Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0069 | 0.0069 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0063 | 0.0044 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.1396 | 0.3792 | 1 |
Plasmodium falciparum | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex | 0.0128 | 0.0324 | 0.0423 |
Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0035 | 0.0208 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0103 | 0.0079 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0029 | 0.001 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0049 | 0.0024 |
Schistosoma mansoni | dihydrolipoamide S-acetyltransferase | 0.0128 | 0.0324 | 0.0324 |
Mycobacterium leprae | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) | 0.0497 | 0.1332 | 0.3405 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0033 | 0.0063 | 0.0063 |
Brugia malayi | beta-lactamase | 0.007 | 0.0165 | 0.0145 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0035 | 0.0633 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0029 | 0.0005 |
Onchocerca volvulus | 0.007 | 0.0165 | 1 | |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.003 | 0.0177 |
Treponema pallidum | pyruvate carboxylase subunit B | 0.0128 | 0.0324 | 1 |
Chlamydia trachomatis | acetyl-coenzyme A carboxylase carboxyl transferase subunit beta | 0.0497 | 0.1332 | 0.3756 |
Schistosoma mansoni | dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase | 0.0128 | 0.0324 | 0.0324 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.007 | 0.0165 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0099 | 0.0099 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0099 | 0.0099 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0918 | 0.2484 | 0.247 |
Brugia malayi | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta | 0.0128 | 0.0324 | 0.031 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0046 | 0.0099 | 0.0081 |
Loa Loa (eye worm) | beta-lactamase | 0.007 | 0.0165 | 0.0145 |
Mycobacterium ulcerans | acetyl/propionyl CoA carboxylase subunit beta | 0.0497 | 0.1332 | 0.346 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0069 | 0.005 |
Trypanosoma brucei | pyruvate dehydrogenase complex E3 binding protein, putative | 0.0128 | 0.0324 | 0.0299 |
Plasmodium falciparum | flap endonuclease 1 | 0.0025 | 0.0042 | 0.0033 |
Plasmodium vivax | pyruvate kinase 2, putative | 0.0017 | 0.0019 | 0.0026 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0025 | 0.0042 | 0.0023 |
Leishmania major | carboxylase, putative | 0.1396 | 0.3792 | 0.3776 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0019 | 0.0026 | 0.0044 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0103 | 0.0103 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.003 | 0.0004 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0046 | 0.0099 | 0.0081 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.1396 | 0.3792 | 0.378 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0165 | 0.0226 |
Plasmodium vivax | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative | 0.0128 | 0.0324 | 0.0448 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0497 | 0.1332 | 0.1309 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.003 | 0.0004 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 5 AccD5 | 0.0497 | 0.1332 | 0.346 |
Plasmodium falciparum | dihydrolipoamide acyltransferase component E2 | 0.0128 | 0.0324 | 0.0423 |
Plasmodium falciparum | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex | 0.0128 | 0.0324 | 0.0423 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0146 | 0.0373 | 0.036 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase precursor, putative | 0.0128 | 0.0324 | 0.0484 |
Toxoplasma gondii | ABC1 family protein | 0.007 | 0.0165 | 0.0165 |
Mycobacterium tuberculosis | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) | 0.0497 | 0.1332 | 0.346 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.007 | 0.0165 | 0.036 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.1396 | 0.3792 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.007 | 0.0165 | 0.0226 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0036 | 0.0071 | 0.0053 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0063 | 0.0036 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.003 | 0.0004 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0049 | 0.0031 |
Schistosoma mansoni | flap endonuclease-1 | 0.0023 | 0.0036 | 0.0036 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0135 | 0.0279 |
Toxoplasma gondii | pyruvate carboxylase | 0.1396 | 0.3792 | 0.3792 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0049 | 0.0068 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0146 | 0.0373 | 0.036 |
Chlamydia trachomatis | dihydrolipoamide acetyltransferase | 0.0128 | 0.0324 | 0.0774 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0049 | 0.0024 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.0497 | 0.1332 | 0.1309 |
