Detailed information for compound 866608

Basic information

Technical information
  • TDR Targets ID: 866608
  • Name: N-(2-ethylphenyl)-2-(3-methoxyphenyl)-N-methy l-1-oxoisoquinoline-4-carboxamide
  • MW: 412.48 | Formula: C26H24N2O3
  • H donors: 0 H acceptors: 2 LogP: 4.58 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)n1cc(C(=O)N(c2ccccc2CC)C)c2c(c1=O)cccc2
  • InChi: 1S/C26H24N2O3/c1-4-18-10-5-8-15-24(18)27(2)25(29)23-17-28(19-11-9-12-20(16-19)31-3)26(30)22-14-7-6-13-21(22)23/h5-17H,4H2,1-3H3
  • InChiKey: UUDDYBHSJYNEEK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-ethylphenyl)-2-(3-methoxyphenyl)-N-methyl-1-oxo-isoquinoline-4-carboxamide
  • N-(2-ethylphenyl)-2-(3-methoxyphenyl)-N-methyl-1-oxo-4-isoquinolinecarboxamide
  • N-(2-ethylphenyl)-1-keto-2-(3-methoxyphenyl)-N-methyl-isoquinoline-4-carboxamide
  • E456-2148
  • NCGC00121746-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0007
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.0018 0.0018
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0127 0.0128 0.0167
Echinococcus multilocularis discoidin domain containing receptor 2 0.0032 0.0008 0.0005
Giardia lamblia Tenascin-X 0.0187 0.0203 0.0588
Brugia malayi celfurPC protein 0.5899 0.7401 0.7401
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0045 0.0024 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Brugia malayi protein kinase C II. 0.0084 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1779 0.221 0.3922
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.004 0.0018 0.0014
Brugia malayi EGF-like domain containing protein 0.0187 0.0203 0.0203
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Schistosoma mansoni ATP-binding cassette transporter 0.0035 0.0012 0.0008
Toxoplasma gondii subtilisin SUB12 0.0322 0.0374 0.9124
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0049 0.003 0.0812
Brugia malayi Subtilase family protein 0.0322 0.0374 0.0374
Giardia lamblia Transcriptional regulator, Sir2 family 0.0049 0.003 0.0077
Loa Loa (eye worm) hypothetical protein 0.0133 0.0135 0.0131
Loa Loa (eye worm) glutamate receptor 2 0.0034 0.0011 0.0006
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0121 0.012 0.3211
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1779 0.221 0.2389
Brugia malayi transcriptional regulator, Sir2 family protein 0.0049 0.003 0.003
Schistosoma mansoni protein tyrosine phosphatase 0.004 0.0018 0.0015
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0131 0.0133 0.308
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0335 0.039 0.0522
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.012 0.012 0.0156
Brugia malayi SWIRM domain containing protein 0.0029 0.0004 0.0004
Echinococcus granulosus protein kinase c epsilon type 0.0084 0.0074 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0187 0.0203 0.0199
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0034 0.0011 0.0008
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0069 0.0055 0.107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0069 0.0055 0.1466
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0044 0.0044
Onchocerca volvulus 0.004 0.0018 0.024
Toxoplasma gondii subtilisin SUB7 0.0322 0.0374 0.9124
Loa Loa (eye worm) hypothetical protein 0.0492 0.0587 0.0583
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.003 0.0028
Brugia malayi Protein kinase domain containing protein 0.0032 0.0008 0.0008
Loa Loa (eye worm) integrin beta-2 0.7962 1 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Brugia malayi Protein kinase domain containing protein 0.0069 0.0055 0.0055
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0034 0.0011 0.0007
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0018 0.0015
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.0069 0.0055 0.0051
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1457 0.1804 0.32
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0032 0.0008 0.0006
Echinococcus granulosus disintegrin and metalloproteinase 0.0094 0.0087 0.0089
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0049 0.003 0.0028
Trypanosoma brucei subtilisin peptidase 0.0322 0.0374 0.9378
Loa Loa (eye worm) hypothetical protein 0.0136 0.0139 0.0135
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1567 0.1942 0.262
Schistosoma mansoni dihydroceramide desaturase 0.0094 0.0087 0.0089
Giardia lamblia hypothetical protein 0.0187 0.0203 0.0588
Plasmodium falciparum plasmepsin X 0.0034 0.0011 0.0073
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Toxoplasma gondii subtilisin SUB8 0.0322 0.0374 0.9124
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0065 0.0065
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0069 0.0055 0.0055
Plasmodium vivax subtilisin-like protease 2, putative 0.0322 0.0374 0.8233
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1567 0.1942 0.1939
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0335 0.039 0.9819
Echinococcus multilocularis epidermal growth factor receptor 0.0387 0.0456 0.0611
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.4493 0.5629 0.6092
Echinococcus granulosus integrin beta 2 0.588 0.7376 0.7984
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Onchocerca volvulus 0.037 0.0434 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0051 0.0032 0.0038
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Echinococcus multilocularis adam 0.0484 0.0577 0.0775
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0738 0.0898 0.0968
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0026 0.0001 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.1457 0.1804 0.32
Giardia lamblia Tenascin-37 0.0187 0.0203 0.0588
Plasmodium falciparum plasmepsin VII 0.0034 0.0011 0.0073
Echinococcus multilocularis discoidin domain receptor 0.0032 0.0008 0.0005
Trypanosoma cruzi prolyl endopeptidase 0.0131 0.0133 0.3024
Toxoplasma gondii F5/8 type C domain-containing protein 0.0032 0.0008 0.0085
Echinococcus granulosus integrin alpha 3 0.1195 0.1474 0.1592
