Detailed information for compound 866186

Basic information

Technical information
  • TDR Targets ID: 866186
  • Name: 7-[(4-tert-butylphenyl)-(pyridin-2-ylamino)me thyl]-2-methylquinolin-8-ol
  • MW: 397.512 | Formula: C26H27N3O
  • H donors: 2 H acceptors: 3 LogP: 6.34 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(n1)c(O)c(cc2)C(c1ccc(cc1)C(C)(C)C)Nc1ccccn1
  • InChi: 1S/C26H27N3O/c1-17-8-9-19-12-15-21(25(30)24(19)28-17)23(29-22-7-5-6-16-27-22)18-10-13-20(14-11-18)26(2,3)4/h5-16,23,30H,1-4H3,(H,27,29)
  • InChiKey: IPDZJNIZUSHWQI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-[(4-tert-butylphenyl)-(2-pyridylamino)methyl]-2-methyl-quinolin-8-ol
  • 7-[(4-tert-butylphenyl)-(2-pyridylamino)methyl]-2-methyl-8-quinolinol
  • 7-[(4-tert-butylphenyl)-(pyridin-2-ylamino)methyl]-2-methyl-quinolin-8-ol
  • Oprea1_284783

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.0893 0.1138
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0137
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.011 0.0085
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0666 0.071
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0948 0.3389
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0108 0.0083
Brugia malayi CXXC zinc finger family protein 0.003 0.0097 0.0123
Schistosoma mansoni aldehyde dehydrogenase 0.0022 0.0034 0.0034
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0158 0.1023 0.3657
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0741 0.0944
Brugia malayi intermediate filament protein 0.0028 0.0076 0.0097
Mycobacterium ulcerans beta-lactamase 0.0109 0.0666 0.2338
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0108 0.0108
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0242 0.1633 0.1633
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0043
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0177 0.0177
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.011 0.0085
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0394 0.2731 0.9974
Schistosoma mansoni ferritin light chain 0.0035 0.013 0.013
Brugia malayi Adenosylhomocysteinase 0.0394 0.2731 0.3483
Onchocerca volvulus 0.0109 0.0666 0.071
Echinococcus granulosus histone lysine methyltransferase setb 0.0158 0.1023 0.1023
Mycobacterium ulcerans bacterioferritin BfrA 0.0035 0.013 0.0358
Onchocerca volvulus 0.1251 0.8942 1
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0022 0.0034 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.0022 0.0034 0.0034
Schistosoma mansoni jumonji/arid domain-containing protein 0.0373 0.2575 0.2575
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0108 0.0137
Brugia malayi jmjC domain containing protein 0.0099 0.0593 0.0756
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0394 0.2731 0.3028
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0108 0.0108
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0155 0.0136
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0155 0.0171
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0371 0.2563 0.2563
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0099 0.0593 0.0756
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0893 0.0893
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0022 0.0034 0.0034
Echinococcus granulosus neuropeptide s receptor 0.0994 0.7075 0.7075
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0108 0.0137
Echinococcus multilocularis geminin 0.0339 0.2335 0.2335
Loa Loa (eye worm) hypothetical protein 0.0027 0.0072 0.0092
Echinococcus multilocularis cpg binding protein 0.0032 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0109 0.0666 0.0849
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0159 0.0202
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0137
Onchocerca volvulus 0.0028 0.0076 0.0048
Schistosoma mansoni aldehyde dehydrogenase 0.0395 0.2738 0.2738
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0097 0.0123
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0022 0.0034 0.0034
Echinococcus multilocularis lysine specific demethylase 5A 0.0371 0.2563 0.2563
Echinococcus multilocularis lamin dm0 0.0028 0.0076 0.0076
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0022 0.0034 0.0034
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0893 0.0893
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0108 0.0108
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0741 0.342
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0666 0.071
Mycobacterium ulcerans bacterioferritin BfrB 0.0035 0.013 0.0358
Brugia malayi Pre-SET motif family protein 0.0158 0.1023 0.1304
Schistosoma mansoni phd/f-box containing protein 0.0099 0.0593 0.0593
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0666 0.2344
Brugia malayi 6-phosphofructokinase 0.0119 0.0741 0.0944
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0395 0.2738 0.2738
Echinococcus granulosus cpg binding protein 0.0032 0.0109 0.0109
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.011 0.0085
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0108 0.0137
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0137
Mycobacterium ulcerans hypothetical protein 0.0165 0.1069 0.3828
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0051 0.0051
Schistosoma mansoni aldehyde dehydrogenase 0.0395 0.2738 0.2738
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0035 0.013 0.0198
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0666 0.1293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0108 0.0137
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0076 0.0097
Brugia malayi hypoxia-induced factor 1 0.0163 0.1058 0.1349
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0197 0.1301 0.1301
