein	0.0357	0.272	0.3183
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0144	1
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0144	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0144	0.0169
Schistosoma mansoni	notch	0.0357	0.272	0.3183
Brugia malayi	EGF-like domain containing protein	0.0357	0.272	0.3183
Onchocerca volvulus		0.0357	0.272	0.3183
Brugia malayi	hypothetical protein	0.1005	0.7775	0.9099
Schistosoma mansoni	laminin gamma-3 chain	0.0357	0.272	0.3183
Onchocerca volvulus	Slit protein homolog	0.0357	0.272	0.3183
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0102	0.0515
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0102	0.5175
Echinococcus granulosus	delta-like protein 1	0.0357	0.272	0.3183
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0102	0.5
Brugia malayi	notch-like transmembrane receptor	0.0357	0.272	0.3183
Echinococcus granulosus	neural cadherin	0.0357	0.272	0.3183
Brugia malayi	GCC2 and GCC3 family protein	0.0357	0.272	0.3183
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0102	0.0119
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Onchocerca volvulus		0.0033	0.0197	0.0231
Onchocerca volvulus	Neurogenic locus notch homolog	0.0357	0.272	0.3183
Schistosoma mansoni	hypothetical protein	0.0045	0.0291	0.034
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0102	0.0102
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0.0144	1
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0788	0.0922
Brugia malayi	EGF-like domain containing protein	0.0357	0.272	0.3183
Brugia malayi	Blistered cuticle protein 3	0.1104	0.8544	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0197	0.0231
Onchocerca volvulus		0.0026	0.0144	0.0169
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0102	0.1295
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0108
Brugia malayi	Niemann-Pick C1 protein precursor	0.0109	0.0788	0.0922
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0197	0.0231
Brugia malayi	hypothetical protein	0.1104	0.8544	1
Echinococcus multilocularis	protein jagged 1	0.0357	0.272	0.272
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0102	1
Schistosoma mansoni	notch	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Echinococcus granulosus	Protein patched homolog 1	0.0047	0.0304	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Onchocerca volvulus		0.0357	0.272	0.3183
Echinococcus multilocularis	slit 2 protein	0.0357	0.272	0.272
Brugia malayi	EGF-like domain containing protein	0.0357	0.272	0.3183
Echinococcus granulosus	protein jagged 1	0.0357	0.272	0.3183
Loa Loa (eye worm)	notch protein	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Echinococcus multilocularis	protein dispatched 1	0.0053	0.0355	0.0355
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0197	0.0725
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.011	0.0801	0.0938
Schistosoma mansoni	notch	0.0357	0.272	0.3183
Schistosoma mansoni	ap endonuclease	0.0021	0.0102	0.0119
Brugia malayi	hypothetical protein	0.003	0.017	0.0199
Onchocerca volvulus	Peroxidase homolog	0.1104	0.8544	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0144	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0084	0.5844
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0093	0.5
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0144	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0144	0.183
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Schistosoma mansoni	hypothetical protein	0.003	0.017	0.0199
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Brugia malayi	EGF-like domain containing protein	0.0357	0.272	0.3183
Onchocerca volvulus		0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Echinococcus granulosus	fibropellin Ia	0.0357	0.272	0.3183
Schistosoma mansoni	slit	0.0357	0.272	0.3183
Entamoeba histolytica	hypothetical protein	0.003	0.017	0.216
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0386	0.0452
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0144	0.0169
Brugia malayi	EGF-like domain containing protein	0.0357	0.272	0.3183
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0144	1
Brugia malayi	Animal haem peroxidase family protein	0.1104	0.8544	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0155	0.1152	0.1152
Loa Loa (eye worm)	hypothetical protein	0.1005	0.7775	0.9099
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0188	0.022
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Onchocerca volvulus		0.1104	0.8544	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0144	0.0169
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0047	0.0304	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0102	1
Schistosoma mansoni	hypothetical protein	0.0205	0.1538	0.18
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0144	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0144	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0144	0.0169
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0102	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0144	0.183
Trichomonas vaginalis	set domain proteins, putative	0.0262	0.1981	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0357	0.272	0.272
Schistosoma mansoni	septate junction protein	0.0357	0.272	0.3183
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0144	1
Loa Loa (eye worm)	animal heme peroxidase	0.1104	0.8544	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0102	0.7073
Echinococcus multilocularis	sterol regulatory element binding protein	0.0047	0.0304	0.0304
Brugia malayi	Delta serrate ligand family protein	0.0357	0.272	0.3183
Plasmodium vivax	SET domain protein, putative	0.0033	0.0197	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0093	0.0108
Echinococcus multilocularis	notch	0.0357	0.272	0.272
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Schistosoma mansoni	transcription factor LCR-F1	0.003	0.017	0.0199
Onchocerca volvulus	Putative cubilin	0.0357	0.272	0.3183
Brugia malayi	Calcium binding EGF domain containing protein	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.1104	0.8544	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.023	0.1733	0.2028
Schistosoma mansoni	hypothetical protein	0.0357	0.272	0.3183
Schistosoma mansoni	notch	0.0357	0.272	0.3183
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0102	0.0119
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0144	1
Brugia malayi	Cadherin domain containing protein	0.0357	0.272	0.3183
Brugia malayi	EGF-like domain containing protein	0.0357	0.272	0.3183
Loa Loa (eye worm)	blistered cuticle protein 3	0.1104	0.8544	1
Echinococcus multilocularis	neural cadherin	0.0357	0.272	0.272
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0102	0.5
Brugia malayi	Calcium binding EGF domain containing protein	0.0357	0.272	0.3183
Schistosoma mansoni	hypothetical protein	0.0045	0.0291	0.034
Schistosoma mansoni	peroxidasin	0.1104	0.8544	1
Echinococcus granulosus	slit 2 protein	0.0357	0.272	0.3183
Brugia malayi	Pre-SET motif family protein	0.023	0.1733	0.2028
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.0093	0.6421
Schistosoma mansoni	notch	0.0357	0.272	0.3183
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0144	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0144	0.0169
Loa Loa (eye worm)	animal heme peroxidase	0.1104	0.8544	1
Onchocerca volvulus		0.0357	0.272	0.3183
Schistosoma mansoni	peroxidasin	0.1104	0.8544	1
Loa Loa (eye worm)	animal heme peroxidase	0.1104	0.8544	1
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Brugia malayi	Animal haem peroxidase family protein	0.1104	0.8544	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0047	0.0304	0.0356
Echinococcus granulosus	neurogenic locus notch protein	0.0357	0.272	0.3183
Loa Loa (eye worm)	hypothetical protein	0.0357	0.272	0.3183
Schistosoma mansoni	hypothetical protein	0.0357	0.272	0.3183
Entamoeba histolytica	hypothetical protein	0.003	0.017	0.216
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0102	0.7073

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 865905