TDR Targets

Basic information

Technical information

TDR Targets ID: 866758
Name: methyl 2-[[2-(3-methoxyphenyl)-1-oxoisoquinol ine-4-carbonyl]amino]benzoate
MW: 428.437 | Formula: C25H20N2O5
H donors: 1 H acceptors: 3 LogP: 4 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1)n1cc(C(=O)Nc2ccccc2C(=O)OC)c2c(c1=O)cccc2
InChi: 1S/C25H20N2O5/c1-31-17-9-7-8-16(14-17)27-15-21(18-10-3-4-11-19(18)24(27)29)23(28)26-22-13-6-5-12-20(22)25(30)32-2/h3-15H,1-2H3,(H,26,28)
InChiKey: QWSPBDCHCBCPBE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

methyl 2-[[2-(3-methoxyphenyl)-1-oxo-isoquinoline-4-carbonyl]amino]benzoate
2-[[[2-(3-methoxyphenyl)-1-oxo-4-isoquinolyl]-oxomethyl]amino]benzoic acid methyl ester
2-[[1-keto-2-(3-methoxyphenyl)isoquinoline-4-carbonyl]amino]benzoic acid methyl ester
methyl 2-[[2-(3-methoxyphenyl)-1-oxo-isoquinolin-4-yl]carbonylamino]benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cathepsin L cysteine protease	0.0093	0.0271	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0069	0.012	0.0046
Echinococcus granulosus	cathepsin l1	0.0093	0.0271	0.0198
Onchocerca volvulus		0.0093	0.0271	0.8662
Leishmania major	cathepsin L-like protease	0.0093	0.0271	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Entamoeba histolytica	cysteine proteinase, putative	0.0093	0.0271	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0501	0.2886	0.5479
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0082	0.0199	0.5
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0082	0.0199	0.0125
Trichomonas vaginalis	conserved hypothetical protein	0.0082	0.0199	0.0242
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.0271	0.0383
Leishmania major	cysteine peptidase A (CPA)	0.0093	0.0271	1
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.204	0.3831
Giardia lamblia	Furin precursor putative serine protease	0.042	0.2364	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.0271	0.0383
Echinococcus multilocularis	Furin 1	0.0501	0.2886	0.3682
Onchocerca volvulus		0.0093	0.0271	0.8662
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Trypanosoma cruzi	cysteine peptidase, putative	0.0093	0.0271	1
Mycobacterium leprae	Possible secreted protease	0.0082	0.0199	0.5
Loa Loa (eye worm)	hypothetical protein	0.0799	0.4793	0.4754
Trichomonas vaginalis	conserved hypothetical protein	0.0082	0.0199	0.0242
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0082	0.0199	0.5
Onchocerca volvulus		0.0093	0.0271	0.8662
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Schistosoma mansoni	hypothetical protein	0.0369	0.204	0.1981
Entamoeba histolytica	cysteine proteinase, putative	0.0093	0.0271	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0093	0.0271	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0501	0.2886	0.5479
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.0271	0.0383
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.0271	1
Echinococcus granulosus	membrane bound transcription factor site 1	0.0082	0.0199	0.0125
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Brugia malayi	Cathepsin L-like precursor	0.0093	0.0271	0.0198
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Trichomonas vaginalis	conserved hypothetical protein	0.0069	0.012	0.0089
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0082	0.0199	0.014
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Echinococcus granulosus	wd40 repeat	0.0069	0.012	0.0046
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.204	0.3831
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.0271	1
Onchocerca volvulus		0.0062	0.0074	0.2376
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0082	0.0199	0.0125
Onchocerca volvulus	Cathepsin L homolog	0.0093	0.0271	0.8662
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0082	0.0199	0.5
Onchocerca volvulus		0.0082	0.0199	0.6351
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Schistosoma mansoni	tyrosine kinase	0.0265	0.1372	0.1307
Plasmodium vivax	vivapain-2	0.0093	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.037	0.2043	0.1984
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0224	0.111	0.1043
Entamoeba histolytica	cysteine protease, putative	0.0093	0.0271	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0093	0.0271	0.0198
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0132	0.0522	0.0872
Echinococcus multilocularis		0.1243	0.7636	0.9942
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0501	0.2886	0.5479
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0313	0.024
Brugia malayi	Cathepsin L-like precursor	0.0093	0.0271	0.0198
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.0271	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0093	0.0271	0.0198