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0741 0.0944
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0108 0.0137
Brugia malayi aldehyde dehydrogenase 0.0022 0.0034 0.0043
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0266 0.0863
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0313 0.2141 0.7812
Echinococcus granulosus jumonji domain containing 1A 0.0099 0.0593 0.0593
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0022 0.0034 0.0043
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0481 0.2166
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0893 0.0893
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0022 0.0034 0.0043
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0137
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.011 0.0085
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0666 0.0849
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0181 0.119 0.4277
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0169 0.1102 0.1405
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0481 0.1418
Loa Loa (eye worm) adenosylhomocysteinase 0.0394 0.2731 0.3483
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0155 0.0447
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.0593 0.0756
Schistosoma mansoni ap endonuclease 0.0038 0.0155 0.0155
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0099 0.0593 0.2072
Onchocerca volvulus 0.0039 0.0159 0.0141
Loa Loa (eye worm) transcription factor SMAD2 0.0251 0.1695 0.2161
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0666 0.2344
Schistosoma mansoni tar DNA-binding protein 0.0197 0.1301 0.1301
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0394 0.2731 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0181 0.119 0.4277
Entamoeba histolytica adenosylhomocysteinase, putative 0.0394 0.2731 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0165 0.1069 0.2118
Brugia malayi hypothetical protein 0.0035 0.0128 0.0163
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0741 0.0794
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2101 0.2321
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0108 0.0108
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0108 0.0137
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0741 0.0794
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0893 0.0893
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0741 0.2621
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0115 0.0712 0.0712
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0158 0.1023 0.1023
Toxoplasma gondii ABC1 family protein 0.0109 0.0666 0.2338
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0108 0.0108
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0266 0.0598
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0266 0.0863
Plasmodium falciparum adenosylhomocysteinase 0.0394 0.2731 1
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0741 0.2614
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0108 0.0108
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.011 0.0281
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0666 0.2344
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0101 0.0605 0.0605
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0158 0.1023 0.1023
Plasmodium vivax JmjC domain containing protein 0.0099 0.0593 0.1842
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0108 0.0108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0108 0.0137
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0195 0.0597
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0242 0.1633 0.581
Brugia malayi RNA binding protein 0.0197 0.1301 0.1659
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0155 0.0197
Schistosoma mansoni cpg binding protein 0.0032 0.0109 0.0109
Brugia malayi beta-lactamase family protein 0.0109 0.0666 0.0849
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0242 0.1633 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0195 0.0597
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0159 0.1028 0.2033
Echinococcus multilocularis ferritin 0.0035 0.013 0.013
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0108 0.0108
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0365 0.2518 0.321
Schistosoma mansoni lamin 0.0028 0.0076 0.0076
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0022 0.0034 0.0034
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0108 0.0108
Leishmania major S-adenosylhomocysteine hydrolase 0.0394 0.2731 0.9974
Brugia malayi jmjC domain containing protein 0.0099 0.0593 0.0756
Echinococcus multilocularis JmjC domain containing protein 4 0.0099 0.0593 0.0593
Mycobacterium leprae Probable lipase LipE 0.0109 0.0666 0.2344
Mycobacterium ulcerans hypothetical protein 0.0109 0.0666 0.2338
Schistosoma mansoni apoferritin-2 0.0035 0.013 0.013
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0394 0.2731 0.9974
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0666 0.1293
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2101 0.2321
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0242 0.1633 0.5913
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0158 0.1023 0.1023
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.011 0.0085
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0264 0.0855
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0741 0.0794
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0108 0.0137
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0266 0.0861
Schistosoma mansoni aldehyde dehydrogenase 0.0022 0.0034 0.0034
Entamoeba histolytica hypothetical protein 0.0042 0.0177 0.0532
Loa Loa (eye worm) hypothetical protein 0.0155 0.0996 0.127