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.0374 0.0657
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0085 0.0075 0.1992
Toxoplasma gondii histone deacetylase SIR2 0.0049 0.003 0.0641
Loa Loa (eye worm) hypothetical protein 0.0069 0.0055 0.0051
Brugia malayi ADAMTS-like protease 0.0133 0.0135 0.0135
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.004 0.0018 0.0014
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0322 0.0374 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0335 0.039 0.0418
Echinococcus granulosus membrane bound transcription factor site 1 0.0322 0.0374 0.04
Schistosoma mansoni chromatin regulatory protein sir2 0.0335 0.039 0.0418
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Toxoplasma gondii aspartyl protease ASP1 0.0034 0.0011 0.0165
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.004 0.0018 0.0015
Echinococcus multilocularis disintegrin and metalloproteinase 0.0094 0.0087 0.0111
Mycobacterium ulcerans polyketide synthase 0.008 0.0069 0.1834
Loa Loa (eye worm) hypothetical protein 0.0069 0.0055 0.0051
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0064 0.0065
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4493 0.5629 1
Brugia malayi transcriptional regulator, Sir2 family protein 0.0335 0.039 0.039
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.0046
Schistosoma mansoni protein kinase 0.0127 0.0128 0.0134
Schistosoma mansoni glutamate receptor AMPA 0.0034 0.0011 0.0007
Echinococcus granulosus discoidin domain containing receptor 2 0.0032 0.0008 0.0004
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Echinococcus granulosus neuroendocrine convertase 2 0.4644 0.5819 0.6297
Schistosoma mansoni glutamate receptor NMDA 0.0051 0.0032 0.003
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1457 0.1804 0.32
Toxoplasma gondii prolyl endopeptidase 0.0131 0.0133 0.3171
Echinococcus multilocularis discoidin domain containing receptor 2 0.0032 0.0008 0.0005
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.004 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Schistosoma mansoni hypothetical protein 0.0059 0.0042 0.0041
Schistosoma mansoni protein-tyrosine phosphatase n9 0.004 0.0018 0.0015
Brugia malayi hypothetical protein 0.004 0.0018 0.0018
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0087 0.0077 0.206
Loa Loa (eye worm) hypothetical protein 0.0059 0.0042 0.0038
Toxoplasma gondii hypothetical protein 0.0187 0.0203 0.4913
Brugia malayi neuroendocrine convertase 1 precursor 0.4644 0.5819 0.5819
Brugia malayi EGF-like domain containing protein 0.0187 0.0203 0.0203
Mycobacterium ulcerans monoamine oxidase 0.0069 0.0055 0.1482
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0322 0.0374 1
Onchocerca volvulus Prolyl endopeptidase homolog 0.0131 0.0133 0.2929
Mycobacterium ulcerans polyketide synthase Pks13 0.0121 0.012 0.3211
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0059 0.0042 0.0041
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.0046
Onchocerca volvulus 0.004 0.0018 0.024
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0738 0.0898 0.1208
Loa Loa (eye worm) endoprotease bli-4 0.7357 0.9237 0.9237
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0069 0.0055 0.1482
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.1457 0.1804 0.32
Onchocerca volvulus 0.004 0.0018 0.024
Echinococcus granulosus MAM 0.0069 0.0055 0.0055
Mycobacterium ulcerans dehydrogenase 0.0069 0.0055 0.1482
Schistosoma mansoni hypothetical protein 0.0034 0.0011 0.0007
Echinococcus multilocularis hypothetical protein 0.004 0.0018 0.0018
Onchocerca volvulus 0.004 0.0018 0.024
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0032 0.0008 0.0191
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.004 0.0018 0.0015
Schistosoma mansoni hypothetical protein 0.0069 0.0055 0.0055
Echinococcus multilocularis integrin alpha 3 0.1195 0.1474 0.1987
Loa Loa (eye worm) hypothetical protein 0.037 0.0434 0.043
Loa Loa (eye worm) transcriptional regulator 0.0335 0.039 0.0386
Plasmodium falciparum plasmepsin V 0.0384 0.0452 1
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0032 0.0008 0.0005
Toxoplasma gondii subtilisin SUB9 0.0322 0.0374 0.9124
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0049 0.003 0.0672
Brugia malayi transcriptional regulator, Sir2 family protein 0.0049 0.003 0.003
Echinococcus granulosus protein tyrosine phosphatase n9 0.004 0.0018 0.0015
Echinococcus granulosus fibrillin 2 0.0187 0.0203 0.0215
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.1457 0.1804 0.32
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.008 0.0069 0.1834
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0059 0.0042 0.0042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1779 0.221 0.3922
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0069 0.0055 0.107
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0055 0.107
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Loa Loa (eye worm) RNA binding protein 0.0076 0.0064 0.006
Onchocerca volvulus 0.004 0.0018 0.024
Entamoeba histolytica PH domain containing protein kinase, putative 0.0069 0.0054 0.1296
Echinococcus granulosus discoidin domain containing receptor 2 0.0032 0.0008 0.0004
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0034 0.0011 0.0012
Schistosoma mansoni amine oxidase 0.0069 0.0055 0.0055
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0111 0.0108 0.0104
Mycobacterium leprae Polyketide synthase Pks13 0.0121 0.012 0.3198
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Brugia malayi aspartic protease BmAsp-1, identical 0.0034 0.0011 0.0011
Echinococcus granulosus glutamate receptor subunit protein glur 0.0034 0.0011 0.0007
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.004 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Onchocerca volvulus 0.004 0.0018 0.024
Loa Loa (eye worm) hypothetical protein 0.0227 0.0254 0.025
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0094 0.0087 0.0089