Schistosoma mansoni | pyruvate kinase | 0.0017 | 0.0019 | 0.0019 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0071 | 0.0074 |
Plasmodium vivax | hypothetical protein, conserved | 0.007 | 0.0165 | 0.0229 |
Echinococcus granulosus | dihydrolipoyllysine residue succinyltransferase | 0.0128 | 0.0324 | 0.0306 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.0042 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0165 | 0.0145 |
Onchocerca volvulus | 0.007 | 0.0165 | 1 | |
Mycobacterium tuberculosis | Probable esterase LipL | 0.007 | 0.0165 | 0.036 |
Mycobacterium ulcerans | pyruvate kinase | 0.0033 | 0.0063 | 0.0087 |
Mycobacterium tuberculosis | Conserved protein | 0.007 | 0.0165 | 0.036 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.003 | 0.0066 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0103 | 0.0103 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.007 | 0.0165 | 0.0145 |
Toxoplasma gondii | 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein | 0.0128 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0324 | 0.031 |
Trypanosoma brucei | dihydrolipoamide acetyltransferase E2 subunit, putative | 0.0128 | 0.0324 | 0.0299 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.0135 | 0.0109 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0023 | 0.0035 | 0.001 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0071 | 0.0071 |
Toxoplasma gondii | biotin-requiring enzyme domain-containing protein | 0.0128 | 0.0324 | 0.0324 |
Mycobacterium leprae | Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB | 0.0128 | 0.0324 | 0.0705 |
Onchocerca volvulus | 0.0047 | 0.0103 | 0.3893 | |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.007 | 0.0165 | 0.036 |
Wolbachia endosymbiont of Brugia malayi | carbamoyl phosphate synthase large subunit | 0.0315 | 0.0836 | 0.2143 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.007 | 0.0165 | 1 |
Plasmodium falciparum | carbamoyl phosphate synthetase | 0.0315 | 0.0836 | 0.1133 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase precursor, putative | 0.0128 | 0.0324 | 0.0484 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0036 | 0.0071 | 0.0053 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4 | 0.0497 | 0.1332 | 0.346 |
Trypanosoma brucei | unspecified product | 0.0918 | 0.2484 | 0.2464 |
Echinococcus multilocularis | Biotin lipoyl attachment | 0.0128 | 0.0324 | 0.0306 |
Trypanosoma cruzi | dihydrolipoamide acetyltransferase, putative | 0.0128 | 0.0324 | 0.0484 |
Mycobacterium tuberculosis | Probable hydrolase | 0.007 | 0.0165 | 0.036 |
Trypanosoma brucei | glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative | 0.0315 | 0.0836 | 0.0812 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.3665 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | branched-chain alpha-keto acid dehydrogenase subunit E2 | 0.0128 | 0.0324 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0324 | 0.031 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0046 | 0.0099 | 0.0076 |
Schistosoma mansoni | hypothetical protein | 0.01 | 0.0246 | 0.0246 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0036 | 0.0071 | 0.011 |
Chlamydia trachomatis | biotin carboxylase | 0.1267 | 0.3441 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.0497 | 0.1332 | 0.1315 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.022 | 0.022 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0033 | 0.0063 | 0.0038 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0035 | 0.0014 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.007 | 0.0165 | 0.0147 |
Mycobacterium ulcerans | acetyl-/propionyl-CoA carboxylase subunit beta | 0.0497 | 0.1332 | 0.346 |
Echinococcus multilocularis | pyruvate kinase | 0.0033 | 0.0063 | 0.0044 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0918 | 0.2484 | 0.247 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0063 | 0.0038 |
Echinococcus multilocularis | bloom syndrome protein | 0.0019 | 0.0026 | 0.0007 |
Mycobacterium tuberculosis | Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 | 0.0497 | 0.1332 | 0.346 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0069 | 0.0409 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.022 | 0.0202 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0046 | 0.0099 | 0.0076 |
Echinococcus multilocularis | dihydrolipoyllysine residue acetyltransferase | 0.0128 | 0.0324 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0246 | 0.0229 |
Toxoplasma gondii | dihydrolipoamide acyltransferase, putative | 0.0128 | 0.0324 | 0.0324 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.007 | 0.0165 | 0.036 |