Echinococcus multilocularis muscleblind protein 0.0155 0.0996 0.0996
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0155 0.0585
Echinococcus multilocularis neuropeptide receptor A26 0.0994 0.7075 0.7075
Brugia malayi Probable ClpP-like protease 0.0242 0.1633 0.2082
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0115 0.0712 0.0712
Schistosoma mansoni hypothetical protein 0.0042 0.0177 0.0177
Onchocerca volvulus 0.0109 0.0666 0.071
Echinococcus multilocularis jumonji domain containing 1A 0.0099 0.0593 0.0593
Echinococcus granulosus muscleblind protein 0.0155 0.0996 0.0996
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0022 0.0034 0.0034
Mycobacterium ulcerans aldehyde dehydrogenase 0.0395 0.2738 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0666 0.0849
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0108 0.0108
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0155 0.0197
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0481 0.1418
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0177 0.0177
Echinococcus multilocularis adenosylhomocysteinase 0.0394 0.2731 0.2731
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0108 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0108 0.0137
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0159 0.1028 0.2033
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0697 0.4923 1
Schistosoma mansoni tar DNA-binding protein 0.0197 0.1301 0.1301
Schistosoma mansoni phosphatidylserine receptor 0.0099 0.0593 0.0593
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0108 0.0137
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0076 0.0097
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0365 0.2518 0.321
Mycobacterium ulcerans lipase LipD 0.0109 0.0666 0.2338
Schistosoma mansoni ferritin light chain 0.0035 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0137
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0336 0.1118
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0666 0.071
Echinococcus granulosus lamin dm0 0.0028 0.0076 0.0076
Loa Loa (eye worm) latrophilin receptor protein 2 0.0115 0.0712 0.0908
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0158 0.1023 0.1023
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0741 0.2614
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.011 0.0281
Brugia malayi jmjC domain containing protein 0.0099 0.0593 0.0756
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0152 0.0976 0.0976
Brugia malayi PAS domain containing protein 0.0053 0.0258 0.0329
Mycobacterium tuberculosis Conserved protein 0.0109 0.0666 0.1293
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0181 0.119 0.4277
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0197 0.1301 0.1659
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.011 0.0368
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0666 0.0666
Schistosoma mansoni jumonji/arid domain-containing protein 0.0373 0.2575 0.2575
Echinococcus granulosus single minded 2 0.0039 0.0159 0.0159
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.0593 0.0756
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0666 0.1293
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0242 0.1633 1
Brugia malayi hypothetical protein 0.0054 0.0266 0.034
Loa Loa (eye worm) hypoxia-induced factor 1 0.0163 0.1058 0.1349
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0108 0.0108
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0159 0.1028 0.3685
Echinococcus granulosus ferritin 0.0035 0.013 0.013
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0666 0.2338
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0155 0.0136
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0258 0.0258
Brugia malayi hypothetical protein 0.0177 0.1158 0.1476
Loa Loa (eye worm) hypothetical protein 0.0028 0.0076 0.0097
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0099 0.0593 0.2067
Loa Loa (eye worm) hypothetical protein 0.0365 0.2518 0.321
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0666 0.1293
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0108 0.0137
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.0386 0.0386
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0022 0.0034 0.0034
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0741 0.2621
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.015 0.0963 0.1901
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0394 0.2731 0.3028
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1099 0.7842 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.0495 0.1712
Brugia malayi Calcitonin receptor-like protein seb-1 0.0365 0.2518 0.321
Schistosoma mansoni ferritin 0.0035 0.013 0.013
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0099 0.0593 0.2067
Echinococcus granulosus lysine specific demethylase 6a 0.0099 0.0593 0.0593
Schistosoma mansoni jumonji domain containing protein 0.0371 0.2563 0.2563
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0666 0.2344
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0155 0.0585
Loa Loa (eye worm) hypothetical protein 0.0158 0.1023 0.1304
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0155 0.0448
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0242 0.1633 0.5913
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0108 0.0108
Toxoplasma gondii aldehyde dehydrogenase 0.0395 0.2738 1
Brugia malayi 6-phosphofructokinase 0.0119 0.0741 0.0944
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0394 0.2731 1
Brugia malayi phosphofructokinase 0.0119 0.0741 0.0944
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0741 0.0741
Echinococcus multilocularis phd:f box containing protein 0.0099 0.0593 0.0593
