Detailed information for compound 866001

Basic information

Technical information
  • TDR Targets ID: 866001
  • Name: 4-[(3-chloro-4-methylphenyl)amino]-4-oxo-2-(p yridin-2-ylmethylamino)butanoic acid
  • MW: 347.796 | Formula: C17H18ClN3O3
  • H donors: 3 H acceptors: 4 LogP: -0.04 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CC(C(=O)O)NCc1ccccn1)Nc1ccc(c(c1)Cl)C
  • InChi: 1S/C17H18ClN3O3/c1-11-5-6-12(8-14(11)18)21-16(22)9-15(17(23)24)20-10-13-4-2-3-7-19-13/h2-8,15,20H,9-10H2,1H3,(H,21,22)(H,23,24)
  • InChiKey: CWGYSNDQFQOIEC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[(3-chloro-4-methyl-phenyl)amino]-4-oxo-2-(2-pyridylmethylamino)butanoic acid
  • 4-[(3-chloro-4-methylphenyl)amino]-4-oxo-2-(2-pyridylmethylamino)butanoic acid
  • 4-[(3-chloro-4-methyl-phenyl)amino]-4-keto-2-(2-pyridylmethylamino)butyric acid
  • 4-[(3-chloro-4-methyl-phenyl)amino]-4-oxo-2-(pyridin-2-ylmethylamino)butanoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Onchocerca volvulus 0.001 0.001 0.0116
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.001 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.0028 0.037 0.0742
Leishmania major oxidoreductase-like protein 0.0028 0.037 0.0561
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.037 0.0742
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0028 0.037 0.0561
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.001 0.001 0.0034
Echinococcus multilocularis hypothetical protein 0.001 0.001 0.002
Schistosoma mansoni patched 1 0.0066 0.1117 0.3729
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0926 0.0712
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0393 0.0207
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.037 0.0401
Onchocerca volvulus 0.001 0.001 0.0116
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0086 0.1516 1
Onchocerca volvulus 0.001 0.001 0.0116
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0028 0.037 0.0401
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.001 0.001 0.002
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0028 0.037 0.0401
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.037 0.0401
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Onchocerca volvulus 0.001 0.001 0.0116
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.1516 0.119
Onchocerca volvulus 0.001 0.001 0.0116
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.019 0.0281
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.1516 0.1811
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0043 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Onchocerca volvulus 0.001 0.001 0.0116
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Echinococcus granulosus bloom syndrome protein 0.0019 0.019 0.0381
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.001 0.001 0.002
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.016 0.2996 0.6013
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.016 0.2996 0.6013
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.001 0.001 0.002
Onchocerca volvulus 0.001 0.001 0.0116
Loa Loa (eye worm) oxidoreductase 0.0028 0.037 0.0742
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Trichomonas vaginalis DNA helicase recq1, putative 0.0019 0.019 0.022
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.001 0.001 0.0034
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.001 0.001 0.002
Toxoplasma gondii hypothetical protein 0.003 0.0393 0.0393
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0075 0.1301 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.1516 0.3042
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.6419 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0019 0.019 0.0381
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.001 0.001 0.0034
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0028 0.037 0.0401
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0075 0.1301 0.1581
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0019 0.019 0.0381
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Echinococcus multilocularis 0.001 0.001 0.002
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0066 0.1117 0.3729
Brugia malayi hypothetical protein 0.026 0.4983 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.042 0.8175 1
Plasmodium falciparum enoyl-acyl carrier reductase 0.042 0.8175 0.814
Echinococcus multilocularis bloom syndrome protein 0.0019 0.019 0.0381
Brugia malayi hypothetical protein 0.001 0.001 0.002
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0086 0.1516 0.119
Brugia malayi hypothetical protein 0.001 0.001 0.002
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.001 0.002
Brugia malayi Protein-tyrosine phosphatase 0.001 0.001 0.002
Brugia malayi Protein-tyrosine phosphatase 1 0.001 0.001 0.002
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.001 0.001 0.002
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0066 0.1117 0.2242
Trypanosoma brucei oxidoreductase-like protein 0.0028 0.037 0.0561
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0028 0.037 0.0561
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.037 0.0401
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.042 0.8175 0.8105
Loa Loa (eye worm) RecQ helicase 0.0019 0.019 0.0381
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.019 0.019
Schistosoma mansoni pcd6 interacting protein-related 0.001 0.001 0.0034
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.001 0.001 0.0034
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0028 0.037 0.0561
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.001 0.001 0.002
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.037 0.0401
Schistosoma mansoni hypothetical protein 0.0053 0.0859 0.2868
Echinococcus granulosus Niemann Pick C1 protein 0.0066 0.1117 0.2242
Onchocerca volvulus 0.001 0.001 0.0116
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.1516 0.1516
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.001 0.001 0.002
Onchocerca volvulus 0.001 0.001 0.0116
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Brugia malayi hypothetical protein 0.001 0.001 0.002
Plasmodium vivax enoyl-acyl carrier protein reductase 0.042 0.8175 0.8175
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0086 0.1516 0.1516
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0028 0.037 0.0742
Schistosoma mansoni protein tyrosine phosphatase 0.001 0.001 0.0034
Toxoplasma gondii hypothetical protein 0.0053 0.087 0.087
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0075 0.1301 0.1581