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.004 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0187 0.0203 0.0199
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0064 0.0064
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0018 0.0015
Loa Loa (eye worm) TK/ALK protein kinase 0.0069 0.0055 0.0051
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Toxoplasma gondii type I fatty acid synthase, putative 0.0085 0.0075 0.1744
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0052 0.0034 0.0415
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.004 0.0018 0.0018
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0087 0.0077 0.5
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0341 0.0398 0.0532
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.0046
Loa Loa (eye worm) kelch domain-containing protein family protein 0.1239 0.153 0.1526
Echinococcus multilocularis 0.0069 0.0055 0.0069
Plasmodium falciparum protoporphyrinogen oxidase 0.0069 0.0055 0.107
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1779 0.221 0.3922
Plasmodium falciparum subtilisin-like protease 3 0.0322 0.0374 0.8233
Schistosoma mansoni pcd6 interacting protein-related 0.004 0.0018 0.0015
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.004 0.0018 0.0015
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0335 0.039 1
Giardia lamblia High cysteine membrane protein Group 2 0.2713 0.3387 1
Onchocerca volvulus 0.0105 0.01 0.2172
Echinococcus granulosus integrin alpha ps 0.0884 0.1081 0.1167
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0051 0.0032 0.003
Toxoplasma gondii type I fatty acid synthase, putative 0.0059 0.0042 0.0931
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.004 0.0018 0.0015
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0049 0.003 0.0028
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0034 0.0011 0.0007
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0052 0.0034 0.0408
Brugia malayi Integrin alpha pat-2 precursor 0.1621 0.2011 0.2011
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Entamoeba histolytica protein tyrosine phosphatase, putative 0.004 0.0018 0.0354
Onchocerca volvulus 0.004 0.0018 0.024
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0052 0.0034 0.0408
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Onchocerca volvulus 0.0069 0.0055 0.1103
Leishmania major silent information regulator 2, putative 0.0335 0.039 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.008 0.0069 0.1834
Brugia malayi Kelch motif family protein 0.1239 0.153 0.153
Toxoplasma gondii subtilisin SUB10 0.0322 0.0374 0.9124
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0011 0.0007
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0049 0.003 0.0672
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0051 0.0032 0.0038
Brugia malayi endoprotease bli-4 precursor 0.7357 0.9237 0.9237
Giardia lamblia Tenascin-like 0.0187 0.0203 0.0588
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.7357 0.9237 1
Brugia malayi hypothetical protein 0.004 0.0018 0.0018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0187 0.0203 0.0199
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0007
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0077 0.0065 0.0061
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.003 0.0672
Schistosoma mansoni glutamate receptor NMDA 0.0285 0.0327 0.0349
Schistosoma mansoni site-1 peptidase (S08 family) 0.0322 0.0374 0.04
Mycobacterium tuberculosis Possible oxidoreductase 0.0069 0.0055 0.1482
Brugia malayi EGF-like domain containing protein 0.0187 0.0203 0.0203
Loa Loa (eye worm) TK/EGFR protein kinase 0.0387 0.0456 0.0452
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.0046
Schistosoma mansoni hypothetical protein 0.0059 0.0042 0.0041
Loa Loa (eye worm) hypothetical protein 0.0069 0.0055 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.1457 0.1804 0.32
Trichomonas vaginalis hypothetical protein 0.0032 0.0008 0.0006
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0032 0.0008 0.0005
Toxoplasma gondii aspartyl protease 0.0034 0.0011 0.0165
Echinococcus granulosus Furin 1 0.1779 0.221 0.2389
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Onchocerca volvulus 0.0131 0.0133 0.294
Trypanosoma cruzi oligopeptidase b 0.0052 0.0034 0.0408
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Plasmodium vivax aspartyl protease, putative 0.0034 0.0011 0.0073
Plasmodium vivax NAD-dependent deacetylase, putative 0.0049 0.003 0.0506
Echinococcus granulosus discoidin domain receptor 0.0032 0.0008 0.0004
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.004 0.0018 0.0014
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0111 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0098 0.0092 0.0087
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.004 0.0018 0.0354
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1779 0.221 0.3922
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0803 0.098 0.0976
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0064 0.0048 0.1273
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0045 0.0024 0.0024
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0018 0.0015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Onchocerca volvulus 0.004 0.0018 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Brugia malayi hypothetical protein 0.0034 0.0011 0.0011
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.004 0.0018 0.0014
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.4493 0.5629 0.7604
Plasmodium falciparum plasmepsin II 0.0034 0.0011 0.0073
Brugia malayi hypothetical protein 0.004 0.0018 0.0018
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0187 0.0203 0.0354
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.002 0.002
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0049 0.003 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.004 0.0018 0.0018
Schistosoma mansoni dock 0.0032 0.0008 0.0004
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.0074 0.0075