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0893 0.0893
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0108 0.0137
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0155 0.0448
Schistosoma mansoni aldehyde dehydrogenase 0.0022 0.0034 0.0034
Schistosoma mansoni hypothetical protein 0.0339 0.2335 0.2335
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0195 0.0597
Loa Loa (eye worm) hypothetical protein 0.0099 0.0593 0.0756
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2101 0.2321
Echinococcus granulosus expressed protein 0.0035 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0115 0.0712 0.0908
Brugia malayi latrophilin 2 splice variant baaae 0.0249 0.1682 0.2145
Brugia malayi Muscleblind-like protein 0.0155 0.0996 0.127
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0109 0.0666 0.0849
Loa Loa (eye worm) aldehyde dehydrogenase 0.0022 0.0034 0.0043
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.0495 0.1712
Schistosoma mansoni peptidase Clp (S14 family) 0.0242 0.1633 0.1633
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0051 0.0051
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0266 0.0598
Schistosoma mansoni adenosylhomocysteinase 0.0244 0.1643 0.1643
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0666 0.0666
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0666 0.071
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.011 0.0085
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.011 0.0085
Leishmania major mitochondrial DNA polymerase beta 0.0313 0.2141 0.7791
Toxoplasma gondii adenosylhomocysteinase, putative 0.0394 0.2731 0.9974
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0035 0.013 0.0359
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0099 0.0593 0.2072
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0242 0.1633 0.5913
Loa Loa (eye worm) hypothetical protein 0.0249 0.1682 0.2145
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0666 0.071
Loa Loa (eye worm) beta-lactamase 0.0109 0.0666 0.0849
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0108 0.0108
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0022 0.0034 0.0034
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0195 0.0597
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.011 0.0368
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0181 0.119 0.119
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0035 0.013 0.0606
Entamoeba histolytica hypothetical protein 0.0042 0.0177 0.0532
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0108 0.0137
Schistosoma mansoni hypothetical protein 0.0115 0.0712 0.0712
Loa Loa (eye worm) jmjC domain-containing protein 0.0373 0.2575 0.3284
Schistosoma mansoni tar DNA-binding protein 0.0197 0.1301 0.1301
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0666 0.0666
Trichomonas vaginalis esterase, putative 0.0109 0.0666 0.071
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0395 0.2738 0.5532
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0155 0.0756
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2101 0.2321
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0741 0.0944
Schistosoma mansoni hypothetical protein 0.0115 0.0712 0.0712
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0155 0.0996 0.127
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0159 0.0159
Schistosoma mansoni hypothetical protein 0.0249 0.1682 0.1682
Loa Loa (eye worm) hypothetical protein 0.0099 0.0593 0.0756
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0148 0.0948 0.3389
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0158 0.1023 0.1023
Echinococcus granulosus lysine specific demethylase 5A 0.0373 0.2575 0.2575
Echinococcus multilocularis GPCR, family 2 0.0115 0.0712 0.0712
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0108 0.0108
Echinococcus multilocularis neuropeptide s receptor 0.0994 0.7075 0.7075
Plasmodium falciparum JmjC domain-containing protein, putative 0.0099 0.0593 0.1842
Schistosoma mansoni coup transcription factor 0.0032 0.0108 0.0108
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0099 0.0593 0.2072
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0242 0.1633 0.5928
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.011 0.0281
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0115 0.0712 0.0908
Echinococcus granulosus peptidase Clp S14 family 0.0159 0.1028 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0108 0.0137
Schistosoma mansoni hypothetical protein 0.0434 0.3018 0.3018
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0242 0.1633 0.7735
Trichomonas vaginalis ferritin, putative 0.0035 0.013 0.0109
Echinococcus multilocularis musashi 0.0028 0.0076 0.0076
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0155 0.0448
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.0085 0.0495 0.0632
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0108 0.0108
Onchocerca volvulus 0.003 0.0097 0.0071
Schistosoma mansoni adenosylhomocysteinase 0.0394 0.2731 0.2731
Echinococcus granulosus tar DNA binding protein 0.0197 0.1301 0.1301
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0181 0.119 0.119
Onchocerca volvulus 0.0109 0.0666 0.071
Toxoplasma gondii hypothetical protein 0.005 0.0241 0.0768
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.011 0.0282
Schistosoma mansoni hypothetical protein 0.0115 0.0712 0.0712
Echinococcus multilocularis microtubule associated protein 2 0.1397 1 1
Echinococcus multilocularis tar DNA binding protein 0.0197 0.1301 0.1301
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0666 0.1293
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0109 0.0666 0.0849
