Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0077 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0037 | 0.0023 | 0.0023 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0061 | 0.0066 | 0.0066 |
Schistosoma mansoni | lamin | 0.003 | 0.0009 | 0.0009 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0061 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | hypothetical protein | 0.0937 | 0.1652 | 0.1652 |
Echinococcus multilocularis | carboxylesterase 5A | 0.5544 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0937 | 0.1652 | 0.1652 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0332 | 0.0557 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.0293 | 0.0293 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0043 | 0.0034 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.0077 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0157 | 0.024 | 0.3398 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0063 | 0.007 | 0.5 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0047 | 0.0041 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0937 | 0.1652 | 0.1652 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0037 | 0.0023 | 0.0023 |
Echinococcus multilocularis | lamin dm0 | 0.003 | 0.0009 | 0.0009 |
Echinococcus multilocularis | neuroligin | 0.0937 | 0.1652 | 0.1652 |
Brugia malayi | Cytochrome P450 family protein | 0.0054 | 0.0053 | 0.0053 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0156 | 0.0238 | 0.0238 |
Echinococcus granulosus | glutamate receptor 2 | 0.0037 | 0.0023 | 0.0023 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0332 | 0.0557 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.5544 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5544 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.003 | 0.0009 | 0.0009 |
Echinococcus granulosus | carboxylesterase 5A | 0.5544 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.5544 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.5544 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0937 | 0.1652 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0937 | 0.1652 | 0.1652 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0037 | 0.0023 | 0.0023 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.016 | 0.0246 | 0.0246 |
Schistosoma mansoni | lamin | 0.003 | 0.0009 | 0.0009 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0037 | 0.0023 | 0.0023 |
Chlamydia trachomatis | glutamine binding protein | 0.0063 | 0.007 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0057 | 0.0058 | 0.0358 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0037 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0054 | 0.0053 | 0.0053 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0043 | 0.0034 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0045 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0037 | 0.0023 | 0.0023 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.016 | 0.0246 | 0.0246 |
Onchocerca volvulus | 0.0937 | 0.1652 | 1 | |
Echinococcus multilocularis | glutamate receptor 2 | 0.0037 | 0.0023 | 0.0023 |
Echinococcus multilocularis | geminin | 0.0186 | 0.0293 | 0.0293 |
Mycobacterium ulcerans | hypothetical protein | 0.0175 | 0.0272 | 0.1279 |
Onchocerca volvulus | 0.0937 | 0.1652 | 1 | |
Echinococcus granulosus | BC026374 protein S09 family | 0.0937 | 0.1652 | 0.1652 |
Brugia malayi | Carboxylesterase family protein | 0.0937 | 0.1652 | 0.1652 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0937 | 0.1652 | 1 |
Brugia malayi | intermediate filament protein | 0.003 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0937 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | intermediate filament protein | 0.003 | 0.0009 | 0.0009 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0937 | 0.1652 | 0.1652 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0088 | 0.0115 | 0.0115 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0077 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.5544 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5544 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.003 | 0.0009 | 0.0009 |
Echinococcus multilocularis | musashi | 0.003 | 0.0009 | 0.0009 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0088 | 0.0115 | 0.0115 |
Loa Loa (eye worm) | hypothetical protein | 0.0937 | 0.1652 | 0.1652 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0937 | 0.1652 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.003 | 0.0009 | 0.0009 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.016 | 0.0246 | 0.0246 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0045 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0937 | 0.1652 | 0.1652 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.0077 | 0.0077 |
Brugia malayi | Carboxylesterase family protein | 0.0937 | 0.1652 | 0.1652 |
Brugia malayi | Carboxylesterase family protein | 0.0937 | 0.1652 | 0.1652 |
Echinococcus granulosus | geminin | 0.0186 | 0.0293 | 0.0293 |
Loa Loa (eye worm) | hypothetical protein | 0.0937 | 0.1652 | 0.1652 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0037 | 0.0023 | 0.0023 |
Echinococcus multilocularis | acetylcholinesterase | 0.5544 | 1 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0043 | 0.0034 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0063 | 0.007 | 0.5 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0937 | 0.1652 | 0.1652 |
Brugia malayi | Carboxylesterase family protein | 0.5544 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0937 | 0.1652 | 0.1652 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.003 | 0.0009 | 0.0009 |
Schistosoma mansoni | acetylcholinesterase | 0.0937 | 0.1652 | 0.1652 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0037 | 0.0023 | 0.0023 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0045 |
Loa Loa (eye worm) | acetyltransferase | 0.016 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | carboxylesterase | 0.5544 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5544 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0047 | 0.0041 | 0.0041 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0037 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0008 | 0.0008 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0332 | 0.0557 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.0293 | 0.0293 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0937 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.0937 | 0.1652 | 0.1652 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0332 | 0.0557 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0937 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | carboxylesterase | 0.0937 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.0937 | 0.1652 | 0.1652 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0088 | 0.0115 | 0.0115 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0937 | 0.1652 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0061 | 0.0066 | 0.0066 |
Schistosoma mansoni | gliotactin | 0.0937 | 0.1652 | 0.1652 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0937 | 0.1652 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0937 | 0.1652 | 0.1652 |
Echinococcus granulosus | intermediate filament protein | 0.003 | 0.0009 | 0.0009 |
Brugia malayi | Carboxylesterase family protein | 0.0937 | 0.1652 | 0.1652 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0157 | 0.024 | 0.3871 |
Loa Loa (eye worm) | hypothetical protein | 0.0937 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0009 | 0.0009 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.0052 | 0.3215 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0157 | 0.024 | 0.3871 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.0077 | 0.0077 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0208 | 0.0333 | 0.0333 |
Onchocerca volvulus | 0.0937 | 0.1652 | 1 | |
Onchocerca volvulus | 0.0937 | 0.1652 | 1 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0937 | 0.1652 | 0.1652 |
Echinococcus granulosus | lamin | 0.003 | 0.0009 | 0.0009 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0208 | 0.0333 | 0.0333 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.0077 | 0.0045 |
Loa Loa (eye worm) | carboxylesterase | 0.0937 | 0.1652 | 0.1652 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0063 | 0.007 | 0.5 |
Echinococcus multilocularis | lamin | 0.003 | 0.0009 | 0.0009 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0208 | 0.0333 | 0.0333 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0937 | 0.1652 | 0.1652 |
Onchocerca volvulus | 0.0937 | 0.1652 | 1 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0937 | 0.1652 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0175 | 0.0272 | 0.1279 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.