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0018 0.0015
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0011 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Toxoplasma gondii subtilisin SUB6 0.0322 0.0374 0.9124
Onchocerca volvulus 0.0034 0.0011 0.0076
Echinococcus multilocularis chromatin regulatory protein sir2 0.0335 0.039 0.0522
Mycobacterium ulcerans Type I modular polyketide synthase 0.008 0.0069 0.1834
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0007
Schistosoma mansoni hypothetical protein 0.0392 0.0462 0.0496
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0322 0.0374 0.04
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0034 0.0011 0.0165
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.004 0.0018 0.0015
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0127 0.0128 0.0134
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0335 0.039 0.0686
Schistosoma mansoni receptor protein tyrosine phosphatase 0.004 0.0018 0.0015
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0322 0.0374 0.0374
Chlamydia trachomatis glutamine binding protein 0.0087 0.0077 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0322 0.0374 0.9378
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0034 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0187 0.0203 0.0199
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0154 0.0162 0.0162
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0034 0.0011 0.0007
Trichomonas vaginalis hypothetical protein 0.1457 0.1804 0.32
Echinococcus granulosus integrin alpha ps 0.0392 0.0462 0.0496
Brugia malayi Pepsin A precursor 0.0034 0.0011 0.0011
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.008 0.0069 0.1818
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0297 0.0342 0.0366
Mycobacterium ulcerans thioesterase 0.0069 0.0055 0.1464
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0335 0.039 0.0686
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0085 0.0075 0.2007
Toxoplasma gondii F5/8 type C domain-containing protein 0.0032 0.0008 0.0085
Trypanosoma brucei prolyl endopeptidase 0.0131 0.0133 0.3024
Schistosoma mansoni chromatin regulatory protein sir2 0.0335 0.039 0.0418
Plasmodium falciparum subtilisin-like protease 1 0.0322 0.0374 0.8233
Trypanosoma brucei oligopeptidase b 0.0052 0.0034 0.0408
Schistosoma mansoni site-1 peptidase (S08 family) 0.0322 0.0374 0.04
Brugia malayi Furin-like cysteine rich region family protein 0.0387 0.0456 0.0456
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.004 0.0018 0.0015
Brugia malayi Sex muscle abnormal protein 5 0.0124 0.0124 0.0124
Echinococcus multilocularis neuroendocrine convertase 2 0.4644 0.5819 0.7861
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0032 0.0008 0.0003
Brugia malayi Angiotensin-converting enzyme family protein 0.0611 0.0738 0.0738
Echinococcus multilocularis protoporphyrinogen oxidase 0.0069 0.0055 0.0069
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0085 0.0075 0.2007
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0611 0.0738 0.0734
Loa Loa (eye worm) integrin alpha pat-2 0.2295 0.286 0.2857
Echinococcus multilocularis integrin alpha ps 0.0392 0.0462 0.0619
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Schistosoma mansoni hypothetical protein 0.0041 0.002 0.0017
Loa Loa (eye worm) fatty acid synthase 0.0081 0.0071 0.0066
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.006 0.0044 0.0039
Mycobacterium tuberculosis Conserved hypothetical protein 0.0069 0.0055 0.1482
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Brugia malayi Protein-tyrosine phosphatase 1 0.004 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0069 0.0055 0.0055
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.004 0.0018 0.0018
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.004 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.0374 0.0657
Echinococcus multilocularis glutamate receptor 2 0.0051 0.0032 0.0038
Loa Loa (eye worm) hypothetical protein 0.1221 0.1506 0.1502
Trichomonas vaginalis conserved hypothetical protein 0.1457 0.1804 0.32
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.004 0.0018 0.0018
Echinococcus granulosus discoidin domain containing receptor 2 0.0032 0.0008 0.0004
Plasmodium falciparum plasmepsin IX 0.0034 0.0011 0.0073
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Mycobacterium ulcerans fatty acid synthase Fas 0.0026 0.0001 0.0019
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0045 0.0024 0.0027
Brugia malayi proprotein convertase 2 0.4644 0.5819 0.5819
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.004 0.0018 0.0018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0065 0.005 0.1326
Giardia lamblia Neurogenic locus notch-like protein 0.0187 0.0203 0.0588
Brugia malayi Eukaryotic aspartyl protease family protein 0.0034 0.0011 0.0011
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.004 0.0018 0.0018
Trypanosoma cruzi oligopeptidase b 0.0052 0.0034 0.0408
Onchocerca volvulus 0.004 0.0018 0.024
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0069 0.0055 0.126
Echinococcus granulosus prolyl endopeptidase 0.0131 0.0133 0.0139
Loa Loa (eye worm) hypothetical protein 0.7357 0.9237 0.9237
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0052 0.0033 0.089
Loa Loa (eye worm) hypothetical protein 0.0458 0.0545 0.0541
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0007
Brugia malayi Dual specificity protein phosphatase CDC14B 0.004 0.0018 0.0018
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.003 0.0028
Schistosoma mansoni growth factor receptor-bound protein 0.0124 0.0124 0.013
Schistosoma mansoni protein tyrosine phosphatase 0.004 0.0018 0.0015
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0051 0.0032 0.0038
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Schistosoma mansoni tyrosine kinase 0.0387 0.0456 0.0489
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0064 0.006
Brugia malayi Glutamate receptor 2 precursor 0.0034 0.0011 0.0011