Echinococcus granulosus phd:f box containing protein 0.0099 0.0593 0.0593
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0158 0.1023 0.1023
Schistosoma mansoni protein phosphatase 2C 0.0099 0.0593 0.0593
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0741 0.0741
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0266 0.0598
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0741 0.2621
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0394 0.2731 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0108 0.0137
Loa Loa (eye worm) RNA binding protein 0.0197 0.1301 0.1659
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0394 0.2731 1
Onchocerca volvulus 0.0032 0.0108 0.0083
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0666 0.0849
Schistosoma mansoni intermediate filament proteins 0.0028 0.0076 0.0076
Schistosoma mansoni lamin 0.0028 0.0076 0.0076
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0741 0.2621
Echinococcus granulosus JmjC domain containing protein 4 0.0099 0.0593 0.0593
Leishmania major hypothetical protein, conserved 0.0109 0.0666 0.2338
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2101 0.2321
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0108 0.0108
Schistosoma mansoni ferritin 0.0035 0.013 0.013
Echinococcus multilocularis peptidase Clp (S14 family) 0.0159 0.1028 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0108 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0197 0.1301 0.1301
Loa Loa (eye worm) MH2 domain-containing protein 0.0251 0.1695 0.2161
Schistosoma mansoni hypothetical protein 0.0339 0.2335 0.2335
Leishmania major hypothetical protein, conserved 0.0099 0.0593 0.2067
Brugia malayi MH2 domain containing protein 0.0251 0.1695 0.2161
Loa Loa (eye worm) hypothetical protein 0.0177 0.1158 0.1476
Brugia malayi steroid hormone receptor 0.0032 0.0108 0.0137
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0666 0.2122
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.0893 0.1138
Trichomonas vaginalis set domain proteins, putative 0.1251 0.8942 1
Echinococcus granulosus lamin 0.0028 0.0076 0.0076
Entamoeba histolytica hypothetical protein 0.0042 0.0177 0.0532
Echinococcus granulosus intermediate filament protein 0.0028 0.0076 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0893 0.0893
Echinococcus multilocularis lamin 0.0028 0.0076 0.0076
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0242 0.1633 0.5913
Brugia malayi ecdysteroid receptor 0.0032 0.0108 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0108 0.0137
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0741 0.0794
Brugia malayi jmjC domain containing protein 0.0099 0.0593 0.0756
Brugia malayi jmjC domain containing protein 0.0371 0.2563 0.3268
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0741 0.1446
Brugia malayi Pre-SET motif family protein 0.1099 0.7842 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2101 0.2321
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0741 0.0741
Echinococcus granulosus dnaJ subfamily B 0.0434 0.3018 0.3018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0108 0.0137
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0971 0.6908 0.8809
Giardia lamblia Fructose-bisphosphate aldolase 0.0307 0.2101 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.015 0.0963 0.3436
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0076 0.0097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0395 0.2738 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.015 0.0963 0.3445
Schistosoma mansoni hypothetical protein 0.0024 0.0051 0.0051
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0148 0.0948 0.3381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0108 0.0137
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0108 0.0108
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0242 0.1633 1
Schistosoma mansoni adenosylhomocysteinase 0.0244 0.1643 0.1643
Schistosoma mansoni jumonji domain containing protein 0.0099 0.0593 0.0593
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0108 0.0108
Loa Loa (eye worm) TAR-binding protein 0.0197 0.1301 0.1659
Brugia malayi beta-lactamase family protein 0.0109 0.0666 0.0849
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0242 0.1633 0.581
Mycobacterium tuberculosis Conserved protein 0.0109 0.0666 0.1293
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0181 0.119 0.119
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0124 0.0772 0.0829
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0371 0.2563 0.2563
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0108 0.0108
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2101 0.2321
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0022 0.0034 0.0034
Echinococcus multilocularis lysine specific demethylase 6a 0.0099 0.0593 0.0593
Schistosoma mansoni hypothetical protein 0.0022 0.0034 0.0034
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0181 0.119 0.2366
Echinococcus granulosus neuropeptide receptor A26 0.0994 0.7075 0.7075
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0108 0.0108
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0108 0.0108
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0035 0.013 0.0198
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.2141 0.7812
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0741 0.0741
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0099 0.0593 0.0593
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.0593 0.0756
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0108 0.0108
Brugia malayi nuclear hormone receptor 0.0032 0.0108 0.0137
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0115 0.0712 0.0712