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.1117 0.1356
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0043 0.0087
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.037 0.0401
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.037 0.0401
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0028 0.037 0.0183
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0028 0.037 0.0401
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.001 0.001 0.002
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.037 0.0401
Schistosoma mansoni receptor protein tyrosine phosphatase 0.001 0.001 0.0034
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.001 0.001 0.002
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0393 0.003
Schistosoma mansoni peptidase Clp (S14 family) 0.0086 0.1516 0.5059
Echinococcus multilocularis Niemann Pick C1 protein 0.0066 0.1117 0.2242
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0028 0.037 0.0561
Onchocerca volvulus 0.001 0.001 0.0116
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0332 0.6419 1
Schistosoma mansoni rgs-gaip interacting protein gipc 0.001 0.001 0.0034
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0859 0.1724
Plasmodium vivax beta-hydroxyacyl-ACP dehydratase precursor, putative 0.0511 1 1
Brugia malayi CHE-14 protein 0.0066 0.1117 0.2242
Onchocerca volvulus 0.001 0.001 0.0116
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Onchocerca volvulus 0.0028 0.037 0.4301
Mycobacterium ulcerans hypothetical protein 0.0175 0.3288 0.399
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0028 0.037 0.0401
Entamoeba histolytica protein tyrosine phosphatase, putative 0.001 0.001 0.0272
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.037 0.0401
Brugia malayi hypothetical protein 0.001 0.001 0.002
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.042 0.8175 0.8105
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0028 0.037 0.037
Brugia malayi Probable ClpP-like protease 0.0086 0.1516 0.3042
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0057 0.0936 0.1446
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Onchocerca volvulus 0.001 0.001 0.0116
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.016 0.2996 0.6013
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.019 0.0281
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Onchocerca volvulus 0.001 0.001 0.0116
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.037 0.0401
Onchocerca volvulus 0.001 0.001 0.0116
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.019 0.022
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.001 0.001 0.0034
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.037 0.0742
Entamoeba histolytica protein tyrosine phosphatase, putative 0.001 0.001 0.0272
Echinococcus multilocularis protein patched 0.0066 0.1117 0.2242
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0926 0.1857
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.001 0.002
Onchocerca volvulus 0.001 0.001 0.0116
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Brugia malayi Cytochrome P450 family protein 0.0012 0.0043 0.0087
Schistosoma mansoni protein tyrosine phosphatase 0.001 0.001 0.0034
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.016 0.2996 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.001 0.002
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0028 0.037 0.0401
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.2934 0.4562
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0043 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0028 0.037 0.0401
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.001 0.002
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0028 0.037 0.037
Schistosoma mansoni protein-tyrosine phosphatase n9 0.001 0.001 0.0034
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0028 0.037 0.0561
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.001 0.001 0.0272
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.001 0.001 0.002
Onchocerca volvulus 0.001 0.001 0.0116
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.001 0.001 0.0034
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0028 0.037 0.0401
Brugia malayi Dual specificity protein phosphatase CDC14B 0.001 0.001 0.002
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Plasmodium falciparum beta-hydroxyacyl-ACP dehydratase 0.0511 1 1
Echinococcus granulosus survival motor neuron protein 1 0.026 0.4983 1
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.001 0.001 0.002
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.001 0.001 0.002
Onchocerca volvulus 0.0028 0.037 0.4301
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.037 0.0401
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0028 0.037 0.0561
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.016 0.2996 0.466
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.001 0.002
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.001 0.001 0.002
Echinococcus multilocularis survival motor neuron protein 1 0.026 0.4983 1
Onchocerca volvulus 0.001 0.001 0.0116
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0028 0.037 0.0742
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.037 0.0401
Mycobacterium ulcerans oxidoreductase 0.0028 0.037 0.0401
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.019 0.0381
Trichomonas vaginalis DNA helicase recq, putative 0.0019 0.019 0.022
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.001 0.001 0.002
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0019 0.019 0.0381
Onchocerca volvulus 0.001 0.001 0.0116
Mycobacterium tuberculosis Conserved hypothetical protein 0.0175 0.3288 0.3739
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.019 0.0281
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0926 0.1857
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.001 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.016 0.2996 0.6013
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.042 0.8175 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0332 0.6419 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.001 0.002
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.042 0.8175 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0926 0.0712
Onchocerca volvulus 4.1 G protein, putative homolog 0.001 0.001 0.0116
Trypanosoma brucei pteridine reductase 1 0.0028 0.037 0.0561
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0086 0.1516 0.3042
