Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0073 | 0.1014 | 0.0269 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0395 | 0.8105 | 0.8105 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0395 | 0.8105 | 1 |
Brugia malayi | CHE-14 protein | 0.0064 | 0.0817 | 0.2892 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0073 | 0.1014 | 0.0269 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0064 | 0.0817 | 0.2892 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0155 | 0.2827 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0395 | 0.8105 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2827 | 1 |
Onchocerca volvulus | 0.0027 | 0 | 0.5 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0064 | 0.0817 | 0.2892 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0155 | 0.2827 | 1 |
Echinococcus multilocularis | protein patched | 0.0064 | 0.0817 | 0.2892 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0073 | 0.1014 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0155 | 0.2827 | 1 |
Plasmodium vivax | beta-hydroxyacyl-ACP dehydratase precursor, putative | 0.0481 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0073 | 0.1014 | 0.0269 |
Echinococcus multilocularis | protein dispatched 1 | 0.0064 | 0.0817 | 0.2892 |
Schistosoma mansoni | patched 1 | 0.0064 | 0.0817 | 0.2892 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0155 | 0.2827 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0395 | 0.8105 | 0.8105 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0027 | 0 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0064 | 0.0817 | 0.2892 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0155 | 0.2827 | 1 |
Toxoplasma gondii | beta-hydroxyacyl-acyl carrier protein dehydratase (FABZ) | 0.0481 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0817 | 0.2892 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0395 | 0.8105 | 0.8105 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0155 | 0.2827 | 1 |
Wolbachia endosymbiont of Brugia malayi | (3R)-hydroxymyristoyl-ACP dehydratase | 0.0481 | 1 | 1 |
Plasmodium falciparum | beta-hydroxyacyl-ACP dehydratase | 0.0481 | 1 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0395 | 0.8105 | 0.8105 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0064 | 0.0817 | 0.2892 |
Trichomonas vaginalis | hypothetical protein | 0.0395 | 0.8105 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0155 | 0.2827 | 0.3488 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0155 | 0.2827 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0064 | 0.0817 | 0.2892 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0064 | 0.0817 | 0.2892 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0395 | 0.8105 | 0.8105 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0155 | 0.2827 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0395 | 0.8105 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0064 | 0.0817 | 0.2892 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.