Mycobacterium tuberculosis | Conserved protein | 0.007 | 0.0165 | 0.036 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4_2 | 0.0497 | 0.1332 | 0.346 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0019 | 0.0026 | 0.0007 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0069 | 0.0409 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0099 | 0.0076 |
Leishmania major | carbamoyl-phosphate synthase, putative | 0.0315 | 0.0836 | 0.0812 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.007 | 0.0165 | 1 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.0497 | 0.1332 | 0.1332 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.007 | 0.0165 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0299 | 0.079 | 0.0773 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.1396 | 0.3792 | 0.3792 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.1396 | 0.3792 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0046 | 0.0099 | 0.0081 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.022 | 0.022 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.007 | 0.0165 | 0.0147 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.003 | 0.0011 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.0191 | 0.0171 |
Mycobacterium ulcerans | beta-lactamase | 0.007 | 0.0165 | 0.036 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0029 | 0.0062 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.003 | 0.0041 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0036 | 0.0071 | 0.0071 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0135 | 0.0135 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0497 | 0.1332 | 0.1309 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0023 | 0.0035 | 0.021 |
Schistosoma mansoni | DNA helicase recq5 | 0.0019 | 0.0026 | 0.0026 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0063 | 0.0059 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0071 | 0.3253 |
Toxoplasma gondii | carbamoylphosphate synthetase | 0.0315 | 0.0836 | 0.0836 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0049 | 0.0023 |
Echinococcus multilocularis | dihydrolipoyllysine residue succinyltransferase | 0.0128 | 0.0324 | 0.0306 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0019 | 0.0026 | 0.0007 |
Toxoplasma gondii | dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase | 0.0128 | 0.0324 | 0.0324 |
Onchocerca volvulus | 0.007 | 0.0165 | 1 | |
Chlamydia trachomatis | dihydrolipoamide succinyltransferase | 0.0128 | 0.0324 | 0.0774 |
Trypanosoma brucei | pyruvate kinase 1 | 0.0033 | 0.0063 | 0.0036 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0063 | 0.0063 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.003 | 0.0015 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0046 | 0.0099 | 0.0081 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.003 | 0.003 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.3665 | 1 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.3665 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0135 | 0.0279 |
Echinococcus multilocularis | pyruvate kinase | 0.0026 | 0.0044 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0165 | 0.0145 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.003 | 0.0004 |
Mycobacterium ulcerans | hypothetical protein | 0.007 | 0.0165 | 0.036 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.003 | 0.003 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.007 | 0.0165 | 0.0165 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0019 | 0.0026 | 0.0007 |
Schistosoma mansoni | DNA helicase recq1 | 0.0019 | 0.0026 | 0.0026 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.0135 | 0.0116 |
Brugia malayi | beta-lactamase family protein | 0.007 | 0.0165 | 0.0145 |
Trypanosoma brucei | 2-oxoglutarate dehydrogenase E2 component, putative | 0.0128 | 0.0324 | 0.0299 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0033 | 0.0063 | 0.0059 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.022 | 0.0202 |
Mycobacterium leprae | Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) | 0.0497 | 0.1332 | 0.3405 |
Mycobacterium ulcerans | dihydrolipoamide acetyltransferase | 0.0128 | 0.0324 | 0.0782 |
Entamoeba histolytica | Ran family GTPase | 0.0021 | 0.0029 | 0.0173 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.1396 | 0.3792 | 0.3776 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0063 | 0.0038 |
Leishmania major | dihydrolipoamide acetyltransferase precursor, putative | 0.0128 | 0.0324 | 0.0299 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0033 | 0.0063 | 0.0038 |
Leishmania major | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0128 | 0.0324 | 0.0299 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.007 | 0.0165 | 0.0145 |