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.001 0.001 0.002
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.001 0.001 0.0034
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0043 0.0087
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0019 0.019 0.0381
Brugia malayi Cytochrome P450 family protein 0.0012 0.0043 0.0087
Loa Loa (eye worm) retinol dehydrogenase 12 0.0028 0.037 0.0742
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0043 0.0052
Echinococcus granulosus Protein patched homolog 1 0.0066 0.1117 0.2242
Schistosoma mansoni DNA helicase recq5 0.0019 0.019 0.0634
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0028 0.037 0.037
Leishmania major cytochrome p450-like protein 0.0012 0.0043 0.0052
Wolbachia endosymbiont of Brugia malayi (3R)-hydroxymyristoyl-ACP dehydratase 0.0511 1 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.2934 0.4562
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.037 0.0401
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.016 0.2996 0.466
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.037 0.0401
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Onchocerca volvulus 0.001 0.001 0.0116
Schistosoma mansoni survival motor neuron protein 0.0053 0.0859 0.2868
Loa Loa (eye worm) protein-tyrosine phosphatase 0.001 0.001 0.002
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.001 0.001 0.0034
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.037 0.0401
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0047 0.0733 0.1128
Loa Loa (eye worm) hypothetical protein 0.0066 0.1117 0.2242
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.001 0.001 0.002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0733 0.1128
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.001 0.001 0.002
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.016 0.2996 0.466
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0028 0.037 0.0561
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.037 0.0401
Brugia malayi Protein-tyrosine phosphatase 0.001 0.001 0.002
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.037 0.0401
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.016 0.2996 0.466
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0086 0.1516 0.119
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.001 0.002
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0047 0.0733 0.1128
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0028 0.037 0.0401
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0086 0.1516 0.1468
Echinococcus granulosus sterol regulatory element binding protein 0.0066 0.1117 0.2242
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Toxoplasma gondii beta-hydroxyacyl-acyl carrier protein dehydratase (FABZ) 0.0511 1 1
Onchocerca volvulus 0.001 0.001 0.0116
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0028 0.037 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0086 0.1516 0.1516
Echinococcus multilocularis protein tyrosine phosphatase n9 0.001 0.001 0.002
Leishmania major pteridine reductase 1 0.0028 0.037 0.0561
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.001 0.001 0.0034
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0028 0.037 0.0742
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0157 0.2934 0.4562
Onchocerca volvulus 0.001 0.001 0.0116
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0393 0.0393
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.037 0.0401
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.001 0.001 0.0034
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0043 0.0052
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0028 0.037 0.1234
Onchocerca volvulus 0.0053 0.0859 1
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0019 0.019 0.0381
Onchocerca volvulus 0.001 0.001 0.0116
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Echinococcus multilocularis sterol regulatory element binding protein 0.0066 0.1117 0.2242
Schistosoma mansoni DNA helicase recq1 0.0019 0.019 0.0634
Schistosoma mansoni dihydropteridine reductase 0.0028 0.037 0.1234
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.001 0.001 0.0034
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.037 0.0401
Leishmania major mitochondrial DNA polymerase beta 0.0332 0.6419 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.001 0.002
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0028 0.037 0.037
Echinococcus granulosus protein tyrosine phosphatase n9 0.001 0.001 0.002
Entamoeba histolytica recQ family helicase, putative 0.0019 0.019 0.5135
Mycobacterium ulcerans short chain dehydrogenase 0.0028 0.037 0.0401
Loa Loa (eye worm) protein tyrosine phosphatase 0.001 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0075 0.1301 0.1581
Loa Loa (eye worm) hypothetical protein 0.026 0.4983 1
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.042 0.8175 0.8175
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.001 0.001 0.002
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0086 0.1516 0.3042
Giardia lamblia Sgs1 DNA helicase, putative 0.0019 0.019 0.1393
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0019 0.019 0.0381
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0047 0.0733 0.1128
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.001 0.001 0.0034
Onchocerca volvulus 0.001 0.001 0.0116
Brugia malayi Bloom's syndrome protein homolog 0.0019 0.019 0.0381
Echinococcus multilocularis protein dispatched 1 0.0066 0.1117 0.2242
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.001 0.001 0.002
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.001 0.001 0.002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0926 0.0712
Trichomonas vaginalis hypothetical protein 0.042 0.8175 1
Schistosoma mansoni protein tyrosine phosphatase 0.001 0.001 0.0034
Loa Loa (eye worm) hypothetical protein 0.0019 0.019 0.0381
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.016 0.2996 0.3631
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0086 0.1516 0.1352
Brugia malayi hypothetical protein 0.001 0.001 0.002
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.001 0.001 0.002
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.002
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0086 0.1516 0.1811
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0028 0.037 0.0401
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.001 0.001 0.002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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