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0266 0.0863
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0137
Loa Loa (eye worm) hypothetical protein 0.0109 0.0666 0.0849
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0108 0.0108
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0022 0.0034 0.0034
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0108 0.0108
Toxoplasma gondii exonuclease III APE 0.0038 0.0155 0.0447
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0108 0.0137
Toxoplasma gondii hypothetical protein 0.0084 0.0481 0.1655
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.2101 0.7664
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0115 0.0712 0.0712
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0181 0.119 0.1518
Mycobacterium ulcerans aldehyde dehydrogenase 0.0395 0.2738 1
Onchocerca volvulus 0.0028 0.0076 0.0048
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0242 0.1633 0.1633
Brugia malayi Latrophilin receptor protein 2 0.0115 0.0712 0.0908
Schistosoma mansoni microtubule-associated protein tau 0.1397 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0108 0.0108
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0108 0.0108
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0108 0.0083
Schistosoma mansoni ferritin 0.0035 0.013 0.013
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0108 0.0137
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0307 0.2101 0.2321
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0155 0.0247
Schistosoma mansoni ferritin 0.0035 0.013 0.013
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0395 0.2738 0.2738
Echinococcus multilocularis expressed protein 0.0035 0.013 0.013
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0313 0.2141 0.7812
Brugia malayi jmjC domain containing protein 0.0373 0.2575 0.3284
Schistosoma mansoni cpg binding protein 0.003 0.0097 0.0097
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0022 0.0034 0.0043
Schistosoma mansoni single-minded 0.0053 0.0258 0.0258
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0741 0.2621
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0394 0.2731 1
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0666 0.2338
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0394 0.2731 0.5518
Schistosoma mansoni ap endonuclease 0.0038 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0022 0.0034 0.0043
Schistosoma mansoni apoferritin-2 0.0035 0.013 0.013
Loa Loa (eye worm) hypothetical protein 0.0054 0.0266 0.034
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0108 0.0083
Entamoeba histolytica hypothetical protein 0.0042 0.0177 0.0532
Brugia malayi RNA recognition motif domain containing protein 0.0197 0.1301 0.1659
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0108 0.0137
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0155 0.0171
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0084 0.0481 0.166
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0022 0.0034 0.0034
Schistosoma mansoni adenosylhomocysteinase 0.0244 0.1643 0.1643
Schistosoma mansoni aldehyde dehydrogenase 0.0022 0.0034 0.0034
Treponema pallidum fructose-bisphosphate aldolase 0.0307 0.2101 1
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0159 0.0463
Echinococcus granulosus geminin 0.0339 0.2335 0.2335
Echinococcus granulosus GPCR family 2 0.0115 0.0712 0.0712
Loa Loa (eye worm) hypothetical protein 0.0032 0.0108 0.0137
Treponema pallidum bacterioferrin (TpF1) 0.0035 0.013 0.0468
Mycobacterium tuberculosis Conserved protein 0.0109 0.0666 0.1293
Onchocerca volvulus 0.0158 0.1023 0.111
Brugia malayi TAR-binding protein 0.0197 0.1301 0.1659
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0741 0.2621
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0022 0.0034 0.0034
Plasmodium vivax SET domain protein, putative 0.0158 0.1023 0.3483
Brugia malayi nuclear receptor NHR-88 0.0032 0.0108 0.0137
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0108 0.0108
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0155 0.0155
Schistosoma mansoni hypothetical protein 0.0115 0.0712 0.0712
Brugia malayi follicle stimulating hormone receptor 0.0971 0.6908 0.8809
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0395 0.2738 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0307 0.2101 0.7664
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0666 0.1293
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0996 0.0996
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0108 0.0137
Loa Loa (eye worm) hypothetical protein 0.0242 0.1633 0.2082
Brugia malayi Aldehyde dehydrogenase protein 4 0.0022 0.0034 0.0043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0893 0.0893
Echinococcus multilocularis dnaJ subfamily B 0.0434 0.3018 0.3018
Echinococcus granulosus adenosylhomocysteinase 0.0394 0.2731 0.2731
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0108 0.0108
Schistosoma mansoni adenosylhomocysteinase 0.0244 0.1643 0.1643
Loa Loa (eye worm) hypothetical protein 0.0109 0.0666 0.0849
Schistosoma mansoni cpg binding protein 0.0032 0.0109 0.0109
Leishmania major hypothetical protein, conserved 0.0054 0.0266 0.0861
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0155 0.0448
Brugia malayi hypothetical protein 0.0042 0.0177 0.0226
Brugia malayi beta-lactamase 0.0109 0.0666 0.0849
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0155 0.0447
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0101 0.0605 0.0605
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0666 0.1293

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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