Entamoeba histolytica | recQ family helicase, putative | 0.0019 | 0.0026 | 0.0155 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0071 | 0.0424 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0025 | 0.0042 | 0.0042 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.0315 | 0.0836 | 0.0836 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0299 | 0.079 | 0.0794 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0025 | 0.0042 | 0.1164 |
Mycobacterium tuberculosis | Conserved protein | 0.007 | 0.0165 | 0.036 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0019 | 0.0026 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0063 | 0.0038 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0497 | 0.1332 | 0.2121 |
Chlamydia trachomatis | acetyl-CoA carboxylase biotin carboxyl carrier protein | 0.0128 | 0.0324 | 0.0774 |
Echinococcus granulosus | bloom syndrome protein | 0.0019 | 0.0026 | 0.0007 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.0017 | 0.0019 | 0.0019 |
Plasmodium vivax | dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative | 0.0128 | 0.0324 | 0.0448 |
Brugia malayi | follicle stimulating hormone receptor | 0.0232 | 0.0609 | 0.0605 |
Plasmodium vivax | carbamoyl phosphate synthetase, putative | 0.0315 | 0.0836 | 0.1157 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0019 | 0.0026 | 0.001 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0033 | 0.0063 | 0.0087 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.3665 | 1 | 1 |
Brugia malayi | beta-lactamase family protein | 0.007 | 0.0165 | 0.0145 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.0135 | 0.0116 |
Wolbachia endosymbiont of Brugia malayi | Acetyl-CoA carboxylase, carboxyltransferase component | 0.0497 | 0.1332 | 0.346 |
Trypanosoma cruzi | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0128 | 0.0324 | 0.0484 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0165 | 0.0145 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0035 | 0.0009 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.007 | 0.0165 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.1396 | 0.3792 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0035 | 0.001 |
Brugia malayi | dihydrolipoamide S-acetyltransferase precursor, putative | 0.0128 | 0.0324 | 0.031 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.007 | 0.0165 | 0.0165 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.0042 | 0.0016 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0049 | 0.0049 |
Entamoeba histolytica | Flap nuclease, putative | 0.0025 | 0.0042 | 0.0251 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.003 | 0.0267 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.007 | 0.0165 | 0.036 |
Trypanosoma cruzi | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative | 0.0128 | 0.0324 | 0.0484 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.003 | 0.003 |
Mycobacterium ulcerans | branched-chain alpha-keto acid dehydrogenase subunit E2 | 0.0128 | 0.0324 | 0.0782 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.003 | 0.0006 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0918 | 0.2484 | 0.247 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0035 | 0.0633 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.003 | 0.0267 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.009 | 0.022 | 0.022 |
Trypanosoma cruzi | dihydrolipoamide branched chain transacylase, putative | 0.0128 | 0.0324 | 0.0484 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0025 | 0.0042 | 0.0017 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0069 | 0.005 |
Brugia malayi | Inositol-1 | 0.0036 | 0.0071 | 0.0047 |
Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0029 | 0.0003 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0063 | 0.2616 |
Brugia malayi | Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor | 0.0128 | 0.0324 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0165 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0324 | 0.031 |
Mycobacterium tuberculosis | Biotinylated protein TB7.3 | 0.0128 | 0.0324 | 0.0782 |
Schistosoma mansoni | ran | 0.0021 | 0.0029 | 0.0029 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0033 | 0.0063 | 0.0004 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0497 | 0.1332 | 0.2121 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0099 | 0.0099 |
Schistosoma mansoni | inositol monophosphatase | 0.0036 | 0.0071 | 0.0071 |
Mycobacterium tuberculosis | DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase | 0.0128 | 0.0324 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.0373 | 0.036 |
Echinococcus granulosus | neuropeptide s receptor | 0.0918 | 0.2484 | 0.247 |
Mycobacterium leprae | Probable lipase LipE | 0.007 | 0.0165 | 0.0279 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.009 | 0.022 | 0.0202 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0025 | 0.0042 | 0.0016 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.0135 | 0.0279 |