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1457 0.1804 0.32
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0047 0.0027 0.0727
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0087 0.0077 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0064 0.006
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.0046
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0021 0.0401
Onchocerca volvulus 4.1 G protein, putative homolog 0.004 0.0018 0.024
Brugia malayi amine oxidase, flavin-containing family protein 0.0098 0.0092 0.0092
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0335 0.039 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.004 0.0018 0.0018
Mycobacterium tuberculosis Polyketide synthase Pks2 0.008 0.0069 0.1843
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0322 0.0374 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Toxoplasma gondii subtilisin SUB2 0.0322 0.0374 0.9124
Loa Loa (eye worm) WD40 repeat protein 0.0131 0.0133 0.0129
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0018
Giardia lamblia Hypothetical protein 0.0335 0.039 0.1142
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0032 0.0008 0.0006
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0227 0.0254 0.027
Onchocerca volvulus 0.004 0.0018 0.024
Brugia malayi Will die slowly protein 0.0131 0.0133 0.0133
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.0046
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Brugia malayi Reprolysin 0.0133 0.0135 0.0135
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Toxoplasma gondii subtilisin SUB11 0.0322 0.0374 0.9124
Toxoplasma gondii histone lysine-specific demethylase 0.0069 0.0055 0.126
Plasmodium falciparum subtilisin-like protease 2 0.0322 0.0374 0.8233
Toxoplasma gondii subtilisin SUB5 0.0322 0.0374 0.9124
Onchocerca volvulus 0.004 0.0018 0.024
Giardia lamblia High cysteine protein 0.0187 0.0203 0.0588
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Trichomonas vaginalis conserved hypothetical protein 0.1457 0.1804 0.32
Onchocerca volvulus 0.004 0.0018 0.024
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Trichomonas vaginalis hypothetical protein 0.0187 0.0203 0.0354
Loa Loa (eye worm) hypothetical protein 0.0063 0.0047 0.0043
Entamoeba histolytica protein tyrosine phosphatase, putative 0.004 0.0018 0.0354
Brugia malayi Glutamate receptor 1 precursor 0.0034 0.0011 0.0011
Onchocerca volvulus 0.004 0.0018 0.024
Mycobacterium ulcerans Type I modular polyketide synthase 0.008 0.0069 0.1834
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.004 0.0018 0.0015
Echinococcus multilocularis membrane bound transcription factor site 1 0.0322 0.0374 0.0499
Mycobacterium leprae Possible secreted protease 0.0322 0.0374 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0044 0.0039
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0069 0.0055 0.1482
Brugia malayi hypothetical protein 0.0069 0.0055 0.0055
Loa Loa (eye worm) transcriptional regulator 0.0049 0.003 0.0026
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0045 0.0024 0.0027
Schistosoma mansoni furin-1 (S08 family) 0.3186 0.3982 0.4308
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Toxoplasma gondii PA14 domain-containing protein 0.0032 0.0008 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0341 0.0397 1
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0322 0.0374 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0051 0.0032 0.003
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0049 0.003 0.0028
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0285 0.0327 0.0436
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.004 0.0018 0.0018
Echinococcus granulosus serine:threonine protein kinase N2 0.0069 0.0054 0.0054
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0069 0.0055 0.107
Plasmodium falciparum plasmepsin IV 0.0034 0.0011 0.0073
Brugia malayi prolyl oligopeptidase family protein 0.0131 0.0133 0.0133
Schistosoma mansoni integrin alpha-ps 0.0818 0.0999 0.1077
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.003 0.0028
Leishmania major subtilisin-like serine peptidase 0.0322 0.0374 0.9551
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0052 0.0034 0.088
Echinococcus multilocularis MAM 0.0069 0.0055 0.0068
Loa Loa (eye worm) hypothetical protein 0.0049 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.2864 0.3577 0.3574
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0322 0.0374 1
Echinococcus multilocularis NMDA receptor 0.0034 0.0011 0.0008
Toxoplasma gondii aspartyl protease ASP5 0.035 0.0409 1
Loa Loa (eye worm) acyl carrier protein 0.0038 0.0016 0.0011
Onchocerca volvulus 0.0077 0.0065 0.1346
Onchocerca volvulus 0.004 0.0018 0.024
Echinococcus multilocularis protein will die slowly 0.0131 0.0133 0.0174
Brugia malayi angiogenesis inhibito 0.0133 0.0135 0.0135
Echinococcus multilocularis fibrillin 2 0.0187 0.0203 0.0269
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0322 0.0374 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.0018 0.0018
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.0046
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0049 0.003 0.0035
Mycobacterium ulcerans Sir2-like regulatory protein 0.0049 0.003 0.0812
Onchocerca volvulus Fatty acid synthase homolog 0.0149 0.0156 0.3465
Onchocerca volvulus 0.004 0.0018 0.024
Loa Loa (eye worm) hypothetical protein 0.0062 0.0046 0.0041
Schistosoma mansoni discoidin domain receptor 0.0032 0.0008 0.0004
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0032 0.0008 0.0004
Brugia malayi hypothetical protein 0.0034 0.0011 0.0011
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0034 0.0011 0.0007
Toxoplasma gondii subtilisin SUB4 0.0322 0.0374 0.9124
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Trypanosoma brucei prolyl oligopeptidase, putative 0.0052 0.0034 0.0408
Brugia malayi hypothetical protein 0.1221 0.1506 0.1506
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0011 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Giardia lamblia Sirtuin type 2 0.0049 0.003 0.0077