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0082	0.0199	0.6324
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.204	0.3831
Trypanosoma cruzi	cruzipain precursor, putative	0.0093	0.0271	1
Loa Loa (eye worm)	ctsf protein	0.0093	0.0271	0.0198
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.0271	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0501	0.2886	0.5479
Echinococcus granulosus	epidermal growth factor receptor	0.0265	0.1372	0.1307
Onchocerca volvulus		0.0065	0.0093	0.2963
Brugia malayi	proprotein convertase 2	0.125	0.768	0.7662
Trichomonas vaginalis	retinoblastoma binding protein, putative	0.0069	0.012	0.0089
Echinococcus granulosus	protein will die slowly	0.0065	0.0093	0.0018
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.1612	1	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0265	0.1372	0.1307
Loa Loa (eye worm)	endoprotease bli-4	0.1612	1	1
Trypanosoma cruzi	serine peptidase, clan SB, family S8-like protein	0.0082	0.0199	0.6324
Schistosoma mansoni	retinoblastoma binding protein	0.0069	0.012	0.0046
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.0271	1
Onchocerca volvulus		0.0093	0.0271	0.8662
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.0271	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.0271	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Trichomonas vaginalis	conserved hypothetical protein	0.0082	0.0199	0.0242
Brugia malayi	celfurPC protein	0.1243	0.7636	0.7618
Plasmodium vivax	vivapain-2	0.0093	0.0271	1
Trichomonas vaginalis	hypothetical protein	0.0369	0.204	0.3831
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.042	0.2364	0.4461
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.0271	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0369	0.204	0.3831
Echinococcus multilocularis	neuroendocrine convertase 2	0.125	0.768	1
Onchocerca volvulus		0.0091	0.0256	0.819
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.0271	0.0383
Brugia malayi	Will die slowly protein	0.0065	0.0093	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0093	0.0271	0.0383
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0501	0.2886	0.5479
Leishmania major	cathepsin L-like protease	0.0093	0.0271	1
Toxoplasma gondii	cathepsin CPL	0.0093	0.0271	1
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0082	0.0199	0.5
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0082	0.0199	0.0125
Echinococcus granulosus	Furin 1	0.0501	0.2886	0.2833
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Brugia malayi	Subtilase family protein	0.0082	0.0199	0.0125
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0082	0.0199	0.5
Leishmania major	cathepsin L-like protease	0.0093	0.0271	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.0271	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0099	0.0313	0.024
Echinococcus multilocularis	wd40 repeat	0.0069	0.012	0.0036
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0093	0.0271	0.0235
Loa Loa (eye worm)	proprotein convertase 2	0.0501	0.2886	0.2833
Leishmania major	cathepsin L-like protease	0.0093	0.0271	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0313	0.024
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0863	0.5206	1
Loa Loa (eye worm)	subtilase	0.0082	0.0199	0.0125
Loa Loa (eye worm)	hypothetical protein	0.1612	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.204	0.3831
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.204	0.3831
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0265	0.1372	0.1307
Schistosoma mansoni	hypothetical protein	0.0065	0.0093	0.0018
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Loa Loa (eye worm)	cysteine protease	0.0093	0.0271	0.0198
Brugia malayi	neuroendocrine convertase 1 precursor	0.1569	0.9723	0.9721
Loa Loa (eye worm)	WD40 repeat protein	0.0065	0.0093	0.0018
Onchocerca volvulus	Cathepsin F homolog	0.0093	0.0271	0.8662
Trichomonas vaginalis	conserved hypothetical protein	0.0082	0.0199	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0199	0.0125
Trypanosoma cruzi	cysteine peptidase, putative	0.0093	0.0271	1
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.204	0.3831
Loa Loa (eye worm)	fibroinase	0.0093	0.0271	0.0198
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0082	0.0199	0.5
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0082	0.0199	0.5
Onchocerca volvulus		0.0093	0.0271	0.8662
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0082	0.0199	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Schistosoma mansoni	cathepsin F (C01 family)	0.0093	0.0271	0.0198
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.042	0.2364	0.4461
Trypanosoma cruzi	subtilisin peptidase	0.0082	0.0199	0.6324