Giardia lamblia | Pyruvate kinase | 0.0033 | 0.0063 | 0.0262 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.0033 | 0.0063 | 0.2616 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0165 | 0.0145 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0063 | 0.0044 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.0497 | 0.1332 | 0.2121 |
Trypanosoma cruzi | dihydrolipoamide branched chain transacylase, putative | 0.0128 | 0.0324 | 0.0484 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.3536 | 0.9649 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.009 | 0.022 | 0.0202 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0049 | 0.0049 |
Echinococcus granulosus | pyruvate kinase | 0.0033 | 0.0063 | 0.0044 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0146 | 0.0373 | 0.036 |
Trypanosoma brucei | dihydrolipoamide branched chain transacylase, putative | 0.0128 | 0.0324 | 0.0299 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E2 | 0.0128 | 0.0324 | 0.0324 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0019 | 0.0026 | 0.0007 |
Chlamydia trachomatis | dihydrolipoamide succinyltransferase | 0.0128 | 0.0324 | 0.0774 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0049 | 0.0023 |
Schistosoma mansoni | dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase | 0.0128 | 0.0324 | 0.0324 |
Trypanosoma brucei | hypothetical protein, conserved | 0.007 | 0.0165 | 0.0139 |
Plasmodium vivax | pyruvate kinase, putative | 0.0033 | 0.0063 | 0.0086 |
Schistosoma mansoni | pyruvate carboxylase | 0.1396 | 0.3792 | 0.3792 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0071 | 0.0074 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.1396 | 0.3792 | 1 |
Schistosoma mansoni | ran | 0.0021 | 0.0029 | 0.0029 |
Leishmania major | pyruvate kinase | 0.0033 | 0.0063 | 0.0036 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0029 | 0.0003 |
Loa Loa (eye worm) | pyruvate kinase | 0.0033 | 0.0063 | 0.0038 |
Brugia malayi | hypothetical protein | 0.0232 | 0.0609 | 0.0605 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1578 | 0.429 | 0.4279 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0049 | 0.0042 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.0033 | 0.0063 | 0.0036 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.1396 | 0.3792 | 0.6119 |
Trypanosoma cruzi | glutamine-dependent carbamoyl-phosphate synthetase, putative | 0.0315 | 0.0836 | 0.1316 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide acyltransferase E2 component | 0.0128 | 0.0324 | 0.0782 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.1396 | 0.3792 | 0.6119 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.0609 | 0.0605 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0071 | 0.3253 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.2652 | 0.7229 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.3665 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0232 | 0.0609 | 0.0605 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.1396 | 0.3792 | 1 |
Leishmania major | dihydrolipoamide acetyltransferase precursorlike protein | 0.0128 | 0.0324 | 0.0299 |
Toxoplasma gondii | acyl-CoA carboxyltransferase beta chain, putative | 0.0497 | 0.1332 | 0.1332 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0029 | 0.004 |
Mycobacterium ulcerans | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 | 0.0497 | 0.1332 | 0.346 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.3665 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0029 | 0.0003 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0029 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0046 | 0.0099 | 0.0099 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0071 | 0.0045 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.0135 | 0.0135 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.0135 | 0.0279 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.1396 | 0.3792 | 0.3792 |
Trypanosoma cruzi | glutamine dependent carbamoyl-phosphate synthase, putative | 0.0315 | 0.0836 | 0.1316 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.0497 | 0.1332 | 0.1315 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.009 | 0.022 | 0.0202 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.007 | 0.0165 | 0.036 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.0135 | 0.0135 |
Echinococcus granulosus | flap endonuclease 1 | 0.0025 | 0.0042 | 0.0023 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0032 | 0.0061 | 0.0083 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0026 | 0.0026 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0029 | 0.0014 |
Brugia malayi | Flap endonuclease-1 | 0.0025 | 0.0042 | 0.0017 |
Mycobacterium leprae | ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 | 0.0497 | 0.1332 | 0.3405 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0071 | 0.3253 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0232 | 0.0609 | 0.0591 |