Brugia malayi aspartic protease BmAsp-2, identical 0.0034 0.0011 0.0011
Plasmodium falciparum plasmepsin VIII, putative 0.0034 0.0011 0.0073
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0018 0.0015
Plasmodium vivax aspartyl protease, putative 0.0034 0.0011 0.0073
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0335 0.039 0.9819
Trichomonas vaginalis conserved hypothetical protein 0.1457 0.1804 0.32
Trichomonas vaginalis conserved hypothetical protein 0.1457 0.1804 0.32
Echinococcus multilocularis glutamate receptor 2 0.0034 0.0011 0.0008
Onchocerca volvulus 0.0322 0.0374 0.8579
Mycobacterium ulcerans thioesterase TesA 0.0069 0.0055 0.1464
Schistosoma mansoni discoidin domain receptor 0.0032 0.0008 0.0004
Giardia lamblia Protein tyrosine phosphatase 0.004 0.0018 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.0374 0.0657
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0085 0.0075 0.2007
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0049 0.003 0.0077
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0011 0.0007
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0341 0.0397 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.008 0.0069 0.1834
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.007 0.0056 0.0052
Echinococcus multilocularis 0.5899 0.7401 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.0018 0.0018
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0059 0.0043 0.1144
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Brugia malayi Protein-tyrosine phosphatase 0.004 0.0018 0.0018
Giardia lamblia High cysteine protein 0.0187 0.0203 0.0588
Brugia malayi SWIRM domain containing protein 0.037 0.0434 0.0434
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Onchocerca volvulus 0.004 0.0018 0.024
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.0018 0.0015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0007
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0322 0.0374 0.0499
Echinococcus granulosus adam 17 protease 0.0094 0.0087 0.0089
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0094 0.0087 0.0111
Brugia malayi NAD-dependent deacetylase SIRT1 0.0049 0.003 0.003
Echinococcus multilocularis integrin alpha ps 0.0818 0.0999 0.1344
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0322 0.0374 0.0374
Loa Loa (eye worm) reprolysin 0.0227 0.0254 0.025
Onchocerca volvulus 0.004 0.0018 0.024
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0034 0.0011 0.0008
Onchocerca volvulus 0.004 0.0018 0.024
Mycobacterium tuberculosis Probable thioesterase TesA 0.0069 0.0055 0.1464
Loa Loa (eye worm) sirtuin 4 0.0049 0.003 0.0026
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0011 0.0007
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0341 0.0398 0.0426
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0227 0.0254 0.027
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0049 0.003 0.0035
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0049 0.003 0.0035
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0063 0.0047 0.0046
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0077 0.0065 0.1745
Echinococcus multilocularis discoidin domain containing receptor 2 0.0032 0.0008 0.0005
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0049 0.003 0.033
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0034 0.0011 0.0007
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0033 0.001 0.027
Onchocerca volvulus 0.004 0.0018 0.024
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0045 0.0024 0.0022
Brugia malayi Integrin alpha cytoplasmic region family protein 0.1132 0.1394 0.1394
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0059 0.0042 0.0051
Echinococcus multilocularis serine:threonine protein kinase N2 0.0077 0.0065 0.0082
Schistosoma mansoni integrin beta subunit 0.4659 0.5838 0.6318
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0117 0.0115 0.3089
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1567 0.1942 0.2099
Trichomonas vaginalis conserved hypothetical protein 0.1457 0.1804 0.32
Echinococcus multilocularis growth factor receptor bound protein 2 0.0124 0.0124 0.0162
Mycobacterium leprae Probable polyketide synthase Pks1 0.0085 0.0075 0.1992
Giardia lamblia Neurogenic locus Notch protein precursor 0.0187 0.0203 0.0588
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0227 0.0254 0.0337
Echinococcus granulosus furin 0.7357 0.9237 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1779 0.221 0.3922
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.004 0.0018 0.0015
Toxoplasma gondii aspartyl protease ASP3 0.0034 0.0011 0.0165
Echinococcus multilocularis nmda type glutamate receptor 0.012 0.012 0.0156
Loa Loa (eye worm) hypothetical protein 0.1229 0.1517 0.1513
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Mycobacterium ulcerans polyketide synthase Pks9 0.0052 0.0033 0.089
Echinococcus granulosus lysine specific histone demethylase 1A 0.0341 0.0398 0.0426
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.004 0.0018 0.0018
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.003 0.0046
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.003 0.0028
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0045 0.0024 0.002
Toxoplasma gondii F5/8 type C domain-containing protein 0.0032 0.0008 0.0085
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.008 0.0069 0.0069
Onchocerca volvulus 0.0187 0.0203 0.4582
Loa Loa (eye worm) hypothetical protein 0.0069 0.0055 0.0051
Plasmodium vivax plasmepsin V, putative 0.0384 0.0452 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.0018 0.0015
Brugia malayi metalloprotease 0.0063 0.0047 0.0047
Leishmania major UDP-galactopyranose mutase 0.0069 0.0055 0.1002
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0084 0.0074 0.007
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0064 0.0065
Loa Loa (eye worm) hypothetical protein 0.0131 0.0133 0.0128
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0322 0.0374 1