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0093	0.0271	0.0383
Echinococcus multilocularis	cysteine protease	0.0093	0.0271	0.0235
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Leishmania major	cathepsin L-like protease	0.0093	0.0271	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0863	0.5206	1
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.204	0.3831
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.204	0.3831
Onchocerca volvulus		0.0099	0.0313	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Onchocerca volvulus		0.0093	0.0271	0.8662
Brugia malayi	Hypothetical WD-repeat protein F21H12.1 in chromosome II	0.0069	0.012	0.0046
Onchocerca volvulus		0.0093	0.0271	0.8662
Echinococcus multilocularis	cysteine protease	0.0093	0.0271	0.0235
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Leishmania major	cathepsin L-like protease	0.0093	0.0271	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0093	0.0271	0.0198
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Trypanosoma cruzi	cysteine peptidase, putative	0.0093	0.0271	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0093	0.0271	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0271	0.0198
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Trichomonas vaginalis	WD repeat domain, putative	0.0065	0.0093	0.0036
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0863	0.5206	0.674
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Brugia malayi	Cathepsin L-like precursor	0.0093	0.0271	0.0198
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0224	0.111	0.134
Brugia malayi	Cathepsin L-like precursor	0.0093	0.0271	0.0198
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Trichomonas vaginalis	conserved hypothetical protein	0.0082	0.0199	0.0242
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.204	0.3831
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.0271	0.0383
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0093	0.0271	0.0235
Echinococcus granulosus	neuroendocrine convertase 2	0.125	0.768	0.7662
Loa Loa (eye worm)	hypothetical protein	0.0224	0.111	0.1043
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0093	0.0271	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0501	0.2886	0.5479
Echinococcus granulosus	furin	0.1612	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.0271	0.0383
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.0271	0.0383
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.0271	0.0383
Onchocerca volvulus	Cathepsin L homolog	0.0093	0.0271	0.8662
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.204	0.3831
Brugia malayi	Cathepsin L-like precursor	0.0093	0.0271	0.0198
Schistosoma mansoni	site-1 peptidase (S08 family)	0.0082	0.0199	0.0125
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0093	0.0271	0.0198
Leishmania major	cathepsin L-like protease	0.0093	0.0271	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0224	0.111	0.1043
Trichomonas vaginalis	conserved hypothetical protein	0.0369	0.204	0.3831
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0863	0.5206	0.517
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0093	0.0271	0.0383
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0082	0.0199	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0082	0.0199	0.0125
Brugia malayi	Trypsin family protein	0.0099	0.0313	0.024
Trypanosoma cruzi	cysteine peptidase, putative	0.0093	0.0271	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0093	0.0271	0.0383
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0093	0.0271	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.0271	1
Brugia malayi	Papain family cysteine protease containing protein	0.0093	0.0271	0.0198
Echinococcus multilocularis	epidermal growth factor receptor	0.0265	0.1372	0.1686
Echinococcus multilocularis	cathepsin L cysteine protease	0.0093	0.0271	0.0235
Schistosoma mansoni	furin-1 (S08 family)	0.083	0.4992	0.4955
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0093	0.0271	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0099	0.0313	0.024
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0132	0.0522	0.0451
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0082	0.0199	0.0242
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0082	0.0199	0.014
Brugia malayi	Cathepsin L-like precursor	0.0093	0.0271	0.0198
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0082	0.0199	0.0125
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0501	0.2886	0.2833
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0082	0.0199	0.6324
Leishmania major	cathepsin L-like protease	0.0093	0.0271	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 866758