Mycobacterium ulcerans | carbamoyl phosphate synthase large subunit | 0.0315 | 0.0836 | 0.2143 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.1396 | 0.3792 | 0.3776 |
Echinococcus granulosus | Biotin lipoyl attachment | 0.0128 | 0.0324 | 0.0306 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0071 | 0.0047 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0625 | 0.1683 | 1 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0029 | 0.0005 |
Plasmodium falciparum | pyruvate kinase | 0.0033 | 0.0063 | 0.0061 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0449 | 0.1202 | 0.3116 |
Mycobacterium ulcerans | lipase LipD | 0.007 | 0.0165 | 0.036 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0025 | 0.0042 | 0.0141 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0025 | 0.0042 | 0.0059 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 0.079 | 0.079 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0069 | 0.0409 |
Mycobacterium leprae | Probable biotinylated protein homolog TB7.3 | 0.0128 | 0.0324 | 0.0705 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.2269 | 0.6181 | 1 |
Trichomonas vaginalis | esterase, putative | 0.007 | 0.0165 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.01 | 0.0246 | 0.0229 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0049 | 0.0031 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0069 | 0.0409 |
Schistosoma mansoni | dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase | 0.0128 | 0.0324 | 0.0324 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0069 | 0.0044 |
Echinococcus multilocularis | snurportin 1 | 0.0299 | 0.079 | 0.0773 |
Leishmania major | dihydrolipoamide branched chain transacylase, putative | 0.0128 | 0.0324 | 0.0299 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.003 | 0.0011 |
Mycobacterium leprae | conserved hypothetical protein | 0.007 | 0.0165 | 0.0279 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.1396 | 0.3792 | 0.3776 |
Mycobacterium ulcerans | hypothetical protein | 0.0128 | 0.0324 | 0.0782 |
Schistosoma mansoni | carbamoyl-phosphate synthetase | 0.0315 | 0.0836 | 0.0836 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0046 | 0.0099 | 0.0076 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0165 | 0.0145 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0029 | 0.001 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.007 | 0.0165 | 0.036 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0071 | 0.0045 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.3536 | 0.9649 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.2652 | 0.7229 | 1 |
Trichomonas vaginalis | ran, putative | 0.0021 | 0.0029 | 0.0221 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.1396 | 0.3792 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.007 | 0.0165 | 0.036 |
Mycobacterium tuberculosis | Probable branched-chain keto acid dehydrogenase E2 component BkdC | 0.0128 | 0.0324 | 0.0782 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.1396 | 0.3792 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0046 | 0.0099 | 0.0081 |
Schistosoma mansoni | aspartate carbamoyltransferase | 0.0315 | 0.0836 | 0.0836 |
Echinococcus granulosus | dihydrolipoyllysine residue acetyltransferase | 0.0128 | 0.0324 | 0.0306 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0069 | 0.0069 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.009 | 0.022 | 0.0202 |
Leishmania major | hypothetical protein, conserved | 0.007 | 0.0165 | 0.0139 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0232 | 0.0609 | 0.0591 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.003 | 0.0006 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0019 | 0.0026 | 0.0026 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0046 | 0.0099 | 0.0081 |
Schistosoma mansoni | pyruvate kinase | 0.0033 | 0.0063 | 0.0063 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.1396 | 0.3792 | 0.378 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0625 | 0.1683 | 1 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0029 | 0.0029 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0035 | 0.0633 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0071 | 0.011 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 4.33 | Calculated partition coefficient (clogP) | ChEMBL. | 12723954 |
EC50 (functional) | = 140 nM | Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay. | ChEMBL. | 12723954 |
Emax (binding) | = 75 | Emax | ChEMBL. | 12723954 |
NA (functional) | 0 | Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay. | ChEMBL. | 12723954 |
NA (functional) | 0 | Effective concentration required against gastrin releasing peptide receptor (GRP-R) in CHO cells by using FLIPR assay. | ChEMBL. | 12723954 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.