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0034 0.0011 0.0165
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0322 0.0374 0.04
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0085 0.0075 0.1992
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.004 0.0018 0.0015
Plasmodium vivax plasmepsin IV, putative 0.0034 0.0011 0.0073
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1567 0.1942 0.1942
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0064 0.0065
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0018 0.0015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.4493 0.5629 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.004 0.0018 0.0015
Trichomonas vaginalis WD repeat domain, putative 0.0131 0.0133 0.0229
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.004 0.0018 0.0015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Echinococcus granulosus fibrillin 1 0.0188 0.0205 0.0217
Leishmania major sir2-family protein-like protein 0.0049 0.003 0.033
Onchocerca volvulus 0.004 0.0018 0.024
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0227 0.0254 0.027
Echinococcus granulosus chromatin regulatory protein sir2 0.0335 0.039 0.0418
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0007
Echinococcus granulosus nmda type glutamate receptor 0.012 0.012 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.0374 0.0657
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0032 0.0008 0.021
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0051 0.0032 0.003
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0064 0.0081
Loa Loa (eye worm) hypothetical protein 0.0322 0.0374 0.037
Onchocerca volvulus 0.0069 0.0055 0.1103
Schistosoma mansoni glutamate receptor kainate 0.0034 0.0011 0.0007
Echinococcus multilocularis integrin beta 2 0.588 0.7376 0.9966
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.004 0.0018 0.0015
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0052 0.0034 0.0408
Loa Loa (eye worm) angiogenesis inhibito 0.0063 0.0047 0.0043
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.004 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0041 0.002 0.0015
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0052 0.0034 0.0897
Brugia malayi EGF-like domain containing protein 0.0187 0.0203 0.0203
Mycobacterium ulcerans polyketide synthase 0.0085 0.0075 0.2007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0007
Schistosoma mansoni amine oxidase 0.0069 0.0055 0.0055
Mycobacterium ulcerans oxidoreductase 0.0069 0.0055 0.1482
Brugia malayi Protein-tyrosine phosphatase 0.004 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0007
Schistosoma mansoni protein kinase 0.0127 0.0128 0.0134
Echinococcus granulosus growth factor receptor bound protein 2 0.0124 0.0124 0.013
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Echinococcus multilocularis integrin alpha ps 0.0884 0.1081 0.1456
Echinococcus granulosus lysine specific histone demethylase 1A 0.0069 0.0055 0.0055
Loa Loa (eye worm) protein tyrosine phosphatase 0.004 0.0018 0.0014
Giardia lamblia Tenascin precursor 0.0187 0.0203 0.0588
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0052 0.0033 0.0874
Trichomonas vaginalis pten, drome, putative 0.004 0.0018 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Giardia lamblia Furin precursor putative serine protease 0.1457 0.1804 0.5322
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0124 0.0124 0.012
Schistosoma mansoni septate junction protein 0.0032 0.0008 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0322 0.0374 0.0657
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.1457 0.1804 0.32
Toxoplasma gondii histone deacetylase SIR2-like 0.0049 0.003 0.0641
Echinococcus multilocularis protein kinase c epsilon type 0.0084 0.0074 0.0094
Loa Loa (eye worm) hypothetical protein 0.0066 0.0051 0.0046
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0049 0.003 0.0324
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Schistosoma mansoni btb and poz domain-containing protein 0.0032 0.0008 0.0004
Echinococcus multilocularis Furin 1 0.1779 0.221 0.2982
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0131 0.0133 0.0139
Schistosoma mansoni growth factor receptor-bound protein 0.0124 0.0124 0.013
Schistosoma mansoni memapsin-2 (A01 family) 0.0034 0.0011 0.0007
Brugia malayi hypothetical protein 0.004 0.0018 0.0018
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0051 0.0032 0.003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Loa Loa (eye worm) hypothetical protein 0.1132 0.1394 0.139
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0051 0.0032 0.0038
Echinococcus granulosus adam 0.0484 0.0577 0.062
Loa Loa (eye worm) glutamate receptor 1 0.0034 0.0011 0.0006
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0322 0.0374 0.04
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0049 0.003 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Echinococcus multilocularis prolyl endopeptidase 0.0131 0.0133 0.0174
Loa Loa (eye worm) apoptosis regulator protein 0.0059 0.0042 0.0038
Echinococcus granulosus protein will die slowly 0.0131 0.0133 0.014
Trypanosoma brucei SIR2-like protein 4, putative 0.0049 0.003 0.0324
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0064 0.0048 0.129
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0052 0.0034 0.0897
Onchocerca volvulus 0.004 0.0018 0.024
Echinococcus granulosus tar DNA binding protein 0.0076 0.0064 0.0065
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0131 0.0133 0.0139
Echinococcus granulosus glutamate receptor 2 0.0051 0.0032 0.003
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0049 0.003 0.0324
Trypanosoma cruzi subtilisin peptidase 0.0322 0.0374 0.9378
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Loa Loa (eye worm) hypothetical protein 0.0133 0.0135 0.0131
Mycobacterium tuberculosis Probable peptidase 0.0052 0.0034 0.0897
Echinococcus granulosus glutamate NMDA receptor subunit 0.0285 0.0327 0.0349
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0032 0.0008 0.0006
Mycobacterium ulcerans Type I modular polyketide synthase 0.008 0.0069 0.1834
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0045 0.0024 0.0022
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0087 0.0077 0.206
Plasmodium falciparum plasmepsin III 0.0034 0.0011 0.0073
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0069 0.0055 0.1482
Loa Loa (eye worm) hypothetical protein 0.0094 0.0087 0.0082
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0087 0.0077 0.5
Onchocerca volvulus 0.0144 0.0149 0.3313
Echinococcus granulosus epidermal growth factor receptor 0.0387 0.0456 0.0489
Mycobacterium ulcerans NAD-dependent deacetylase 0.0049 0.003 0.0812
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0085 0.0075 0.2007
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0064 0.0048 0.129
Brugia malayi hypothetical protein 0.0069 0.0055 0.0055
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0011 0.0007
Schistosoma mansoni hypothetical protein 0.1457 0.1804 0.1949
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.008 0.0069 0.1818
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0049 0.003 0.0324
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0131 0.0133 0.014
Trypanosoma cruzi UDP-galactopyranose mutase 0.0069 0.0055 0.0984
Toxoplasma gondii subtilisin SUB1 0.0322 0.0374 0.9124
Trichomonas vaginalis conserved hypothetical protein 0.1457 0.1804 0.32
Schistosoma mansoni integrin alpha 0.1621 0.2011 0.2173
Loa Loa (eye worm) transcriptional regulator 0.0049 0.003 0.0026
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0121 0.012 0.3211
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Plasmodium falciparum plasmepsin VI 0.0034 0.0011 0.0073
Schistosoma mansoni integrin alpha-ps 0.0492 0.0587 0.0631
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0335 0.039 0.9819
Echinococcus multilocularis protein jagged 2 0.0187 0.0203 0.0269
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0341 0.0397 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.004 0.0018 0.0018
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1567 0.1942 0.2099
Loa Loa (eye worm) subtilase 0.0322 0.0374 0.037
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0008 0.0006
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0054 0.0036 0.0769
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0064 0.0065
Loa Loa (eye worm) aspartyl protease 6 0.0034 0.0011 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0044 0.0044
Echinococcus multilocularis 0.004 0.0018 0.0018
Plasmodium vivax subtilisin-like protease 1 0.0322 0.0374 0.8233
Plasmodium falciparum plasmepsin I 0.0034 0.0011 0.0073
Loa Loa (eye worm) hypothetical protein 0.0341 0.0398 0.0394
Brugia malayi hypothetical protein 0.0297 0.0342 0.0342
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0034 0.0011 0.0009
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1779 0.221 0.3922
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0026 0 0.0006
Schistosoma mansoni rgs-gaip interacting protein gipc 0.004 0.0018 0.0015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Loa Loa (eye worm) hypothetical protein 0.004 0.0018 0.0014
Plasmodium vivax subtilisin-like serine protease, putative 0.0322 0.0374 0.8233
Leishmania major oligopeptidase b 0.0052 0.0034 0.0415
Brugia malayi Disintegrin family protein 0.0094 0.0087 0.0087
Onchocerca volvulus 0.004 0.0018 0.024
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0055 0.107
Schistosoma mansoni protein tyrosine phosphatase 0.004 0.0018 0.0015
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.004 0.0018 0.0018
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0069 0.0055 0.1448
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0069 0.0055 0.107
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.008 0.0069 0.1843
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0034 0.0011 0.0007
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.004 0.0018 0.0018
Trypanosoma cruzi UDP-galactopyranose mutase 0.0069 0.0055 0.0984
Schistosoma mansoni hypothetical protein 0.0032 0.0008 0.0004
Loa Loa (eye worm) hypothetical protein 0.0341 0.0398 0.0394
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.004 0.0018 0.0015
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0059 0.0042 0.0041
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0011 0.0007
Brugia malayi ADAM-TS Spacer 1 family protein 0.0133 0.0135 0.0135
Echinococcus multilocularis fibrillin 1 0.0188 0.0205 0.0271
Schistosoma mansoni apoptosis regulator bax 0.0059 0.0042 0.0041
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.008 0.0069 0.1834
Echinococcus multilocularis protein tyrosine phosphatase n9 0.004 0.0018 0.0018
Onchocerca volvulus 0.004 0.0018 0.024
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0085 0.0075 0.2007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Onchocerca volvulus 0.0034 0.0011 0.0076
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0322 0.0374 0.0657
Schistosoma mansoni glutamate receptor AMPA 0.0034 0.0011 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0049 0.003 0.0506
Plasmodium vivax aspartyl protease, putative 0.0034 0.0011 0.0073
Schistosoma mansoni hypothetical protein 0.0059 0.0042 0.0041
Loa Loa (eye worm) proprotein convertase 2 0.1779 0.221 0.2207
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0322 0.0374 1
Brugia malayi hypothetical protein 0.004 0.0018 0.0018
Brugia malayi TAR-binding protein 0.0076 0.0064 0.0064
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0335 0.039 0.0418
Loa Loa (eye worm) metalloprotease 0.0063 0.0047 0.0043
Schistosoma mansoni protein kinase 0.0127 0.0128 0.0134
Loa Loa (eye worm) protein-tyrosine phosphatase 0.004 0.0018 0.0014
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.004 0.0018 0.0015
Brugia malayi RNA binding protein 0.0076 0.0064 0.0064
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0322 0.0374 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.